PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid

Biochemical and Biophysical Research Communications

Volumn 365, Issue 2, 2008, Pages 298-303

  Holback, Sofia ^a   Adlerz, Linda ^a   Gatsinzi, Tom ^a   Jacobsen, Kristin T ^a   Iverfeldt, Kerstin ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

ADAM10; APP; BACE1; BDNF; PI3 kinase; Protein kinase C; Retinoic acid; TACE

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BISINDOLYLMALEIMIDE; MESSENGER RNA; METALLOPROTEINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; RETINOIC ACID;

ARTICLE; HUMAN; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; UPREGULATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMYLOID BETA-PROTEIN PRECURSOR; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NEUROBLASTOMA; PROTEIN KINASE C; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRETINOIN; UP-REGULATION;

EID: 36249000086     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.167     Document Type: Article

References (33)

1. Esler W.P., and Wolfe M.S. A portrait of Alzheimer secretases: new features and familiar faces. Science 5534 (2001) 1449-1454
2. Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., Haass C., and Fahrenholz F. Constitutive and regulated α-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. USA 96 (1999) 3922-3927
3. Buxbaum J.D., Liu K.N., Luo Y., Slack J.L., Stocking K.L., Peschon J.J., Johnson R.S., Castner B.J., Cerretti D.P., and Black R.A. Evidence that tumor necrosis factor α-converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273 (1998) 27765-27767
4. Merlos-Suárez A., Fernández-Larrea J., Reddy P., Baselga J., and Arribas J. Pro-tumor necrosis factor-α processing activity is tightly controlled by a component that does not affect notch processing. J. Biol. Chem. 38 (1998) 24955-24962
5. Postina R., Schroeder A., Dewachter I., Bohl J., Schmitt U., Kojro E., Prinzen C., Endres K., Hiemke C., Blessing M., Flamez P., Dequenne A., Godaux E., van Leuven F., and Fahrenholz F. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J. Clin. Invest. 113 (2004) 1456-1464
6. Hussain I., Powell D., Howlett D.R., Tew D.G., Meek T.D., Chapman C., Gloger I.S., Murphy K.E., Southan C.D., Ryan D.M., Smith T.S., Simmons D.L., Walsh F.S., Dingwall C., and Christie G. Identification of a novel aspartic protease (Asp 2) as β-secretase. Mol. Cell. Neurosci. 14 (1999) 419-427
7. Sinha S., Anderson J.P., Barbour R., Basi G.S., Caccavello R., Davis D., Doan M., Dovey H.F., Frigon N., Hong J., Jacobson-Croak K., Jewett N., Keim P., Knops J., Lieberburg I., Power M., Tan H., Tatsuno G., Tung J., Schenk D., Seubert P., Suomensaari S.M., Wang S., Walker D., Zhao J., McConlogue L., and Johan V. Purification and cloning of amyloid precursor protein β-secretase from human brain. Nature 6761 (1999) 537-540
8. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., and Citron M. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 (1999) 735-740
9. Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., Pauley A.M., Brashier J.R., Stratman N.C., Mathews W.R., Buhl A.E., Carter D.B., Tomasselli A.G., Parodi L.A., Heinrikson R.L., and Gurney M.E. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature 6761 (1999) 533-537
10. Luo Y., Bolon B., Kahn S., Bennett B.D., Babu-Khan S., Denis P., Fan W., Kha H., Zhang J., Gong Y., Martin L., Louis J.C., Yan Q., Richards W.G., Citron M., and Vassar R. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation. Nat. Neurosci. 3 (2001) 231-232
11. Beckman M., and Iverfeldt K. Increased gene expression of β-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid. Neurosci. Lett. 221 (1997) 73-76
12. Adlerz L., Beckman M., Holback S., Tehranian R., Cortes Toro V., and Iverfeldt K. Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction. Brain Res. Mol. Brain Res. 119 (2003) 62-72
13. Holback S., Adlerz L., and Iverfeldt K. Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J. Neurochem. 95 (2005) 1059-1068
14. Rinaldi P., Polidori M.C., Metastasio A., Mariani E., Mattioli P., Cherubini A., Catani M., Cecchetti R., Senin U., and Mecocci P. Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol. Aging 24 (2003) 915-919
15. Connor B., Young D., Yan Q., Faull R.L., Synek B., and Dragunow M. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res. Mol. Brain Res. 49 (1997) 71-81
16. Goodman A.B., and Pardee A.B. Evidence for defective retinoic transport and function in late onset Alzheimer's disease. Proc. Natl. Acad. Sci. USA 100 (2003) 2901-2905
17. Marshall A.J., Rattray M., and Vaughan P.F. Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels. Brain Res. 1099 (2006) 18-24
18. Anders A., Gilbert S., Garten W., Postina R., and Fahrenholz F. Regulation of the α-secretase ADAM10 by its prodomain and proprotein convertases. FASEB J. 10 (2001) 1837-1839
19. Howard L., Xiaohong L., Mitchell S., Griffiths S., and Glynn P. Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Biochem. J. 317 (1996) 45-50
20. Srour N., Lebel A., McMahon S., Fournier I., Fugèrre M., Day R., and Dubois C.M. TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity. FEBS Lett. 554 (2003) 275-283
21. Prinzen C., Müller U., Endres K., Fahrenholz F., and Postina R. Genomic structure and functional characterization of the human ADAM10 promoter. FASEB J. 19 (2005) 1522-1524
22. Endres K., Postina R., Schroeder A., Mueller U., and Fahrenholz F. Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases. FEBS J. 272 (2005) 5808-5820
23. Benjannet S., Elagoz A., Wickham L., Mamarbachi M., Munzer J.S., Basak A., Lazure C., Cromlish J.A., Sisodia S., Checler F., Chétien M., and Seidah N.G. Post-translational processing of β-secretase (β-amyloid converting enzyme) and its ectodomain shedding. J. Biol. Chem. 276 (2001) 10879-10887
24. Lee J.H., and Kim K.T. Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells. J. Neurochem. 91 (2004) 634-647
25. Pan J., Kao Y.L., Josh S., Jeetendran S., Dipette D., and Singh U.S. Activation of Rac1 by phosphatidylinositol 3-kinase in vivo: role in activation of mitogen-activated protein kinase (MAPK) pathways and retinoic acid-induced neuronal differentiation of SH-SY5Y cells. J. Neurochem. 93 (2005) 571-583
26. Lopez-Carballo G., Moreno L., Masia S., Perez P., and Barettino D. Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. J. Biol. Chem. 277 (2002) 25297-25304
27. Clagett-Dame M., McNeill E.M., and Muley P.D. Role of all-trans retinoic acid in neurite outgrowth and axonal elongation. J. Neurobiol. 66 (2006) 739-756
28. Mills J., Laurent Charest D., Lam F., Beyreuther K., Ida N., Pelech S.L., and Reiner P.B. Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway. J. Neurosci. 17 (1997) 9415-9422
29. Gruber J.R., Desai S., Blusztajn J.K., and Niles R.M. Retinoic acid specifically increases nuclear PKC alpha and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells. Exp. Cell Res. 221 (1995) 377-384
30. Lopez-Andreo M., Torrecillas A., Conesa-Zamora P., Corbala-Garcia S., and Gomez-Fernandez J.C. Retinoic acid as a modulator of the activity of protein kinase C. J. Biol. Chem. 44 (2005) 11353F-11360F
31. Caporaso G.L., Gandy S.E., Buxbaum J.D., Ramabhadran T.V., and Greengard P. Protein phopsphorylation regulates secretion of Alzheimer beta/A4-amyloid precursor protein. Proc. Natl. Acad. Sci. USA 89 (1992) 3055-3059
32. Buxbaum J.D., Koo E.H., and Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc. Natl. Acad. Sci. USA 90 (1993) 9195-9198
33. Merlos-Suarez A., Fernandez-Larrea J., Reddy P., Baselga J., and Arribas J. Pro-tumor necrosis factor-α processing activity is tightly controlled by a component that does not affect Notch processing. J. Biol. Chem. 278 (1998) 24955-24962