Effects of acute acetaldehyde, chronic ethanol, and pargyline treatment on agonist responses of the rat aorta

Toxicology and Applied Pharmacology

Volumn 136, Issue 1, 1996, Pages 170-178

  Brown, Ricardo A ^a   Savage, Adedapo O ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; CARBACHOL; MONOAMINE OXIDASE INHIBITOR; N(G) NITROARGININE; NORADRENALIN; PARGYLINE; PHENTOLAMINE; PHENTOLAMINE MESYLATE; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INOTROPISM; MALE; NONHUMAN; RAT; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

EID: 0030030929     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0021     Document Type: Article

References (41)

1. Agarwal, D. P., Harada, S., and Goedde, H. W. (1981). Racial differences in biological sensitivity to ethanol. The role of alcohol dehydrogenase and aldehyde dehydrogenase isoenzymes. Alcoholism Clin. Exp. Res. 5, 12-16.
2. Altura, B. M., and Altura, B. T. (1982). Microvascular and smooth muscle actions of ethanol, acetaldehyde, and acetate. Fed. Proc. 41, 2447-2451.
3. Altura, B. M., Edgarian, H., and Altura, B. T. (1976). Differential effects of ethanol and mannitol on contraction of arterial smooth muscle. J. Pharmcol. Exp. Ther. 197, 352-361.
4. Altura, B. M., Carella, A., and Altura, B. T. (1978). Acetaldehyde on vascular smooth muscle: Possible role in the vasodilator action of ethanol. Eur. J. Pharmacol. 52, 73-83.
5. Altura, B. M., Altura, B. T., and Carella, A. (1983). Ethanol produces coronary vasospasm: Evidence for a direct action of ethanol on vascular muscle. Br. J. Pharmacol. 78, 260-262.
6. Altura, B. T., Pohorecky, L. A., and Altura, B. M. (1980). Demonstration of tolerance to ethanol in non-nervous tissue: Effects on vascular smooth muscle. Alcoholism Clin. Exp. Res. 4, 62-69.
7. Carpentier, R. G., and Gallardo-Carpentier, A. (1987). Acute and chronic effects of ethanol on sinoatrial electrophysiology in the rat heart. J. Cardiovasc. Pharmacol. 10, 616-621.
8. Chan, T. C. K., and M. C. Sutter (1983). Ethanol consumption and blood pressure. Life Sci. 33, 1965-1973.
9. Cohen, G., MacNamee, D., and Dambiec, D. (1975). Elevation in blood acetaldehyde by pargyline during ethanol administration. Biochem. Pharmacol. 24, 313-316.
10. DeMaster, E. G., and Nagasawa, H. T. (1978). Inhibition of aldehyde dehydrogenase by propiolaldehyde a possible metabolite of pargyline. Res. Commun. Chem. Pathol. Pharmacol. 21, 497-505.
11. DiPadova, C., Worner, T. M., and Lieber, C. S. (1987). Effect of abstinence on the blood acetaldehyde response to a test dose of alcohol in alcoholics. Alcoholism Clin. Exp. Res. 11, 559-561.
12. Edgarian, H., and Altura, B. M. (1976). Ethanol and contraction of venous smooth muscle. Anesthesiology 44, 311-317.
13. Furchgott, R. F. (1983). Role of endothelium in responses of vascular smooth muscle. Circ. Res. 53, 557-573.
14. Furchgott, R. F., and Zawadzki, J. V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle to acetylcholine. Nature 288, 373-376.
15. Harris, K. H., and MacLeod, K. M. (1988). Influence of the endothelium on contractile responses of arteries from diabetic rats. Eur. J. Pharmacol. 153, 55-64.
16. Hatake, K., Wakabayashi, I., Kakishita, E., Taniguchi, T., Ouchi, H., Sakaki, N., and Hishida, S. (1989). Inhibitory effect of ethanol on endothelium-dependent vascular responsiveness. Eur. J. Pharmacol. 168, 277-283.
17. Hatake, K., Wakabayashi, I., Taniguchi, T., and Hishida, S. (1994). Increased endothelium-dependent vascular relaxation in ethanol-fed rats. Alcoholism Clin. Exp. Res. 18, 1018-1023.
18. Hawkins, R. D., and Kalant, H. (1972). The metabolism of ethanol and its metabolic effects. Pharmacol. Rev. 24, 67-157.
19. Ireland, M., Vandongen, R., Davidson, L., Beilin, L., and I. Rouse (1983). Pressor effect of moderate alcohol consumption in man: A proposed mechanism. Clin. Exp. Pharmacol. Physiol. 10, 375-379.
20. Kesaniemi, Y. A., and Sippel, H. W. (1975). Placental and fetal metabolism of acetaldehyde in rat. I. Contents of ethanol and acetaldehyde in placenta and fetus of the pregnant rat during ethanol oxidation. Acta Pharmacol. Toxicol. 37, 43-48.
21. Klatsky, A. L., Friedman, G. D., Siegelaub, A. B., and M. J. Gerald (1977). Alcohol consumption and blood pressure. N. Engl. J. Med. 296, 1194-2000.
22. Kynch, E. T. (1992). Endothelium-dependent tolerance to ethanol-induced contraction of rat aorta: Effect of inhibition of EDRF action and nitric oxide synthesis. Alcoholism Clin. Exp. Res. 16, 58-63.
23. Lieber, C. S., and DeCarli, L. M. (1986). The feeding of ethanol in liquid diets, 1986 update. Alcoholism: Clin. Exp. Res. 10, 550-553.
24. Lindros, K. O., Stowell, A., Pikkarainen, P., and Salaspuro, M. (1980). Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination. Pharmacol. Biochem. Behav. 13(Suppl. 1), 119-24.
25. Majchrowicz, E., and Mendelson, J. H. (1970). Blood concentrations of acetaldehyde and ethanol in chronic alcoholics. Science 168, 1100-1102.
26. Maling, H. M., Fleisch, J. H., and Saul, W. F. (1971). Species differences in aortic responses to vasoactive amines: The effects of compound 48/ 80, cocaine, reserpine, and 6-hydroxytryptamine. J. Pharmacol. Exp. Ther. 176, 672-683.
27. Paul, P. N., Fudge, K., and Jacobwitz, D. (1972). Steric aspects of adrenergic drugs. XVIII. Alpha adrenergic receptors of mammalian aorta. Eur. J. Pharmacol. 19, 79-87.
28. Peterson, D. R., Atkinson, N., and Little, R. G. (1983). Effects of chlorpropamide and tolbutamide on in vivo acetaldehyde oxidation. Toxicologist 3, 83.
29. Randall, C. L., Taylor, W. J., Tabakoff, B., and Walker, D. W. (1977). Ethanol as a teratogen. In Alcohol and Aldehyde Metabolizing Systems (R. G. Thurman, J. R. Williamson, H. R. Drott, and B. Chance, Eds), pp. 659-670. Academic Press, New York.
30. Regan, T. J. (1982). Regional circulatory responses to alcohol and its congeners. Fed. Proc. 41, 2438-2442.
31. Shepherd, J. T., and Vanhoutte. P. M. (1975). Veins and Their Control. Saunders, Philadelphia.
32. Shirota, F. N., DeMaster, E. G., and Nagasawa, H. T. (1979). Propiolaldehyde, the metabolite of pargyline responsible for aldehyde dehydrogenase inhibition: Isolation from a hepatic microsomal system. J. Med. Chem. 22, 463-64.
33. Strickland, J. A., and Wooles, W. A. (1988). Effect of acute and chronic ethanol on the agonist responses of vascular smooth muscle. Eur. J. Pharmacol. 152, 83-91.
34. Tabakoff, B., Eriksson, C. J. P., and von Wartburg, J. P. (1989). Methionine lowers circulating levels of acetaldehyde after acetaldehyde ingestion. Alcoholism Clin. Exp. Res. 13, 164-171.
35. Takeda, R., and Momose, Y. (1978) Effects of acetaldehyde on electrical and mechanical activities of guinea-pig taenia coli. Arch. Int. Pharmacodyn. Thér. 232, 14-27.
36. Toda, N., Konishi, M., Miyazaki, M., and Komura, S. (1983). The effects of ethanol and acetaldehyde on dog arterial smooth muscle. J. Stud. Alcohol. 44, 1-16.
37. Watanabe, A., Kobayashi M., Hobara N., Nakatsukasa H., Nagashima H., and Fujimoto, A. (1985). A report of unusually high blood ethanol and acetaldehyde levels in two surviving patients. Alcoholism Clin. Exp. Res. 9, 14-16.
38. Weishaar, R., Bertuglia, S., Ashikawa, K., Sarma, J. S. M., and Bing, R. J. (1978). Comparative effects of chronic ethanol and acetaldehyde exposure on myocardial function in rats. J. Clin. Pharmacol. 18, 377-387.
39. Wen, Y. A., Lin, S. J., Wu, S. S., and Wu, H. L. (1994). Trace analysis of acetaldehyde as flurogenic derivative by high performance liquid chromatography. Kaohsiung J. Med Sci. 10, 295-300.
40. Williams, S. P., Adams, R. D., and Mustafa, S. J. (1990). The effects of chronic ethanol treatment on endothelium-dependent responses in rat thoracic aorta. Alcohol 7, 121-127.
41. Zhang, A., Cheng, T. P. O., and Altura B. M. (1992). Ethanol decreases cytosolic-free calcium ions in vascular smooth muscle cells as assessed by digital image analysis. Alcoholism Clin. Exp. Res. 16, 55-57.