MMP-9 sheds the β2 integrin subunit (CD18) from macrophages

Molecular and Cellular Proteomics

Volumn 8, Issue 5, 2009, Pages 1044-1060

  Vaisar, Tomáš ^a   Kassim, Sean Y ^a   Gomez, Ivan G ^a   Green, Pattie S ^a   Hargarten, Sara ^a   Gough, Peter J ^a,b   Parks, William C ^a   Wilson, Carole L ^a   Raines, Elaine W ^a   Heinecke, Jay W ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA2 INTEGRIN; CD18 ANTIGEN; GELATINASE B;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME SUBSTRATE; LIQUID CHROMATOGRAPHY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEOMICS; TANDEM MASS SPECTROMETRY; WILD TYPE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIGENS, CD18; CELL EXTRACTS; CELL LINE; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA, CONDITIONED; ENZYME ACTIVATION; MACROPHAGES; MASS SPECTROMETRY; MATRIX METALLOPROTEINASE 9; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY;

EID: 67449093858     PISSN: 15359476     EISSN: None     Source Type: Journal    
DOI: 10.1074/mcp.M800449-MCP200     Document Type: Article

References (87)

1. Woessner, J. F., and Nagase, H. (2000) Matrix metalloproteinases and TIMPs, Oxford University Press, Oxford
2. Mott, J. D., and Werb, Z. (2004) Regulation of matrix biology by matrix metalloproteinases. Curr. Opin. Cell Biol. 16, 558-564 (Pubitemid 39201241)
3. Parks, W. C., Wilson, C. L., and Lopez-Boado, Y. S. (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat. Rev. Immunol. 4, 617-629 (Pubitemid 39025047)
4. Shapiro, S. D. (2003) Proteolysis in the lung. Eur. Respir. J. Suppl. 44, 30s-32s
5. Thompson, R. W. (1996) Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem. Curr. Opin. Cardiol. 11, 504-518 (Pubitemid 26320991)
6. Galis, Z. S., and Khatri, J. J. (2002) Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ. Res. 90, 251-262 (Pubitemid 34633925)
7. Birkedal-Hansen, H., Moore, W. G., Bodden, M. K., Windsor, L. J., Birkedal-Hansen, B., DeCarlo, A., and Engler, J. A. (1993) Matrix metalloproteinases: a review. Crit. Rev. Oral Biol. Med. 4, 197-250
8. Libby, P., and Aikawa, M. (1998) New insights into plaque stabilisation by lipid lowering. Drugs 56, Suppl. 1, 9-13, 33
9. Pepper, M. S. (2001) Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler. Thromb. Vasc. Biol. 21, 1104-1117 (Pubitemid 34215137)
10. La Fleur, M., Underwood, J. L., Rappolee, D. A., and Werb, Z. (1996) Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1. J. Exp. Med. 184, 2311-2326 (Pubitemid 27023731)
11. Davies, M. J. (1996) Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation 94, 2013-2020 (Pubitemid 26349317)
12. Thompson, R. W., and Parks, W. C. (1996) Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann. N. Y. Acad. Sci. 800, 157-174 (Pubitemid 27028953)
13. Overall, C. M., and Dean, R. A. (2006) Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer. Cancer Metastasis Rev. 25, 69-75 (Pubitemid 43723983)
14. Owen, C. A., Hu, Z., Barrick, B., and Shapiro, S. D. (2003) Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils. Am. J. Respir. Cell Mol. Biol. 29, 283-294 (Pubitemid 37093986)
15. Parks, W. C., Lopez-Boado, Y. S., and Wilson, C. L. (2001) Matrilysin in epithelial repair and defense. Chest 120, (suppl.) 36S-41S
16. Guo, L., Eisenman, J. R., Mahimkar, R. M., Peschon, J. J., Paxton, R. J., Black, R. A., and Johnson, R. S. (2002) A proteomic approach for the identification of cell-surface proteins shed by metalloproteases. Mol. Cell. Proteomics 1, 30-36
17. Overall, C. M., and Blobel, C. P. (2007) In search of partners: linking extracellular proteases to substrates. Nat. Rev. Mol. Cell Biol. 8, 245-257 (Pubitemid 46316033)
18. Van den Steen, P. E., Proost, P., Wuyts, A., Van Damme, J., and Opdenakker, G. (2000) Neutrophil gelatinase B potentiates interieukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact. Blood 96, 2673-2681
19. McQuibban, G. A., Gong, J. H., Wong, J. P., Wallace, J. L., Clark-Lewis, I., and Overall, C. M. (2002) Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood 100, 1160-1167 (Pubitemid 34864266)
20. Park, H. I., Ni, J., Gerkema, F. E., Liu, D., Belozerov, V. E., and Sang, Q. X. (2000) Identification and characterization of human endometase (matrix metalloproteinase-26) from endometrial tumor. J. Biol. Chem. 275, 20540-20544 (Pubitemid 30457636)
21. Knauper, V., Cowell, S., Smith, B., Lopez-Otin, C., O'Shea, M., Morris, H., Zardi, L., and Murphy, G. (1997) The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J. Biol. Chem. 272, 7608-7616 (Pubitemid 27137308)
22. Overall, C. M. (2002) Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites. Mol. Biotechnol. 22, 51-86
23. Overall, C. M., McQuibban, G. A., and Clark-Lewis, I. (2002) Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics. Biol. Chem. 383, 1059-1066 (Pubitemid 35215050)
24. Hwang, I. K., Park, S. M., Kim, S. Y., and Lee, S. T. (2004) A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma. Biochim. Biophys. Acta 1702, 79-87 (Pubitemid 39265471)
25. Tam, E. M., Morrison, C. J., Wu, Y. I., Stack, M. S., and Overall, C. M. (2004) Membrane protease proteomics: isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proc. Natl. Acad. Sci. U. S. A. 101, 6917-6922 (Pubitemid 38596418)
26. Greenlee, K. J., Corry, D. B., Engler, D. A., Matsunami, R. K., Tessier, P., Cook, R. G., Werb, Z., and Kheradmand, F. (2006) Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J. Immunol. 177, 7312-7321 (Pubitemid 44715101)
27. Xu, D., Suenaga, N., Edelmann, M. J., Fridman, R., Muschel, R. J., and Kessler, B. M. (2008) Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach. Mol. Cell. Proteomics 7, 2215-2228
28. Bech-Serra, J. J., Santiago-Josefat, B., Esselens, C., Saftig, P., Baselga, J., Arribas, J., and Canals, F. (2006) Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis. Mol. Cell. Biol. 26, 5086-5095 (Pubitemid 43955821)
29. Dean, R. A., and Overall, C. M. (2007) Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome. Mol. Cell. Proteomics 6, 611-623 (Pubitemid 46630094)
30. Dieguez-Acuna, F. J., Gerber, S. A., Kodama, S., Elias, J. E., Beausoleil, S. A., Faustman, D., and Gygi, S. P. (2005) Characterization of mouse spleen cells by subtractive proteomics. Mol. Cell. Proteomics 4, 1459-1470 (Pubitemid 41555472)
31. Schirmer, E. C., Florens, L., Guan, T., Yates, J. R., III, and Gerace, L. (2003) Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science 301, 1380-1382 (Pubitemid 37075814)
32. Garton, K. J., Ferri, N., and Raines, E. W. (2002) Efficient expression of exogenous genes in primary vascular cells using IRES-based retroviral vectors. BioTechniques 32, 830, 832, 834 passim (Pubitemid 34298711)
33. Gough, P. J., Gomez, I. G., Wille, P. T., and Raines, E. W. (2006) Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J. Clin. Investig. 116, 59-69 (Pubitemid 43121791)
34. Shipley, J. M., Wesselschmidt, R. L., Kobayashi, D. K., Ley, T. J., and Shapiro, S. D. (1996) Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc. Natl. Acad. Sci. U. S. A. 93, 3942-3946 (Pubitemid 26144227)
35. Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., Chea, H., Knopp, R. H., Brunzell, J., Geary, R., Chart, A., Zhao, X. Q., Elkon, K., Marcovina, S., Ridker, P., Oram, J. F., and Heinecke, J. W. (2007) Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL. J. Clin. Investig. 117, 746-756 (Pubitemid 46348533)
36. Keller, A., Nesvizhskii, A. I., Kolker, E., and Aebersold, R. (2002) Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal. Chem. 74, 5383-5392 (Pubitemid 35215372)
37. Nesvizhskii, A. I., Keller, A., Kolker, E., and Aebersold, R. (2003) A statistical model for identifying proteins by tandem mass spectrometry. Anal. Chem. 75, 4646-4658 (Pubitemid 37082259)
38. Liu, H., Sadygov, R. G., and Yates, J. R., III (2004) A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Anal. Chem. 76, 4193-4201
39. Old, W. M., Meyer-Arendt, K., Aveline-Wolf, L., Pierce, K. G., Mendoza, A., Sevinsky, J. R., Resing, K. A., and Ahn, N. G. (2005) Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol. Cell. Proteomics 4, 1487-1502 (Pubitemid 41555475)
40. Lu, P., Vogel, C., Wang, R., Yao, X., and Marcotte, E. M. (2007) Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat. Biotechnol. 25, 117-124 (Pubitemid 46087910)
41. Fu, X., Gharib, S. A., Green, P. S., Aitken, M. L., Frazer, D. A., Park, D. R., Vaisar, T., and Heinecke, J. W. (2008) Spectral index for assessment of differential protein expression in shotgun proteomics. J. Proteome Res. 7, 845-854
42. Green, P. S., Vaisar, T., Pennathur, S., Kulstad, J. J., Moore, A. B., Marcovina, S., Brunzell, J., Knopp, R. H., Zhao, X.-Q., and Heinecke, J. W. (2008) Combined statin and niacin therapy remodels the high-density lipoprotein proteome. Circulation 118, 1259-1267
43. Chelius, D., and Bondarenko, P. V. (2002) Quantitative profiling of proteins in complex mixtures using liquid chromatography and mass spectrometry. J. Proteome Res. 1, 317-323 (Pubitemid 36395872)
44. Wang, W., Zhou, H., Lin, H., Roy, S., Shaler, T. A., Hill, L. R., Norton, S., Kumar, P., Anderle, M., and Becker, C. H. (2003) Quantification of proteins and metabolites by mass spectrometry without isotopic labeling or spiked standards. Anal. Chem. 75, 4818-4826 (Pubitemid 37139783)
45. Resing, K. A., Meyer-Arendt, K., Mendoza, A. M., Aveline-Wolf, L. D., Jonscher, K. R., Pierce, K. G., Old, W. M., Cheung, H. T., Russell, S., Wattawa, J. L., Goehle, G. R., Knight, R. D., and Ahn, N. G. (2004) Improving reproducibility and sensitivity in identifying human proteins by shotgun proteomics. Anal. Chem. 76, 3556-3568 (Pubitemid 38868816)
46. Feutren, G., Lacour, B., and Bach, J. F. (1984) Immune lysis of hepatocytes in culture: accurate detection by aspartate aminotransferase release measurement. J. Immunol. Methods 75, 85-94 (Pubitemid 15198811)
47. Kulstad, J. J., Green, P. S., Cook, D. G., Watson, G. S., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Rhoads, K., Mehta, P. D., and Craft, S. (2006) Differential modulation of plasma β-amyloid by insulin in patients with Alzheimer disease. Neurology 66, 1506-1510 (Pubitemid 43958544)
48. Dennis, G., Jr., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., and Lempicki, R. A. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, P3
49. Maere, S., Heymans, K., and Kuiper, M. (2005) BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics 21, 3448-3449 (Pubitemid 41222459)
50. Bolshev, L. N. (1962) On the comparison of parameters of Poisson distributions. Theory Probab. Appl. 7, 113-114
51. Fisher, K. E., Fei, Q., Laird, E. R., Stock, J. L., Allen, M. R., Sahagan, B. G., and Strick, C. A. (2002) Engineering autoactivating forms of matrix metalloproteinase-9 and expression of the active enzyme in cultured cells and transgenic mouse brain. Biochemistry 41, 8289-8297 (Pubitemid 34705482)
52. Brule, S., Chamaux, N., Sutton, A., Ledoux, D., Chaigneau, T., Saffar, L., and Gattegno, L. (2006) The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9. Glycobioiogy 16, 488-501 (Pubitemid 43779045)
53. Washburn, M. P., Ulaszek, R. R., and Yates, J. R., III (2003) Reproducibility of quantitative proteomic analyses of complex biological mixtures by multidimensional protein identification technology. Anal. Chem. 75, 5054-5061
54. Ong, S. E., and Mann, M. (2005) Mass spectrometry-based proteomics turns quantitative. Nat. Chem. Biol. 1, 252-262
55. Fernandes, J. M., and Smith, V. J. (2002) A novel antimicrobial function for a ribosomal peptide from rainbow trout skin. Biochem. Biophys. Res. Commun. 296, 167-171 (Pubitemid 35002073)
56. Hiemstra, P. S., van den Barselaar, M. T., Roest, M., Nibbering, P. H., and van Furth, R. (1999) Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages. J. Leukoc. Biol. 66, 423-428 (Pubitemid 29439249)
57. Stinchcombe, J. C., and Griffiths, G. M. (1999) Regulated secretion from hemopoietic cells. J. Cell Biol. 147, 1-6
58. Stinchcombe, J. C., and Griffiths, G. M. (2001) Normal and abnormal secretion by haemopoietic cells. Immunology 103, 10-16 (Pubitemid 32453094)
59. Sondag, C. M., and Combs, C. K. (2004) Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells. J. Biol. Chem. 279, 14456-14463
60. Stefanidakis, M., and Koivunen, E. (2006) Cell-surface association between matrix metalloproteinases: role of the complexes in leukocyte migration and cancer progression. Blood 108, 1441-1450 (Pubitemid 44316107)
61. Postina, R. (2008) A closer look at α-secretase. Curr. Alzheimer Res. 5, 179-186
62. De Strooper, B., and Annaert, W. (2000) Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Sci. 113, 1857-1870 (Pubitemid 30386490)
63. Backstrom, J. R., Lim, G. P., Cullen, M. J., and Tokes, Z. A. (1996) Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-β peptide (1-40). J. Neurosci. 16, 7910-7919
64. Bauer, J., Konig, G., Strauss, S., Jonas, U., Ganter, U., Weidemann, A., Monning, U., Masters, C. L., Volk, B., Berger, M., and Beyreuther, K. (1991) In-vitro matured human macrophages express Alzheimer's β A4-amyloid precursor protein indicating synthesis in microglial cells. FEBS Lett. 282, 335-340
65. Ley, K., Laudanna, C., Cybulsky, M. I., and Nourshargh, S. (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7, 678-689
66. Mazzone, A., and Ricevuti, G. (1995) Leukocyte CD11/CD18 integrins: biological and clinical relevance. Haematologica 80, 161-175
67. Garton, K. J., Gough, P. J., and Raines, E. W. (2006) Emerging roles for ectodomain shedding in the regulation of inflammatory responses. J. Leukoc. Biol. 79, 1105-1116
68. Huovila, A. P., Turner, A. J., Pelto-Huikko, M., Karkkainen, I., and Ortiz, R. M. (2005) Shedding light on ADAM metalloproteinases. Trends Biochem. Sci. 30, 413-422
69. Mayadas, T. N., and Cullere, X. (2005) Neutrophil β2 integrins: moderators of life or death decisions. Trends Immunol. 26, 388-395 (Pubitemid 40835845)
70. Wild, M. K., Huang, M. C., Schulze-Horsel, U., van der Merwe, P. A., and Vestweber, D. (2001) Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1. J. Biol. Chem. 276, 31602-31612
71. Stipp, C. S., Kolesnikova, T. V., and Hemler, M. E. (2003) EWI-2 regulates α3β1 integrin-dependent cell functions on laminin-5. J. Cell Biol. 163, 1167-1177 (Pubitemid 37541891)
72. Cerwenka, A., Bakker, A. B., McClanahan, T., Wagner, J., Wu, J., Phillips, J. H., and Lanier, L. L. (2000) Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12, 721-727
73. Bryceson, Y. T., March, M. E., Ljunggren, H. G., and Long, E. O. (2006) Activation, coactivation, and costimulation of resting human natural killer cells. Immunol. Rev. 214, 73-91
74. Hamerman, J. A., Ogasawara, K., and Lanier, L. L. (2004) Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J. Immunol. 172, 2001-2005 (Pubitemid 38182343)
75. Weber, C. (2003) Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules. J. Mol. Med. 81, 4-19
76. Lee, S. H., and Corry, D. B. (2004) Homing alone? CD18 in infectious and allergic disease. Trends Mol. Med. 10, 258-262
77. Evans, B. J., McDowall, A., Taylor, P. C., Hogg, N., Haskard, D. O., and Landis, R. C. (2006) Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response. Blood 107, 3593-3599
78. Stefanidakis, M., Ruohtula, T., Borregaard, N., Gahmberg, C. G., and Koivunen, E. (2004) Intracellular and cell surface localization of a complex between αMβ2 integrin and promatrix metalloproteinase-9 progelatinase in neutrophils. J. Immunol. 172, 7060-7068 (Pubitemid 38669148)
79. Hardy, J., and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (Pubitemid 34790756)
80. Talamagas, A. A., Efthimiopoulos, S., Tsilibary, E. C., Figueiredo-Pereira, M. E., and Tzinia, A. K. (2007) Aβ(1-40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP. Neurobiol. Dis. 28, 304-315
81. Allinson, T. M. J., Parkin, E. T., Turner, A. J., and Hooper, N. M. (2003) ADAMs family members as amyloid precursor protein α-secretases. J. Neurosci. Res. 74, 342-352
82. Yin, K. J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., Bateman, R., Song, H., Hsu, F. F., Turk, J., Xu, J., Hsu, C. Y., Mills, J. C., Holtzman, D. M., and Lee, J. M. (2006) Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-β peptide catabolism. J. Neurosci. 26, 10939-10948 (Pubitemid 44772184)
83. Yan, P., Hu, X., Song, H., Yin, K., Bateman, R. J., Cirrito, J. R., Xiao, Q., Hsu, F. F., Turk, J. W., Xu, J., Hsu, C. Y., Holtzman, D. M., and Lee, J. M. (2006) Matrix metalloproteinase-9 degrades amyloid-β fibrils in vitro and compact plaques in situ. J. Biol. Chem. 281, 24566-24574
84. Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., Crystal, R. G., Besmer, P., Lyden, D., Moore, M. A., Werb, Z., and Rafii, S. (2002) Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109, 625-637 (Pubitemid 34628725)
85. Ortega, N., Behonick, D. J., Colnot, C., Cooper, D. N., and Werb, Z. (2005) Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol. Biol. Cell 16, 3028-3039 (Pubitemid 40741245)
86. Sheu, B. C., Hsu, S. M., Ho, H. N., Lien, H. C., Huang, S. C., and Lin, R. H. (2001) A novel role of metalloproteinase in cancer-mediated immunosuppression. Cancer Res. 61, 237-242 (Pubitemid 32095723)
87. Ito, A., Mukaiyama, A., Itoh, Y., Nagase, H., Thogersen, I. B., Enghild, J. J., Sasaguri, Y., and Mori, Y. (1996) Degradation of interleukin 1β by matrix metalloproteinases. J. Biol. Chem. 271, 14657-14660 (Pubitemid 26194936)