An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): Effects of the sequence variant on transcription factor binding and promoter strength

Alcoholism: Clinical and Experimental Research

Volumn 23, Issue 6, 1999, Pages 963-968

  Chou, Wan Yin ^a   Stewart, Mark J ^a   Carr, Lucinda G ^a   Zheng, Daisy ^a   Stewart, Trent R ^a   Williams, Adrienne ^a   Pinaire, Jane ^a   Crabb, David W ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Emerson Hall 312 ^*  (United States)

Author keywords

Alcoholism; Enzyme; Gene; Polymorphic Locus; Promoter; Sequencing

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; MITOCHONDRIAL ENZYME; UNCLASSIFIED DRUG;

ALCOHOLISM; ALLELE; ANIMAL CELL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE LOCUS; GENE MUTATION; GENETIC POLYMORPHISM; HEPATOMA CELL; MONKEY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW;

EID: 0032982139     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04213.x     Document Type: Review

References (19)

1. Castelein H, Janssen A, Declerq PE, Baes M (1996) Sequence requirements for high affinity retinoid X receptor alpha homodimer binding. Mol Cell Endocrinol 119:11-20.
2. Crabb DW, Dixon JE (1987) A method of increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells. Anal Biochem 163:88-92.
3. Crabb DW, Edenberg HJ, Bosron WF, Li T-K (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2*2 allele is dominant. J Clin Invest 83:314-316.
4. Crabb DW, Stewart MJ, Xiao Q (1995) Hormonal and chemical influences on expression of class 2 aldehyde dehydrogenases in rat H4IIEC3 and human HuH7 hepatoma cells. Alcohol Clin Exp Res 19:1414-1419.
5. Ge R, Rhee M, Malik S, Karathanasis SK (1994) Transcriptional repression of apolipoprotein AI gene expression by orphan receptor ARP-1. J Biol Chem 269:13185-13192.
6. Gorman CM, Merlino GT, Willinham MC, Pastan I, Howard BH (1982) The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Nat Acad Sci USA 79:6777-6781.
7. Harada S, Agarwal DP, Goedde HW (1981) Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet 2:982.
8. Harada S, Agarwal DP, Goedde HW, Ishikawa B (1983) Aldehyde dehydrogenase isozyme variation and alcoholism in Japan. Pharmacol Biochem Behav 18:151-153.
9. Harada S, Agarwal DP, Goedde HW, Tagaki S, Ishikawa B (1982) Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet 2:827.
10. Hempel J, Kaiser R, Jornvall H (1984) Human liver mitochondrial aldehyde dehydrogenase: A C-terminal segment positions and defines the structure corresponding to the one reported to differ in the Oriental enzyme variant. FEBS Lett 173:367-373.
11. Higuchi S, Matsushita S, Imazeki H, Kinoshita T, Takagki S, Kono H (1994) Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343:741-742.
12. Higuchi S, Muramatsu T, Shigemori K, Saito M, Kono H, Dufour MC, Harford TC (1992) The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. J Stud Alcohol 53:170-175.
13. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Kazuhiko U, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM (1995) The nuclear receptor superfamily: The second decade. Cell 83:835-839.
14. Novoradovsky A, Tsai SJ, Goldfarb L, Peterson R, Long JC, Goldman D (1995) Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: Detection of new ALDH2 alleles. Alcohol Clin Exp Res 19:1105-1110.
15. Stewart MJ, Dipple KM, Crabb DW (1996) The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene. Gene 173:155-161.
16. Stewart MJ, Dipple KM, Estonius M, Nakshatri H, Everett LM, Crabb DW (1998) Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4. Biochim Biophys Acta 1399:181-186.
17. Tsai SY, Tsai M-J (1997) Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): Coming of age. Endocr Rev 18:229-240.
18. Widom RL, Rhee M, Karathanasis SK (1992) Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXR alpha and retinoic acid. Mol Cell Biol 12:3380-3389.
19. Yang YZ, Subauste JS, Koenig RJ (1995) Retinoid X receptor alpha binds with the highest affinity to an imperfect direct repeat response element. Endocrinology 136:2896-2903.