ALDH2 in alcoholic heart diseases: Molecular mechanism and clinical implications

Pharmacology and Therapeutics

Volumn 132, Issue 1, 2011, Pages 86-95

  Zhang, Yingmei ^a,b   Ren, Jun ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Alcohol; ALDH2; Enzyme; Metabolism; Myocardial; Transgenic mice

Indexed keywords

ACETALDEHYDE; ACETYL COENZYME A; ACTIN; ADENYLATE KINASE; ALCOHOL; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ATRIAL NATRIURETIC FACTOR; CALCIUM CHANNEL; CASPASE 3; CYTOCHROME P450 2E1; GLUTAMIC ACID; INSULIN RECEPTOR SUBSTRATE; KETONE BODY; LYSINE; MAMMALIAN TARGET OF RAPAMYCIN; NOTCH1 RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FKHRL1; TROPONIN T;

AFRICAN AMERICAN; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALCOHOL OXIDATION; ALCOHOLIC CARDIOMYOPATHY; ALCOHOLISM; AMERICAN INDIAN; APOPTOSIS; ASIAN; AUTOPHAGY; CALCIUM TRANSPORT; CANCER RISK; CARCINOGENESIS; CELL SURVIVAL; CHROMOSOME 12; CONGESTIVE CARDIOMYOPATHY; CYTOTOXICITY; DETOXIFICATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA BINDING; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; ETHNIC DIFFERENCE; FOLATE METABOLISM; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEART ARRHYTHMIA; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; HUMAN; HYPOTENSION; INOTROPISM; LIPID PEROXIDATION; LIVER CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TRANSGENIC ORGANISM; UPREGULATION; VASODILATATION;

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; AUTOPHAGY; CARDIOMYOPATHY, ALCOHOLIC; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FEMALE; HEART; HUMANS; MALE; MYOCARDIUM; POLYMORPHISM, GENETIC;

EID: 79960585511     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.05.008     Document Type: Review

References (153)

1. N.S. Aberle II, L. Burd, B.H. Zhao, and J. Ren Acetaldehyde-induced cardiac contractile dysfunction may be alleviated by vitamin B1 but not by vitamins B6 or B12 Alcohol Alcohol 39 2004 450 454 (Pubitemid 39232236)
2. N.S. Aberle II, M.J. Picklo Sr., V. Amarnath, and J. Ren Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal Cardiovasc Toxicol 4 2004 21 28 (Pubitemid 38506961)
3. N.S. Aberle II, J.R. Privratsky, L. Burd, and J. Ren Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid Neurotoxicol Teratol 25 2003 731 736 (Pubitemid 37415160)
4. I.N. Aberle, and J. Ren Experimental assessment of the role of acetaldehyde in alcoholic cardiomyopathy Biol Proced Online 5 2003 1 12 (Pubitemid 38097494)
5. N.S. Aberle II, and J. Ren Short-term acetaldehyde exposure depresses ventricular myocyte contraction: role of cytochrome P450 oxidase, xanthine oxidase, and lipid peroxidation Alcohol Clin Exp Res 27 2003 577 583 (Pubitemid 36460696)
6. G.L. Aistrup, J.E. Kelly, M.R. Piano, and J.A. Wasserstrom Biphasic changes in cardiac excitation-contraction coupling early in chronic alcohol exposure Am J Physiol Heart Circ Physiol 291 2006 H1047 H1057 (Pubitemid 44343648)
7. M. Arad, C.E. Seidman, and J.G. Seidman AMP-activated protein kinase in the heart: role during health and disease Circ Res 100 2007 474 488 (Pubitemid 46673257)
8. A.R. Aroor, and S.D. Shukla MAP kinase signaling in diverse effects of ethanol Life Sci 74 2004 2339 2364 (Pubitemid 38293254)
9. E.H. Awtry, and G.J. Philippides Alcoholic and cocaine-associated cardiomyopathies Prog Cardiovasc Dis 52 2010 289 299
10. T.M. Badger, M.J. Ronis, H.K. Seitz, E. Albano, M. Ingelman-Sundberg, and C.S. Lieber Alcohol metabolism: role in toxicity and carcinogenesis Alcohol Clin Exp Res 27 2003 336 347 (Pubitemid 36236657)
11. K. Bessembinders, J. Wielders, and A. van de Wiel Severe Hypertriglyceridemia Influenced by Alcohol (SHIBA) Alcohol Alcohol 2011, Jan.
12. R.A. Brown, M.J. Anthony, P. Petrovski, and J. Ren The influence of gender, diabetes, and acetaldehyde on the intrinsic contractile properties of isolated rat myocardium Cardiovasc Toxicol 1 2001 35 42
13. R.A. Brown, and R.G. Carpentier Effects of acetaldehyde on the automaticity of the guinea pig sinus node Alcohol 6 1989 103 107 (Pubitemid 19142070)
14. R.A. Brown, and R.G. Carpentier Effects of acetaldehyde on membrane potentials of sinus node pacemaker fibers Alcohol 7 1990 33 36 (Pubitemid 20090076)
15. R.A. Brown, L. Jefferson, N. Sudan, T.C. Lloyd, and J. Ren Acetaldehyde depresses myocardial contraction and cardiac myocyte shortening in spontaneously hypertensive rats: role of intracellular Ca2+ Cell Mol Biol (Noisy-le-Grand) 45 1999 453 465
16. R.A. Brown, and A.O. Savage Effects of acute acetaldehyde, chronic ethanol, and pargyline treatment on agonist responses of the rat aorta Toxicol Appl Pharmacol 136 1996 170 178 (Pubitemid 26049723)
17. G.R. Budas, E.N. Churchill, M.H. Disatnik, L. Sun, and D. Mochly-Rosen Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury Cardiovasc Res 88 2010 83 92
18. G.R. Budas, M.H. Disatnik, and D. Mochly-Rosen Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? Trends Cardiovasc Med 19 2009 158 164
19. L. Cai Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress J Mol Cell Cardiol 44 2008 979 982
20. A.I. Cederbaum, Y. Lu, and D. Wu Role of oxidative stress in alcohol-induced liver injury Arch Toxicol 83 2009 519 548
21. A.I. Cederbaum, D. Wu, M. Mari, and J. Bai CYP2E1-dependent toxicity and oxidative stress in HepG2 cells Free Radic Biol Med 31 2001 1539 1543 (Pubitemid 34024976)
22. S.M. Chan, A.P. Weng, R. Tibshirani, J.C. Aster, and P.J. Utz Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia Blood 110 2007 278 286 (Pubitemid 47026845)
23. C.H. Chen, G.R. Budas, E.N. Churchill, M.H. Disatnik, T.D. Hurley, and D. Mochly-Rosen Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart Science 321 2008 1493 1495
24. Y.C. Chen, R.B. Lu, G.S. Peng, M.F. Wang, H.K. Wang, H.C. Ko, Y.C. Chang, J.J. Lu, T.K. Li, and S.J. Yin Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele Alcohol Clin Exp Res 23 1999 1853 1860
25. Y.C. Chen, G.S. Peng, M.F. Wang, T.P. Tsao, and S.J. Yin Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences Chem Biol Interact 178 2009 2 7
26. C.H. Chen, L. Sun, and D. Mochly-Rosen Mitochondrial aldehyde dehydrogenase and cardiac diseases Cardiovasc Res 88 2010 51 57
27. W.Y. Chou, M.J. Stewart, L.G. Carr, D. Zheng, T.R. Stewart, A. Williams, J. Pinaire, and D.W. Crabb An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): effects of the sequence variant on transcription factor binding and promoter strength Alcohol Clin Exp Res 23 1999 963 968 (Pubitemid 29283490)
28. A. Clerk, S.M. Cole, T.E. Cullingford, J.G. Harrison, M. Jormakka, and D.M. Valks Regulation of cardiac myocyte cell death Pharmacol Ther 97 2003 223 261 (Pubitemid 36167840)
29. D.W. Crabb, M. Matsumoto, D. Chang, and M. You Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology Proc Nutr Soc 63 2004 49 63 (Pubitemid 38543873)
30. P.A. Dickson, M.R. James, A.C. Heath, G.W. Montgomery, N.G. Martin, J.B. Whitfield, and A.J. Birley Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans Alcohol Clin Exp Res 30 2006 1093 1100 (Pubitemid 43892897)
31. L. Djousse, and J.M. Gaziano Alcohol consumption and heart failure: a systematic review Curr Atheroscler Rep 10 2008 117 120 (Pubitemid 351486145)
32. L. Djousse, I.M. Lee, J.E. Buring, and J.M. Gaziano Alcohol consumption and risk of cardiovascular disease and death in women: potential mediating mechanisms Circulation 120 2009 237 244
33. L. Djousse, D. Levy, E.J. Benjamin, S.J. Blease, A. Russ, M.G. Larson, J.M. Massaro, R.B. D'Agostino, P.A. Wolf, and R.C. Ellison Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study Am J Cardiol 93 2004 710 713 (Pubitemid 38338559)
34. T.A. Doser, S. Turdi, D.P. Thomas, P.N. Epstein, S.Y. Li, and J. Ren Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction Circulation 119 2009 1941 1949
35. N. Druesne-Pecollo, B. Tehard, Y. Mallet, M. Gerber, T. Norat, S. Hercberg, and P. Latino-Martel Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer Lancet Oncol 10 2009 173 180
36. J. Duan, L.B. Esberg, G. Ye, A.J. Borgerding, B.H. Ren, N.S. Aberle, P.N. Epstein, and J. Ren Influence of gender on ethanol-induced ventricular myocyte contractile depression in transgenic mice with cardiac overexpression of alcohol dehydrogenase Comp Biochem Physiol A Mol Integr Physiol 134 2003 607 614 (Pubitemid 36205096)
37. J. Duan, G.E. McFadden, A.J. Borgerding, F.L. Norby, B.H. Ren, G. Ye, P.N. Epstein, and J. Ren Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes Am J Physiol Heart Circ Physiol 282 2002 H1216 H1222 (Pubitemid 34654871)
38. C. Espinet, and J.M. Argiles Ethanol and acetaldehyde concentrations in the rat foeto-maternal system after an acute ethanol administration given to the mother Arch Int Physiol Biochim 92 1984 339 344 (Pubitemid 15109394)
39. J. Fernandez-Sola, F. Fatjo, E. Sacanella, R. Estruch, X. Bosch, A. Urbano-Marquez, and J.M. Nicolas Evidence of apoptosis in alcoholic cardiomyopathy Hum Pathol 37 2006 1100 1110 (Pubitemid 44080824)
40. D.V. Folden, A. Gupta, A.C. Sharma, S.Y. Li, J.T. Saari, and J. Ren Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism Br J Pharmacol 139 2003 1310 1316 (Pubitemid 37026414)
41. C.M. Gao, T. Takezaki, J.Z. Wu, X.M. Zhang, H.X. Cao, J.H. Ding, Y.T. Liu, S.P. Li, J. Cao, K. Matsuo, N. Hamajima, and K. Tajima Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males World J Gastroenterol 14 2008 5078 5083
42. W. Ge, Q. Li, S. Turdi, X.M. Wang, and J. Ren Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK J Cell Mol Med. 2011 "Postprint";10.1111/j.1582-4934.2010.01158.x
43. Ge, W. & Ren, J. in press. mTOR-STAT3-Notch signaling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. J. Cell. Mol. Med. "Accepted Article"; doi:10.1111/j.1582-4934.2011.01347.x.
44. A. George, and V.M. Figueredo Alcohol and arrhythmias: a comprehensive review J Cardiovasc Med (Hagerstown) 11 2010 221 228
45. R.A. Gottlieb, and R.S. Carreira Autophagy in health and disease. 5. Mitophagy as a way of life Am J Physiol Cell Physiol 299 2010 C203 C210
46. R.A. Gottlieb, and R.M. Mentzer Autophagy during cardiac stress: joys and frustrations of autophagy Annu Rev Physiol 72 2010 45 59
47. R. Guo, and J. Ren Alcohol and acetaldehyde in public health: from marvel to menace Int J Environ Res Public Health 7 2010 1285 1301
48. R. Guo, and J. Ren Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway PLoS One 5 2010 e8757
49. R. Guo, G.I. Scott, and J. Ren Involvement of AMPK in alcohol dehydrogenase accentuated myocardial dysfunction following acute ethanol challenge in mice PLoS One 5 2010 e11268
50. R. Guo, L. Zhong, and J. Ren Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver Clin Exp Pharmacol Physiol 36 2009 463 468
51. N. Gurusamy, and D.K. Das Autophagy, redox signaling, and ventricular remodeling Antioxid Redox Signal 11 2009 1975 1988
52. N. Gurusamy, and D.K. Das Is autophagy a double-edged sword for the heart? Acta Physiol Hung 96 2009 267 276
53. M. Hamer, L. Malan, A.E. Schutte, H.W. Huisman, J.M. van Rooyen, R. Schutte, C.M. Fourie, N.T. Malan, and Y.K. Seedat Conventional and behavioral risk factors explain differences in sub-clinical vascular disease between black and Caucasian South Africans: the SABPA study Atherosclerosis 215 2010, Dec. 237 242
54. M.L. Hannuksela, M.K. Liisanantti, and M.J. Savolainen Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis Crit Rev Clin Lab Sci 39 2002 225 283 (Pubitemid 34753845)
55. P.P. Hao, L. Xue, X.L. Wang, Y.G. Chen, J.L. Wang, W.Q. Ji, F. Xu, S.J. Wei, and Y. Zhang Association between aldehyde dehydrogenase 2 genetic polymorphism and serum lipids or lipoproteins: a meta-analysis of seven East Asian populations Atherosclerosis 212 2010 213 216
56. S. Harada, D.P. Agarwal, and H.W. Goedde Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese Lancet 2 1981 982 (Pubitemid 11026670)
57. D. Hering, W. Kucharska, T. Kara, V.K. Somers, and K. Narkiewicz Potentiated sympathetic and hemodynamic responses to alcohol in hypertensive vs. normotensive individuals J Hypertens 29 2011, Jan. 537 541
58. A. Higashiyama, I. Wakabayashi, Y. Ono, M. Watanabe, Y. Kokubo, A. Okayama, Y. Miyamoto, and T. Okamura Association with serum gamma- glutamyltransferase levels and alcohol consumption on stroke and coronary artery disease: the Suita Study Stroke 42 2011 1764 1767
59. K.K. Hintz, D.P. Relling, J.T. Saari, A.J. Borgerding, J. Duan, B.H. Ren, K. Kato, P.N. Epstein, and J. Ren Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion Alcohol Clin Exp Res 27 2003 1090 1098 (Pubitemid 36890386)
60. A. Hishimoto, M. Fukutake, K. Mouri, Y. Nagasaki, M. Asano, Y. Ueno, N. Nishiguchi, and O. Shirakawa Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population Genes Brain Behav 9 2010 498 502
61. A. Iacovoni, R. De Maria, and A. Gavazzi Alcoholic cardiomyopathy J Cardiovasc Med (Hagerstown) 11 2010 884 892
62. T. Ishibashi, A. Taguchi, Y. Yamamoto, and S. Harada Evaluation of the use of self-reported facial flushing and ethanol patch test for ALDH2 genotypes Nihon Arukoru Yakubutsu Igakkai Zasshi 45 2010 464 476
63. T. Isse, K. Matsuno, T. Oyama, K. Kitagawa, and T. Kawamoto Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages Alcohol Clin Exp Res 29 2005 1959 1964 (Pubitemid 41790833)
64. P.I. Jaatinen, P. Saukko, M. Sarviharju, K. Kiianmaa, and A. Hervonen Effects of lifelong ethanol consumption on the ultrastructure and lipopigmentation of rat heart Alcohol Alcohol 29 1994 269 282 (Pubitemid 24215900)
65. A.J. Jacob, K.M. McLaren, and N.A. Boon Effects of abstinence on alcoholic heart muscle disease Am J Cardiol 68 1991 805 807
66. H. Jankala, C.J. Eriksson, K.K. Eklund, M. Harkonen, and T. Maki Combined calcium carbimide and ethanol treatment induces high blood acetaldehyde levels, myocardial apoptosis and altered expression of apoptosis-regulating genes in rat Alcohol Alcohol 37 2002 222 228 (Pubitemid 34578524)
67. H. Jankala, C.J.P. Eriksson, N.E. Petersen, M. Harkonen, and T. Maki Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats Alcohol Alcohol 35 2000 331 335 (Pubitemid 30604021)
68. K.S. Jeong, Y. Soh, J. Jeng, M.R. Felder, J.P. Hardwick, and B.J. Song Cytochrome P450 2E1 (CYP2E1)-dependent production of a 37-kDa acetaldehyde-protein adduct in the rat liver Arch Biochem Biophys 384 2000 81 87
69. L. Jing, L.J. Zhou, W.M. Li, F.M. Zhang, L. Yuan, S. Li, J. Song, and Y. Sang Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy Med Sci Monit 17 2011 BR1-9
70. S.A. Jo, E.K. Kim, M.H. Park, C. Han, H.Y. Park, Y. Jang, B.J. Song, and I. Jo A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men Clin Chim Acta 382 2007 43 47 (Pubitemid 46805086)
71. W.K. Jones A murine model of alcoholic cardiomyopathy: a role for zinc and metallothionein in fibrosis Am J Pathol 167 2005 301 304 (Pubitemid 43026087)
72. R.A. Kloner, and S.H. Rezkalla To drink or not to drink? That is the question Circulation 116 2007 1306 1317 (Pubitemid 47517542)
73. K. Koda, M. Salazar-Rodriguez, F. Corti, N.Y. Chan, R. Estephan, R.B. Silver, D. Mochly-Rosen, and R. Levi Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells Circulation 122 2010 771 781
74. C.H. Lang, R.A. Frost, A.D. Summer, and T.C. Vary Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart Int J Biochem Cell Biol 37 2005 2180 2195 (Pubitemid 41206830)
75. I. Laonigro, M. Correale, M. Di Biase, and E. Altomare Alcohol abuse and heart failure Eur J Heart Fail 11 2009 453 462
76. B. Levine, and G. Kroemer Autophagy in the pathogenesis of disease Cell 132 2008 27 42
77. S.Y. Li, S.A. Gilbert, Q. Li, and J. Ren Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress J Mol Cell Cardiol 47 2009 247 255
78. S.Y. Li, M. Gomelsky, J. Duan, Z. Zhang, L. Gomelsky, X. Zhang, P.N. Epstein, and J. Ren Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase J Biol Chem 279 2004 11244 11252 (Pubitemid 38401620)
79. S.Y. Li, Q. Li, J.J. Shen, F. Dong, V.K. Sigmon, Y. Liu, and J. Ren Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling J Mol Cell Cardiol 40 2006 283 294 (Pubitemid 43152384)
80. Q. Li, and J. Ren Cardiac overexpression of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of rapamycin and ribosomal p70s6 kinase Alcohol Alcohol 41 2006 585 592 (Pubitemid 44742374)
81. S.Y. Li, and J. Ren Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress J Mol Cell Cardiol 44 2008 992 1001
82. Q. Liang, E.C. Carlson, A.J. Borgerding, and P.N. Epstein A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy J Pharmacol Exp Ther 291 1999 766 772 (Pubitemid 29503551)
83. C.S. Lieber Alcohol and fibrogenesis Alcohol Alcohol Suppl 1 1991 339 344
84. H. Ma, R. Guo, L. Yu, Y. Zhang, and J. Ren Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde Eur Heart J 32 2011 1025 1038
85. H. Ma, J. Li, F. Gao, and J. Ren Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor J Am Coll Cardiol 54 2009 2187 2196
86. J. Ma, Y. Meng, D.J. Kwiatkowski, X. Chen, H. Peng, Q. Sun, X. Zha, F. Wang, Y. Wang, Y. Jing, S. Zhang, R. Chen, L. Wang, E. Wu, G. Cai, I. Malinowska-Kolodziej, Q. Liao, Y. Liu, Y. Zhao, Q. Sun, K. Xu, J. Dai, J. Han, L. Wu, R.C. Zhao, H. Shen, and H. Zhang Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade J Clin Invest 120 2010 103 114
87. H. Ma, L. Yu, E.A. Byra, N. Hu, K. Kitagawa, K.I. Nakayama, T. Kawamoto, and J. Ren Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases J Mol Cell Cardiol 49 2010 322 329
88. S. Manzo-Avalos, and A. Saavedra-Molina Cellular and mitochondrial effects of alcohol consumption Int J Environ Res Public Health 7 2010 4281 4304
89. K.H. McDonough Antioxidant nutrients and alcohol Toxicology 189 2003 89 97 (Pubitemid 36725025)
90. M. Melis, M. Diana, P. Enrico, M. Marinelli, and M.S. Brodie Ethanol and acetaldehyde action on central dopamine systems: mechanisms, modulation, and relationship to stress Alcohol 43 2009 531 539
91. J.A. Morales, J.L. Ram, J. Song, and R.A. Brown Acetaldehyde inhibits current through voltage-dependent calcium channels Toxicol Appl Pharmacol 143 1997 70 74 (Pubitemid 27130608)
92. O. Niemela Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress Front Biosci 4 1999 D506 D513
93. O. Niemela Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury Free Radic Biol Med 31 2001 1533 1538 (Pubitemid 34024975)
94. N. Nishida, M. Tanaka, N. Hayashi, H. Nagata, T. Takeshita, K. Nakayama, K. Morimoto, and S. Shizukuishi Association of ALDH(2) genotypes and alcohol consumption with periodontitis J Dent Res 83 2004 161 165 (Pubitemid 41713802)
95. N. Nishida, M. Tanaka, S. Sekine, T. Takeshita, K. Nakayama, K. Morimoto, and S. Shizukuishi Association of ALDH2 genotypes with periodontitis progression J Dent Res 89 2010 138 142
96. F.T. Nishimura, T. Fukunaga, H. Kajiura, K. Umeno, H. Takakura, T. Ono, and H. Nishijo Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects Auton Neurosci 102 2002 60 70 (Pubitemid 35305008)
97. H. Nuutinen, K.O. Lindros, and M. Salaspuro Determinants of blood acetaldehyde level during ethanol oxidation in chronic alcoholics Alcohol Clin Exp Res 7 1983 163 168 (Pubitemid 13094442)
98. T. Oba, Y. Maeno, and K. Ishida Differential contribution of clinical amounts of acetaldehyde to skeletal and cardiac muscle dysfunction in alcoholic myopathy Curr Pharm Des 11 2005 791 800 (Pubitemid 40347981)
99. T. Oba, Y. Maeno, M. Nagao, N. Sakuma, and T. Murayama Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum Am J Physiol Heart Circ Physiol 294 2008 H121 H133
100. T. Ohira, T. Tanigawa, M. Tabata, H. Imano, A. Kitamura, M. Kiyama, S. Sato, T. Okamura, R. Cui, K.A. Koike, T. Shimamoto, and H. Iso Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among Japanese men Hypertension 53 2009 13 19
101. J.H. O'Keefe, K.A. Bybee, and C.J. Lavie Alcohol and cardiovascular health: the razor-sharp double-edged sword J Am Coll Cardiol 50 2007 1009 1014 (Pubitemid 47348233)
102. V.B. Patel, H.J. Why, P.J. Richardson, and V.R. Preedy The effects of alcohol on the heart Adverse Drug React Toxicol Rev 16 1997 15 43 (Pubitemid 27230650)
103. R.M. Pautassi, R. Camarini, I.M. Quadros, K.A. Miczek, and Y. Israel Genetic and environmental influences on ethanol consumption: perspectives from preclinical research Alcohol Clin Exp Res 34 2010 976 987
104. G.S. Peng, Y.C. Chen, T.P. Tsao, M.F. Wang, and S.J. Yin Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele Pharmacogenet Genomics 17 2007 845 855
105. G.S. Peng, M.F. Wang, C.Y. Chen, S.U. Luu, H.C. Chou, T.K. Li, and S.J. Yin Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians Pharmacogenetics 9 1999 463 476
106. G.S. Peng, and S.J. Yin Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations Hum Genomics 3 2009 121 127
107. G.S. Peng, J.H. Yin, M.F. Wang, J.T. Lee, Y.D. Hsu, and S.J. Yin Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes J Formos Med Assoc 101 2002 769 774
108. M.R. Piano Alcoholic cardiomyopathy: incidence, clinical characteristics, and pathophysiology Chest 121 2002 1638 1650 (Pubitemid 34499683)
109. V.R. Preedy, J. Adachi, T.J. Peters, S. Worrall, S. Parkkila, O. Niemela, M. Asamo, Y. Ueno, K. Takeda, M. Yamauchi, K. Sakamoto, M. Takagi, H. Nakajima, and G. Toda Recent advances in the pathology of alcoholic myopathy Alcohol Clin Exp Res 25 2001 54S 59S
110. V.R. Preedy, D.W. Crabb, J. Farres, and P.W. Emery Alcoholic myopathy and acetaldehyde Novartis Found Symp 285 2007 158 177 discussion 177-82, 198-9
111. J. Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models Novartis Found Symp 285 2007 69 76 discussion 76-9, 198-9
112. J. Ren, S.A. Babcock, Q. Li, A.F. Huff, S.Y. Li, and T.A. Doser Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex Toxicol Lett 187 2009 149 156
113. J. Ren, A.J. Davidoff, and R.A. Brown Acetaldehyde depresses shortening and intracellular Ca2+ transients in adult rat ventricular myocytes Cell Mol Biol (Noisy-le-Grand) 43 1997 825 834
114. J. Ren, G.J. Wang, P. Petrovski, B.H. Ren, and R.A. Brown Influence of hypertension on acetaldehyde-induced vasorelaxation in rat thoracic aorta Pharmacol Res 45 2002 195 199 (Pubitemid 35418361)
115. J. Ren, and L.E. Wold Mechanisms of alcoholic heart disease Ther Adv Cardiovasc Dis 2 2008 497 506
116. P.J. Richardson, V.B. Patel, and V.R. Preedy Alcohol and the myocardium Novartis Found Symp 216 1998 35 45 discussion 45-50
117. M. Romanowicz, J.E. Schmidt, J.M. Bostwick, D.A. Mrazek, and V.M. Karpyak Changes in heart rate variability associated with acute alcohol consumption: current knowledge and implications for practice and research Alcohol Clin Exp Res 35 2011 1092 1105
118. D. Russo, V. Purohit, L. Foudin, and M. Salin Workshop on Alcohol Use and Health Disparities 2002: a call to arms Alcohol 32 2004 37 43 (Pubitemid 38452292)
119. A.O. Savage, J.C. Dunbar, and R.A. Brown Effects of acetaldehyde on the isolated papillary muscle of diabetic rats J Cardiovasc Pharmacol 26 1995 251 258
120. M. Schoppet, and B. Maisch Alcohol and the heart Herz 26 2001 345 352 (Pubitemid 32851441)
121. S. Sciarretta, N. Hariharan, Y. Monden, D. Zablocki, and J. Sadoshima Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol 32 2010 275 281
122. F.R. Seiva, J.F. Amauchi, K.K. Rocha, G.X. Ebaid, G. Souza, A.A. Fernandes, A.C. Cataneo, and E.L. Novelli Alcoholism and alcohol abstinence: N-acetylcysteine to improve energy expenditure, myocardial oxidative stress, and energy metabolism in alcoholic heart disease Alcohol 43 2009 649 656
123. Y. Shimizu, A. Sakai, K. Menuki, T. Mori, T. Isse, T. Oyama, T. Kawamoto, and T. Nakamura Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice Bone 48 2011, Jan 1075 1086
124. T. Siddiq, P.J. Richardson, W.D. Mitchell, J. Teare, and V.R. Preedy Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde Cell Biochem Funct 11 1993 45 54 (Pubitemid 23087811)
125. C.E. Skotzko, A. Vrinceanu, L. Krueger, and R. Freudenberger Alcohol use and congestive heart failure: incidence, importance, and approaches to improved history taking Heart Fail Rev 41 2007 51 55
126. C.E. Skotzko, A. Vrinceanu, L. Krueger, and R. Freudenberger Alcohol use and congestive heart failure: incidence, importance, and approaches to improved history taking Heart Fail Rev 14 2009 51 55
127. N.A. Sokolova, L.I. Chudakov, I.P. Ashmarin, T.M. Vinogradova, N.D. Volodin, G.P. Vlasov, and I.N. Nikonova The positive chronotropic effects of salsolinol on the isolated rat heart Fiziol Zh SSSR Im I M Sechenova 76 1990 1043 1047 (Pubitemid 20359646)
128. C.D. Spies, M. Sander, K. Stangl, J. Fernandez-Sola, V.R. Preedy, E. Rubin, S. Andreasson, E.Z. Hanna, and W.J. Kox Effects of alcohol on the heart Curr Opin Crit Care 7 2001 337 343 (Pubitemid 33064363)
129. T. Takeshita, X. Yang, and K. Morimoto The ALDH2 genotype, alcohol intake, and liver-function biomarkers among Japanese male workers Hum Genet 106 2000 589 593 (Pubitemid 30427011)
130. R. Talhout, A. Opperhuizen, and J.G. van Amsterdam Role of acetaldehyde in tobacco smoke addiction Eur Neuropsychopharmacol 17 2007 627 636 (Pubitemid 47268752)
131. Y. Tominaga Use of acetaldehyde and methanol as markers of alcohol abuse and their measurement Nihon Arukoru Yakubutsu Igakkai Zasshi 44 2009 26 37
132. S. Tsukamoto, T. Muto, T. Nagoya, M. Shimamura, M. Saito, and H. Tainaka Determinations of ethanol, acetaldehyde and acetate in blood and urine during alcohol oxidation in man Alcohol Alcohol 24 1989 101 108 (Pubitemid 19100965)
133. L.A. Turcotte, N.S. Aberle, F.L. Norby, G.J. Wang, and J. Ren Influence of prenatal ethanol exposure on vascular contractile response in rat thoracic aorta Alcohol 26 2002 75 81 (Pubitemid 34462230)
134. K. Uchida Role of reactive aldehyde in cardiovascular diseases Free Radic Biol Med 28 2000 1685 1696 (Pubitemid 30628655)
135. T.C. Vary, G. Deiter, and R. Lantry Chronic alcohol feeding impairs mTOR(Ser 2448) phosphorylation in rat hearts Alcohol Clin Exp Res 32 2008 43 51 (Pubitemid 350301900)
136. T.C. Vary, and A.D. Summer Deleterious effects of alcohol intoxication on heart: arrhymias to cardiomyopathies V. Preedy, Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake (Watson RR 2004 CRC Press Boca Raton 117 141
137. M. Vaswani, P. Prasad, and S. Kapur Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India Hum Genomics 3 2009 213 220
138. G. Wang, R. Konig, G.A. Ansari, and M.F. Khan Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4+ T cells Free Radic Biol Med 44 2008 1475 1482
139. L. Wang, Z. Zhou, J.T. Saari, and Y.J. Kang Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation Am J Pathol 167 2005 337 344 (Pubitemid 43026091)
140. A. Watanabe, M. Kobayashi, N. Hobara, H. Nakatsukasa, H. Nagashima, and A. Fujimoto A report of unusually high blood ethanol and acetaldehyde levels in two surviving patients Alcohol Clin Exp Res 9 1985 14 16 (Pubitemid 15132044)
141. S. Worrall, O. Niemela, S. Parkkila, T.J. Peters, and V.R. Preedy Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region Eur J Clin Invest 31 2001 723 730 (Pubitemid 32756621)
142. D. Wu, and A.I. Cederbaum Oxidative stress and alcoholic liver disease Semin Liver Dis 29 2009 141 154
143. D. Wu, X. Wang, R. Zhou, and A. Cederbaum CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells Biochem Biophys Res Commun 402 2010 116 122
144. X. Xie, Y.T. Ma, Y.N. Yang, Z.Y. Fu, X. Ma, D. Huang, X.M. Li, B.D. Chen, F. Liu, Y. Huang, C. Liu, X.L. Zhang, Y.Y. Zheng, G. Baituola, B.Z. Wang, L. Du, and X. Gao Alcohol consumption and carotid atherosclerosis in China: the Cardiovascular Risk Survey Eur J Cardiovasc Prev Rehabil 2011 (Electronic publication ahead of print)
145. J. Yamaguchi, Y. Hasegawa, M. Kawasaki, T. Masui, T. Kanoh, N. Ishiguro, and N. Hamajima ALDH2 polymorphisms and bone mineral density in an elderly Japanese population Osteoporos Int 17 2006 908 913 (Pubitemid 43781505)
146. S.J. Yang, A. Yokoyama, T. Yokoyama, Y.C. Huang, S.Y. Wu, Y. Shao, J. Niu, J. Wang, Y. Liu, X.Q. Zhou, and C.X. Yang Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis World J Gastroenterol 16 2010 4210 4220
147. S.J. Yin, and G.S. Peng Acetaldehyde, polymorphisms and the cardiovascular system Novartis Found Symp 285 2007 52 63 discusion 63-8, 198-9
148. A. Yokoyama, T. Omori, and T. Yokoyama Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians Keio J Med 59 2010 115 130
149. H.S. Yu, T. Oyama, T. Isse, K. Kitagawa, T.T. Pham, M. Tanaka, and T. Kawamoto Formation of acetaldehyde-derived DNA adducts due to alcohol exposure Chem Biol Interact 188 2010 367 375
150. X. Zhang, A.L. Klein, N.S. Alberle, F.L. Norby, B.H. Ren, J. Duan, and J. Ren Cardiac-specific overexpression of catalase rescues ventricular myocytes from ethanol-induced cardiac contractile defect J Mol Cell Cardiol 35 2003 645 652 (Pubitemid 36677448)
151. X. Zhang, S.Y. Li, R.A. Brown, and J. Ren Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress Alcohol 32 2004 175 186 (Pubitemid 39013249)
152. Y. Zhang, and J. Ren Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: slayer or savior? Autophagy 6 2010 1212 1213
153. B. Zhang, S. Turdi, Q. Li, F.L. Lopez, A.R. Eason, P. Anversa, and J. Ren Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: roles of Akt, mTOR, GSK3beta, and PTEN Free Radic Biol Med 49 2010 1238 1253