New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα

Journal of Medicinal Chemistry

Volumn 46, Issue 3, 2003, Pages 364-373

  Kozikowski, Alan P ^a   Nowak, Ireneusz ^a   Petukhov, Pavel A ^a   Etcheberrigaray, Rene ^b   Mohamed, Ali ^b   Tan, Mathew ^b   Lewin, Nancy ^c   Hennings, Henry ^c   Pearce, Larry L ^c   Blumberg, Peter M ^c  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NeuroLogic Inc   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 (2,4 HEXADIENOYLAMINO)BENZOLACTAM V; 8 (5 PHENYL 2,4 PENTADIENOYLAMINO)BENZOLACTAM V; 8 (5 PHENYLPENTANOYLAMINO)BENZOLACTAM V; 8 (HEXANOYLAMINO)BENZOLACTAM V; 8 [5 [3,5 BIS(TRIFLUOROMETHYL)PHENYL] 2,4 PENTADIENOYLAMINO]BENZOLACTAM V; 8 [5 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]PENTANOYLAMINO]BENZOLACTAM V; 8 [5 [4 (3,3,4,4,5,5,6,6,7,7,8,8,8 TRIDECAFLUOROOCT 1 ENYL)PHENYL] 2,4 PENTADIENOYLAMINO]BENZOLACTAM V; 8 [5 [4 (3,3,4,4,5,5,6,6,7,7,8,8,8 TRIDECAFLUOROOCTYL)PHENYL]PENTANOYLAMINO]BENZOLACTAM V; 8 [5 [4 (TRIFLUOROMETHYL)PHENYL] 2,4 PENTADIENOYLAMINO]BENZOLACTAM V; 8 [5 [4 (TRIFLUOROMETHYL)PHENYL]PENTANOYLAMINO]BENZOLACTAM V; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; LACTAM DERIVATIVE; MEZEREIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL LINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERPLASIA; LIPOPHILICITY; MOUSE; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN SECRETION; STRUCTURE ANALYSIS;

ALZHEIMER DISEASE; AMIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BENZODIAZEPINONES; BINDING, COMPETITIVE; CELL LINE; ENZYME ACTIVATORS; EPIDERMIS; HUMANS; HYPERPLASIA; LACTAMS; LIGANDS; MICE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037472674     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020350r     Document Type: Article

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