Susceptibility of amyloid β peptide degrading enzymes to oxidative damage: A potential Alzheimer's disease spiral

Biochemistry

Volumn 44, Issue 46, 2005, Pages 15345-15350

  Shinall, Heather ^a   Song, Eun Suk ^a   Hersh, Louis B ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; HYDROGEN PEROXIDE; IRON COMPOUNDS; OXIDATION; PROTEINS;

AMYLOID Β PEPTIDE; INSULYSIN (IDE); IRON-ASCORBATE OXIDATION SYSTEM; NEPRILYSIN (NEP);

ENZYMES;

2,2' AZOBIS(2 AMIDINOPROPANE); 2,4 DINITROPHENYLHYDRAZINE; AMYLOID BETA PROTEIN; FERROUS ASCORBATE; HYDROGEN PEROXIDE; INSULINASE; MEMBRANE METALLOENDOPEPTIDASE;

ALZHEIMER DISEASE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; ENZYME DEGRADATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; NEUROPATHOLOGY; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

ALDEHYDES; ALZHEIMER DISEASE; AMIDINES; AMYLOID BETA-PROTEIN; ASCORBIC ACID; CHYMOTRYPSIN; FERRIC COMPOUNDS; HYDROGEN PEROXIDE; INSULYSIN; NEPRILYSIN; OXIDATION-REDUCTION; TRYPSIN;

EID: 27944440133     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050650l     Document Type: Article

References (31)

1. Selkoe, D. (2001) Clearing the brain's amyloid cobwebs, Neuron 32, 177-180.
2. Iwata, N., Tsubuki, S., Takaki, Y., Shirotani, K., Lu, B., Gerard, N. P., Gerard, C, Hama, E, Lee, H. J., and Saido, T. C. (2001) Metabolic regulation of brain Abeta by neprilysin, Science 292, 1550-1552.
3. Miller, B. C., Eckman, E. A., Sambamurti, K., Dobbs, N., Chow, K. M., Eckman, C. B., Hersh, L. B., and Thiele, D. L. (2003). Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo, Proc. Natl. Acad. Sci. U.S.A. 100, 6221-6226.
4. Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., Eckman, C. B., Tanzi, R. E., Selkoe, D. J., and Guenette, S. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo, Proc. Natl. Acad. Sci. U.S.A. 100, 4162-4167.
5. Eckman, E. A., Watson, M., Marlow, L., Sambamurti, K., and Eckman, C. B. (2003) Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme, J. Biol. Chem. 278, 2081-2084.
6. Iwata, N., Takaki, Y., Fukami, S., Tsubuki, S., and Saido, T. C. (2002) Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging, J. Neurosci. Res. 70, 493-500.
7. Caccamo, A., Salvatore, O., Sugarman, C., Akbari, Y., and LaFerla, F. M. (2005) Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders, Neurobiol. Aging 26, 645-654.
8. Yasojima, K., Akiyama, H. McGeer, E. G., and McGeer, P. L. (2001) Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide, Neurosci. Lett. 297, 97-100.
9. Yasojima, K., McGeer, E. G., and. McGeer, P. L., (2001) Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain, Brain Res. 919, 115-121.
10. Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., and Markesbery, W. R (1991) Oxidative stress in Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A. 88, 10540-10543.
11. Smith, M. A., Sayre L., and Perry, G. (1996) Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer's disease, Alzheimer's Dis. Rev. 1, 63-67.
12. Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K., and Perry, G. (2000) Oxidative stress in Alzheimer's disease, Biochim. Biophys. Acta 1502, 139-144.
13. Harman, D. (1993) Free radical theory of aging: a hypothesis on pathogenesis of senile dementia of the Alzheimer's type, Age 16, 23-30.
14. Olanow, C. W. (1993) A radical hypothesis for neurodegeneration, Trends Neurosci. 16, 439-444.
15. Volicer, L., and Crino, P. B. (1990) Involvement of free radicals in dementia of the Alzheimer type: A hypothesis, Neurobiol. Aging 11, 567-571.
16. Varadarajan, S., Yatin, S., Aksenova, M., and Butterfield, D. A. (2000) Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity, J. Struct. Biol. 130, 184-208.
17. Ghanbari, H. A., Ghanbari, K., Harris, P. L., Jones, P. K., Kubat, Z., Castellani, R. J., Wolozin, B. L., Smith, M. A., Perry, G. (2004) Aging Cell 3, 41-44.
18. Nunomura, A., Perry, G., Pappolla, M. A., Friedland, R. P., Hirai, K., Chiba, S., and Smith, M. A. (2000) Oxidative damage is the earliest event in Alzheimer disease, J. Neuropathol. Exp. Neurol. 59, 1011-1017.
19. Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., Chiba, S., Atwood, C. S., Petersen, R. B., Smith, M. A. (2001) Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome, J. Neuropathol. Exp. Neurol. 60, 759-767.
20. Wang, D. S., Iwata, N., Hama, E., Saido, T. C., and Dickson, D. W. (2003) Oxidized neprilysin in aging and Alzheimer's disease brains, Biochem. Biophys. Res. Commun. 310, 236-241.
21. Song, E. S., Juliano, M. A., Juliano, L., and Hersh, L. B. (2003) Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development, J. Biol. Chem. 278, 49789-49794.
22. Li, C, and Hersh, L. B. (1995) Neprilysin: assay methods, purification, and characterization, Methods Enzymol. 248, 253-263.
23. Thompson, M. W., Govindaswami, M., and Hersh, L. B. (2003) Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein, Arch. Biochem. Biophys. 413, 236-242.
24. Stadtman, E. R. (1997) in Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance (Ozben, T., Ed.) NATO ASI Series, Series A, Life Sciences, Vol. 296, pp 1321-143, Plenum, New York.
25. Levine, R. L. (1983) Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system, J. Biol. Chem. 258, 11823-11827.
26. Rivett, A. J., and Levine, R. L. (1990) Metal-catalyzed oxidation of Escherichia coli glutamine synthetase: correlation of structural and functional changes, Arch. Biochem. Biophys. 278, 26-34.
27. Ma, Y. S., Chao, C. C., and Stadtman, E. R. (1999) Oxidative modification of glutamine synthetase by 2,2′-azobis(2-amidinopropane) dihydrochloride, Arch. Biochem. Biophys. 363, 129-134.
28. Hersh, L. B. (2003) Peptidases, proteases and amyloid beta-peptide catabolism, Curr. Pharm. Des. 9, 449-454.
29. Carson, J. A., and Turner, A. J. (2002) Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?, J. Neurochem. 81, 1-8.
30. Carpentier, M., Robitaille, Y., DesGroseillers, L., Boileau, G., and Marcinkiewicz, M. (2002) Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathy, J. Neuropathol. Exp. Neurol. 61, 849-856.
31. Cook, D. G., Leverenz, J. B., McMillan, P. J., Kulstad, J. J., Ericksen, S., Roth, R. A., Schellenberg, G. D., Jin, L. W., Kovacina, K. S., and Craft, S. (2003) Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele Am. J. Pathol. 162, 313-319.