Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

Journal of Virology

Volumn 71, Issue 8, 1997, Pages 6011-6019

  Diepolder, Helmut M ^a,b   Gerlach, Jörn Tilman ^b   Zachoval, Reinhart ^a   Hoffmann, Robert M ^a,b   Jung, Maria Christina ^a,b   Wierenga, Eddy A ^c   Scholz, Siegfried ^b   Santantonio, Teresa ^d   Houghton, Michael ^e   Southwood, Scott ^f   Sette, Alessandro ^f   Pape, Gerd R ^a,b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UNIVERSITY OF BARI   (Italy)

^e NOVARTIS PHARMA AG   (Switzerland)

^f CYTEL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN;

ALLELE; ARTICLE; CHRONIC DISEASE; HEPATITIS C VIRUS; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNE SYSTEM; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

EID: 0030790664     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.8.6011-6019.1997     Document Type: Article

References (25)

1. Alter, M. J. 1995. Epidemiology of hepatitis C in the West. Semin. Liver Dis. 15:5-14.
2. Alter, M. J., H. S. Margolis, K. Krawczynski, F. N. Judson, A. Mares, W. J. Alexander, P. Y. Hu, J. K. Miller, M. A. Gerber, R. E. Sampliner, E. L. Meeks, and M. J. Beach. 1992. The natural history of community-acquired hepatitis C in the United States. N. Engl. J. Med. 327:1899-1905.
3. Botarelli, P., M. R. Brunetto, M. A. Minutello, P. Calvo, D. Unutmaz, A. J. Weiner, Q.-L. Choo, J. R. Shuster, G. Kuo, F. Bonino, M. Houghton, and S. Abrignani. 1993. T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology 104:580-587.
4. Buus, S., A. Sette, S. M. Colon, and H. M. Grey. 1988. Autologous peptides constitutively occupy the antigen binding site on Ia. Science 242:1045-1047.
5. Diepolder, H. M., et al. Unpublished data.
6. Diepolder, H. M., R. Zachoval, R. M. Hoffmann, E. A. Wierenga, T. Santantonio, M. C. Jung, D. Eichenlaub, and G. R. Pape. 1995. Possible mechanism involving T-lymphocyte response to nonstructural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346:1006-1007.
7. Falk, K., O. Rötzschke, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1994. Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules. Immunogenetics 39:230-242.
8. Ferrari, C., A. Valli, L. Galati, A. Penna, P. Scaccaglia, T. Giuberti, C. Schianchi, G. Missale, M. G. Marin, and F. Fiaccadori. 1994. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology 19:286-295.
9. Gorga, J. C., V. Horejsí, D. R. Johnson, R. Raghupathy, and J. L. Strominger. 1987. Purification and characterization of class II histocompatibility antigens from a heterozygous human B cell line. J. Biol. Chem. 262: 16087-16094.
10. + lymphocytes expressing CD45RO and CD45RA. J. Immunol. Methods 163:173-179.
11. + T cells anergized by high dose feeding establish oral tolerance to antibody responses when transferred in SCID and nude mice. J. Immunol. 154:6238-6245.
12. + T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection. Hepatology 21: 632-638.
13. Kimura, A., R. P. Dong, H. Harada, and T. Sasazuki. 1992. DNA typing of HLA class II genes in B-lymphoblastoid cell lines homozygous for HLA. Tissue Antigens 40:5-12.
14. Kimura, A., and T. Sasazuki. 1992. 11th International Histocompatibility Workshop reference protocol for the HLA DNA typing technique, p. 397-419. In K. Tsuji, M. Aizawa, and T. Sasazuki (ed.), HLA 1991. Oxford University Press, Oxford, United Kingdom.
15. Kuo, G., Q. L. Choo, H. J. Alter, G. L. Gitnick, A. G. Redeker, R. H. Purcell, T. Miyamura, J. L. Dienstag, M. J. Alter, C. E. Stevens, G. E. Tegtmeier, F. Bonino, M. Colombo, W. S. Lee, C. Kuo, K. Berger, J. R. Shuster, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362.
16. Mansell, C. J., and S. A. Locarnini. 1995. Epidemiology of hepatitis C in the East. Semin. Liver Dis. 15:15-32.
17. Missale, G., R. Bertoni, V. Lamonaca, A. Valli, M. Massari, C. Mori, M. G. Rumi, M. Houghton, F. Fiaccadori, and C. Ferrari. 1996. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Invest. 98: 706-714.
18. Moskophidis, D., F. Lechner, H. Pircher, and R. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector cells. Nature 362:758-761.
19. Nevinny-Stickel, C., M. P. Bettinotti, A. Andreas, M. Hinzpeter, K. Mühlegger, G. Schmitz, and E. D. Albert. 1991. Nonradioactive HLA class II typing using polymerase chain reaction and digoxigenin-11-2′-3′-dideoxy-uridine-triphosphate labeled oligonucleotide probes. Hum. Immunol. 31:7-13.
20. O'Sullivan, D., T. Arrhenius, J. Sidney, M. F. Del Guercio, M. Albertson, M. Wall, C. Oseroff, S. Southwood, S. M. Colon, F. C. A. Gaeta, and A. Sette. 1991. On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs. J. Immunol. 147: 2663-2669.
21. Sette, A., S. Buus, S. Colon, C. Miles, and H. M. Grey. 1989. Structural analysis of peptides capable of binding to more than one Ia antigen. J. Immunol. 42:35-40.
22. Valli, A., A. Sette, L. Kappos, C. Oseroff, J. Sidney, G. Miescher, M. Hochberger, E. D. Albert, and L. Adorini. 1993. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J. Clin. Invest. 91:616-628.
23. Van der Meide, P. H., M. Dubbeld, and H. Schellekens. 1985. Monoclonal antibodies to human interferon-gamma and their use in a sensitive solid phase ELISA. J. Immunol. Methods 79:293-305.
24. Van der Pouw-Kraan, V. T., I. Rensink, and L. Aarden. 1992. Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production. Eur. J. Immunol. 22:1237-1241.
25. Weiner, H. L., A. Friedman, A. Miller, S. J. Khoury, A. Al-Sabbagh, L. Santos, M. Sayegh, R. B. Nussenblatt, D. E. Trentham, and D. A. Hafler. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12:809-837.