Reduction of β-amyloid levels by novel protein kinase Ċactivators

Journal of Biological Chemistry

Volumn 284, Issue 50, 2009, Pages 34514-34521

  Nelson, Thomas J ^a   Cui, Changhai ^a   Luo, Yuan ^b   Alkon, Daniel L ^a  

^a Blanchette Rockefeller Neurosciences Institute   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PEPTIDES; AMYLOID PRECURSOR PROTEINS; CONTROL LEVEL; CYCLOPROPANATION; DIACYLGLYCEROL; DOSE-DEPENDENT MANNER; DOWN-REGULATION; ENDOTHELIN-CONVERTING ENZYMES; ISOFORMS; NEURONAL CELL; NOVEL PROTEINS; PHORBOL ESTERS; POLYUNSATURATED FATTY ACIDS; PROTEIN KINASE C; SECRETASES; SUSTAINED ACTIVATION; THERAPEUTIC AGENTS;

AMINES; BINDING ENERGY; BINDING SITES; CELL CULTURE; ENVIRONMENTAL PROTECTION AGENCY; ENZYMES; ESTERS; FATTY ACIDS; GLYCEROL; GLYCOPROTEINS;

CHEMICAL ACTIVATION;

8 [2 (2 PENTYL CYCLOPROPYLMETHYL) CYCLOPROPYL] OCTANOIC ACID; ALPHA SECRETASE; AMYLOID BETA PROTEIN; BRYOSTATIN; DOCOSAHEXAENOIC ACID; ENDOTHELIN CONVERTING ENZYME; ENZYME ACTIVATOR; ICOSAPENTAENOIC ACID; LINOLEIC ACID; PHORBOL ESTER; PROTEIN KINASE C EPSILON; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME BINDING; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; CYCLOPROPANES; ENZYME ACTIVATION; ENZYME ACTIVATORS; FATTY ACIDS, UNSATURATED; HUMANS; MICE; MOLECULAR STRUCTURE; NEURONS; PROTEIN KINASE C-EPSILON; RATS; RATS, SPRAGUE-DAWLEY;

EID: 71749109421     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.016683     Document Type: Article

References (44)

1. Scheff, S. W., Price, D. A., Schmitt, F. A., and Mufson, E. J. (2006) Neurobiol. Aging 27, 1372-1384
2. Marcello, E., Epis, R., and Di Luca, M. (2008) Eur. J. Pharmacol. 585, 109-118
3. Etcheberrigaray, R., Matzel, L. D., Lederhendler, I. I., and Alkon, D. L. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 7184-7188
4. Sun, M. K., and Alkon, D. L. (2005) Eur. J. Pharmacol. 512, 43-51
5. Sun, M. K., Hongpaisan, J., Nelson, T. J., and Alkon, D. L. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 13620-13625
6. Wang, D., Darwish, D. S., Schreurs, B. G., and Alkon, D. L. (2008) Behav. Pharmacol. 19, 245-256
7. Kuzirian, A. M., Epstein, H. T., Gagliardi, C. J., Nelson, T. J., Sakakibara, M., Taylor, C., Scioletti, A. B., and Alkon, D. L. (2006) Biol. Bull. 210, 201-214
8. Hongpaisan, J., and Alkon, D. L. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 19751-19756
9. Racchi, M., Mazzucchelli, M., Pascale, A., Sironi, M., and Govoni, S. (2003) Mol. Psychiatry 8, 209-216
10. Zhu, G., Wang, D., Lin, Y. H., McMahon, T., Koo, E. H., and Messing, R. O. (2001) Biochem. Biophys. Res. Commun. 285, 997-1006
11. Kanno, T., Yamamoto, H., Yaguchi, T., Hi, R., Mukasa, T., Fujikawa, H., Nagata, T., Yamamoto, S., Tanaka, A., and Nishizaki, T. (2006) J. Lipid Res. 47, 1146-1156
12. Jin, G., Huang, X., Black, R., Wolfson, M., Rauch, C., McGregor, H., Ellestad, G., and Cowling, R. (2002) Anal. Biochem. 302, 269-275
13. Nelson, T. J., and Alkon, D. L. (1995) J. Neurochem. 65, 2350-2357
14. Johnson, G. D., and Ahn, K. (2000) Anal. Biochem. 286, 112-118
15. Tanaka, A., and Nishizaki, T. (2003) Bioorg. Med. Chem. Lett. 13, 1037-1040
16. Furukawa, J., Kawabata, N., and Nishimura, J. (1968) Tetrahedron 24, 53-58
17. Denmark, S. E., and Edwards, J. P. (1991) J. Org. Chem. 56, 6974-6981
18. Nelson, T. J., and Alkon, D. L. (2009) Trends Biochem. Sci. 34, 136-145
19. Lorenzo, P. S., Bögi, K., Hughes, K. M., Beheshti, M., Bhattacharyya, D., Garfield, S. H., Pettit, G. R., and Blumberg, P. M. (1999) Cancer Res. 59, 6137-6144
20. Lee, H. W., Smith, L., Pettit, G. R., and Smith, J. B. (1997) Mol. Pharmacol. 51, 439-447
21. Lu, Z., Hornia, A., Jiang, Y. W., Zang, Q., Ohno, S., and Foster, D. A. (1997) Mol. Cell. Biol. 17, 3418-3428
22. da Cruz e Silva, O. A., Rebelo, S., Vieira, S. I., Gandy, S., da Cruz e Silva, E. F., and Greengard, P. (2009) J. Neurochem. 108, 319-330
23. Petanceska, S. S., Seeger, M., Checler, F., and Gandy, S. (2000) J. Neurochem. 74, 1878-1884
24. Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B., and Sisodia, S. S. (1996) J. Biol. Chem. 271, 9390-9397
25. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998) J. Biol. Chem. 273, 27765-27767
26. Buxbaum, J. D., Koo, E. H., and Greengard, P. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 9195-9198
27. Etcheberrigaray, R., Tan, M., Dewachter, I., Kuipéri, C., Van der Auwera, I., Wera, S., Qiao, L., Bank, B., Nelson, T. J., Kozikowski, A. P., Van Leuven, F., and Alkon, D. L. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 11141-11146
28. Choi, D. S., Wang, D., Yu, G. Q., Zhu, G., Kharazia, V. N., Paredes, J. P., Chang, W. S., Deitchman, J. K., Mucke, L., and Messing, R. O. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 8215-8220
29. Mischak, H., Goodnight, J. A., Kolch, W., Martiny-Baron, G., Schaechtle, C., Kazanietz, M. G., Blumberg, P. M., Pierce, J. H., and Mushinski, J. F. (1993) J. Biol. Chem. 268, 6090-6096
30. Van Kolen, K., Pullan, S., Neefs, J. M., and Dautzenberg, F. M. (2008) J. Neurochem. 104, 1-13
31. Wetsel, W. C., Khan, W. A., Merchenthaler, I., Rivera, H., Halpern, A. E., Phung, H. M., Negro-Vilar, A., and Hannun, Y. A. (1992) J. Cell Biol. 117, 121-133
32. Shirai, Y., Adachi, N., and Saito, N. (2008) FEBS J. 275, 3988-3994
33. Leach, K. L., and Blumberg, P. M. (1985) Cancer Res. 45, 1958-1963
34. Lanni, C., Mazzucchelli, M., Porrello, E., Govoni, S., and Racchi, M. (2004) Eur. J. Biochem. 271, 3068-3075
35. Rossner, S., Ueberham, U., Schliebs, R., Perez-Polo, J. R., and Bigl, V. (1998) Prog. Neurobiol. 56, 541-569
36. Caccamo, A., Oddo, S., Billings, L. M., Green, K. N., Martinez-Coria, H., Fisher, A., and LaFerla, F. M. (2006) Neuron 49, 671-682
37. Barnes, P. J., Haddad, E. B., and Rousell, J. (1997) Life Sci. 60, 1015-1021
38. VanDeMark, K., Guizzetti, M., Giordano, G., and Costa, L. G. (2009) J. Pharmacol. Exp. Ther. 329, 532-542
39. Du, X., and Iacovitti, L. (1997) J. Neurochem. 68, 564-569
40. Lallemend, F., Hadjab, S., Hans, G., Moonen, G., Lefebvre, P. P., and Malgrange, B. (2005) J. Cell Sci. 118, 4511-4525
41. Rankin, S. L., Guy, C. S., Rahimtula, M., and Mearow, K. M. (2008) Brain Res. 1217, 10-24
42. Rossner, S., Ueberham, U., Schliebs, R., Perez-Polo, J. R., and Bigl, V. (1998) J. Neurochem. 71, 757-766
43. Zampieri, N., and Chao, M. V. (2006) Biochem. Soc. Trans. 34, 607-611
44. Ahmed, Z., Mazibrada, G., Seabright, R. J., Dent, R. G., Berry, M., and Logan, A. (2006) FASEB J. 20, 1939-1941