Is there a relationship between the substrate preferences and structural flexibility of cytochromes P450?

Current Drug Metabolism

Volumn 13, Issue 2, 2012, Pages 130-142

  Otyepka, Michal ^a   Berka, Karel ^a   Anzenbacher, Pavel ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Cytochrome P450; Flexibility; Molecular dynamics; Protein dynamics; Substrate selectivity

Indexed keywords

3 HYDROXYIBUPROFEN; BIFONAZOLE; CAMPHOR; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 2B1; DRUG METABOLIZING ENZYME; HEME; HEMOPROTEIN; IBUPROFEN; IBUPROFEN DERIVATIVE; LIGAND; METYRAPONE; TEMAZEPAM; TESTOSTERONE; TICLOPIDINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; DEUTERON NUCLEAR MAGNETIC RESONANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME CONFORMATION; ENZYME DENATURATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; GENOME; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; INFRARED SPECTROSCOPY; LIGAND BINDING; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RAMAN SPECTROMETRY; SIMULATION; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; SPECTRUM ANALYSIS; SUBSTRATE SPECIFICITY;

EID: 84857569031     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920012798918372     Document Type: Article

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