메뉴 건너뛰기




Volumn 17, Issue 1, 2011, Pages

Carnitine regulates myocardial metabolism by peroxisome proliferator-activated receptor-α (PPARα) in alcoholic cardiomyopathy

Author keywords

Alcoholic cardiomyopathy; Carnitine; Mechanism; Metabolism; Structural remodeling

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE TRIPHOSPHATASE; ALCOHOL; CARNITINE; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; ACYL COENZYME A DEHYDROGENASE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; PHOSPHATE;

EID: 78651364560     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.881311     Document Type: Article
Times cited : (14)

References (39)
  • 1
    • 0036246990 scopus 로고    scopus 로고
    • Alcoholic cardiomyopathy: Incidence, clinical characteristics, and pathophysiology
    • Piano MR: Alcoholic cardiomyopathy: incidence, clinical characteristics, and pathophysiology. Chest, 2002; 121: 1638-50
    • (2002) Chest , vol.121 , pp. 1638-1650
    • Piano, M.R.1
  • 2
    • 33644816320 scopus 로고    scopus 로고
    • Toxic cardiopathies
    • Van Camp G: Toxic cardiopathies. Acta Clinica Belgica, 2005; 60: 293-300
    • (2005) Acta Clinica Belgica , vol.60 , pp. 293-300
    • van Camp, G.1
  • 3
    • 0033388495 scopus 로고    scopus 로고
    • Dilated cardiomyopathies: Changing pathophysiological concepts and mechanisms of dysfunction
    • De Keulenaer GW, Brutsaert DL: Dilated cardiomyopathies: changing pathophysiological concepts and mechanisms of dysfunction. J Card Surg, 1999; 14: 64-74
    • (1999) J Card Surg , vol.14 , pp. 64-74
    • de Keulenaer, G.W.1    Brutsaert, D.L.2
  • 4
    • 0029257721 scopus 로고
    • Heart failure: Evaluation and care of patients with left ventricular systolic dysfunction
    • Konstam MA, Dracup K, Baker DW et al: Heart failure: evaluation and care of patients with left ventricular systolic dysfunction. J Card Fail, 1995: 183-87
    • (1995) J Card Fail , pp. 183-187
    • Konstam, M.A.1    Dracup, K.2    Baker, D.W.3
  • 5
    • 0033590646 scopus 로고    scopus 로고
    • Consensus recommendations for the management of chronic heart failure
    • Packer M, Cohn JN, Abraham WT: Consensus recommendations for the management of chronic heart failure. Am J Cardiol, 1999; 83: 1A-38A
    • (1999) Am J Cardiol , vol.83
    • Packer, M.1    Cohn, J.N.2    Abraham, W.T.3
  • 6
    • 44649127369 scopus 로고    scopus 로고
    • Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: Role of insulin signaling and ER stress
    • Li SY, Ren J: Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. J Mol Cell Cardiol, 2008; 44: 992-1001
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 992-1001
    • Li, S.Y.1    Ren, J.2
  • 7
    • 34548184469 scopus 로고    scopus 로고
    • Pressure overload - Induced cardiomyopathy in heterozygous carrier mice of carnitine transporter gene mutation
    • Takahashi R, Asai T, Murakami H et al: Pressure overload - Induced cardiomyopathy in heterozygous carrier mice of carnitine transporter gene mutation. Hypertension, 2007; 50: 497-502
    • (2007) Hypertension , vol.50 , pp. 497-502
    • Takahashi, R.1    Asai, T.2    Murakami, H.3
  • 8
    • 4444315751 scopus 로고    scopus 로고
    • Carnitine: A nutritional, biosynthetic, and functional perspective
    • Steiber A, Kerner J, Hoppel CL: Carnitine: a nutritional, biosynthetic, and functional perspective. Mol. Aspects Med, 2004; 25: 455-73
    • (2004) Mol. Aspects Med , vol.25 , pp. 455-473
    • Steiber, A.1    Kerner, J.2    Hoppel, C.L.3
  • 9
    • 33750101041 scopus 로고    scopus 로고
    • Short-term effects of nocturnal haemodialysis on carnitine metabolism
    • Hothi DK, Geary DF, Fisher L et al: Short-term effects of nocturnal haemodialysis on carnitine metabolism. Nephrol Dial Transplant, 2006; 21: 2637-41
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 2637-2641
    • Hothi, D.K.1    Geary, D.F.2    Fisher, L.3
  • 10
    • 34249724327 scopus 로고    scopus 로고
    • New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle
    • Stephens FB, Constantin-Teodosiu D, Greenhaff PL: New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol, 2007; 581: 431-44
    • (2007) J Physiol , vol.581 , pp. 431-444
    • Stephens, F.B.1    Constantin-Teodosiu, D.2    Greenhaff, P.L.3
  • 11
    • 75349096489 scopus 로고    scopus 로고
    • L-Arginine in Heart Failure Study Group: Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure
    • Fontanive P, Saponati G, Iurato A et al, L-Arginine in Heart Failure Study Group: Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure. Med Sci Monit, 2009; 15(12): CR606-11
    • (2009) Med Sci Monit , vol.15 , Issue.12
    • Fontanive, P.1    Saponati, G.2    Iurato, A.3
  • 12
    • 0018669174 scopus 로고
    • A simple and sensitive colorimetric method for the determination of long-chain free fatty acids in subcelluar or ganelles
    • Nixon M: A simple and sensitive colorimetric method for the determination of long-chain free fatty acids in subcelluar or ganelles. Anal Biochem, 1979; 97: 403-9.
    • (1979) Anal Biochem , vol.97 , pp. 403-409
    • Nixon, M.1
  • 13
    • 0031949339 scopus 로고    scopus 로고
    • Determination of free and total carnitine with a random access chemistry analyzer
    • Wan L, Hubbard RW: Determination of free and total carnitine with a random access chemistry analyzer. Clin Chem, 1998; 44: 8102-6
    • (1998) Clin Chem , vol.44 , pp. 8102-8106
    • Wan, L.1    Hubbard, R.W.2
  • 14
    • 0021986181 scopus 로고
    • The respiration and calcium content of heart mitochondria from rats with vitamin D-induced cardionecrosis
    • Zydowo MM, Swierczynski J, Nagel G: The respiration and calcium content of heart mitochondria from rats with vitamin D-induced cardionecrosis. Biochem J, 1985; 226: 155-61
    • (1985) Biochem J , vol.226 , pp. 155-161
    • Zydowo, M.M.1    Swierczynski, J.2    Nagel, G.3
  • 15
    • 0039990185 scopus 로고    scopus 로고
    • Alteration of the ADP/ATP translocase isoform pattern improves ATP expenditure in developing rat liver mitochondria
    • Florian V, Schonfeld P: Alteration of the ADP/ATP translocase isoform pattern improves ATP expenditure in developing rat liver mitochondria. FEBS Lett, 1998; 433: 261-64
    • (1998) FEBS Lett , vol.433 , pp. 261-264
    • Florian, V.1    Schonfeld, P.2
  • 16
    • 0028786786 scopus 로고
    • Developmental changes of the adenine nucleotide translocation in rat brain
    • Schonfeld P, Bohnensack R: Developmental changes of the adenine nucleotide translocation in rat brain. Biochim Biophys Acta, 1995; 1232: 75-80
    • (1995) Biochim Biophys Acta , vol.1232 , pp. 75-80
    • Schonfeld, P.1    Bohnensack, R.2
  • 17
    • 0029862430 scopus 로고    scopus 로고
    • Expression of the ADP/ATP carrier and expansion of the mitochondrial (ATP+ADP) pool contribute to postnatal maturation of the rat heart
    • Schonfeld P, Schild L, Bohnensack R: Expression of the ADP/ATP carrier and expansion of the mitochondrial (ATP+ADP) pool contribute to postnatal maturation of the rat heart. Eur J Biochem, 1996; 241: 895-900
    • (1996) Eur J Biochem , vol.241 , pp. 895-900
    • Schonfeld, P.1    Schild, L.2    Bohnensack, R.3
  • 18
    • 0017164281 scopus 로고
    • A rapid method for the assay of mitochondrial ATPase activity
    • Monk BC, Kellerman GM: A rapid method for the assay of mitochondrial ATPase activity. Analytical Biochemistry, 1976; 73: 187-91
    • (1976) Analytical Biochemistry , vol.73 , pp. 187-191
    • Monk, B.C.1    Kellerman, G.M.2
  • 19
    • 38449089751 scopus 로고    scopus 로고
    • Early and progressing alcohol cardiomyopathy
    • Kozlovski IV: Early and progressing alcohol cardiomyopathy. Klin Med, 2007; 85: 51-54
    • (2007) Klin Med , vol.85 , pp. 51-54
    • Kozlovski, I.V.1
  • 20
    • 58149088294 scopus 로고    scopus 로고
    • Alcohol use and congestive heart failure: Incidence, importance, and approaches to improved history taking
    • Skotzko CE, Vrinceanu A, Krueger L et al: Alcohol use and congestive heart failure: incidence, importance, and approaches to improved history taking. Heart Failure Reviews, 2007; 22: 43-46
    • (2007) Heart Failure Reviews , vol.22 , pp. 43-46
    • Skotzko, C.E.1    Vrinceanu, A.2    Krueger, L.3
  • 21
    • 0031770664 scopus 로고    scopus 로고
    • L-Carnitine supplementation in childhood epilepsy: Current perspectives
    • De Vivo DC, Bohan TP, Coulter DL et al: L-Carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia, 1998; 39: 1216-25
    • (1998) Epilepsia , vol.39 , pp. 1216-1225
    • de Vivo, D.C.1    Bohan, T.P.2    Coulter, D.L.3
  • 22
    • 0035217004 scopus 로고    scopus 로고
    • Postinfarction heart failure in rats is associated with upregulation of GLUT-1 and downregulation of genes of fatty acid metabolism
    • Rosenblatt-Velin N, Montessuit C, Papageorgiou I et al: Postinfarction heart failure in rats is associated with upregulation of GLUT-1 and downregulation of genes of fatty acid metabolism. Cardiovasc Res, 2001; 52: 407-16
    • (2001) Cardiovasc Res , vol.52 , pp. 407-416
    • Rosenblatt-Velin, N.1    Montessuit, C.2    Papageorgiou, I.3
  • 23
    • 36348962871 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 reduces cardiac growth and pressure overload induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases
    • Zhai P, Gao S, Holle E et al: Glycogen synthase kinase-3 reduces cardiac growth and pressure overload induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. J Biol Chem, 2007; 45: 33181-91
    • (2007) J Biol Chem , vol.45 , pp. 33181-33191
    • Zhai, P.1    Gao, S.2    Holle, E.3
  • 24
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J, Moller DE: The mechanisms of action of PPARs. Annu Rev Med, 2002; 53: 409-35
    • (2002) Annu Rev Med , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 25
    • 32644460092 scopus 로고    scopus 로고
    • From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
    • Feige JN, Gelman L, Michalik L et al: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res, 2006; 45: 120-59
    • (2006) Prog Lipid Res , vol.45 , pp. 120-159
    • Feige, J.N.1    Gelman, L.2    Michalik, L.3
  • 26
    • 0033933236 scopus 로고    scopus 로고
    • Deactivation of peroxisome proliferator- activated receptor-alpha during cardiac hypertrophic growth
    • Barger PM, Brandt JM, Leone TC et al: Deactivation of peroxisome proliferator- activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest, 2000; 105: 1723-30
    • (2000) J Clin Invest , vol.105 , pp. 1723-1730
    • Barger, P.M.1    Brandt, J.M.2    Leone, T.C.3
  • 27
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARalphamediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • Finck BN, Han X, Courtois M et al: A critical role for PPARalphamediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci USA, 2003; 100: 1226-31
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3
  • 28
    • 21244473058 scopus 로고    scopus 로고
    • Fatty acid oxidation defects as a cause of neuromyopathic disease in infants and adults
    • Olpin SE: Fatty acid oxidation defects as a cause of neuromyopathic disease in infants and adults. Clin Lab, 2005; 51: 289-306
    • (2005) Clin Lab , vol.51 , pp. 289-306
    • Olpin, S.E.1
  • 29
    • 30544442097 scopus 로고    scopus 로고
    • Acetylcarnitine and cellular stress response: Roles in nutritional redox homeostasis and regulation of longevity genes
    • Calabrese V, Giuffrida Stella AM, Calvani M et al: Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. J Nutri Biochem, 2006; 17: 73-88
    • (2006) J Nutri Biochem , vol.17 , pp. 73-88
    • Calabrese, V.1    Giuffrida Stella, A.M.2    Calvani, M.3
  • 31
    • 33744949740 scopus 로고    scopus 로고
    • Mitochondrial ATP synthase. crystal structure of the catalytic F1 unit in a vanadate-induced transition- like state and implications for mechanism
    • Chen C, Saxena AK, Simcoke WN et al: Mitochondrial ATP synthase. crystal structure of the catalytic F1 unit in a vanadate-induced transition- like state and implications for mechanism. J Biol Chem, 2006; 281: 13777-83
    • (2006) J Biol Chem , vol.281 , pp. 13777-13783
    • Chen, C.1    Saxena, A.K.2    Simcoke, W.N.3
  • 32
    • 33745626133 scopus 로고    scopus 로고
    • Requirement of medium ADP for the steady-state hydrolysis of ATP by the proton-translocating Paracoccus denitrificans Fo.F1-ATP synthase
    • Zharova TV, Vinogradov AD: Requirement of medium ADP for the steady-state hydrolysis of ATP by the proton-translocating Paracoccus denitrificans Fo.F1-ATP synthase. Biochim Biophys Acta, 2006; 1757: 304-10
    • (2006) Biochim Biophys Acta , vol.1757 , pp. 304-310
    • Zharova, T.V.1    Vinogradov, A.D.2
  • 33
    • 0035408265 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis in mouse liver: Fasand cytochrome c-mediated caspase-3 activation pathway
    • Zhou Z, Sun X, Kang YJ: Ethanol-induced apoptosis in mouse liver: Fasand cytochrome c-mediated caspase-3 activation pathway. Am J Pathol, 2001; 159: 329-38
    • (2001) Am J Pathol , vol.159 , pp. 329-338
    • Zhou, Z.1    Sun, X.2    Kang, Y.J.3
  • 34
    • 0036521544 scopus 로고    scopus 로고
    • Metallothionein protection against alcoholic liver injury through inhibition of oxidative Stress
    • Zhou Z, Sun X, James Kang Y: Metallothionein protection against alcoholic liver injury through inhibition of oxidative Stress. Exp Biol Med, 2002; 227: 214-22
    • (2002) Exp Biol Med , vol.227 , pp. 214-222
    • Zhou, Z.1    Sun, X.2    James Kang, Y.3
  • 35
    • 0041422646 scopus 로고    scopus 로고
    • A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-a production
    • Zhou Z, Wang L, Song Z et al: A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-a production. Am J Pathol, 2003; 163: 1137-46
    • (2003) Am J Pathol , vol.163 , pp. 1137-1146
    • Zhou, Z.1    Wang, L.2    Song, Z.3
  • 36
    • 2942626026 scopus 로고    scopus 로고
    • Myocardial oxidative stress and toxicity induced by acute ethanol exposure in mice
    • Kannan M, Wang L, Kang YJ: Myocardial oxidative stress and toxicity induced by acute ethanol exposure in mice. Exp Biol Med, 2004; 229: 553-59
    • (2004) Exp Biol Med , vol.229 , pp. 553-559
    • Kannan, M.1    Wang, L.2    Kang, Y.J.3
  • 37
    • 64249100372 scopus 로고    scopus 로고
    • Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction
    • Doser TA, Turdi S, Thomas DP et al: Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. Circulation, 2009; 119: 1941-49
    • (2009) Circulation , vol.119 , pp. 1941-1949
    • Doser, T.A.1    Turdi, S.2    Thomas, D.P.3
  • 38
    • 31444433353 scopus 로고    scopus 로고
    • Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: Role of MAP kinase signaling
    • Li SY, Li Q, Shen JJ, Dong F et al: Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J Mol Cell Cardiol, 2006; 40: 283-94
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 283-294
    • Li, S.Y.1    Li, Q.2    Shen, J.J.3    Dong, F.4
  • 39
    • 3543029270 scopus 로고    scopus 로고
    • Ethanol and acetaldehyde in alcoholic cardiomyopathy: From bad to ugly en route to oxidative stress
    • Zhang X, Li SY, Brown RA, Ren J: Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. Alcohol, 2004; 437: 175-86
    • (2004) Alcohol , vol.437 , pp. 175-186
    • Zhang, X.1    Li, S.Y.2    Brown, R.A.3    Ren, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.