Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases

Journal of Molecular and Cellular Cardiology

Volumn 49, Issue 2, 2010, Pages 322-329

  Ma, Heng ^a   Yu, Lu ^a,b   Byra, Emily A ^b   Hu, Nan ^b   Kitagawa, Kyoko ^c   Nakayama, Keiichi I ^d   Kawamoto, Toshihiro ^e   Ren, Jun ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING   (United States)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Akt; ALDH2; Cardiomyocyte; Contractile function; Ethanol; Protein phosphatase

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CYANAMIDE; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B;

ALCOHOLIC CARDIOMYOPATHY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ALDEHYDE DEHYDROGENASE; ANIMALS; BIOMECHANICS; ENVIRONMENTAL EXPOSURE; ETHANOL; GLYCOGEN SYNTHASE KINASE 3; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

MUS;

EID: 77953708564     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.03.017     Document Type: Article

References (51)

1. Laonigro I., Correale M., Di Biase M., Altomare E. Alcohol abuse and heart failure. Eur J Heart Fail 2009, 11(5):453-462.
2. Marmot M.G. Alcohol and coronary heart disease. Int J Epidemiol 2001, 30(4):724-729.
3. Spies C.D., Sander M., Stangl K., Fernandez-Sola J., Preedy V.R., Rubin E., et al. Effects of alcohol on the heart. Curr Opin Crit Care 2001, 7(5):337-343.
4. Richardson P.J., Patel V.B., Preedy V.R. Alcohol and the myocardium. Novartis Found Symp 1998, 216:35-45. [discussion -50].
5. Szabo G., Hoek J.B., Darley-Usmar V., Hajnoczky G., Knudsen T., Mochly-Rosen D., et al. RSA 2004: combined basic research satellite symposium-session three: alcohol and mitochondrial metabolism: at the crossroads of life and death. Alcohol Clin Exp Res 2005, 29(9):1749-1752.
6. Hannuksela M.L., Liisanantti M.K., Savolainen M.J. Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis. Crit Rev Clin Lab Sci 2002, 39(3):225-283.
7. Zhang X., Li S.Y., Brown R.A., Ren J. Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. Alcohol 2004, 32(3):175-186.
8. Brien J.F., Loomis C.W. Pharmacology of acetaldehyde. Can J Physiol Pharmacol 1983, 61(1):1-22.
9. Ren J., Brown R.A. Influence of chronic alcohol ingestion on acetaldehyde-induced depression of rat cardiac contractile function. Alcohol Alcohol 2000, 35(6):554-560.
10. Ren J., Wold L.E., Epstein P.N. Diabetes enhances acetaldehyde-induced depression of cardiac myocyte contraction. Biochem Biophys Res Commun 2000, 269(3):697-703.
11. 2+. Cell Mol Biol (Noisy-le-grand) 1999, 45(4):453-465.
12. Niemela O. Acetaldehyde adducts in circulation. Novartis Found Symp 2007, 285:183-192. [discussion 93-7].
13. Li S.Y., Ren J. Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. J Mol Cell Cardiol 2008, 44(6):992-1001.
14. Duan J., McFadden G.E., Borgerding A.J., Norby F.L., Ren B.H., Ye G., et al. Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes. Am J Physiol Heart Circ Physiol 2002, 282(4):H1216-H1222.
15. Doser T.A., Turdi S., Thomas D.P., Epstein P.N., Li S.Y., Ren J. Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. Circulation 2009, 119(14):1941-1949.
16. Li S.Y., Li Q., Shen J.J., Dong F., Sigmon V.K., Liu Y., et al. Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J Mol Cell Cardiol 2006, 40(2):283-294.
17. Nishimura F.T., Fukunaga T., Kajiura H., Umeno K., Takakura H., Ono T., et al. Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects. Auton Neurosci 2002, 102(1-2):60-70.
18. Wang R.S., Nakajima T., Kawamoto T., Honma T. Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. Drug Metab Dispos 2002, 30(1):69-73.
19. Yu H.S., Oyama T., Isse T., Kitakawa K., Ogawa M., Pham T.T., et al. Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. Toxicol Mech Methods 2009, 19(9):535-540.
20. Kitagawa K., Kawamoto T., Kunugita N., Tsukiyama T., Okamoto K., Yoshida A., et al. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 2000, 476(3):306-311.
21. Zhang X., Dong F., Li Q., Borgerding A.J., Klein A.L., Ren J. Cardiac overexpression of catalase antagonizes ADH-associated contractile depression and stress signaling after acute ethanol exposure in murine myocytes. J Appl Physiol 2005, 99(6):2246-2254.
22. Hintz K.K., Relling D.P., Saari J.T., Borgerding A.J., Duan J., Ren B.H., et al. Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion. Alcohol Clin Exp Res 2003, 27(7):1090-1098.
23. Ren J. Interaction between high-fat diet and alcohol dehydrogenase on ethanol-elicited cardiac depression in murine myocytes. Obesity (Silver Spring) 2007, 15(12):2932-2941.
24. Lucas D.L., Brown R.A., Wassef M., Giles T.D. Alcohol and the cardiovascular system research challenges and opportunities. J Am Coll Cardiol 2005, 45(12):1916-1924.
25. Di Lisa F., Blank P.S., Colonna R., Gambassi G., Silverman H.S., Stern M.D., et al. Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition. J Physiol 1995, 486(Pt 1):1-13.
26. Ren J., Brown R.A. Hypertension augments ethanol-induced depression of cell shortening and intracellular Ca(2+) transients in adult rat ventricular myocytes. Biochem Biophys Res Commun 1999, 261(1):202-208.
27. Tremblay M.L., Giguere V. Phosphatases at the heart of FoxO metabolic control. Cell Metab 2008, 7(2):101-103.
28. Ni Y.G., Wang N., Cao D.J., Sachan N., Morris D.J., Gerard R.D., et al. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A 2007, 104(51):20517-20522.
29. Zuluaga S., Alvarez-Barrientos A., Gutierrez-Uzquiza A., Benito M., Nebreda A.R., Porras A. Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. Cell Signal 2007, 19(1):62-74.
30. Hajnoczky G., Buzas C.J., Pacher P., Hoek J.B., Rubin E. Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization. Alcohol Clin Exp Res 2005, 29(5):693-701.
31. Boffetta P., Garfinkel L. Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study. Epidemiology 1990, 1(5):342-348.
32. O'Keefe J.H., Bybee K.A., Lavie C.J. Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol 2007, 50(11):1009-1014.
33. Cubero I., Navarro M., Carvajal F., Lerma-Cabrera J.M., Thiele T.E. Ethanol-induced increase of Agouti-related protein (AgRP) immunoreactivity in the arcuate nucleus of the hypothalamus of C57BL/6J, but not 129/SvJ, inbred mice. Alcohol Clin Exp Res 2010, 34(4):693-701.
34. Guo R., Ren J. Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway. PLoS One 2010, 5(1):e8757.
35. Walker J.E., Odden A.R., Jeyaseelan S., Zhang P., Bagby G.J., Nelson S., et al. Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication. Alcohol Clin Exp Res 2009, 33(2):357-365.
36. Trejbal K., Mitro P. ECG changes in alcoholic intoxication. Vnitr Lek 2008, 54(4):410-414.
37. Ma H., Li J., Gao F., Ren J. Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor. J Am Coll Cardiol 2009, 54(23):2187-2196.
38. Panos R.J., Sutton F.J., Young-Hyman P., Peters R. Sudden death associated with alcohol consumption. Pacing Clin Electrophysiol 1988, 11(4):423-424.
39. Ren J., Wold L.E. Mechanisms of alcoholic heart disease. Ther Adv Cardiovasc Dis 2008, 2(6):497-506.
40. Hoek J.B., Cahill A., Pastorino J.G. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 2002, 122(7):2049-2063.
41. Schoppet M., Maisch B. Alcohol and the heart. Herz 2001, 26(5):345-352.
42. Avkiran M., Rowland A.J., Cuello F., Haworth R.S. Protein kinase d in the cardiovascular system: emerging roles in health and disease. Circ Res 2008, 102(2):157-163.
43. Li Q., Ren J. Cardiac overexpression of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of rapamycin and ribosomal p70s6 kinase. Alcohol Alcohol 2006, 41(6):585-592.
44. Bijur G.N., Jope R.S. Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J Neurochem 2003, 87(6):1427-1435.
45. Lin C.F., Chen C.L., Chiang C.W., Jan M.S., Huang W.C., Lin Y.S. GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. J Cell Sci 2007, 120(Pt 16):2935-2943.
46. Hall J.L., Chatham J.C., Eldar-Finkelman H., Gibbons G.H. Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis. Role of GSK3beta. Diabetes 2001, 50(5):1171-1179.
47. Song J.Q., Teng X., Cai Y., Tang C.S., Qi Y.F. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis 2009, 14(11):1299-1307.
48. Juhaszova M., Zorov D.B., Kim S.H., Pepe S., Fu Q., Fishbein K.W., et al. Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 2004, 113(11):1535-1549.
49. Lee S., Chanoit G., McIntosh R., Zvara D.A., Xu Z. Molecular mechanism underlying Akt activation in zinc-induced cardioprotection. Am J Physiol Heart Circ Physiol 2009, 297(2):H569-H575.
50. Espinet C., Argiles J.M. Ethanol and acetaldehyde concentrations in the rat foeto-maternal system after an acute ethanol administration given to the mother. Arch Int Physiol Biochim 1984, 92(5):339-344.
51. Ren J. Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. Novartis Found Symp 2007, 285:69-76. [discussion -9, 198-9].