Differential requirements for NAIP5 in activation of the NLRC4 inflammasome

Infection and Immunity

Volumn 79, Issue 4, 2011, Pages 1606-1614

  Lightfield, Karla L ^a,d   Persson, Jenny ^a,e   Trinidad, Norver J ^a   Brubaker, Sky W ^a,f   Kofoed, Eric M ^a   Sauer, John Demian ^a   Dunipace, Eric A ^a   Warren, Sarah E ^b,c   Miao, Edward A ^b   Vance, Russell E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d STANFORD UNIVERSITY   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

^f BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; FLAGELLIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; LEUCINE; NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT PROTEIN NAIP 5; NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT PROTEIN NLRC 4; PROINTERLEUKIN 1BETA; PROTEIN PRECURSOR; PROTEIN PRGJ; REGULATOR PROTEIN; RETROVIRUS VECTOR; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERIAL IMMUNITY; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSFECTION; LEGIONELLA PNEUMOPHILA; LISTERIA; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SALMONELLA ENTERICA; TYPE III SECRETION SYSTEM; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CYTOTOXICITY, IMMUNOLOGIC; FLAGELLIN; FLOW CYTOMETRY; IMMUNITY, INNATE; INFLAMMASOMES; LEGIONELLA PNEUMOPHILA; LEGIONELLOSIS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONAL APOPTOSIS-INHIBITORY PROTEIN; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM;

EID: 79953315378     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01187-10     Document Type: Article

References (30)

1. Amer, A., et al. 2006. Regulation of Legionella phagosome maturation and infection through flagellin and host IPAF. J. Biol. Chem. 281:35217-35223.
2. Bergsbaken, T., S. L. Fink, and B. T. Cookson. 2009. Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7:99-109.
3. Boyden, E. D., and W. F. Dietrich. 2006. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat. Genet. 38:240-244.
4. Coers, J., R. E. Vance, M. F. Fontana, and W. F. Dietrich. 2007. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell Microbiol. 9:2344-2357.
5. Damiano, J. S., V. Oliveira, K. Welsh, and J. C. Reed. 2004. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem. J. 381:213-219.
6. Decker, T., and M. L. Lohmann-Matthes. 1988. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J. Immunol. Methods 115:61-69.
7. Fernandes-Alnemri, T., et al. 2010. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 11:385-393.
8. Fischetti, V. A., and American Society for Microbiology. 2006. Gram-positive pathogens, 2nd ed. ASM Press, Washington, DC.
9. Franchi, L., et al. 2006. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 7:576-582.
10. Janeway, C. A., Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54(Pt 1):1-13.
11. Jones, J. W., et al. 2010. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc. Natl. Acad. Sci. U. S. A. 107:9771-9776.
12. Kim, S., et al. 2010. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur. J. Immunol. 40:1545-1551.
13. Lauer, P., M. Y. Chow, M. J. Loessner, D. A. Portnoy, and R. Calendar. 2002. Construction, characterization, and use of two Listeria monocytogenes sitespecific phage integration vectors. J. Bacteriol. 184:4177-4186.
14. Lightfield, K. L., et al. 2008. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat. Immunol. 9:1171-1178.
15. Mariathasan, S., et al. 2004. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218.
16. Martinon, F., K. Burns, and J. Tschopp. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10:417-426.
17. Miao, E. A., et al. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7:569-575.
18. Miao, E. A., et al. 2010. Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc. Natl. Acad. Sci. U. S. A. 107:3076-3080.
19. Molofsky, A. B., et al. 2006. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J. Exp. Med. 203: 1093-1104.
20. Ormö, M., et al. 1996. Crystal structure of the Aequorea victoria green fluorescent protein. Science 273:1392-1395.
21. Rathinam, V. A., et al. 2010. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11:395- 402.
22. Ren, T., D. S. Zamboni, C. R. Roy, W. F. Dietrich, and R. E. Vance. 2006. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog. 2:e18.
23. Sauer, J. D., et al. 2010. Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host Microbe 7:412-419.
24. Schroder, K., R. Zhou, and J. Tschopp. 2010. The NLRP3 inflammasome: a sensor for metabolic danger? Science 327:296-300.
25. Sun, Y. H., H. G. Rolan, and R. M. Tsolis. 2007. Injection of flagellin into the host cell cytosol by Salmonella enterica serotype typhimurium. J. Biol. Chem. 282:33897-33901.
26. Takeuchi, O., and S. Akira. 2010. Pattern recognition receptors and inflammation. Cell 140:805-820.
27. Vance, R. E., R. R. Isberg, and D. A. Portnoy. 2009. Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 6:10-21.
28. Warren, S. E., et al. 2010. Cutting edge: cytosolic bacterial DNA activates the inflammasome via Aim2. J. Immunol. 185:818-821.
29. Yonekura, K., S. Maki-Yonekura, and K. Namba. 2003. Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy. Nature 424:643-650.
30. Zamboni, D. S., et al. 2006. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat. Immunol. 7:318-325.