Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5438-5449

  Yoo, Byong Hoon ^a   Wu, Xue ^a   Li, Yongling ^a   Haniff, Mehnaaz ^a   Sasazuki, Takehiko ^b   Shirasawa, Senji ^c   Eskelinen, Eeva Liisa ^d   Rosen, Kirill V ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES;

CANCER PROGRESSION; DOWN-REGULATION; EPITHELIAL CELLS; EXTRACELLULAR MATRICES; INDUCED APOPTOSIS; INTESTINAL EPITHELIAL CELLS; MALIGNANT TRANSFORMATIONS; RNA INTERFERENCE;

CELL DEATH;

BECLIN 1; CALPAIN; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN P21; RHOA PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CANCER TISSUE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN HCT116; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM CELL; MALIGNANT TRANSFORMATION; ONCOGENE RAS; PATHOPHYSIOLOGY; PHAGOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL TRANSFORMATION; EPITHELIUM CELL; GENETICS; INTESTINE MUCOSA; INTESTINE TUMOR; METABOLISM; TUMOR CELL CULTURE;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; EPITHELIAL CELLS; HUMANS; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; MEMBRANE PROTEINS; PHAGOSOMES; PROTO-ONCOGENE PROTEINS P21(RAS); RHOA GTP-BINDING PROTEIN; S PHASE; TUMOR CELLS, CULTURED;

EID: 77949324323     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.046789     Document Type: Article

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