Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing

Journal of Neurochemistry

Volumn 106, Issue 1, 2008, Pages 392-404

  Marcade, Maryline ^a   Bourdin, Jérôme ^a   Loiseau, Nadia ^a   Peillon, Hélène ^a   Rayer, Aurélie ^a   Drouin, Dominique ^a   Schweighoffer, Fabien ^a   Désiré, Laurent ^a  

^a ExonHit Therapeutics   (France)

Author keywords

Alpha secretase; Alzheimer's disease; Amyloid protein; Etazolate; GABA; Soluble APP ectodomain

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BACLOFEN; ETAZOLATE; MUSCIMOL;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; GUINEA PIG; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ETAZOLATE; GABA AGENTS; GABA AGONISTS; GABA ANTAGONISTS; GUINEA PIGS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PHOSPHODIESTERASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION;

CAVIA; RATTUS;

EID: 45249124737     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05396.x     Document Type: Article

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