-
1
-
-
0036227791
-
Update information on human P450s
-
Guengerich, F.P. Update information on human P450s. Drug Metub. Rev., 2002, 34(1-2), 7-15.
-
(2002)
Drug Metub. Rev.
, vol.34
, Issue.1-2
, pp. 7-15
-
-
Guengerich, F.P.1
-
2
-
-
0034917716
-
The human ATP-binding cassette (ABC) transporter superfamily
-
DOI 10.1101/gr.GR-1649R
-
Dean, M.; Rzhetsky, A.; Allikmets, R. The human ATP-binding cassette (ABC) transporter superfamily. Genome. Res., 2001, 11(7), 1156-1166. (Pubitemid 32677289)
-
(2001)
Genome Research
, vol.11
, Issue.7
, pp. 1156-1166
-
-
Dean, M.1
Rzhetsky, A.2
Allikmets, R.3
-
3
-
-
1242340323
-
The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction
-
Hediger, M.A.; Romero, M.F.; Peng, J.B.; Rolfs, A.; Takanaga, H.; Bruford, E.A. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction. Plugers Arch., 2004, 447(5), 465-468.
-
(2004)
Plugers Arch.
, vol.447
, Issue.5
, pp. 465-468
-
-
Hediger, M.A.1
Romero, M.F.2
Peng, J.B.3
Rolfs, A.4
Takanaga, H.5
Bruford, E.A.6
-
4
-
-
85012854081
-
Uptake transporters
-
nd ed; McQueeen, CA., Series Ed., Elsevier: Oxford, U. K., in press.
-
nd ed; McQueeen, CA., Series Ed., Elsevier: Oxford, U. K., 2010, Vol. 4, in press.
-
(2010)
Biotransformation
, vol.4
-
-
Ho, R.H.1
Kim, R.B.2
-
5
-
-
85012825285
-
Efflux transporters
-
nd ed.; McQueeen, C.A., Series Ed.; Elsevier: Oxford, U. K., in press.
-
nd ed.; McQueeen, C.A., Series Ed.; Elsevier: Oxford, U. K., 2010, Vol. 4, in press.
-
(2010)
Biotransformation
, vol.4
-
-
Vore, M.E.1
-
6
-
-
6944221357
-
Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUQ/AUC) ratios
-
Williams, J.A.; Hyland, R.; Jones, B.C.; Smith, D.A.; Hurst, S.; Goosen, T.C.; Peterkin, V.; Koup, J.R.; Ball, S.E. Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUQ/AUC) ratios. Drug Metab. Dispos., 2004,32(11), 1201-1208.
-
(2004)
Drug Metab. Dispos.
, vol.32
, Issue.11
, pp. 1201-1208
-
-
Williams, J.A.1
Hyland, R.2
Jones, B.C.3
Smith, D.A.4
Hurst, S.5
Goosen, T.C.6
Peterkin, V.7
Koup, J.R.8
Ball, S.E.9
-
7
-
-
27644596457
-
Predicting in vivo drug interactions from in vitro drug discovery data
-
DOI 10.1038/nrd1851, PII N1851
-
Wienkers, L.C.; Heath, T.G. Predicting in vivo drug interactions from, in vitro drug discovery data. Nat. Rev. Drug Discov., 2005, 4(10), 825-833. (Pubitemid 41553963)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.10
, pp. 825-833
-
-
Wienkers, L.C.1
Heath, T.G.2
-
8
-
-
4644301430
-
The structure of human microsomal cytochrome P450 3A4 determined, by X-ray crystallography to 2.05 Å resolution
-
Yano, J.K.; Wester, M.R.; Schoch, G.A.; Griffin, K.J.; Stout, CD.; Johnson, E.F. The structure of human microsomal cytochrome P450 3A4 determined, by X-ray crystallography to 2.05 Å resolution. J. Biol. Chem., 2004, 279(37), 38091-38094.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.37
, pp. 38091-38094
-
-
Yano, J.K.1
Wester, M.R.2
Schoch, G.A.3
Griffin, K.J.4
Stout, C.D.5
Johnson, E.F.6
-
9
-
-
0025992864
-
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
-
Guengerich, F.P.; Shimada, T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem. Res. Toxicol., 1991, 4(4), 391-407.
-
(1991)
Chem. Res. Toxicol.
, vol.4
, Issue.4
, pp. 391-407
-
-
Guengerich, F.P.1
Shimada, T.2
-
10
-
-
84892246340
-
Human cytochrome P450 enzymes
-
rd ed.; Ortiz de Montellano, P.R., Ed; Kluwer Academic/Plenum Press: New York
-
rd ed.; Ortiz de Montellano, P.R., Ed; Kluwer Academic/Plenum Press: New York, 2005, pp. 377-530.
-
(2005)
Cytochrome P450: Structure, Mechanism, and Biochemistry
, pp. 377-530
-
-
Guengerich, F.P.1
-
11
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola,I.;Landis,J.Canthepharmaceuticalindustryreduceattritionrates?Nat. Rev.DrugDiscov.,2004,3(6),711-715.(Pubitemid39173511)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.8
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
13
-
-
19444376971
-
Drug metabolism, and variability among patients in drug response
-
Wilkinson, G.R. Drug metabolism, and variability among patients in drug response. N. Engl, J. Med., 2005, 352(21), 2211-2221.
-
(2005)
N. Engl, J. Med.
, vol.352
, Issue.21
, pp. 2211-2221
-
-
Wilkinson, G.R.1
-
14
-
-
0017695082
-
Polymorphic hydroxylation of debrisoquine in man
-
Mahgoub, A.; Idle, J.R; Dring, L.G; Lancaster, R.; Smith, R.L. Polymorphic hydroxylation of debrisoquine in man. Lancet, 1977, 2(8038), 584-586.
-
(1977)
Lancet
, vol.2
, Issue.8038
, pp. 584-586
-
-
Mahgoub, A.1
Idle, J.R.2
Dring, L.G.3
Lancaster, R.4
Smith, R.L.5
-
15
-
-
0027168405
-
Oxidation of the antihistaminic drug terfenadine in human liver microsomes: Role of cytochrome P450 3A(4) in N-dealkylation and C-hydroxylation
-
Yun, C-H.; Okerholm, R.A.; Guengerich, F.P. Oxidation of the antihistaminic drug terfenadine in human liver microsomes: role of cytochrome P450 3A(4) in N-dealkylation and C-hydroxylation. Drug Metab. Dispos., 1993, 21(3), 403-409.
-
(1993)
Drug Metab. Dispos.
, vol.21
, Issue.3
, pp. 403-409
-
-
Yun, C.-H.1
Okerholm, R.A.2
Guengerich, F.P.3
-
16
-
-
70249092889
-
High throughput screening of potential, cytochrome P450 inhibitors with fluorescence reactions
-
Cheng, Q.; Sohl, C.D.; Guengerich, F.P. High throughput screening of potential, cytochrome P450 inhibitors with fluorescence reactions. Nat. Protoc., 2009, 4(9), 1258-1261.
-
(2009)
Nat. Protoc.
, vol.4
, Issue.9
, pp. 1258-1261
-
-
Cheng, Q.1
Sohl, C.D.2
Guengerich, F.P.3
-
17
-
-
85137874192
-
Inhibition of drug metabolizing enzymes: Molecular and biochemical aspects
-
nd ed; Wienkers, L.; Pearson, P., Eds.; Marcel Dekker: New York
-
nd ed; Wienkers, L.; Pearson, P., Eds.; Marcel Dekker: New York, 2009, pp. 203-226.
-
(2009)
Handbook of Drug Metabolism
, pp. 203-226
-
-
Guengerich, F.P.1
-
18
-
-
16444377083
-
Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs
-
DOI 10.2165/00003088-200544030-00005
-
Zhou, S; Yung Chan, S.; Cher Goh, B.; Chan, E.; Duan, W.; Huang, M.; McLeod, H.L. Mechanism-based inhibition, of cytochrome P450 3A4 by therapeutic drugs. Clin. Pharmacokinet., 2005, 44(3), 279-304. (Pubitemid 40477790)
-
(2005)
Clinical Pharmacokinetics
, vol.44
, Issue.3
, pp. 279-304
-
-
Zhou, S.1
Chan, S.Y.2
Goh, B.C.3
Chan, E.4
Duan, W.5
Huang, M.6
McLeod, H.L.7
-
19
-
-
0023762744
-
Mechanism of multidrug resistance
-
Bradley, G.; Juranka, P.F.; Ling, V. Mechanism of multidrug resistance. Biochim. Biophys. Acta, 1988, 948(1), 87-128.
-
(1988)
Biochim. Biophys. Acta
, vol.948
, Issue.1
, pp. 87-128
-
-
Bradley, G.1
Juranka, P.F.2
Ling, V.3
-
20
-
-
0032907322
-
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
-
Kim,R.B.;Wandel,C.;Leake,B.;Cvetkovic,M.;Fromm,M.F.;Dempsey,P.J.;Roden,M. M.;Roden,D.M.;Belas,F.;Chaudhary,A.K.;Wilkinson,G.R.;Wood,A.J.J. Interrelationshipsbetweensubstratesandinhibitorsofhuman.CYP3AandP-glycoprotein. Pharm.Res.,1999,16(3),408-414.(Pubitemid29162099)
-
(1999)
Pharmaceutical Research
, vol.16
, Issue.3
, pp. 408-414
-
-
Kim, R.B.1
Wandel, C.2
Leake, B.3
Cvetkovic, M.4
Fromm, M.F.5
Dempsey, P.J.6
Roden, M.M.7
Belas, F.8
Chaudhary, A.K.9
Roden, D.M.10
Wood, A.J.J.11
Wilkinson, G.R.12
-
21
-
-
0029616617
-
Interindividual variation in expression of P-glycoprotein in normal, human liver and secondary hepatic neoplasms
-
Schuetz, E.G.; Furuya, K.N.; Schuetz, J.D. Interindividual variation in expression of P-glycoprotein in normal, human liver and secondary hepatic neoplasms. J. Pharmacol. Exp. Ther., 1995, 275(2), 1011-1018.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, Issue.2
, pp. 1011-1018
-
-
Schuetz, E.G.1
Furuya, K.N.2
Schuetz, J.D.3
-
22
-
-
0029892497
-
PGlycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
Schinkel, A.H.; Wagenaar, E.; Mol, C.A.A.M.; van Deemter, L. PGlycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest, 1996, 97(11), 2517-2524.
-
(1996)
J. Clin. Invest
, vol.97
, Issue.11
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.A.M.3
Van Deemter, L.4
-
23
-
-
0030059953
-
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately upregulate these proteins in human colon carcinoma cells
-
Schuetz, E.G.; Beck, W.T.; Schuetz, J.D. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately upregulate these proteins in human colon carcinoma cells. Mol. Pharmacol, 1996, 49(2), 311-318.
-
(1996)
Mol. Pharmacol
, vol.49
, Issue.2
, pp. 311-318
-
-
Schuetz, E.G.1
Beck, W.T.2
Schuetz, J.D.3
-
24
-
-
0030963724
-
Identification of a Pglycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism
-
Umbenhauer, D.R.; Lankas, G.R.; Pippert, T.R.; Wise, L.D.; Cartwright, M.E.; Hall, S.J.; Beare, C.M. Identification of a Pglycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism. Toxicol. Appl. Pharmacol., 1997, 146(1), 88-94.
-
(1997)
Toxicol. Appl. Pharmacol.
, vol.146
, Issue.1
, pp. 88-94
-
-
Umbenhauer, D.R.1
Lankas, G.R.2
Pippert, T.R.3
Wise, L.D.4
Cartwright, M.E.5
Hall, S.J.6
Beare, C.M.7
-
25
-
-
0033984216
-
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes
-
Schuetz, E.G.; Umbenhauer, D.R.; Yasuda, K.; Brimer, C.; Nguyen, L.; Relling, M.V.; Schuetz, J.D.; Schinkel, A.H. Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. Mol. Pharmacol, 2000, 57(1), 188-197.
-
(2000)
Mol. Pharmacol
, vol.57
, Issue.1
, pp. 188-197
-
-
Schuetz, E.G.1
Umbenhauer, D.R.2
Yasuda, K.3
Brimer, C.4
Nguyen, L.5
Relling, M.V.6
Schuetz, J.D.7
Schinkel, A.H.8
-
26
-
-
0036784516
-
Interaction of cytochrome P450 3A inhibitors with Pglycoprotein
-
Yasuda, K.; Lan, L.B.; Sanglard, D.; Furuya, K.; Schuetz, J.D.; Schuetz, E.G. Interaction of cytochrome P450 3A inhibitors with Pglycoprotein. J. Pharmacol. Exp. Ther., 2002, 303(1), 323-332.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, Issue.1
, pp. 323-332
-
-
Yasuda, K.1
Lan, L.B.2
Sanglard, D.3
Furuya, K.4
Schuetz, J.D.5
Schuetz, E.G.6
-
27
-
-
4644301418
-
Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATPlB.l:S'LC2./A6)-mediated hepatic uptake and CYP2C8-mediated metabolism, of cerivastatin: Analysis of the mechanism, of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
-
Shitara, Y.; Hirano, M.; Sato, H.; Sugiyama, Y. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATPlB.l:S'LC2./A6)-mediated hepatic uptake and CYP2C8-mediated metabolism, of cerivastatin: analysis of the mechanism, of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J. Pharmacol. Exp. Ther., 2004, 311(1), 228-236.
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.311
, Issue.1
, pp. 228-236
-
-
Shitara, Y.1
Hirano, M.2
Sato, H.3
Sugiyama, Y.4
-
28
-
-
33745216692
-
Rosuvastatin: An independent analysis of risks and benefits
-
Zipes, D.P.; Zvaifler, N.J.; Glassock, R.J.; Gilman, S.; Munoz, A.; Gogolak, V.; Gordis, L.; Dedon, P.C.; Guengerich, F.P.; Wasserman, S.I.; Witztum, J.L.; Wogan, G.N. Rosuvastatin: an independent analysis of risks and benefits. Med. Gen. Med., 2006, 8(2), e73.
-
(2006)
Med. Gen. Med.
, vol.8
, Issue.2
-
-
Zipes, D.P.1
Zvaifler, N.J.2
Glassock, R.J.3
Gilman, S.4
Munoz, A.5
Gogolak, V.6
Gordis, L.7
Dedon, P.C.8
Guengerich, F.P.9
Wasserman, S.I.10
Witztum, J.L.11
Wogan, G.N.12
-
29
-
-
67650753944
-
Gentic polymorphisms of uptake (OATP1B1, 1B3) ad efflux (MRP2, BCRP) transporters: Implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs
-
Ieiri, I.; Higushi, S.; Sugiyama, Y. Gentic polymorphisms of uptake (OATP1B1, 1B3) ad efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs. Exp. Opin. Pharmacol. Toxicol, 2009, 5(7), 703-729.
-
(2009)
Exp. Opin. Pharmacol. Toxicol
, vol.5
, Issue.7
, pp. 703-729
-
-
Ieiri, I.1
Higushi, S.2
Sugiyama, Y.3
|