메뉴 건너뛰기




Volumn 19, Issue 6, 2012, Pages 821-830

Carbonic anhydrase IX as a target for designing novel anticancer drugs

Author keywords

Anti tumor drugs; Carbonic anhydrase IX; Inhibitors; Monoclonal antibody; Structure based drug design

Indexed keywords

ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE IX; COUMARIN; IMATINIB; MONOCLONAL ANTIBODY; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR; SULFONAMIDE;

EID: 84857555235     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712799034851     Document Type: Review
Times cited : (52)

References (113)
  • 1
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • DOI 10.1038/nrd2467, PII NRD2467
    • Supuran, C. T. Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov., 2008, 7, 168-181. (Pubitemid 351194064)
    • (2008) Nature Reviews Drug Discovery , vol.7 , Issue.2 , pp. 168-181
    • Supuran, C.T.1
  • 2
    • 42149143745 scopus 로고    scopus 로고
    • Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding
    • DOI 10.1021/cr050262p
    • Krishnamurthy, V. M.; Kaufman, G. K.; Urbach, A. R.; Gitlin, I.; Gudiksen, K. L.; Weibel, D. B.; Whitesides, G. M. Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem. Rev., 2008, 108, 946-1051. (Pubitemid 351577855)
    • (2008) Chemical Reviews , vol.108 , Issue.3 , pp. 946-1051
    • Krishnamurthy, V.M.1    Kaufman, G.K.2    Urbach, A.R.3    Gitlin, I.4    Gudiksen, K.L.5    Weibel, D.B.6    Whitesides, G.M.7
  • 5
    • 0014135426 scopus 로고
    • Carbonic anhydrase: Chemistry, physiology, and inhibition
    • Maren, T. H. Carbonic anhydrase: Chemistry, physiology, and inhibition. Physiol. Rev., 1967, 47, 595-781.
    • (1967) Physiol. Rev. , vol.47 , pp. 595-781
    • Maren, T.H.1
  • 7
    • 0029975564 scopus 로고    scopus 로고
    • Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
    • DOI 10.1006/geno.1996.0223
    • Opavsk, R.; Pastoreková, S.; Zelnik, V.; Gibadulinová, A.; Stanbridge, E.J.; Závada, J.; Kettmann, R.; Pastorek, J. Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. Genomics, 1996, 33, 480-487. (Pubitemid 26159864)
    • (1996) Genomics , vol.33 , Issue.3 , pp. 480-487
    • Opavsky, R.1    Pastorekova, S.2    Zelnik, V.3    Gibadulinova, A.4    Stanbridge, E.J.5    Zavada, J.6    Kettmann, R.7    Pastorek, J.8
  • 8
    • 78649882049 scopus 로고    scopus 로고
    • Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII
    • Supuran, C.T.; Di Fiore, A.; Alterio, V.; Monti, S.M.; De Simone, G. Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII. Curr. Pharm. Des., 2010, 16, 3246-3254.
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 3246-3254
    • Supuran, C.T.1    Di Fiore, A.2    Alterio, V.3    Monti, S.M.4    De Simone, G.5
  • 9
    • 74449091486 scopus 로고
    • Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
    • De Simone, G.; Supuran, C.T. Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target. Biochim. Biophys. Acta, 2010, 1804, 404-409.
    • (1804) Biochim. Biophys. Acta , vol.2010 , pp. 404-409
    • De Simone, G.1    Supuran, C.T.2
  • 10
    • 77953521863 scopus 로고    scopus 로고
    • Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII
    • Guler, O.O.; De Simone, G.; Supuran, C.T. Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII. Curr. Med. Chem., 2010, 17, 1516-1526.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 1516-1526
    • Guler, O.O.1    De Simone, G.2    Supuran, C.T.3
  • 11
    • 78649813619 scopus 로고    scopus 로고
    • Carbonic anhydrase IX as an anticancer therapy target: Preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain
    • Zatovicova, M.; Jelenska, L.; Hulikova, A.; Csaderova, L.; Ditte, Z.; Ditte, P.; Goliasova, T.; Pastorek, J.; Pastorekova, S. Carbonic anhydrase IX as an anticancer therapy target: Preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain. Curr. Pharm. Des., 2010, 16, 3255-3263.
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 3255-3263
    • Zatovicova, M.1    Jelenska, L.2    Hulikova, A.3    Csaderova, L.4    Ditte, Z.5    Ditte, P.6    Goliasova, T.7    Pastorek, J.8    Pastorekova, S.9
  • 12
    • 42149164854 scopus 로고    scopus 로고
    • Cancer-associated carbonic anhydrases and their inhibition
    • DOI 10.2174/138161208783877893
    • Pastorekova, S.; Zatovicova, M.; Pastorek, J. Cancer-Associated carbonic anhydrases and their inhibition. Curr. Pharm. Des., 2008, 14, 685-698. (Pubitemid 351736449)
    • (2008) Current Pharmaceutical Design , vol.14 , Issue.7 , pp. 685-698
    • Pastorekova, S.1    Zatovicova, M.2    Pastorek, J.3
  • 14
    • 0031040821 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
    • DOI 10.1053/gast.1997.v112.pm9024293
    • Pastoreková, S.; Parkkila, S.; Parkkila, A.K.; Opavsk, R.; Zelník, V.; Saarnio, J.; Pastorek, J. Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Gastroenterology, 1997, 112, 398-408. (Pubitemid 27078826)
    • (1997) Gastroenterology , vol.112 , Issue.2 , pp. 398-408
    • Pastorekova, S.1    Parkkila, S.2    Parkkila, A.-K.3    Opavsky, R.4    Zelnik, V.5    Saarnio, J.6    Pastorek, J.7
  • 16
    • 77952878558 scopus 로고    scopus 로고
    • Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy
    • Stillebroer, A.B.; Mulders, P.F.; Boerman, O.C.; Oyen, W.J.; Oosterwijk, E. Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy. Eur. Urol., 2010, 58, 75-83.
    • (2010) Eur. Urol. , vol.58 , pp. 75-83
    • Stillebroer, A.B.1    Mulders, P.F.2    Boerman, O.C.3    Oyen, W.J.4    Oosterwijk, E.5
  • 18
    • 0028235153 scopus 로고
    • Receptor tyrosine phosphatase β is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin
    • Barnea, G.; Grumet, M.; Milev, P.; Silvennoinen, O.; Levy, J.B.; Sap, J.; Schlessinger, J. Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin. J. Biol. Chem., 1994, 269, 14349-14352. (Pubitemid 24193978)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.20 , pp. 14349-14352
    • Barnea, G.1    Grumet, M.2    Milev, P.3    Silvennoinen, O.4    Levy, J.B.5    Sap, J.6    Schlessinger, J.7
  • 20
    • 35048889059 scopus 로고    scopus 로고
    • A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones
    • Parent, A.S.; Mungenast, A.E.; Lomniczi, A.; Sandau, U.S.; Peles, E.; Bosch, M.A.; Rønnekleiv, O.K.; Ojeda, S.R. A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones. J. Neuroendocrinol., 2007, 19, 847-859.
    • (2007) J. Neuroendocrinol. , vol.19 , pp. 847-859
    • Parent, A.S.1    Mungenast, A.E.2    Lomniczi, A.3    Sandau, U.S.4    Peles, E.5    Bosch, M.A.6    Rønnekleiv, O.K.7    Ojeda, S.R.8
  • 22
    • 0033785674 scopus 로고    scopus 로고
    • Keratan sulfate: Structure, biosynthesis, and function
    • Funderburgh, J. L. Keratan sulfate: Structure, biosynthesis, and function. Glycobiology, 2000, 10, 951-958.
    • (2000) Glycobiology , vol.10 , pp. 951-958
    • Funderburgh, J.L.1
  • 23
    • 28244451574 scopus 로고    scopus 로고
    • The role of carbonic anhydrase IX overexpression in kidney cancer
    • DOI 10.1016/j.ejca.2005.09.011, PII S0959804905008415
    • Dorai, T.; Sawczuk, I.S.; Pastorek, J.; Wiernik, P.H.; Dutcher, J.P. The role of carbonic anhydrase IX overexpression in kidney cancer. Eur. J. Cancer., 2005, 41, 2935-2947. (Pubitemid 41713134)
    • (2005) European Journal of Cancer , vol.41 , Issue.18 , pp. 2935-2947
    • Dorai, T.1    Sawczuk, I.S.2    Pastorek, J.3    Wiernik, P.H.4    Dutcher, J.P.5
  • 28
    • 0037490210 scopus 로고    scopus 로고
    • Hypoxia-inducible factor and its biomedical relevance
    • DOI 10.1074/jbc.R200030200
    • Huang, L.E.; Bunn, H.F. Hypoxia-inducible factor and its biomedical relevance J. Biol. Chem., 2003, 278, 19575-19578. (Pubitemid 36799137)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.22 , pp. 19575-19578
    • Huang, L.E.1    Bunn, H.F.2
  • 29
    • 35248824187 scopus 로고    scopus 로고
    • Oxygen sensing and hypoxia-induced responses
    • Coleman, M.L.; Ratcliffe, P.J. Oxygen sensing and hypoxia-induced responses. Essays Biochem., 2007, 43, 1-15.
    • (2007) Essays Biochem. , vol.43 , pp. 1-15
    • Coleman, M.L.1    Ratcliffe, P.J.2
  • 32
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • DOI 10.1016/S1357-4310(99)01615-9, PII S1357431099016159
    • Stubbs, M.; McSheehy, P.M.; Griffiths, J.R.; Bashford, C.L. Causes and consequences of tumour acidity and implications for treatment. Mol. Med. Today, 2000, 6, 15-19. (Pubitemid 30010232)
    • (2000) Molecular Medicine Today , vol.6 , Issue.1 , pp. 15-19
    • Stubbs, M.1    McSheehy, P.M.J.2    Griffiths, J.R.3    Bashford, C.L.4
  • 33
    • 0036554644 scopus 로고    scopus 로고
    • Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
    • Helmlinger, G.; Sckell, A.; Dellian, M.; Forbes, N.S.; Jain, R.K. Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin. Cancer Res., 2002, 8, 1284-1291. (Pubitemid 35177386)
    • (2002) Clinical Cancer Research , vol.8 , Issue.4 , pp. 1284-1291
    • Helmlinger, G.1    Sckell, A.2    Dellian, M.3    Forbes, N.S.4    Jain, R.K.5
  • 34
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize
    • DOI 10.1002/jcb.21187
    • Fukumura, D.; Jain, R.K. Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize. J. Cell Biochem., 2007, 101, 937-949. (Pubitemid 47040874)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.4 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 35
    • 78650308850 scopus 로고    scopus 로고
    • New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
    • Swietach, P.; Hulikova, A.; Vaughan-Jones, R.D.; Harris, A.L. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene, 2010, 29, 6509-6521.
    • (2010) Oncogene , vol.29 , pp. 6509-6521
    • Swietach, P.1    Hulikova, A.2    Vaughan-Jones, R.D.3    Harris, A.L.4
  • 36
    • 0027373117 scopus 로고
    • Vacuolartype H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells
    • Martinez-Zaguilan, R.; Lynch, R.M.; Martinez, G.M.; Gillies, R.J. Vacuolartype H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am. J. Physiol., 1993, 265, C1015-C1029.
    • (1993) Am. J. Physiol. , vol.265
    • Martinez-Zaguilan, R.1    Lynch, R.M.2    Martinez, G.M.3    Gillies, R.J.4
  • 37
    • 0032080644 scopus 로고    scopus 로고
    • Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells
    • Lee, A.H.; Tannock, I.F. Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res., 1998, 58, 1901-1908. (Pubitemid 28217465)
    • (1998) Cancer Research , vol.58 , Issue.9 , pp. 1901-1908
    • Lee, A.H.1    Tannock, I.F.2
  • 39
    • 10344248930 scopus 로고    scopus 로고
    • Regulation of intracellular pH
    • Boron, W.F. Regulation of intracellular pH. Adv. Physiol. Educ., 2004, 28, 160-179.
    • (2004) Adv. Physiol. Educ. , vol.28 , pp. 160-179
    • Boron, W.F.1
  • 40
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
    • Chiche, J.; Brahimi-Horn, M.C.; Pouysségur, J. Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer. J. Cell. Mol. Med. 2010, 14, 771-794.
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouysségur, J.3
  • 41
    • 35248828654 scopus 로고    scopus 로고
    • Hypoxia in cancer cell metabolism and pH regulation
    • Brahimi-Horn, M.C.; Pouysségur, J. Hypoxia in cancer cell metabolism and pH regulation. Essays Biochem., 2007, 43, 165-178.
    • (2007) Essays Biochem. , vol.43 , pp. 165-178
    • Brahimi-Horn, M.C.1    Pouysségur, J.2
  • 42
    • 34447547148 scopus 로고    scopus 로고
    • Regulation of tumor pH and the role of carbonic anhydrase 9
    • DOI 10.1007/s10555-007-9064-0, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
    • Swietach, P.; Vaughan-Jones, R.D.; Harris, A.L. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev., 2007, 26, 299-310. (Pubitemid 47101667)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 299-310
    • Swietach, P.1    Vaughan-Jones, R.D.2    Harris, A.L.3
  • 45
    • 44449125717 scopus 로고    scopus 로고
    • Tumor-Associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths
    • Swietach, P.; Wigfield, S.; Supuran, C.T.; Harris, A.L.; Vaughan-Jones, R.D. Tumor-Associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. BJU Int., 2008, 101, Suppl 4:22-24.
    • (2008) BJU Int. , vol.101 , Issue.SUPPL. 4 , pp. 22-24
    • Swietach, P.1    Wigfield, S.2    Supuran, C.T.3    Harris, A.L.4    Vaughan-Jones, R.D.5
  • 46
    • 67749145635 scopus 로고    scopus 로고
    • The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths
    • Swietach, P.; Patiar, S.; Supuran, C.T.; Harris A.L.; Vaughan-Jones, R.D. The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths. J. Biol. Chem. 2009, 284, 20299-20310.
    • (2009) J. Biol. Chem. , vol.284 , pp. 20299-20310
    • Swietach, P.1    Patiar, S.2    Supuran, C.T.3    Harris, A.L.4    Vaughan-Jones, R.D.5
  • 47
    • 33947423405 scopus 로고    scopus 로고
    • Why bicarbonate?
    • DOI 10.1139/O06-184
    • Casey, J.R. Why bicarbonate? Biochem. Cell Biol., 2006, 84, 930-939. (Pubitemid 46450693)
    • (2006) Biochemistry and Cell Biology , vol.84 , Issue.6 , pp. 930-939
    • Casey, J.R.1
  • 48
    • 22744446294 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
    • DOI 10.1021/jm0501073
    • Cecchi, A.; Hulikova, A.; Pastorek, J.; Pastoreková, S.; Scozzafava, A.; Winum, J.Y.; Montero, J.L.; Supuran, C.T. Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-Associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J. Med. Chem., 2005, 48, 4834-4841. (Pubitemid 41033126)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.15 , pp. 4834-4841
    • Cecchi, A.1    Hulikova, A.2    Pastorek, J.3    Pastorekova, S.4    Scozzafava, A.5    Winum, J.-Y.6    Montero, J.-L.7    Supuran, C.T.8
  • 49
    • 34250322126 scopus 로고    scopus 로고
    • Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors
    • DOI 10.1016/j.radonc.2007.04.018, PII S0167814007001752, Highlights from the 10th International ESTRO-Wolfsberg Meeting on Molecular Radiation Biology/Oncology 2007
    • Dubois, L.; Douma, K.; Supuran, C.T.; Chiu, R.K.; van Zandvoort, M.A.; Pastoreková, S.; Scozzafava, A.; Wouters, B.G.; Lambin, P. Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors. Radiother. Oncol., 2007, 83, 367-373. (Pubitemid 46915545)
    • (2007) Radiotherapy and Oncology , vol.83 , Issue.3 , pp. 367-373
    • Dubois, L.1    Douma, K.2    Supuran, C.T.3    Chiu, R.K.4    Van Zandvoort, M.A.M.J.5    Pastorekova, S.6    Scozzafava, A.7    Wouters, B.G.8    Lambin, P.9
  • 50
    • 0142121458 scopus 로고    scopus 로고
    • Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin
    • DOI 10.1016/S0014-4827(03)00351-3
    • Svastová, E.; Zilka, N.; Zat'ovicová, M.; Gibadulinová, A.; Ciampor, F.; Pastorek, J.; Pastoreková, S. Carbonic anhydrase IX reduces E-cadherinmediated adhesion of MDCK cells via interaction with beta-catenin. Exp. Cell Res., 2003, 290, 332-345. (Pubitemid 37272176)
    • (2003) Experimental Cell Research , vol.290 , Issue.2 , pp. 332-345
    • Svastova, E.1    Zilka, N.2    Zat'ovicova, M.3    Gibadulinova, A.4    Ciampor, F.5    Pastorek, J.6    Pastorekova, S.7
  • 51
    • 25144484490 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment
    • Zavadova, Z.; Zavada, J. Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment. Oncol. Rep., 2005, 13, 977-982.
    • (2005) Oncol. Rep. , vol.13 , pp. 977-982
    • Zavadova, Z.1    Zavada, J.2
  • 52
    • 0034024783 scopus 로고    scopus 로고
    • Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion
    • Závada, J.; Závadová, Z.; Pastorek, J.; Biesová, Z.; Jezek, J.; Velek, J. Human tumour-Associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion. Br. J. Cancer., 2000, 82, 1808-1813. (Pubitemid 30307393)
    • (2000) British Journal of Cancer , vol.82 , Issue.11 , pp. 1808-1813
    • Zavada, J.1    Zavadova, Z.2    Pastorek, J.3    Biesova, Z.4    Jezek, J.5    Velek, J.6
  • 54
    • 0021284401 scopus 로고
    • Structure, refinement, and function of carbonic anhydrase isozymes: Refinement of human carbonic anhydrase I
    • Kannan, K. K.; Ramanadham, M.; Jones, T. A. Structure, refinement, and function of carbonic anhydrase isozymes: Refinement of human carbonic anhydrase I. Ann. N.Y. Acad. Sci., 1984, 429, 49-60. (Pubitemid 14085829)
    • (1984) Annals of the New York Academy of Sciences , vol.429 , pp. 49-60
    • Kannan, K.K.1    Ramanadham, M.2    Jones, T.A.3
  • 55
    • 0024218294 scopus 로고
    • - ion to the zinc at high pH
    • DOI 10.1002/prot.340040407
    • Eriksson, A. E.; Kylsten, P. M.; Jones, T. A.; Liljas, A. Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: A pentacoordinated binding of the SCN-ion to the zinc at high pH. Proteins, 1988, 4, 283-293. (Pubitemid 19094187)
    • (1988) Proteins: Structure, Function and Genetics , vol.4 , Issue.4 , pp. 283-293
    • Eriksson, A.E.1    Kylsten, P.M.2    Jones, T.A.3    Liljas, A.4
  • 56
    • 0027215631 scopus 로고
    • Refined structure of bovine carbonic anhydrase III at 2.0 A resolution
    • Eriksson, A. E.; Liljas, A. Refined structure of bovine carbonic anhydrase III at 2.0 A resolution. Proteins, 1993, 16, 29-42. (Pubitemid 23129870)
    • (1993) Proteins: Structure, Function and Genetics , vol.16 , Issue.1 , pp. 29-42
    • Eriksson, A.E.1    Liljas, A.2
  • 57
    • 0028867081 scopus 로고
    • Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: Implications for catalytic proton transfer and inhibitor design
    • Boriack-Sjodin, P. A.; Heck, R. W.; Laipis, P. J.; Silverman, D. N.; Christianson, D. W. Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: Implications for catalytic proton transfer and inhibitor design. Proc. Natl. Acad. Sci. U.S.A., 1995, 92, 10949-10953.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 10949-10953
    • Boriack-Sjodin, P.A.1    Heck, R.W.2    Laipis, P.J.3    Silverman, D.N.4    Christianson, D.W.5
  • 58
    • 0030447975 scopus 로고    scopus 로고
    • Crystal structure of the secretory form of membrane-Associated human carbonic anhydrase IV at 2.8-A resolution
    • Stams, T.; Nair, S. K.; Okuyama, T.; Waheed, A.; Sly, W. S.; Christianson, D. W. Crystal structure of the secretory form of membrane-Associated human carbonic anhydrase IV at 2.8-A resolution. Proc. Natl. Acad. Sci. U.S.A., 1996, 93, 13589-13594.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 13589-13594
    • Stams, T.1    Nair, S.K.2    Okuyama, T.3    Waheed, A.4    Sly, W.S.5    Christianson, D.W.6
  • 60
    • 1342304082 scopus 로고    scopus 로고
    • Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: Implications for selective inhibition of membrane-associated isozymes
    • DOI 10.1074/jbc.M310809200
    • Whittington, D. A.; Grubb, J. H.; Waheed, A.; Shah, G. N.; Sly, W. S.; Christianson, D. W. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: Implications for selective inhibition of membrane-Associated isozymes. J. Biol. Chem., 2004, 279, 7223-7228. (Pubitemid 38248870)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.8 , pp. 7223-7228
    • Whittington, D.A.1    Grubb, J.H.2    Waheed, A.3    Shah, G.N.4    Sly, W.S.5    Christianson, D.W.6
  • 66
    • 0026035371 scopus 로고
    • Carbon dioxide binding to human carbonic anhydrase II
    • Merz, K. M. Jr. Carbon dioxide binding to human carbonic anhydrase II. J. Am. Chem. Soc., 1991, 113, 406-411.
    • (1991) J. Am. Chem. Soc. , vol.113 , pp. 406-411
    • Merz Jr., K.M.1
  • 67
    • 0024421430 scopus 로고
    • Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant
    • Tu, C. K.; Silverman, D. N.; Forsman, C.; Jonsson, B. H.; Lindskog, S. Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant. Biochemistry, 1989, 28, 7913-7918. (Pubitemid 19238127)
    • (1989) Biochemistry , vol.28 , Issue.19 , pp. 7913-7918
    • Tu, C.1    Silverman, D.N.2    Forsman, C.3    Johnsson, B.-H.4    Lindskog, S.5
  • 68
    • 34548724094 scopus 로고    scopus 로고
    • Solvent-mediated proton transfer in catalysis by carbonic anhydrase
    • Silverman, D. N.; McKenna, R. Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Acc. Chem. Res., 2007, 40, 669-675.
    • (2007) Acc. Chem. Res. , vol.40 , pp. 669-675
    • Silverman, D.N.1    McKenna, R.2
  • 69
    • 34548823782 scopus 로고    scopus 로고
    • Identification of proton-transfer pathways in human carbonic anhydrase II
    • DOI 10.1021/jp073499t
    • Roy, A.; Taraphder, S. Identification of proton-transfer pathways in human carbonic anhydrase II. J. Phys. Chem. Sect. B., 2007, 111, 10563-10576. (Pubitemid 47441861)
    • (2007) Journal of Physical Chemistry B , vol.111 , Issue.35 , pp. 10563-10576
    • Roy, A.1    Taraphder, S.2
  • 70
    • 33947414441 scopus 로고    scopus 로고
    • Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: Insights into the proton transfer mechanism
    • DOI 10.1021/bi062066y
    • Fisher, S. Z.; Maupin, C. M.; Budayova-Spano, M.; Govindasamy, L.; Tu, C. K.; Agbandje-McKenna, M.; Silverman, D. N.; Voth, G. A.; McKenna, R. Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: Insights into the proton transfer mechanism. Biochemistry, 2007, 46, 2930-2937. (Pubitemid 46449117)
    • (2007) Biochemistry , vol.46 , Issue.11 , pp. 2930-2937
    • Fisher, S.Z.1    Maupin, C.M.2    Budayova-Spano, M.3    Govindasamy, L.4    Tu, C.5    Agbandje-McKenna, M.6    Silverman, D.N.7    Voth, G.A.8    McKenna, R.9
  • 71
    • 0038118505 scopus 로고    scopus 로고
    • 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma
    • DOI 10.1002/ijc.11142
    • Chrastina, A.; Závada, J.; Parkkila, S.; Kaluz, S.; Kaluzová, M.; Rajcáni, J.; Pastorek, J.; Pastoreková, S. Biodistribution and pharmacokinetics of 125Ilabeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma. Int. J. Cancer., 2003, 105, 873-881. (Pubitemid 36706114)
    • (2003) International Journal of Cancer , vol.105 , Issue.6 , pp. 873-881
    • Chrastina, A.1    Zavada, J.2    Parkkila, S.3    Kaluz, S.4    Kaluzova, M.5    Rajcani, J.6    Pastorek, J.7    Pastorekova, S.8
  • 73
    • 44449091079 scopus 로고    scopus 로고
    • Immunohistochemical expression of carbonic anhydrase IX assessed over time and during treatment in renal cell carcinoma
    • Jensen, H.K.; Nordsmark, M.; Donskov, F.; Marcussen, N.; von der Maase, H. Immunohistochemical expression of carbonic anhydrase IX assessed over time and during treatment in renal cell carcinoma. BJU Int., 2008, 101, 41-44.
    • (2008) BJU Int. , vol.101 , pp. 41-44
    • Jensen, H.K.1    Nordsmark, M.2    Donskov, F.3    Marcussen, N.4    Von Der Maase, H.5
  • 74
    • 0022502868 scopus 로고
    • Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney
    • Oosterwijk, E.; Ruiter, D.J.; Hoedemaeker, P.J.; Pauwels, E.K.; Jonas, U.; Zwartendijk, J.; Warnaar, S.O. Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney. Int. J. Cancer, 1986, 38, 489-494. (Pubitemid 16006918)
    • (1986) International Journal of Cancer , vol.38 , Issue.4 , pp. 489-494
    • Oosterwijk, E.1    Ruiter, D.J.2    Hoedemaeker Ph., J.3
  • 77
    • 44449089520 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: Historical and future perspectives
    • Oosterwijk, E. Carbonic anhydrase IX: Historical and future perspectives. BJU Int., 2008, 101, Suppl 4:2-7.
    • (2008) BJU Int. , vol.101 , Issue.SUPPL. 4 , pp. 2-7
    • Oosterwijk, E.1
  • 82
    • 79954591401 scopus 로고    scopus 로고
    • Correlation of in vivo and in vitro measures of carbonic anhydrase IX antigen expression in renal masses using antibody 124I-cG250
    • Pryma, D.A.; O'Donoghue, J.A.; Humm, J.L.; Jungbluth, A.A.; Old, L.J.; Larson, S.M.; Divgi, C.R. Correlation of in vivo and in vitro measures of carbonic anhydrase IX antigen expression in renal masses using antibody 124I-cG250. J. Nucl. Med., 2011, 52, 535-540.
    • (2011) J. Nucl. Med. , vol.52 , pp. 535-540
    • Pryma, D.A.1    O'Donoghue, J.A.2    Humm, J.L.3    Jungbluth, A.A.4    Old, L.J.5    Larson, S.M.6    Divgi, C.R.7
  • 84
    • 78751650361 scopus 로고    scopus 로고
    • A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-Alpha-2a in metastatic renal cell carcinoma patients
    • Siebels, M.; Rohrmann, K.; Oberneder, R.; Stahler, M.; Haseke, N.; Beck, J.; Hofmann, R.; Kindler, M.; Kloepfer, P.; Stief, C. A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-Alpha-2a in metastatic renal cell carcinoma patients. World J. Urol., 2011, 29, 121-126.
    • (2011) World J. Urol. , vol.29 , pp. 121-126
    • Siebels, M.1    Rohrmann, K.2    Oberneder, R.3    Stahler, M.4    Haseke, N.5    Beck, J.6    Hofmann, R.7    Kindler, M.8    Kloepfer, P.9    Stief, C.10
  • 85
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert, J.M. Antibody-based therapeutics to watch in 2011. MAbs, 2011, 3, 76-99.
    • (2011) MAbs , vol.3 , pp. 76-99
    • Reichert, J.M.1
  • 87
    • 84857601328 scopus 로고    scopus 로고
    • 111In]-Labeled divalent Fab fragment of chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX
    • Bethesda (MD): National Center for Biotechnology Information (US)
    • Chopra, A. [111In]-Labeled divalent Fab fragment of chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2010. 2010.
    • (2004) Molecular Imaging and Contrast Agent Database (MICAD) [Internet] , pp. 2010
    • Chopra, A.1
  • 88
    • 84857601328 scopus 로고    scopus 로고
    • 111In]-Labeled monovalent Fab fragment of chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX
    • Bethesda (MD): National Center for Biotechnology Information (US)
    • Chopra A. [111In]-Labeled monovalent Fab fragment of chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2010.2010.
    • (2004) Molecular Imaging and Contrast Agent Database (MICAD) [Internet] , pp. 2010
    • Chopra, A.1
  • 89
    • 84857601328 scopus 로고    scopus 로고
    • 111In]-Labeled chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX
    • Bethesda (MD): National Center for Biotechnology Information (US)
    • Chopra A. [111In]-Labeled chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2010. 2010.
    • (2004) Molecular Imaging and Contrast Agent Database (MICAD) [Internet] , pp. 2010
    • Chopra, A.1
  • 92
    • 68749119336 scopus 로고    scopus 로고
    • Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours
    • Ahlskog, J.K.; Schliemann, C.; Mårlind, J.; Qureshi, U.; Ammar, A.; Pedley, R.B.; Neri, D. Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours. Br. J. Cancer, 2009, 101, 645-657.
    • (2009) Br. J. Cancer , vol.101 , pp. 645-657
    • Ahlskog, J.K.1    Schliemann, C.2    Marlind, J.3    Qureshi, U.4    Ammar, A.5    Pedley, R.B.6    Neri, D.7
  • 93
    • 77949716901 scopus 로고    scopus 로고
    • Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology
    • Xu, C.; Lo, A.; Yammanuru, A.; Tallarico, A.S.; Brady, K.; Murakami, A.; Barteneva, N.; Zhu, Q.; Marasco, W.A. Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS One, 2010, 5, e9625.
    • (2010) PLoS One , vol.5
    • Xu, C.1    Lo, A.2    Yammanuru, A.3    Tallarico, A.S.4    Brady, K.5    Murakami, A.6    Barteneva, N.7    Zhu, Q.8    Marasco, W.A.9
  • 95
    • 42149158230 scopus 로고    scopus 로고
    • Carbonic anhydrases as drug targets
    • Supuran, C.T. Carbonic anhydrases as drug targets. Curr. Pharm. Des., 2008, 14, 601-602.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 601-602
    • Supuran, C.T.1
  • 96
    • 2542592581 scopus 로고    scopus 로고
    • Modulation of carbonic anhydrase activity and its applications in therapy
    • DOI 10.1517/13543776.14.5.667
    • Scozzafava, A.; Mastrolorenzo, A.; Supuran, C.T. Modulation of carbonic anhydrase activity and its applications in therapy. Expert Opin. Ther. Pat., 2004, 14, 667-702. (Pubitemid 38702328)
    • (2004) Expert Opinion on Therapeutic Patents , vol.14 , Issue.5 , pp. 667-702
    • Scozzafava, A.1    Mastrolorenzo, A.2    Supuran, C.T.3
  • 98
    • 77954218410 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors
    • Supuran, C. T. Carbonic anhydrase inhibitors. Bioorg. Med. Chem. Lett., 2010, 20, 3467-3474.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3467-3474
    • Supuran, C.T.1
  • 100
    • 0842281270 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX
    • DOI 10.1016/j.bmcl.2003.12.029
    • Pastorekova, S.; Casini, A.; Scozzafava, A.; Vullo, D.; Pastorek, J.; Supuran, C.T. Carbonic anhydrase inhibitors: The first selective, membraneimpermeant inhibitors targeting the tumor-Associated isozyme IX. Bioorg. Med. Chem. Lett., 2004, 14, 869-873. (Pubitemid 38167605)
    • (2004) Bioorganic and Medicinal Chemistry Letters , vol.14 , Issue.4 , pp. 869-873
    • Pastorekova, S.1    Casini, A.2    Scozzafava, A.3    Vullo, D.4    Pastorek, J.5    Supuran, C.T.6
  • 101
    • 33750082400 scopus 로고    scopus 로고
    • Targeting tumor-associated carbonic anhydrase IX in cancer therapy
    • DOI 10.1016/j.tips.2006.09.002, PII S0165614706002203
    • Thiry, A.; Dogné, J.-M.; Masereel, B.; Supuran C.T. Targeting tumorassociated carbonic anhydrase IX in cancer therapy. Trends Pharmacol. Sci., 2006, 27, 566-573. (Pubitemid 44574507)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.11 , pp. 566-573
    • Thiry, A.1    Dogne, J.-M.2    Masereel, B.3    Supuran, C.T.4
  • 102
    • 67651091693 scopus 로고    scopus 로고
    • In vivo targeting of tumor-Associated carbonic anhydrases using acetazolamide derivatives
    • Ahlskog, J.K.J.; Dumelin, C.E.; Trüssel, S.; Marlind, J.; Neri, D. In vivo targeting of tumor-Associated carbonic anhydrases using acetazolamide derivatives. Bioorg. Med. Chem. Lett., 2009, 19, 4851-4856.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4851-4856
    • Ahlskog, J.K.J.1    Dumelin, C.E.2    Trüssel, S.3    Marlind, J.4    Neri, D.5
  • 103
    • 69949128698 scopus 로고    scopus 로고
    • Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model
    • Dubois, L.; Lieuwes, N.G.; Maresca, A.; Thiry, A.; Supuran, C.T.; Scozzafava, A.; Wouters, B.G.; Lambin, P. Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model. Radiother. Oncol., 2009, 92, 423-428.
    • (2009) Radiother. Oncol. , vol.92 , pp. 423-428
    • Dubois, L.1    Lieuwes, N.G.2    Maresca, A.3    Thiry, A.4    Supuran, C.T.5    Scozzafava, A.6    Wouters, B.G.7    Lambin, P.8
  • 105
    • 79952808077 scopus 로고    scopus 로고
    • Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis
    • Pacchiano, F.; Carta, F.; McDonald, P.C.; Lou, Y.; Vullo, D.; Scozzafava, A.; Dedhar, S.; Supuran, C.T. Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J. Med. Chem., 2011, 54, 1896-902.
    • (2011) J. Med. Chem. , vol.54 , pp. 1896-902
    • Pacchiano, F.1    Carta, F.2    McDonald, P.C.3    Lou, Y.4    Vullo, D.5    Scozzafava, A.6    Dedhar, S.7    Supuran, C.T.8
  • 107
    • 74849118851 scopus 로고    scopus 로고
    • Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins
    • Maresca, A.; Temperini, C.; Pochet, L.; Masereel, B.; Scozzafava, A.; Supuran, C.T. Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J. Med Chem., 2010, 53, 335-344.
    • (2010) J. Med Chem. , vol.53 , pp. 335-344
    • Maresca, A.1    Temperini, C.2    Pochet, L.3    Masereel, B.4    Scozzafava, A.5    Supuran, C.T.6
  • 108
    • 77955424195 scopus 로고    scopus 로고
    • Coumarins incorporating hydroxy-And chloromoieties selectively inhibit the transmembrane, tumor-Associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II
    • Maresca, A.; Supuran, C.T. Coumarins incorporating hydroxy-And chloromoieties selectively inhibit the transmembrane, tumor-Associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. Bioorg Med. Chem. Lett., 2010, 20, 4511-4514.
    • (2010) Bioorg Med. Chem. Lett. , vol.20 , pp. 4511-4514
    • Maresca, A.1    Supuran, C.T.2
  • 110
    • 78449303755 scopus 로고    scopus 로고
    • 7,8-Disubstituted-but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumorassociated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range
    • Maresca, A.; Scozzafava, A.; Supuran, C.T. 7,8-Disubstituted-but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumorassociated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. Bioorg. Med. Chem. Lett., 2010, 20, 7255-7258.
    • (2010) Bioorg. Med. Chem Lett. , vol.20 , pp. 7255-7258
    • Maresca, A.1    Scozzafava, A.2    Supuran, C.T.3
  • 111
    • 67649946943 scopus 로고    scopus 로고
    • The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian β-carbonic anhydrase isoforms
    • Parkkila, S.; Innocenti, A.; Kallio, H.; Hilvo, M.; Scozzafava, A.; Supuran, C.T. The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian β-carbonic anhydrase isoforms. Bioorg. Med. Chem. Lett., 2009, 19, 4102-4106.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4102-4106
    • Parkkila, S.1    Innocenti, A.2    Kallio, H.3    Hilvo, M.4    Scozzafava, A.5    Supuran, C.T.6
  • 112
    • 38949118663 scopus 로고    scopus 로고
    • Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8
    • DOI 10.1016/j.str.2007.11.009, PII S0969212608000051
    • Li, S.; Kussie, P.; Ferguson, K.M. Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure, 2008, 16, 216-227. (Pubitemid 351215209)
    • (2008) Structure , vol.16 , Issue.2 , pp. 216-227
    • Li, S.1    Kussie, P.2    Ferguson, K.M.3
  • 113
    • 78649795438 scopus 로고    scopus 로고
    • Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody
    • Freeman, M.M.; Seaman, M.S.; Rits-Volloch, S.; Hong, X.; Kao, C.Y.; Ho, D.D.; Chen, B. Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody. Structure, 2010, 18, 1632-1641.
    • (2010) Structure , vol.18 , pp. 1632-1641
    • Freeman, M.M.1    Seaman, M.S.2    Rits-Volloch, S.3    Hong, X.4    Kao, C.Y.5    Ho, D.D.6    Chen, B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.