Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes

Journal of the Formosan Medical Association

Volumn 101, Issue 11, 2002, Pages 769-774

  Peng, Giia Sheun ^a   Yin, Jiu Haw ^a   Wang, Ming Fang ^a   Lee, Jiuun Tay ^a   Hsu, Yaw Don ^a   Yin, Shih Jiun ^a  

^a TAO YUAN GENERAL HOSPITAL   (Taiwan)

Author keywords

Alcohol dehydrogenase; Alcohol sensitivity; Alcoholism; Aldehyde dehydrogenase; Genotype

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; BETA 2 ALCOHOL DEHYDROGENASE; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOLISM; ALLELE; ARTICLE; BODY MASS; CAPILLARY FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; ENZYME BLOOD LEVEL; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEART RATE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MALE; NUTRITIONAL STATUS; PHARMACOGENETICS; SENSITIVITY ANALYSIS; TAIWAN;

ADULT; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; BLOOD FLOW VELOCITY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FACE; GENOTYPE; HEART RATE; HUMANS; MALE; TAIWAN;

EID: 0036868270     PISSN: 09296646     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Klatsky AL, Friedman GD, Siegelaub AB, et al: Alcohol consumption and blood pressure. Kaiser-Permanente multiphasic health examination data. N Engl J Med 1977; 296:1194-200.
2. Rimm EB, Giovannucci EL, Willett WC, et al: Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 1991;338:464-8.
3. Gill JS, Zezulka AV, Shipley MJ, et al: Stroke and alcohol consumption. N Engl J Med 1986;315:1041-6.
4. Crabb DW, Edenberg HJ, Thomasson HR, et al: Genetic factors that reduce risk for developing alcoholism in animals and humans. In: Begleiter H, Kissin B, eds. The Genetics of Alcoholism. Oxford: Oxford University Press, 1995:202-20.
5. Lieber CS: Medical disorder of alcoholism. N Engl J Med 1995;333:1058-65.
6. Yin SJ: Alcohol dehydrogenase: enzymology and metabolism. In: Saunders JB, Whitfield JB, eds. The Biology of Alcohol Problems. Oxford: Elsevier Science Ltd, 1996: 113-9.
7. Yoshida A, Hsu LC, Yasunami M: Genetics of human alcohol-metabolizing enzymes. Prog Nucleic Acid Res Mol Biol 1991;40:255-87.
8. Edenberg HJ, Bosron WF: Alcohol dehydrogenase. In: Guengerich FP, ed. Comprehensive Toxicology. New York: Elsevier Science Inc, 1997;3:119-31.
9. Peng GS, Wang MF, Chen CY, et al: Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 1999;9:463-76.
10. Chen CC, Lu RB, Chen YC, et al: Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 1999;65:795-807.
11. Yin SJ, Wang MF, Han CL, et al: Substrate binding pocket structure of human aldehyde dehydrogenases. A substrate specificity approach. In: Weiner H, Holmes RS, Wermuth B, eds. Enzymology and Molecular Biology of Carbonyl Metabolism. New York: Plenum Press, 1995;9-16.
12. Farrés J, Wang X, Takahashi K, et al: Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 1994;269:13854-60.
13. Chen WJ, Loh EW, Hsu YPP, et al: Alcohol-metabolizing genes and alcoholism among Taiwanese Han men. Br J Psychiatry 1996;168:762-7.
14. Thomasson HR, Edenberg HJ, Crabb DW, et al: Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 1991;48:677-81.
15. Shen YC, Fan JH, Howard JE, et al: Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res 1997;21:1272-7.
16. Higuchi S: Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. In: Saunders JB, Whitfield JB, eds. The Biology of Alcohol Problems. Oxford: Elsevier Science Ltd, 1996;29-34.
17. Higuchi S, Matsushita S, Imazeki H, et al: Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 1994;343:741-2.
18. Higuchi S, Matsushita S, Murayama M, et al: Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatry 1995;152:1219-21.
19. Higuchi S, Muramatsu T, Matsushita S, et al: Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2. Hum Genet 1996;97:431-4.
20. Iwahashi K, Matsuo Y, Suwaki H, et al: CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese. Alcohol Clin Exp Res 1995;19:564-6.
21. Maezawa Y, Yamauchi M, Toda G, et al: Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan. Alcohol Clin Exp Res 1995;19:951-4.
22. Nakamura K, Iwahashi K, Matsuo Y, et al: Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2. I. A comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. Alcohol Clin Exp Res 1996;20:52-5.
23. Tanaka F, Shiratori Y, Yokosuka O, et al: Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men. Alcohol Clin Exp Res 1997;21:596-601.
24. Ewing JA, Rouse BA, Pellizzari ED: Alcohol sensitivity and ethnic background. Am J Psychiatry 1974;131:206-10.
25. Wolff PH: Ethnic differences in alcohol sensitivity. Science 1972;175:449-50.
26. Agarwal DP, Harada S, Goedde HW: Racial differences in biological sensitivity to ethanol: the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes. Alcohol Clin Exp Res 1981;5:12-6.
27. Harada S, Agarwal DP, Goedde HW: Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet 1981;ii:982.
28. Kupari M, Eriksson CJP, Heikkilä J, et al: Alcohol and the heart. Intense hemodynamic changes associated with alcohol flush in Orientals. Acta Med Scand 1983;213:91-8.
29. Mizoi Y, Ijiri I, Tatsuno Y, et al: Relationship between facial flushing and blood acetaldehyde levels after alcohol intake. Pharmacol Biochem Behav 1979;10:303-11.
30. 2 (atypical) allele in Caucasian, Oriental and African black populations determined by the restriction profile of PCR-amplified DNA. Mol Cell Probes 1995;9:189-93.
31. Ung-Chhun NS, Collins MA: Estimation of blood acetaldehyde during ethanol metabolism: a sensitive HPLC/fluorescence microassay with negligible artifactual interference. Alcohol 1987;4:473-6.
32. Thomasson HR, Crabb DW, Edenberg HJ, et al: Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 1993;23:131-6.
33. Wall TL, Peterson CM, Peterson KP, et al: Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase. Ann Intern Med 1997; 127:376-9.
34. Xiao Q, Weiner H, Johnston T, et al: The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. J Clin Invest 1995;96: 2180-6.
35. Morikawa Y, Matsuzaka J, Kuratsune M, et al: Plethysmographic study of effects of alcohol. Nature 1968;220:186-7.