Caspases-2 and -8 are involved in the presenilin1/γ-secretase- dependent cleavage of amyloid precursor protein after the induction of apoptosis

Journal of Neuroscience Research

Volumn 88, Issue 9, 2010, Pages 1926-1933

  Chae, San Sook ^a   Yoo, Chul Bae ^a   Jo, Chulman ^a   Yun, Sang Moon ^a   Jo, Sangmee Ahn ^a   Koh, Young Ho ^a  

^a Korea National Institute of Health   (South Korea)

Author keywords

secretase; Alzheimer's disease; Apoptosis; Caspase

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE 2; CASPASE 3; CASPASE 5; CASPASE 6; CASPASE 8; CASPASE 9; CYSTEINE PROTEINASE INHIBITOR; GAMMA SECRETASE; INTERLEUKIN 1BETA CONVERTING ENZYME; PRESENILIN 1; SMALL INTERFERING RNA; STAUROSPORINE; UNCLASSIFIED DRUG; Z VDVAD FMK;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTHRACENES; APOPTOSIS; CASPASE 2; CASPASE 8; CASPASES; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME INHIBITORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; OLIGOPEPTIDES; PRESENILIN-1; RECEPTORS, CELL SURFACE; RNA, SMALL INTERFERING; STAUROSPORINE; TRANSFECTION;

EID: 77953488403     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22356     Document Type: Article

References (27)

1. Ashkenazi A, Dixit VM. 1999. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 11:255-260.
2. de la Monte SM, Sohn YK, Wands JR. 1997. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci 152: 73-83.
3. Ethell DW, Buhler LA. 2003. Fas ligand-mediated apoptosis in degenerative disorders of the brain. J Clin Immunol 23:363-370.
4. Ferrer I, Puig B, Krupinsk J, Carmona M, Blanco R. 2001. Fas and Fas ligand expression in Alzheimer's disease. Acta Neuropathol 102:121-131. (Pubitemid 32771659)
5. Fischer H, Koenig U, Eckhart L, Tschachler E. 2002. Human caspase 12 has acquired deleterious mutations. Biochemical and Biophysical Research Communications 293:722-726.
6. Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW. 1999. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 97:395-406.
7. Hansson CA, Popescu BO, Laudon H, Cedazo-Minguez A, Popescu LM, Winblad B, Ankarcrona M. 2006. Caspase cleaved presenilin-1 is part of active gamma-secretase complexes. J Neurochem 97:356-364.
8. Iwatsubo T. 2004. The gamma-secretase complex: machinery for intramembrane proteolysis. Curr Opin Neurobiol 14:379-383.
9. Jin SM, Cho HJ, Jung ES, Shim MY, Mook-Jung I. 2008. DNA damage-inducing agents elicit gamma-secretase activation mediated by oxidative stress. Cell Death Differ 15:1375-1384.
10. Juo P, Kuo CJ, Yuan J, Blenis J. 1998. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr Biol 8:1001-1008. (Pubitemid 28448072)
11. Kuo LH, Hu MK, Hsu WM, Tung YT, Wang BJ, Tsai WW, Yen CT, Liao YF. 2008. Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. Mol Biol Cell 19:4201-4212.
12. Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS. 2004. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem 279:49523-49532.
13. Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A. 2003. Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. J Biol Chem 278:28294-28302.
14. Martinez M, Fernandez-Vivancos E, Frank A, De la Fuente M, Hernanz A. 2000. Increased cerebrospinal fluid fas (Apo-1) levels in Alzheimer's disease. Relationship with IL-6 concentrations. Brain Res 869:216-219.
15. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817-827.
16. Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M. 2009. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981-989.
17. Park CS, Kim OS, Yun SM, Jo SA, Jo I, Koh YH. 2008. Presenilin 1/gamma-secretase is associated with cadmium-induced E-cadherin cleavage and COX-2 gene expression in T47D breast cancer cells. Toxicol Sci 106:413-422.
18. Pellegrini L, Passer BJ, Tabaton M, Ganjei JK, D'Adamio L. 1999. Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8. J Biol Chem 274:21011-21016. (Pubitemid 129519603)
19. Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH. 2001. Activation of caspase-8 in the Alzheimer's disease brain. Neurobiol Dis 8: 1006-1016.
20. Roth KA. 2001. Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion. J Neuropathol Exp Neurol 60:829-838.
21. Satou T, Cummings BJ, Cotman CW. 1995. Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity. Brain Res 697:35-43.
22. Shimohama S, Tanino H, Fujimoto S. 1999. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. Biochem Biophy Res Comm 256:381-384.
23. Stefanis L, Burke RE, Greene LA. 1997. Apoptosis in neurode-generative disorders. Curr Opin Neurol 10:299-305.
24. Su JH, Zhao M, Anderson AJ, Srinivasan A, Cotman CW. 2001. Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. Brain Res 898:350-357.
25. Tesco G, Koh YH, Tanzi RE. 2003. Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). J Biol Chem 278:46074-46080.
26. Wagner KW, Engels IH, Deveraux QL. 2004. Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway. J Biol Chem 279:35047-35052.
27. Yew DT, Ping Li W, Liu WK. 2004. Fas and activated caspase 8 in normal, Alzheimer and multiple infarct brains. Neurosci Lett 367:113-117.