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Volumn 4, Issue 1, 2008, Pages 46-53

Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism

Author keywords

Cellular defense; Cytomegalovirus; LC3; mTOR; Xenophagy

Indexed keywords

LITHIUM CHLORIDE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN P62; RAPAMYCIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN ICP34.5;

EID: 38049029041     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5184     Document Type: Article
Times cited : (115)

References (47)
  • 1
    • 0000974298 scopus 로고    scopus 로고
    • Cytomegalovirus
    • Fields BN, Knipe DM, Howley PM, eds, Philadelphia: Lippincott-Raven Publishers
    • Pass RF. Cytomegalovirus. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology. Philadelphia: Lippincott-Raven Publishers, 2001:2675-705.
    • (2001) Fields Virology , pp. 2675-2705
    • Pass, R.F.1
  • 2
    • 0035199196 scopus 로고    scopus 로고
    • Potential infectious etiologies of atherosclerosis: A multifactorial perspective
    • O'Connor S, Taylor C, Campbell LA, Epstein S, Libby P. Potential infectious etiologies of atherosclerosis: A multifactorial perspective. Emerg Infect Dis 2001; 7:780-8.
    • (2001) Emerg Infect Dis , vol.7 , pp. 780-788
    • O'Connor, S.1    Taylor, C.2    Campbell, L.A.3    Epstein, S.4    Libby, P.5
  • 3
    • 38049011156 scopus 로고    scopus 로고
    • Endothelial cells' activation and apoptosis induced by a subset of antibodies against human cytomegalovirus: Relevance to the pathogenesis of atherosclerosis
    • Lunardi C, Dolcino M, Peterlana D, et al. Endothelial cells' activation and apoptosis induced by a subset of antibodies against human cytomegalovirus: Relevance to the pathogenesis of atherosclerosis. PLoS ONE 2007; 2:e473.
    • (2007) PLoS ONE , vol.2
    • Lunardi, C.1    Dolcino, M.2    Peterlana, D.3
  • 4
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306:990-5.
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 5
    • 33749052075 scopus 로고    scopus 로고
    • Signalling and autophagy regulation in health, aging and disease
    • Meijer AJ, Codogno P. Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med 2006; 27:411-25.
    • (2006) Mol Aspects Med , vol.27 , pp. 411-425
    • Meijer, A.J.1    Codogno, P.2
  • 6
    • 10744225487 scopus 로고    scopus 로고
    • A unified nomenclature for yeast autophagy-related genes
    • Klionsky DJ, Cregg JM, Dunn Jr WA, et al. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5:539-45.
    • (2003) Dev Cell , vol.5 , pp. 539-545
    • Klionsky, D.J.1    Cregg, J.M.2    Dunn Jr, W.A.3
  • 8
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3
  • 9
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000; 275:992-8.
    • (2000) J Biol Chem , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.3    Meijer, A.J.4    Codogno, P.5
  • 10
    • 2142752480 scopus 로고    scopus 로고
    • Cellular autophagy: Surrender, avoidance and subversion by microorganisms
    • Kirkegaard K, Taylor MP, Jackson WT. Cellular autophagy: Surrender, avoidance and subversion by microorganisms. Nat Rev Microbiol 2004; 2:301-14.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 301-314
    • Kirkegaard, K.1    Taylor, M.P.2    Jackson, W.T.3
  • 11
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004; 119:753-66.
    • (2004) Cell , vol.119 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 12
    • 8344247016 scopus 로고    scopus 로고
    • Autophagy defends cells against invading group A Streptococcus
    • Nakagawa I, Amano A, Mizushima N, et al. Autophagy defends cells against invading group A Streptococcus. Science 2004; 306:1037-40.
    • (2004) Science , vol.306 , pp. 1037-1040
    • Nakagawa, I.1    Amano, A.2    Mizushima, N.3
  • 14
    • 34447543924 scopus 로고    scopus 로고
    • Involvement of autophagy in viral infections: Antiviral function and subversion by viruses
    • Espert L, Codogno P, Biard-Piechaczyk M. Involvement of autophagy in viral infections: Antiviral function and subversion by viruses. J Mol Med 2007.
    • (2007) J Mol Med
    • Espert, L.1    Codogno, P.2    Biard-Piechaczyk, M.3
  • 15
    • 0033798416 scopus 로고    scopus 로고
    • Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: An autophagy-like origin for virus-induced vesicles
    • Suhy DA, Giddings Jr TH, Kirkegaard K. Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: An autophagy-like origin for virus-induced vesicles. J Virol 2000; 74:8953-65.
    • (2000) J Virol , vol.74 , pp. 8953-8965
    • Suhy, D.A.1    Giddings Jr, T.H.2    Kirkegaard, K.3
  • 16
    • 33846594517 scopus 로고    scopus 로고
    • Topology of double-membraned vesicles and the opportunity for non-lytic release of cytoplasm
    • Kirkegaard K, Jackson WT. Topology of double-membraned vesicles and the opportunity for non-lytic release of cytoplasm. Autophagy 2005; 1:182-4.
    • (2005) Autophagy , vol.1 , pp. 182-184
    • Kirkegaard, K.1    Jackson, W.T.2
  • 17
    • 21344452171 scopus 로고    scopus 로고
    • Subversion of cellular autophagosomal machinery by RNA viruses
    • Jackson WT, Giddings Jr TH, Taylor MP, et al. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol 2005; 3:e156.
    • (2005) PLoS Biol , vol.3
    • Jackson, W.T.1    Giddings Jr, T.H.2    Taylor, M.P.3
  • 18
    • 0001488499 scopus 로고    scopus 로고
    • Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
    • Liang XH, Kleeman LK, Jiang HH, et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 1998; 72:8586-96.
    • (1998) J Virol , vol.72 , pp. 8586-8596
    • Liang, X.H.1    Kleeman, L.K.2    Jiang, H.H.3
  • 19
    • 19344368318 scopus 로고    scopus 로고
    • Autophagy regulates programmed cell death during the plant innate immune response
    • Liu Y, Schiff M, Czymmek K, Talloczy Z, Levine B, Dinesh-Kumar SP. Autophagy regulates programmed cell death during the plant innate immune response. Cell 2005; 121:567-77.
    • (2005) Cell , vol.121 , pp. 567-577
    • Liu, Y.1    Schiff, M.2    Czymmek, K.3    Talloczy, Z.4    Levine, B.5    Dinesh-Kumar, S.P.6
  • 20
    • 0037039442 scopus 로고    scopus 로고
    • Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
    • Talloczy Z, Jiang W, Virgin HWI, et al. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway. Proc Natl Acad Sci USA 2002; 99:190-5.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 190-195
    • Talloczy, Z.1    Jiang, W.2    Virgin, H.W.I.3
  • 21
    • 33947715151 scopus 로고    scopus 로고
    • HSV-1 ICP34.5 confers neurovirulence by targeting the beclin 1 autophagy protein
    • Orvedahl A, Alexander A, Talloczy Z, et al. HSV-1 ICP34.5 confers neurovirulence by targeting the beclin 1 autophagy protein. Cell Host and Microbe 2007; 1:23-35.
    • (2007) Cell Host and Microbe , vol.1 , pp. 23-35
    • Orvedahl, A.1    Alexander, A.2    Talloczy, Z.3
  • 22
    • 0036646149 scopus 로고    scopus 로고
    • Immunomodulation by cytomegaloviruses: Manipulative strategies beyond evasion
    • Mocarski Jr ES. Immunomodulation by cytomegaloviruses: Manipulative strategies beyond evasion. Trends Microbiol 2002; 10:332-9.
    • (2002) Trends Microbiol , vol.10 , pp. 332-339
    • Mocarski Jr, E.S.1
  • 23
    • 33947399734 scopus 로고    scopus 로고
    • Human cytomegalovirus UL38 protein blocks apoptosis
    • Terhune S, Torigoi E, Moorman N, et al. Human cytomegalovirus UL38 protein blocks apoptosis. J Virol 2007; 81:3109-23.
    • (2007) J Virol , vol.81 , pp. 3109-3123
    • Terhune, S.1    Torigoi, E.2    Moorman, N.3
  • 24
    • 0017891276 scopus 로고
    • Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. III. Cytochemical localization of lysosomal enzymes in infected cells
    • Smith JD, de Harven E. Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. III. Cytochemical localization of lysosomal enzymes in infected cells. J Virol 1978; 26:102-9.
    • (1978) J Virol , vol.26 , pp. 102-109
    • Smith, J.D.1    de Harven, E.2
  • 25
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927-39.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3
  • 26
    • 0020673448 scopus 로고
    • Practical protocol for cytomegalovirus isolation: Use of MRC-5 cell monolayers incubated for 2 weeks
    • Gregory WW, Menegus MA. Practical protocol for cytomegalovirus isolation: Use of MRC-5 cell monolayers incubated for 2 weeks. J Clin Microbiol 1983; 17:605-9.
    • (1983) J Clin Microbiol , vol.17 , pp. 605-609
    • Gregory, W.W.1    Menegus, M.A.2
  • 27
    • 0028899789 scopus 로고
    • Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
    • Blommaart EF, Luiken JJ, Blommaart PJ, van Woerkom GM, Meijer AJ. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 1995; 270:2320-6.
    • (1995) J Biol Chem , vol.270 , pp. 2320-2326
    • Blommaart, E.F.1    Luiken, J.J.2    Blommaart, P.J.3    van Woerkom, G.M.4    Meijer, A.J.5
  • 28
    • 25444483066 scopus 로고    scopus 로고
    • Lithium induces autophagy by inhibiting inositol monophosphatase
    • Sarkar S, Floto RA, Berger Z, et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 2005; 170:1101-11.
    • (2005) J Cell Biol , vol.170 , pp. 1101-1111
    • Sarkar, S.1    Floto, R.A.2    Berger, Z.3
  • 29
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein
    • Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein. J Biol Chem 2007; 282:5641-52.
    • (2007) J Biol Chem , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 30
    • 26844531363 scopus 로고    scopus 로고
    • Maturation of autophagic vacuoles in Mammalian cells
    • Eskelinen EL. Maturation of autophagic vacuoles in Mammalian cells. Autophagy 2005; 1:1-10.
    • (2005) Autophagy , vol.1 , pp. 1-10
    • Eskelinen, E.L.1
  • 31
    • 33746108329 scopus 로고    scopus 로고
    • Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
    • Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 2005; 1:84-91.
    • (2005) Autophagy , vol.1 , pp. 84-91
    • Tanida, I.1    Minematsu-Ikeguchi, N.2    Ueno, T.3    Kominami, E.4
  • 32
    • 34250900953 scopus 로고    scopus 로고
    • LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: Caution in the interpretation of LC3 localization
    • Kuma A, Matsui M, Mizushima N. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: Caution in the interpretation of LC3 localization. Autophagy 2007; 3:323-8.
    • (2007) Autophagy , vol.3 , pp. 323-328
    • Kuma, A.1    Matsui, M.2    Mizushima, N.3
  • 33
    • 9144224360 scopus 로고    scopus 로고
    • Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes
    • Tanida I, Ueno T, Kominami E. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. J Biol Chem 2004; 279:47704-10.
    • (2004) J Biol Chem , vol.279 , pp. 47704-47710
    • Tanida, I.1    Ueno, T.2    Kominami, E.3
  • 34
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy G, Lamark T, Brech A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603-14.
    • (2005) J Cell Biol , vol.171 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3
  • 35
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3:542-5.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 36
    • 0001593941 scopus 로고    scopus 로고
    • Cytomegaloviruses and their replication
    • Fields BN, Knipe DM, Howley PM, eds, Philadelphia: Lippincott-Raven Publishers
    • Mocarski Jr ES, Courcelle CT. Cytomegaloviruses and their replication. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology. Philadelphia: Lippincott-Raven Publishers, 2001:2629-73.
    • (2001) Fields Virology , pp. 2629-2673
    • Mocarski Jr, E.S.1    Courcelle, C.T.2
  • 37
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • Codogno P, Meijer AJ. Autophagy and signaling: Their role in cell survival and cell death. Cell Death Differ 2005; 12:1509-18.
    • (2005) Cell Death Differ , vol.12 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 38
    • 33644609471 scopus 로고    scopus 로고
    • Talloczy Z, Virgin HWI, Levine B. PKR-dependent autophagic degradation of Herpes Simplex Virus type 1. Autophagy 2005; 2:24-9.
    • Talloczy Z, Virgin HWI, Levine B. PKR-dependent autophagic degradation of Herpes Simplex Virus type 1. Autophagy 2005; 2:24-9.
  • 39
    • 2542444572 scopus 로고    scopus 로고
    • Consequences of human cytomegalovirus mimicry
    • Michelson S. Consequences of human cytomegalovirus mimicry. Hum Immunol 2004; 65:465-75.
    • (2004) Hum Immunol , vol.65 , pp. 465-475
    • Michelson, S.1
  • 40
    • 33746691954 scopus 로고    scopus 로고
    • Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4
    • Espert L, Denizot M, Grimaldi M, et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest 2006; 116:2161-72.
    • (2006) J Clin Invest , vol.116 , pp. 2161-2172
    • Espert, L.1    Denizot, M.2    Grimaldi, M.3
  • 41
    • 32244442749 scopus 로고    scopus 로고
    • Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
    • Zeng X, Overmeyer JH, Maltese WA. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci 2006; 119:259-70.
    • (2006) J Cell Sci , vol.119 , pp. 259-270
    • Zeng, X.1    Overmeyer, J.H.2    Maltese, W.A.3
  • 42
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N, Yu J, Byfield M, Pattingre S, Levine B. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005; 1:46-52.
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 43
    • 33750805015 scopus 로고    scopus 로고
    • Thinking globally and acting locally with TOR
    • Arsham AM, Neufeld TP. Thinking globally and acting locally with TOR. Curr Opin Cell Biol 2006; 18:589-97.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 589-597
    • Arsham, A.M.1    Neufeld, T.P.2
  • 44
    • 4644252994 scopus 로고    scopus 로고
    • Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
    • Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. J Virol 2004; 78:11030-9.
    • (2004) J Virol , vol.78 , pp. 11030-11039
    • Kudchodkar, S.B.1    Yu, Y.2    Maguire, T.G.3    Alwine, J.C.4
  • 45
    • 0031017382 scopus 로고    scopus 로고
    • He B, Gross M, Roizman B. The γ(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase la to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc Natl Acad Sci USA 1997; 94:843-8.
    • He B, Gross M, Roizman B. The γ(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase la to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc Natl Acad Sci USA 1997; 94:843-8.
  • 46
    • 21644460103 scopus 로고    scopus 로고
    • Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infection
    • Cassady KA. Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infection. J Virol 2005; 79:8707-15.
    • (2005) J Virol , vol.79 , pp. 8707-8715
    • Cassady, K.A.1
  • 47
    • 0346995213 scopus 로고    scopus 로고
    • Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1
    • Child SJ, Hakki M, De Niro KL, Gebaile AP. Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1. J Virol 2004; 78:197-205.
    • (2004) J Virol , vol.78 , pp. 197-205
    • Child, S.J.1    Hakki, M.2    De Niro, K.L.3    Gebaile, A.P.4


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