Regulation of intracellular pH

American Journal of Physiology - Advances in Physiology Education

Volumn 28, Issue 4, 2004, Pages 160-179

  Boron, Walter F ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bicarbonate; Cotransporter; Exchanger; Hydrogen ions

Indexed keywords

BICARBONATE; COTRANSPORTER; PROTON;

ACID BASE BALANCE; AIR CONDITIONING; CELL PH; COLD STRESS; CONFERENCE PAPER; FURNACE; HEAT; HEAT STRESS; KINETICS; THERMOREGULATION;

EID: 10344248930     PISSN: 10434046     EISSN: 15221229     Source Type: Journal    
DOI: 10.1152/advan.00045.2004     Document Type: Article

References (53)

1. Aalkjær C and Hughes A. Chloride and bicarbonate transport in rat resistance arteries. J Physiol 436: 57-73, 1991.
2. Apkon M and Boron WF. Extracellular and intracellular alkalinization and the constriction of rat cerebral arterioles. J Physiol 484: 743-753, 1995.
3. Apkon M, Weed RA, and Boron WF. Motor responses of cultured rat cerebral vascular smooth muscle cells to intra- and extracellular pH changes. Am J Physiol Heart Circ Physiol 273: H434-H445, 1997.
4. Boron WF. Intracellular pH transients in giant barnacle muscle fibers. Am J Physiol Cell Physiol 233: C61-C73, 1977.
5. Boron WF. Acid-base physiology. In: Medical Physiology. A Cellular and Molecular Approach, edited by Boron WF and Boulpaep EL. Philadelphia, PA: Saunders, p. 633-653, 2003.
6. - transport. J Gen Physiol 81: 53-94, 1983.
7. - blocked by cyanide. Nature 259: 240-241, 1976.
8. 3 and metabolic inhibitors. J Gen Physiol 67: 91-112, 1976.
9. Boron WF, McCormick WC, and Roos A. pH regulation in barnacle muscle fibers: dependence on intracellular and extracellular pH. Am J Physiol Cell Physiol 237: C185-C193, 1979.
10. Boron WF, McCormick WC, and Roos A. pH regulation in barnacle muscle fibers: dependence on extracellular sodium and bicarbonate. Am J Physiol Cell Physiol 240: C80-C89, 1981.
11. Boron WF and Russell JM. Stoichiometry and ion dependencies of the intracellular-pH-regulating mechanism in squid giant axons. J Gen Physiol 81: 373-399, 1983.
12. Bouyer P, Bradley SR, Zhao J, Wang W, Richerson GB, and Boron WF. Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphe or hippocampus. J Physiol 559: 85-101, 2004.
13. Boyarsky G, Ganz MB, Cragoe EJ Jr, and Boron WF. Intracellular pH dependence of Na-H exchange and acid loading in quiescent and arginine vasopressin-activated mesangial cells. Proc Natl Acad Sci USA 87: 5921-5924, 1990.
14. - on intracellular pH in isolated type-1 cells of the neonatal rat carotid body. J Physiol 444: 703-721, 1991.
15. -. Am J Physiol Renal Fluid Electrolyte Physiol 268: F179-F192, 1995.
16. -. Am J Physiol Renal Fluid Electrolyte Physiol 268: F193-F203, 1995.
17. Choi I, Aalkjær C, Boulpaep EL, and Boron WF. An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Nature 405: 571-575, 2000.
18. Deitmer JW and Schlue WR. An inwardly directed electrogenic sodiumbicarbonate cotransport in leech glial cells. J Physiol 411: 179-194, 1989.
19. Gillies RJ, Martínez-Zaguilán R, Peterson EP, and Perona R. Role of intracellular pH in mammalian cell proliferation. Cell Physiol Biochem 2: 159-179, 1992.
20. 3 exchanger. J Biol Chem 276: 8358-8363, 2001.
21. Gross E, Hawkins K, Abuladze N, Pushkin A, Cotton CU, Hopfer U, and Kurtz I. The stoichiometry of the electrogenic sodium bicarbonate cotransporter NBC1 is cell-type dependent. J Physiol 531: 597-603, 2001.
22. + channel, TALK-1. Am J Physiol Cell Physiol 285: C529-C538, 2003.
23. +-dependent Cl-HCO3 exchange in NIH-3T3 fibroblasts. J Biol Chem 269: 4116-4124, 1994.
24. Kopito RR and Lodish HF. Primary structure and transmembrane orientation of the murine anion exchange protein. Nature 316: 234-238, 1985.
25. Krishtal OA and Pidoplichko VI. A receptor for protons in the membrane of sensory neurons may participate in nociception. Neuroscience 6: 2599-2601, 1981.
26. Lesage F. Pharmacology of neuronal background potassium channels. Neuropharmacology 44: 1-7, 2003.
27. Murer H, Hopfer U, and Kinne R. Sodium/proton antiport in brushborder-membrane vesicles isolated from rat small intestine and kidney. Biochem J 154: 597-604, 1976.
28. Orlowski J and Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflügers Arch 447: 549-565, 2004.
29. Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, and Kurtz I. Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family. J Biol Chem 274: 16569-16575, 1999.
30. + channel. An extracellular histidine as pH sensor. J Biol Chem 275: 16650-16657, 2000.
31. Ritucci NA, Chambers-Kersh L, Dean JB, and Putnam RW. Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla. Am J Physiol Regul Integr Comp Physiol 275: R1152-R1163, 1998.
32. Ritucci NA, Dean JB, and Putnam RW. Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla. Am J Physiol Regul Integr Comp Physiol 273: R433-R441, 1997.
33. - transporters. Pflügers Arch 447: 495-509, 2004.
34. - cotransporter. Nature 387: 409-413, 1997.
35. +-driven anion exchanger (NDAE1). A new bicarbonate transporter. J Biol Chem 275: 24552-24559, 2000.
36. Roos A and Boron WF. Intracellular pH. Physiol Rev 61: 296-434, 1981.
37. Russell JM and Boron WF. Role of chloride transport in regulation of intracellular pH. Nature 264: 73-74, 1976.
38. Russell JM, Boron WF, and Brodwick MS. Intracellular pH and Na fluxes in barnacle muscle with evidence for reversal of the ionic mechanism of intracellular pH regulation. J Gen Physiol 82: 47-78, 1983.
39. + antiporter. Cell 56: 271-280, 1989.
40. Stubbs M, McSheehy PM, Griffiths JR, and Bashford CL. Causes and consequences of tumour acidity and implications for treatment. Mol Med Today 6: 15-19, 2000.
41. + pump in a snail neurone. Nature 262: 54-55, 1976.
42. Thomas RC. The effect of carbon dioxide on the intracellular pH and buffering power of snail neurones. J Physiol 255: 715-735, 1976.
43. Thomas RC. The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones. J Physiol 273: 317-338, 1977.
44. Vaughan-Jones RD. Regulation of chloride in quiescent sheep-heart Purkinje fibres studied using intracellular chloride and pH-sensitive microelectrodes. J Physiol 295: 111-137, 1979.
45. Vaughan-Jones RD. Chloride-bicarbonate exchange in the sheep cardiac Purkinje fibre. In: Intracellular pH: Its Measurement, Regulation and Utilization in Cellular Functions, edited by Nuccitelli R. New York: Liss, 1982, p. 239-252.
46. Waldmann R, Champigny G, Bassilana F, Heurteaux C, and Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature 386: 173-177, 1997.
47. Wang W and Richerson GB. Chemosensitivity of non-respiratory rat CNS neurons in tissue culture. Brain Res 860: 119-129, 2000.
48. 3 cotransporter. Nature 374: 636-639, 1995.
49. - reabsorption by rabbit S2 proximal tubule. Am J Physiol Renal Physiol 285: F359-F369, 2003.
50. 2 proximal tubule: Blockade by genistein (Abstract). FASEB J 17: A1221, 2003.
51. 3 reabsorption by rabbit S2 proximal tubules (Abstract). FASEB J 18: A1016, 2004.
52. 3 reabsorption by rabbit S2 proximal tubules (Abstract). FASEB J 18: A1016, 2004.
53. 2-sensor (Abstract). FASEB J 15: A142, 2001.