Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 11, 2005, Pages 1959-1964

  Isse, Toyohi ^a   Matsuno, Koji ^b   Oyama, Tsunehiro ^a   Kitagawa, Kyoko ^c   Kawamoto, Toshihiro ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetaldehyde; Aldehyde Dehydrogenase 2; Area Under Curve; Ethanol; Gene Targeting Mouse

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; BRAIN LEVEL; CALCULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRINKING; ENZYME ACTIVITY; FEEDING; GAS CHROMATOGRAPHY; GENE TARGETING; LIVER LEVEL; MASS SPECTROMETRY; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; WILD TYPE;

ACETALDEHYDE; ADMINISTRATION, ORAL; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ANIMALS; AREA UNDER CURVE; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPECIES SPECIFICITY; WATER;

ANIMALIA; MUS MUSCULUS;

EID: 29044441551     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000187161.07820.21     Document Type: Article

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