Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1

FEBS Letters

Volumn 530, Issue 1-3, 2002, Pages 73-78

  Grenier, Jill M ^a   Wang, Lin ^a   Manji, Gulam A ^a,b   Huang, Waan Jeng ^a   Al Garawi, Amal ^a   Kelly, Roxanne ^a   Carlson, Adam ^a   Merriam, Sarah ^a   Lora, Jose M ^a   Briskin, Michael ^a   DiStefano, Peter S ^a,c   Bertin, John ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b ELAN PHARMACEUTICALS   (United States)

^c Elixir Pharmaceuticals Inc   (United States)

Author keywords

ASC; Caspase 1; Inflammation; NF B; PYPAF5; PYRIN containing Apaf 1 like protein

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN; PROTEIN ASC; PROTEIN PYPAF; PROTEIN PYPAF2; PROTEIN PYPAF3; PROTEIN PYPAF4; PROTEIN PYPAF5; PROTEIN PYPAF6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME REGULATION; GRANULOCYTE; IMMUNOCOMPETENT CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CASPASE 1; CELL LINE; COS CELLS; DNA PRIMERS; ENZYME ACTIVATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES; MOLECULAR SEQUENCE DATA; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 18644368579     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)03416-6     Document Type: Article

References (30)

1. Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Cell. 90:1997;405-413.
2. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cell. 91:1997;479-489.
3. Bertin J., Nir W.J., Fischer C.M., Tayber O.V., Errada P.R., Grant J.R., Keilty J.J., Gosselin M.L., Robison K.E., Wong G.H., Glucksmann M.A., DiStefano P.S. J. Biol. Chem. 274:1999;12955-12958.
4. Inohara N, Koseki T., del Peso L., Hu Y., Yee C., Chen S., Carrio R., Merino J., Liu D., Ni J., Nunez G. J. Biol. Chem. 274:1999;14560-14567.
5. Ogura Y., Inohara N., Benito A., Chen F.F., Yamaoka S., Nunez G. J. Biol. Chem. 276:2001;4812-4818.
6. Geddes B.J., Wang L., Huang W.-J., Lavellee M., Manji G.A., Brown M., Jurman M., Cao J., Morgenstern J., Merriam S., Glucksmann M.A., DiStefano P.S., Bertin J. Biochem. Biophys. Res. Commun. 284:2001;77-82.
7. Poyet J.L., Srinivasula S.M., Tnani M., Razmara M., Fernandes-Alnemri T., Alnemri E.S. J. Biol. Chem. 276:2001;28309-28313.
8. Damiano J.S., Stehlik C., Pio F., Godzik A., Reed J.C. Genomics. 75:2001;77-83.
9. Kobayashi K., Inohara N., Hernandez L.D., Galan J.E., Nunez G., Janeway C.A., Medzhitov R., Flavell R.A. Nature. 416:2002;194-199.
10. Chin A.I., Dempsey P.W., Bruhn K., Miller J.F., Xu Y., Cheng G. Nature. 416:2002;190-194.
11. Hugot J.P., Chamaillard M., Zouali H., Lesage S., Cezard J.P., Belaiche J., Almer S., Tysk C., O'Morain C.A., Gassull M., Binder V., Finkel Y., Cortot A., Modigliani R., Laurent-Puig P., Gower-Rousseau C., Macry J., Colombel J.F., Sahbatou M., Thomas G. Nature. 411:2001;537-539.
12. Ogura Y., Bonen D.K., Inohara N., Nicolae D.L., Chen F.F., Ramos R., Britton H., Moran T., Karaliuskas R., Duerr R.H., Achkar J.P., Brant S.R., Bayless T.M., Kirschner B.S., Hanauer S.B., Nunez G., Cho J.H. Nature. 411:2001;603-606.
13. Miceli-Richard C., Lesage S., Rybojad M., Prieur A.M., Manouvrier-Hanu S., Hafner R., Chamaillard M., Zouali H., Thomas G., Hugot J.P. Nat. Genet. 29:2001;19-20.
14. Bertin J., DiStefano P.S. Cell Death Differ. 7:2000;1273-1274.
15. Martinon F., Hofmann K., Tschopp J. Curr. Biol. 11:2001;118-120.
16. Staub E., Dahl E., Rosenthal A. Trends Biochem. Sci. 26:2000;83-85.
17. Fairbrother W.J., Gordon N.C., Humke E.W., O'Rourke K.M., Starovasnik M.A., Jian-Ping Y., Dixit V.M. Protein Sci. 10:2001;1911-1918.
18. Manji G., Wang L., Geddes B., Brown M., Merriam S., Al-Garawi A., Mak S., Lora J.M., Briskin M., Jurman M., Cao J., DiStefano P.S., Bertin J. J. Biol. Chem. 277:2002;11570-11575.
19. Wang L., Manji G.A., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M., Geddes B.J., Briskin M., DiStefano P.S., Bertin J. J. Biol. Chem. 277:2002;29874-29880.
20. The International FMF Consortium (1997) Cell 90, 797-807.
21. Hoffman H.M., Mueller J.L., Broide D.H., Wanderer A.A., Kolodner R.D. Nat. Genet. 29:2001;301-305.
22. Feldmann J., Prieur A-M., Quartier P., Berquin P., Certain S., Cortis E., Teillac-Hamel D., Fischer A., de Saint Basile G. Am. J. Hum. Genet. 71:2002;198-203.
23. Dode C., Le Du N., Cuisset L., Letourneur F., Berthelot J.M., Vaudour G., Meyrier A., Watts R.A., Scott D.G., Nicholls A., Granel B., Frances C., Garcier F., Edery P., Boulinguez S., Domergues J.P., Delpech M., Grateau G. Am. J. Hum. Genet. 70:2002;1498-1506.
24. Srinivasula S.M., Poyet J.-L., Razmara M., Datta P., Zhang Z.-J., Alnemri E.S. J. Biol. Chem. 277:2002;21119-21122.
25. Wang L., Guo Y., Huang W.J., Ke X., Poyet J.L., Manji G.A., Merriam S., Glucksmann M.A., DiStefano P.S., Alnemri E.S., Bertin J. J. Biol. Chem. 276:2001;21405-21409.
26. Masumoto J., Taniguchi S., Ayukawa K., Sarvotham H., Kishino T., Niikawa N., Hidaka E., Katsuyama T., Higuchi T., Sagara J. J. Biol. Chem. 274:1999;33835-33838.
27. Koonin E.V., Aravind L. Trends Biochem. Sci. 25:2000;223-224.
28. Lee S.H., Stehlik C., Reed J.C. J. Biol. Chem. 276:2001;34495-34500.
29. Salvesen G.S., Dixit V.M. Proc. Natl. Acad. Sci. USA. 96:1999;10964-10967.
30. Fantuzzi G., Dinarello C.A. J. Clin. Immunol. 19:1999;1-11.