Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase Cα, src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C

Molecular Brain Research

Volumn 102, Issue 1-2, 2002, Pages 62-72

  Canet Aviles, Rosa Maria ^a   Anderton, Mark ^a   Hooper, Nigel M ^a   Turner, Anthony J ^a   Vaughan, Peter F T ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Amyloid precursor protein; Epidermal growth factor; MAPKinase; Muscarinic receptors; Protein kinase C

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINE; MUSCARINIC AGENT; PHOSPHOLIPASE C; PRKCA PROTEIN, HUMAN; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN TYROSINE KINASE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ENZYME INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; WORTMANNIN;

ALZHEIMER DISEASE; ARTICLE; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; NERVE CELL; NEUROBLASTOMA; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; SIGNAL TRANSDUCTION; UPREGULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN CELL; INHIBITION KINETICS; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN SECRETION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCARINE; MUSCARINIC AGONISTS; NEUROBLASTOMA; NEURONS; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TUMOR CELLS, CULTURED; UP-REGULATION; HUMAN; SUPPORT, NON-U.S. GOV'T;

EID: 0037097492     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(02)00184-5     Document Type: Article

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