Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6

Journal of Biological Chemistry

Volumn 280, Issue 13, 2005, Pages 12279-12291

  Yun, Chul Ho ^a   Kim, Keon Hee ^a   Calcutt, M Wade ^b   Guengerich, F Peter ^b  

^a Chonnam National University   (South Korea)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; BINDING ENERGY; DEUTERIUM; ELECTRON TRANSITIONS; HYDROXYLATION; IRON ALLOYS; OXIDATION; REDUCTION; SUBSTRATES;

ELECTRON TRANSFER; KINETIC ANALYSIS; REACTION RATE; SUBSTRATE BINDING;

ENZYME KINETICS;

7 ETHOXYCOUMARIN DEETHYLASE; CARBON; COUMARIN DERIVATIVE; CYTOCHROME P450 2A6; DEUTERIUM; FERRIC ION; FERROUS ION; HYDROGEN; ISOTOPE; OXYGEN; UMBELLIFERONE;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL BOND; ELECTRON TRANSPORT; HYDROXYLATION; KINETICS; LINEAR SYSTEM; OXIDATION; PRIORITY JOURNAL; TEMPERATURE;

7-ALKOXYCOUMARIN O-DEALKYLASE; ANTICOAGULANTS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; BINDING, COMPETITIVE; CARBON; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CYTOCHROMES B5; ELECTRON TRANSPORT; ELECTRONS; HUMANS; HYDROGEN; HYDROGEN BONDING; HYDROXYLATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; OXYGEN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 16844371090     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411019200     Document Type: Article

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