Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides

Neurobiology of Aging

Volumn 32, Issue 1, 2011, Pages 42-53

  Zhang, Qipeng ^a,c   Yang, Guang ^a   Li, Wenxia ^a   Fan, Zhiqin ^a   Sun, Anyang ^c   Luo, Jia ^a,b   Ke, Zun Ji ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF KENTUCKY   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

Amyloid peptide; Secretase; Alzheimer's disease; Oxidative stress; Thiamine deficiency

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; GAMMA SECRETASE; REACTIVE OXYGEN METABOLITE; THIAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROCESSING; THIAMINE DEFICIENCY; UPREGULATION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; CELL DEATH; CELL LINE, TUMOR; CHROMANS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PYRITHIAMINE; REACTIVE OXYGEN SPECIES; THIAMINE; THIAMINE DEFICIENCY; TIME FACTORS;

EID: 78449300244     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2009.01.005     Document Type: Article

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