메뉴 건너뛰기




Volumn 58, Issue 1, 2010, Pages 75-83

Carbonic Anhydrase IX in Renal Cell Carcinoma: Implications for Prognosis, Diagnosis, and Therapy

Author keywords

Antigen; CAIX; Carbonic anhydrase 9; Clear cell renal cell carcinoma; Diagnosis; Prognosis; RCC; Therapy

Indexed keywords

ANGIOGENESIS INHIBITOR; CARBONATE DEHYDRATASE IX; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; IODINE 124; IODINE 131; LUTETIUM 177; MONOCLONAL ANTIBODY G250; MONOCLONAL ANTIBODY G250 I 131; MONOCLONAL ANTIBODY G250 IN 111; RADIOPHARMACEUTICAL AGENT; RHENIUM 186; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; YTTRIUM 90;

EID: 77952878558     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2010.03.015     Document Type: Review
Times cited : (183)

References (74)
  • 2
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer R.J., Hutson T.E., Tomczak P., et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356 (2007) 115-124
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 3
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer R.J., Hutson T.E., Tomczak P., et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27 (2009) 3584-3590
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 4
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe G., Fisher R.I., Rosenberg S.A., Sznol M., Parkinson D.R., and Louie A.C. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 13 (1995) 688-696
    • (1995) J Clin Oncol , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3    Sznol, M.4    Parkinson, D.R.5    Louie, A.C.6
  • 5
    • 36448930484 scopus 로고    scopus 로고
    • Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: results of a randomized controlled trial
    • Negrier S., Perol D., Ravaud A., et al. Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: results of a randomized controlled trial. Cancer 110 (2007) 2468-2477
    • (2007) Cancer , vol.110 , pp. 2468-2477
    • Negrier, S.1    Perol, D.2    Ravaud, A.3
  • 6
    • 70350772288 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors-a review on pharmacology, metabolism and side effects
    • Hartmann J.T., Haap M., Kopp H.G., and Lipp H.P. Tyrosine kinase inhibitors-a review on pharmacology, metabolism and side effects. Curr Drug Metab 10 (2009) 470-481
    • (2009) Curr Drug Metab , vol.10 , pp. 470-481
    • Hartmann, J.T.1    Haap, M.2    Kopp, H.G.3    Lipp, H.P.4
  • 7
    • 67651233821 scopus 로고    scopus 로고
    • Non-clear cell renal cancer: features and medical management
    • Heng D.Y., and Choueiri T.K. Non-clear cell renal cancer: features and medical management. J Natl Compr Canc Netw 7 (2009) 659-665
    • (2009) J Natl Compr Canc Netw , vol.7 , pp. 659-665
    • Heng, D.Y.1    Choueiri, T.K.2
  • 8
    • 0022502868 scopus 로고
    • Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney
    • Oosterwijk E., Ruiter D.J., Hoedemaeker P.J., et al. Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney. Int J Cancer 38 (1986) 489-494
    • (1986) Int J Cancer , vol.38 , pp. 489-494
    • Oosterwijk, E.1    Ruiter, D.J.2    Hoedemaeker, P.J.3
  • 9
    • 0034099829 scopus 로고    scopus 로고
    • Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250
    • Grabmaier K., Vissers J.L., De Weijert M.C., et al. Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250. Int J Cancer 85 (2000) 865-870
    • (2000) Int J Cancer , vol.85 , pp. 865-870
    • Grabmaier, K.1    Vissers, J.L.2    De Weijert, M.C.3
  • 10
    • 0029975564 scopus 로고    scopus 로고
    • Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships
    • Opavsky R., Pastorekova S., Zelnik V., et al. Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. Genomics 33 (1996) 480-487
    • (1996) Genomics , vol.33 , pp. 480-487
    • Opavsky, R.1    Pastorekova, S.2    Zelnik, V.3
  • 11
    • 2442579987 scopus 로고    scopus 로고
    • Carbonic anhydrases: catalytic and inhibition mechanisms, distribution and physiological roles
    • Supuran C.T., Scozzafava A., and Conway J. (Eds), CRC Press, Boca Raton, Florida
    • Supuran C.T. Carbonic anhydrases: catalytic and inhibition mechanisms, distribution and physiological roles. In: Supuran C.T., Scozzafava A., and Conway J. (Eds). Carbonic anhydrase: its inhibitors and activators (2004), CRC Press, Boca Raton, Florida 1-23
    • (2004) Carbonic anhydrase: its inhibitors and activators , pp. 1-23
    • Supuran, C.T.1
  • 12
    • 0348047338 scopus 로고    scopus 로고
    • Quantification of G250 mRNA expression in renal epithelial neoplasms by real-time reverse transcription-PCR of dissected tissue from paraffin sections
    • Bismar T.A., Bianco F.J., Zhang H., et al. Quantification of G250 mRNA expression in renal epithelial neoplasms by real-time reverse transcription-PCR of dissected tissue from paraffin sections. Pathology 35 (2003) 513-517
    • (2003) Pathology , vol.35 , pp. 513-517
    • Bismar, T.A.1    Bianco, F.J.2    Zhang, H.3
  • 13
    • 0035164633 scopus 로고    scopus 로고
    • Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours
    • Saarnio J., Parkkila S., Parkkila A.K., et al. Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours. J Hepatol 35 (2001) 643-649
    • (2001) J Hepatol , vol.35 , pp. 643-649
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3
  • 14
    • 33750082400 scopus 로고    scopus 로고
    • Targeting tumor-associated carbonic anhydrase IX in cancer therapy
    • Thiry A., Dogne J.M., Masereel B., and Supuran C.T. Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Trends Pharmacol Sci 27 (2006) 566-573
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 566-573
    • Thiry, A.1    Dogne, J.M.2    Masereel, B.3    Supuran, C.T.4
  • 15
    • 0036069159 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2
    • Bartosova M., Parkkila S., Pohlodek K., et al. Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2. J Pathol 197 (2002) 314-321
    • (2002) J Pathol , vol.197 , pp. 314-321
    • Bartosova, M.1    Parkkila, S.2    Pohlodek, K.3
  • 16
    • 0035107383 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer
    • Ivanov S., Liao S.Y., Ivanova A., et al. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol 158 (2001) 905-919
    • (2001) Am J Pathol , vol.158 , pp. 905-919
    • Ivanov, S.1    Liao, S.Y.2    Ivanova, A.3
  • 17
    • 33845515875 scopus 로고    scopus 로고
    • Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours
    • Hynninen P., Vaskivuo L., Saarnio J., et al. Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours. Histopathology 49 (2006) 594-602
    • (2006) Histopathology , vol.49 , pp. 594-602
    • Hynninen, P.1    Vaskivuo, L.2    Saarnio, J.3
  • 18
    • 0033902802 scopus 로고    scopus 로고
    • Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors
    • Kivela A., Parkkila S., Saarnio J., et al. Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors. Am J Pathol 156 (2000) 577-584
    • (2000) Am J Pathol , vol.156 , pp. 577-584
    • Kivela, A.1    Parkkila, S.2    Saarnio, J.3
  • 19
    • 0033775150 scopus 로고    scopus 로고
    • Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours
    • Kivela A.J., Parkkila S., Saarnio J., et al. Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours. Histochem Cell Biol 114 (2000) 197-204
    • (2000) Histochem Cell Biol , vol.114 , pp. 197-204
    • Kivela, A.J.1    Parkkila, S.2    Saarnio, J.3
  • 20
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio J., Parkkila S., Parkkila A.K., et al. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol 153 (1998) 279-285
    • (1998) Am J Pathol , vol.153 , pp. 279-285
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3
  • 21
    • 36048987954 scopus 로고    scopus 로고
    • Carbonic anhydrase IX is not an independent predictor of outcome for patients with clear cell renal cell carcinoma
    • Leibovich B.C., Sheinin Y., Lohse C.M., et al. Carbonic anhydrase IX is not an independent predictor of outcome for patients with clear cell renal cell carcinoma. J Clin Oncol 25 (2007) 4757-4764
    • (2007) J Clin Oncol , vol.25 , pp. 4757-4764
    • Leibovich, B.C.1    Sheinin, Y.2    Lohse, C.M.3
  • 22
    • 62749124795 scopus 로고    scopus 로고
    • Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?
    • Kaluz S., Kaluzova M., Liao S.Y., Lerman M., and Stanbridge E.J. Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?. Biochim Biophys Acta 1795 (2009) 162-172
    • (2009) Biochim Biophys Acta , vol.1795 , pp. 162-172
    • Kaluz, S.1    Kaluzova, M.2    Liao, S.Y.3    Lerman, M.4    Stanbridge, E.J.5
  • 23
    • 3342967945 scopus 로고    scopus 로고
    • Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma
    • Grabmaier K., Weijert M.C.A., Verhaegh G.W., Schalken J.A., and Oosterwijk E. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene 23 (2004) 5624-5631
    • (2004) Oncogene , vol.23 , pp. 5624-5631
    • Grabmaier, K.1    Weijert, M.C.A.2    Verhaegh, G.W.3    Schalken, J.A.4    Oosterwijk, E.5
  • 24
    • 33847106005 scopus 로고    scopus 로고
    • Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole
    • Shin K.H., az-Gonzalez J.A., Russell J., et al. Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole. Cancer Biol Ther 6 (2007) 70-75
    • (2007) Cancer Biol Ther , vol.6 , pp. 70-75
    • Shin, K.H.1    az-Gonzalez, J.A.2    Russell, J.3
  • 25
    • 33846562017 scopus 로고    scopus 로고
    • Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia
    • Ihnatko R., Kubes M., Takacova M., et al. Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia. Int J Oncol 29 (2006) 1025-1033
    • (2006) Int J Oncol , vol.29 , pp. 1025-1033
    • Ihnatko, R.1    Kubes, M.2    Takacova, M.3
  • 26
    • 1842852597 scopus 로고    scopus 로고
    • Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells
    • Rafajova M., Zatovicova M., Kettmann R., Pastorek J., and Pastorekova S. Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Int J Oncol 24 (2004) 995-1004
    • (2004) Int J Oncol , vol.24 , pp. 995-1004
    • Rafajova, M.1    Zatovicova, M.2    Kettmann, R.3    Pastorek, J.4    Pastorekova, S.5
  • 27
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J., Ilc K., Laferriere J., et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 69 (2009) 358-368
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3
  • 28
    • 0037314709 scopus 로고    scopus 로고
    • Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy
    • Bui M.H., Seligson D., Han K.R., et al. Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. Clin Cancer Res 9 (2003) 802-811
    • (2003) Clin Cancer Res , vol.9 , pp. 802-811
    • Bui, M.H.1    Seligson, D.2    Han, K.R.3
  • 30
    • 44949119410 scopus 로고    scopus 로고
    • Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma
    • Patard J.J., Fergelot P., Karakiewicz P.I., et al. Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma. Int J Cancer 123 (2008) 395-400
    • (2008) Int J Cancer , vol.123 , pp. 395-400
    • Patard, J.J.1    Fergelot, P.2    Karakiewicz, P.I.3
  • 31
    • 67649791966 scopus 로고    scopus 로고
    • CA9 gene: single nucleotide polymorphism predicts metastatic renal cell carcinoma prognosis
    • de Martino M., Klatte T., Seligson D.B., et al. CA9 gene: single nucleotide polymorphism predicts metastatic renal cell carcinoma prognosis. J Urol 182 (2009) 728-734
    • (2009) J Urol , vol.182 , pp. 728-734
    • de Martino, M.1    Klatte, T.2    Seligson, D.B.3
  • 32
    • 41149087157 scopus 로고    scopus 로고
    • Mathematical models for prognostic prediction in patients with renal cell carcinoma
    • Galfano A., Novara G., Iafrate M., et al. Mathematical models for prognostic prediction in patients with renal cell carcinoma. Urol Int 80 (2008) 113-123
    • (2008) Urol Int , vol.80 , pp. 113-123
    • Galfano, A.1    Novara, G.2    Iafrate, M.3
  • 33
    • 20244386849 scopus 로고    scopus 로고
    • Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma
    • Kim H.L., Seligson D., Liu X., et al. Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma. J Urol 173 (2005) 1496-1501
    • (2005) J Urol , vol.173 , pp. 1496-1501
    • Kim, H.L.1    Seligson, D.2    Liu, X.3
  • 34
    • 4143060340 scopus 로고    scopus 로고
    • Using protein expressions to predict survival in clear cell renal carcinoma
    • Kim H.L., Seligson D., Liu X., et al. Using protein expressions to predict survival in clear cell renal carcinoma. Clin Cancer Res 10 (2004) 5464-5471
    • (2004) Clin Cancer Res , vol.10 , pp. 5464-5471
    • Kim, H.L.1    Seligson, D.2    Liu, X.3
  • 35
    • 40849088208 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing 2 antibodies
    • Al-Ahmadie H.A., Alden D., Qin L.X., et al. Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing 2 antibodies. Am J Surg Pathol 32 (2008) 377-382
    • (2008) Am J Surg Pathol , vol.32 , pp. 377-382
    • Al-Ahmadie, H.A.1    Alden, D.2    Qin, L.X.3
  • 36
    • 67650072493 scopus 로고    scopus 로고
    • Antibody-specific detection of CAIX in breast and prostate cancers
    • Li Y., Wang H., Oosterwijk E., et al. Antibody-specific detection of CAIX in breast and prostate cancers. Biochem Biophys Res Commun 386 (2009) 488-492
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 488-492
    • Li, Y.1    Wang, H.2    Oosterwijk, E.3
  • 37
    • 21044442672 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer
    • Atkins M., Regan M., McDermott D., et al. Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin Cancer Res 11 (2005) 3714-3721
    • (2005) Clin Cancer Res , vol.11 , pp. 3714-3721
    • Atkins, M.1    Regan, M.2    McDermott, D.3
  • 38
    • 77952881369 scopus 로고    scopus 로고
    • Accessed March 9, 2010
    • McDermott D. The High-Dose Aldesleukin (IL-2) "Select" Trial for Patients With Metastatic Renal Cell Carcinoma (SELECT). http://clinicaltrials.gov/ct2/show/NCT00554515. Accessed March 9, 2010.
    • The High-Dose Aldesleukin (IL-2) Select
    • McDermott, D.1
  • 39
    • 51349145100 scopus 로고    scopus 로고
    • Prospective evaluation of carbonic anhydrase IX (CAIX) as a molecular marker in metastatic renal cell carcinoma [abstract]
    • Klatte T., Zomorodian N., Kabinavar F.F., Belldegrun A., and Pantuck A. Prospective evaluation of carbonic anhydrase IX (CAIX) as a molecular marker in metastatic renal cell carcinoma [abstract]. J Clin Oncol 25 Suppl (2007) 5112
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL , pp. 5112
    • Klatte, T.1    Zomorodian, N.2    Kabinavar, F.F.3    Belldegrun, A.4    Pantuck, A.5
  • 40
    • 77952883674 scopus 로고    scopus 로고
    • Prognostic and predictive values of carbonic anhydrase IX (CAIX) and pathologic features in patients with metastatic clear cell renal cell carcinoma receiving targeted therapy [abstract]
    • Choueiri T.K., Regan M., Oh W., et al. Prognostic and predictive values of carbonic anhydrase IX (CAIX) and pathologic features in patients with metastatic clear cell renal cell carcinoma receiving targeted therapy [abstract]. J Clin Oncol 27 Suppl (2009) 16067
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL , pp. 16067
    • Choueiri, T.K.1    Regan, M.2    Oh, W.3
  • 41
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins M.B., Hidalgo M., Stadler W.M., et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 22 (2004) 909-918
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 42
    • 35348858663 scopus 로고    scopus 로고
    • Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma
    • Cho D., Signoretti S., Dabora S., et al. Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer 5 (2007) 379-385
    • (2007) Clin Genitourin Cancer , vol.5 , pp. 379-385
    • Cho, D.1    Signoretti, S.2    Dabora, S.3
  • 44
    • 34247379134 scopus 로고    scopus 로고
    • Molecular positron emission tomography and PET/CT imaging in urological malignancies
    • Powles T., Murray I., Brock C., Oliver T., and Avril N. Molecular positron emission tomography and PET/CT imaging in urological malignancies. Eur Urol 51 (2007) 1511-1521
    • (2007) Eur Urol , vol.51 , pp. 1511-1521
    • Powles, T.1    Murray, I.2    Brock, C.3    Oliver, T.4    Avril, N.5
  • 45
    • 30844450356 scopus 로고    scopus 로고
    • F-18 FDG PET in detecting renal cell carcinoma
    • Ak I., and Can C. F-18 FDG PET in detecting renal cell carcinoma. Acta Radiol 46 (2005) 895-899
    • (2005) Acta Radiol , vol.46 , pp. 895-899
    • Ak, I.1    Can, C.2
  • 46
    • 0031724558 scopus 로고    scopus 로고
    • Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma
    • Divgi C.R., Bander N.H., Scott A.M., et al. Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma. Clin Cancer Res 4 (1998) 2729-2739
    • (1998) Clin Cancer Res , vol.4 , pp. 2729-2739
    • Divgi, C.R.1    Bander, N.H.2    Scott, A.M.3
  • 47
    • 17544404888 scopus 로고    scopus 로고
    • Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250
    • Steffens M.G., Boerman O.C., Oosterwijk-Wakka J.C., et al. Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250. J Clin Oncol 15 (1997) 1529-1537
    • (1997) J Clin Oncol , vol.15 , pp. 1529-1537
    • Steffens, M.G.1    Boerman, O.C.2    Oosterwijk-Wakka, J.C.3
  • 48
    • 0036107091 scopus 로고    scopus 로고
    • 131 I-cG250 monoclonal antibody immunoscintigraphy versus [18 F]FDG-PET imaging in patients with metastatic renal cell carcinoma: a comparative study
    • Brouwers A.H., Dorr U., Lang O., et al. 131 I-cG250 monoclonal antibody immunoscintigraphy versus [18 F]FDG-PET imaging in patients with metastatic renal cell carcinoma: a comparative study. Nucl Med Commun 23 (2002) 229-236
    • (2002) Nucl Med Commun , vol.23 , pp. 229-236
    • Brouwers, A.H.1    Dorr, U.2    Lang, O.3
  • 49
    • 0141568092 scopus 로고    scopus 로고
    • Targeting of metastatic renal cell carcinoma with the chimeric monoclonal antibody G250 labeled with (131)I or (111)In: an intrapatient comparison
    • Brouwers A.H., Buijs W.C., Oosterwijk E., et al. Targeting of metastatic renal cell carcinoma with the chimeric monoclonal antibody G250 labeled with (131)I or (111)In: an intrapatient comparison. Clin Cancer Res 9 (2003) 3953S-3960S
    • (2003) Clin Cancer Res , vol.9
    • Brouwers, A.H.1    Buijs, W.C.2    Oosterwijk, E.3
  • 50
    • 27244448455 scopus 로고    scopus 로고
    • Lack of efficacy of two consecutive treatments of radioimmunotherapy with 131I-cG250 in patients with metastasized clear cell renal cell carcinoma
    • Brouwers A.H., Mulders P.F., De Mulder P.H., et al. Lack of efficacy of two consecutive treatments of radioimmunotherapy with 131I-cG250 in patients with metastasized clear cell renal cell carcinoma. J Clin Oncol 23 (2005) 6540-6548
    • (2005) J Clin Oncol , vol.23 , pp. 6540-6548
    • Brouwers, A.H.1    Mulders, P.F.2    De Mulder, P.H.3
  • 51
    • 26444449997 scopus 로고    scopus 로고
    • Radioimmunotherapy with [131I]cG250 in patients with metastasized renal cell cancer: dosimetric analysis and immunologic response
    • Brouwers A.H., Buijs W.C., Mulders P.F., et al. Radioimmunotherapy with [131I]cG250 in patients with metastasized renal cell cancer: dosimetric analysis and immunologic response. Clin Cancer Res 11 (2005) 7178s-7186s
    • (2005) Clin Cancer Res , vol.11
    • Brouwers, A.H.1    Buijs, W.C.2    Mulders, P.F.3
  • 52
    • 33947504376 scopus 로고    scopus 로고
    • Preoperative characterisation of clear-cell renal carcinoma using iodine-124-labelled antibody chimeric G250 (124I-cG250) and PET in patients with renal masses: a phase I trial
    • Divgi C.R., Pandit-Taskar N., Jungbluth A.A., et al. Preoperative characterisation of clear-cell renal carcinoma using iodine-124-labelled antibody chimeric G250 (124I-cG250) and PET in patients with renal masses: a phase I trial. Lancet Oncol 8 (2007) 304-310
    • (2007) Lancet Oncol , vol.8 , pp. 304-310
    • Divgi, C.R.1    Pandit-Taskar, N.2    Jungbluth, A.A.3
  • 54
    • 0030017852 scopus 로고    scopus 로고
    • Anti-renal-cell carcinoma chimeric antibody G250 facilitates antibody-dependent cellular cytotoxicity with in vitro and in vivo interleukin-2-activated effectors
    • Surfus J.E., Hank J.A., Oosterwijk E., et al. Anti-renal-cell carcinoma chimeric antibody G250 facilitates antibody-dependent cellular cytotoxicity with in vitro and in vivo interleukin-2-activated effectors. J Immunother Emphasis Tumor Immunol 19 (1996) 184-191
    • (1996) J Immunother Emphasis Tumor Immunol , vol.19 , pp. 184-191
    • Surfus, J.E.1    Hank, J.A.2    Oosterwijk, E.3
  • 55
    • 34548083337 scopus 로고    scopus 로고
    • A phase I multiple dose, dose escalation study of cG250 monoclonal antibody in patients with advanced renal cell carcinoma
    • Davis I.D., Wiseman G.A., Lee F.T., et al. A phase I multiple dose, dose escalation study of cG250 monoclonal antibody in patients with advanced renal cell carcinoma. Cancer Immun 7 (2007) 13
    • (2007) Cancer Immun , vol.7 , pp. 13
    • Davis, I.D.1    Wiseman, G.A.2    Lee, F.T.3
  • 56
    • 11144354471 scopus 로고    scopus 로고
    • A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients
    • Bleumer I., Knuth A., Oosterwijk E., et al. A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients. Br J Cancer 90 (2004) 985-990
    • (2004) Br J Cancer , vol.90 , pp. 985-990
    • Bleumer, I.1    Knuth, A.2    Oosterwijk, E.3
  • 57
    • 77952878375 scopus 로고    scopus 로고
    • Monoclonal Antibody Therapy (Rencarex) in Treating Patients Who Have Undergone Surgery for Non-Metastatic Kidney Cancer. http://www.clinicaltrials.gov/ct2/show/NCT00087022. Accessed March 9, 2010.
    • Monoclonal Antibody Therapy (Rencarex) in Treating Patients Who Have Undergone Surgery for Non-Metastatic Kidney Cancer. http://www.clinicaltrials.gov/ct2/show/NCT00087022. Accessed March 9, 2010.
  • 58
    • 0036217460 scopus 로고    scopus 로고
    • Anti-renal cell carcinoma chimeric antibody G250: cytokine enhancement of in vitro antibody-dependent cellular cytotoxicity
    • Liu Z., Smyth F.E., Renner C., Lee F.T., Oosterwijk E., and Scott A.M. Anti-renal cell carcinoma chimeric antibody G250: cytokine enhancement of in vitro antibody-dependent cellular cytotoxicity. Cancer Immunol Immunother 51 (2002) 171-177
    • (2002) Cancer Immunol Immunother , vol.51 , pp. 171-177
    • Liu, Z.1    Smyth, F.E.2    Renner, C.3    Lee, F.T.4    Oosterwijk, E.5    Scott, A.M.6
  • 59
    • 29144503225 scopus 로고    scopus 로고
    • A clinical trial with chimeric monoclonal antibody WX-G250 and low dose interleukin-2 pulsing scheme for advanced renal cell carcinoma
    • Bleumer I., Oosterwijk E., Oosterwijk-Wakka J.C., et al. A clinical trial with chimeric monoclonal antibody WX-G250 and low dose interleukin-2 pulsing scheme for advanced renal cell carcinoma. J Urol 175 (2006) 57-62
    • (2006) J Urol , vol.175 , pp. 57-62
    • Bleumer, I.1    Oosterwijk, E.2    Oosterwijk-Wakka, J.C.3
  • 60
    • 0032694512 scopus 로고    scopus 로고
    • Phase I radioimmunotherapy of metastatic renal cell carcinoma with 131I-labeled chimeric monoclonal antibody G250
    • Steffens M.G., Boerman O.C., De Mulder P.H., et al. Phase I radioimmunotherapy of metastatic renal cell carcinoma with 131I-labeled chimeric monoclonal antibody G250. Clin Cancer Res 5 Suppl 10 (1999) 3268s-3274s
    • (1999) Clin Cancer Res , vol.5 , Issue.SUPPL. 10
    • Steffens, M.G.1    Boerman, O.C.2    De Mulder, P.H.3
  • 61
    • 0028198974 scopus 로고
    • The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels
    • Shih L.B., Thorpe S.R., Griffiths G.L., et al. The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels. J Nucl Med 35 (1994) 899-908
    • (1994) J Nucl Med , vol.35 , pp. 899-908
    • Shih, L.B.1    Thorpe, S.R.2    Griffiths, G.L.3
  • 62
    • 9244224115 scopus 로고    scopus 로고
    • Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells
    • Press O.W., Shan D., Howell-Clark J., et al. Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells. Cancer Res 56 (1996) 2123-2129
    • (1996) Cancer Res , vol.56 , pp. 2123-2129
    • Press, O.W.1    Shan, D.2    Howell-Clark, J.3
  • 63
    • 8544267259 scopus 로고    scopus 로고
    • Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22
    • Sharkey R.M., Behr T.M., Mattes M.J., et al. Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22. Cancer Immunol Immunother 44 (1997) 179-188
    • (1997) Cancer Immunol Immunother , vol.44 , pp. 179-188
    • Sharkey, R.M.1    Behr, T.M.2    Mattes, M.J.3
  • 64
    • 1542399581 scopus 로고    scopus 로고
    • Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re
    • Brouwers A.H., van Eerd J.E., Frielink C., et al. Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re. J Nucl Med 45 (2004) 327-337
    • (2004) J Nucl Med , vol.45 , pp. 327-337
    • Brouwers, A.H.1    van Eerd, J.E.2    Frielink, C.3
  • 65
    • 77952876999 scopus 로고    scopus 로고
    • Study of Lutetium-177 Labeled cG250 in Patients With Advanced Renal Cancer. http://www.clinicaltrials.gov/ct2/show/NCT00142415. Accessed March 9, 2010.
    • Study of Lutetium-177 Labeled cG250 in Patients With Advanced Renal Cancer. http://www.clinicaltrials.gov/ct2/show/NCT00142415. Accessed March 9, 2010.
  • 66
    • 4544260382 scopus 로고    scopus 로고
    • Phase I clinical trial with fractionated radioimmunotherapy using 131I-labeled chimeric G250 in metastatic renal cancer
    • Divgi C.R., O'Donoghue J.A., Welt S., et al. Phase I clinical trial with fractionated radioimmunotherapy using 131I-labeled chimeric G250 in metastatic renal cancer. J Nucl Med 45 (2004) 1412-1421
    • (2004) J Nucl Med , vol.45 , pp. 1412-1421
    • Divgi, C.R.1    O'Donoghue, J.A.2    Welt, S.3
  • 67
    • 0033230634 scopus 로고    scopus 로고
    • The renal cell carcinoma-associated antigen G250 encodes a human leukocyte antigen (HLA)-A2.1-restricted epitope recognized by cytotoxic T lymphocytes
    • Vissers J.L., De Vries I.J.M., Schreurs M.W.J., et al. The renal cell carcinoma-associated antigen G250 encodes a human leukocyte antigen (HLA)-A2.1-restricted epitope recognized by cytotoxic T lymphocytes. Cancer Res 59 (1999) 5554-5559
    • (1999) Cancer Res , vol.59 , pp. 5554-5559
    • Vissers, J.L.1    De Vries, I.J.M.2    Schreurs, M.W.J.3
  • 68
    • 33846021299 scopus 로고    scopus 로고
    • Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells
    • Bleumer I., Tiemessen D.M., Oosterwijk-Wakka J.C., et al. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. J Immunother 30 (2007) 116-122
    • (2007) J Immunother , vol.30 , pp. 116-122
    • Bleumer, I.1    Tiemessen, D.M.2    Oosterwijk-Wakka, J.C.3
  • 69
    • 33645697721 scopus 로고    scopus 로고
    • A phase I trial of vaccination of CA9-derived peptides for HLA-A24-positive patients with cytokine-refractory metastatic renal cell carcinoma
    • Uemura H., Fujimoto K., Tanaka M., et al. A phase I trial of vaccination of CA9-derived peptides for HLA-A24-positive patients with cytokine-refractory metastatic renal cell carcinoma. Clin Cancer Res 12 (2006) 1768-1775
    • (2006) Clin Cancer Res , vol.12 , pp. 1768-1775
    • Uemura, H.1    Fujimoto, K.2    Tanaka, M.3
  • 70
    • 0035503010 scopus 로고    scopus 로고
    • Induction of G250-targeted and T-cell-mediated antitumor activity against renal cell carcinoma using a chimeric fusion protein consisting of G250 and granulocyte/monocyte-colony stimulating factor
    • Tso C.L., Zisman A., Pantuck A., et al. Induction of G250-targeted and T-cell-mediated antitumor activity against renal cell carcinoma using a chimeric fusion protein consisting of G250 and granulocyte/monocyte-colony stimulating factor. Cancer Res 61 (2001) 7925-7933
    • (2001) Cancer Res , vol.61 , pp. 7925-7933
    • Tso, C.L.1    Zisman, A.2    Pantuck, A.3
  • 71
    • 10744230408 scopus 로고    scopus 로고
    • Novel kidney cancer immunotherapy based on the granulocyte-macrophage colony-stimulating factor and carbonic anhydrase IX fusion gene
    • Hernandez J.M., Bui M.H., Han K.R., et al. Novel kidney cancer immunotherapy based on the granulocyte-macrophage colony-stimulating factor and carbonic anhydrase IX fusion gene. Clin Cancer Res 9 (2003) 1906-1916
    • (2003) Clin Cancer Res , vol.9 , pp. 1906-1916
    • Hernandez, J.M.1    Bui, M.H.2    Han, K.R.3
  • 73
    • 66149113671 scopus 로고    scopus 로고
    • Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNg
    • Bauer S., Oosterwijk-Wakka J.C., Adrian N., et al. Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNg. Int J Cancer 125 (2009) 115-123
    • (2009) Int J Cancer , vol.125 , pp. 115-123
    • Bauer, S.1    Oosterwijk-Wakka, J.C.2    Adrian, N.3
  • 74
    • 0027462558 scopus 로고
    • Antibody localization in human renal cell carcinoma: a phase I study of monoclonal antibody G250
    • Oosterwijk E., Bander N.H., Divgi C.R., et al. Antibody localization in human renal cell carcinoma: a phase I study of monoclonal antibody G250. J Clin Oncol 11 (1993) 738-750
    • (1993) J Clin Oncol , vol.11 , pp. 738-750
    • Oosterwijk, E.1    Bander, N.H.2    Divgi, C.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.