Using molecular dynamics to probe the structural basis for enhanced stability in thermal stable cytochromes P450

Biochemistry

Volumn 49, Issue 31, 2010, Pages 6680-6686

  Meharenna, Yergalem T ^a   Poulos, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROMES P450; DOUBLE MUTANTS; ENHANCED STABILITY; EXPERIMENTAL TEST; HIGH TEMPERATURE; HOT SPOT; IN-SILICO; MD SIMULATION; MELTING TEMPERATURES; NONPOLAR INTERACTIONS; STRUCTURAL BASIS; STRUCTURAL FEATURE; THERMAL MELTING; THERMAL STABILITY; WILD TYPES; WILD-TYPE ENZYMES;

BIOLOGICAL ORGANS; LIGANDS; MELTING POINT; METAL MELTING; MOLECULAR DYNAMICS; PORPHYRINS;

STABILITY;

CYSTEINE; CYTOCHROME P450; CYTOCHROME P450 119; GLYCINE; HEME; LEUCINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HIGH TEMPERATURE; MELTING POINT; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; THERMOSTABILITY;

ARCHAEAL PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; HOT TEMPERATURE; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE; PROTEIN DENATURATION; PROTEIN STABILITY;

EID: 77955237792     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100929x     Document Type: Article

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