Post-transcriptional contribution of a cAMP-dependent pathway to the formation of α- and β/y-secretases-derived products of βAPP maturation in human cells expressing wildtype and swedish mutated βAPP

Molecular Medicine

Volumn 4, Issue 11, 1998, Pages 715-723

  Marambaud, P ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BUCLADESINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DACTINOMYCIN; FORSKOLIN; PROTEIN KINASE C;

ARTICLE; CARBOXY TERMINAL SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BUCLADESINE; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DACTINOMYCIN; ENDOPEPTIDASES; FORSKOLIN; HUMANS; MUTATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; TRANSFECTION;

EID: 0032436113     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401766     Document Type: Article

References (34)

1. Hardy J, AIlsop D. (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12: 383-388.
2. Glenner GG, Wong CW. (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120: 885-890.
3. Masters CL, Simons G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. (1985) Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc. Natl. Acad. Sci. U.S.A. 82: 4245-4249.
4. Selkoe DJ. (1994) Normal and abnormal biology of the beta-amyloid precursor protein. Annu. Rev. Neurosci. 17: 489-517.
5. Checler F. (1995) Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65: 1431-1444.
6. Maury CPJ. (1995) Molecular pathogenesis of β-amyloidosis in Alzheimer's disease and other cerebral amyloidoses. Lab. Invest. 72: 4-16.
7. Esch FS, Keim PS, Beattie EC, et al. (1990) Cleavage of amyloid β peptide during constitutive processing of its precursor. Science 248: 1122-1128.
8. Sisodia S. (1992) β-amyloid precursor protein cleavage by a membrane-bound protease. Proc. Natl. Acad. Sci. U.S.A. 89: 6075-6079.
9. Caporaso L, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P. (1992) Protein phosphorylation regulates secretion of Alzheimer β/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 89: 3055-3059.
10. Gillespie S, Golde TE, Younkin SG. (1992) Secretory processing of the Alzheimer amyloid β/A4 protein precursor is increased by protein phosphorylation. Biochem. Biophys. Res. Commun. 187: 1285-1290.
11. Buxbaum JD, Koo EH, Greengard P. (1993) Protein phosphorylation inhibits production of Alzheimer amyloid β/A4 peptide. Proc. Natl. Acad. Sci. U.S.A. 90: 9195-9198.
12. Hung AY, Haass C, Nitsch RM, et al. (1993) Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J. Biol. Chem. 268: 22959-22962.
13. Marambaud P, Wilk S, Checler F. (1996) Protein kinase A phosphorylation of the proteasome: a contribution to the a-secretase pathway in human cells. J. Neurochem. 67: 2616-2619.
14. Xu H, Sweeney D, Greengard P, Gandy S. (1996) Metabolism of Alzheimer β-amyloid precursor protein: regulation by protein kinase A in intact cells and in cell-free system. Proc. Natl. Acad. Sci. U.S.A. 93: 4081-4084.
15. 1. Gegelashvili G, Bock E, Schousboe A, Linnemann D. (1996) Two types of amyloid precursor protein (APP) mRNA in rat glioma cell lines: upregulation via a cyclic AMP-dependent pathway. Mol. Brain. Res. 37: 151-156.
16. Bourbonnière M, Shekarabi M, Nalbantoglu J. (1997) Enhanced expression of amyloid precursor protein in response to dibutyryl cyclic AMP is not mediated by the transcription factor AP-2. J. Neurochem. 68: 909-916.
17. Shekarahi M, Bourbonnière M, Dagenais A, Nalbantoglu J. (1997) Transcriptional regulation of amyloid precursor protein during dibutyryl cyclic AMP-induced differentiation of NG108-15 cells. J. Neurochem. 68: 970-978.
18. Lee RKK, Araki W, Wurtman RJ. (1997) Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proc. N all. Acad. Sci. U.S.A. 94: 5422-5426.
19. Marambaud P, Chevallier N, Barelli H, Wilk S, Glieder F. (1997) Proteasome contributes to the a-secretase pathway of amyloid precursor protein in human cells. J. Neurochem, 68: 698-703.
20. Chevallier N, Jiracek J, Vincent B, et al. (1997) Examination of the role of endopeptidase 3.4.24.15 in Aβ secretion by human transfected cells. Er. J. Pharmacol. 121: 556-562.
21. Chun J, Jaenisch R. (1996) Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses. Mol. Cell. Neurosd. 7: 304-321.
22. Ida N, Johannes H, Pantel J, et al. (1996) Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem. 271: 22908-22914.
23. Marambaud P, Lopez-Perez E, Wilk S, Checler F. (1997) Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's β amyloid precursor protein: different control of early and late events by the proteasome. J. Neurochem. 69: 2500-2505.
24. Barelli H, Lebeau A, Vizzavona J, et al. (1997) Characterization of new polyclonal antibodies specific for 40 and 42 aminoacid-long amyloid β peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases. Mol. Med. 3: 695-707.
25. Shoji M, Golde TE, Ghiso J, et al. (1992) Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258: 126-129.
26. De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. (1995) Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. EMBO J. 14: 4932-4938.
27. Xu H, Gouras GK, Greenfield JP, et al. (1998) Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides. Nat. Med. 4: 447-451.
28. Haass C, Lemere CA, Capell A, et al. (1995) The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway. Nat. Med. 1: 1291-1296.
29. Trudeau L-E, Emery DG, Haydon PG. (1996) Direct modulation of the secretory machinery underlies PKA-dependent synaptic facilitation in hippocampal neurons. Neuron 17: 789-797.
30. Marambaud P, Ancolio K, Alves da Costa, C, and Checler F. ( 1998) Protein kinase A inhibitors drastically reduce constitutive production of Aβ40 and Aβ42 by human cells expressing normal and familial Alzheimer's disease-linked mutated βAPP and presenilin 1. Brit. J. Pharmacol. (in press).
31. Cook DG, Forman MS, Sung JC, et al. (1997) Alzheimer's Aβ(1-42) is generated in the endoplasmic reticulum/intermediate compatment of NT2N cells. Nat. Med. 3: 1021-1023.
32. Hartmann T, Bieger SC, Brühl B, et al. (1997) Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides. Nat. Med. 3: 1016-1020.
33. Marambaud P, Ancolio K, Lopez-Perez E, Checler F. (1998) Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and trigger increased Aβ42 secretion by human cells. Mol. Med. 4: 146-156.
34. Savage M, Trusko SP, Howland DS, et al. (1998) Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18: 1743-1752.