Distribution of ethanol-induced protein adducts in vivo: Relationship to tissue injury

Free Radical Biology and Medicine

Volumn 31, Issue 12, 2001, Pages 1533-1538

  Niemelä, Onni ^a,b  

^a EP Central Hospital Laboratory   (Finland)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

Acetaldehyde; Alcoholic liver disease; Free radical; Iron; Lipid peroxidation; Malondialdehyde

Indexed keywords

ACETALDEHYDE; ALCOHOL; AUTOANTIBODY; EPITOPE;

ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; BRAIN; CELL FUNCTION; DISEASE SEVERITY; ERYTHROCYTE; FIBROGENESIS; HEMATOPOIESIS; HUMAN; IMMUNE RESPONSE; IRON THERAPY; LIPID DIET; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; MUSCLE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; REVIEW; TISSUE INJURY;

ANIMALIA;

EID: 0035894063     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00744-4     Document Type: Article

References (51)

1. Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress
2. The functional implications of acetaldehyde binding to cell constituents
3. Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts
4. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein
5. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration
6. Ethanol-derived immunoreactive species formed by free radical mechanisms
7. Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol
8. Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as delta-2-3-ketosteroid 5-beta-reductase
9. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol
10. Cytochrome P450 2E1 (CYP2E1)-dependent production of a 37-kDa acetaldehyde-protein adduct in the rat liver
11. Immunohistochemical demonstration of acetaldehyde containing epitopes in human liver after ethanol ingestion
12. Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation
13. Centri-lobular distribution of acetaldehyde and collagen in the ethanol-fed micropig
14. Sequential acetaldehyde production, lipid peroxidation and fibrogenesis in micropig model of alcohol-induced liver disease
15. Early alcoholic liver injury: Formation of protein adducts with acetaldehyde and lipid peroxidation products, and expression of CYP2E1 and CYP3A
16. Cellular and subcellular localization of acetaldehyde-protein adducts in liver biopsies from alcoholic patients
17. Binding of anti-acetaldehyde IgG antibodies to hepatocytes with an acetaldehyde-phosphatidylethanolamine adduct on their surface
18. Acetaldehyde-modified epitopes in liver biopsy specimens of alcoholic and nonalcoholic patients: Localization and association with progression of liver fibrosis
19. Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease
20. In situ detection of lipid peroxidation by-products in chronic liver diseases
21. Formation of 4-hydroxynonenal adducts with cytochrome c oxidase in rats following short-term ethanol intake
22. Hepatic lipid peroxidation in hereditary hemochro-matosis
23. Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases
24. Experimental liver disease induced by alcohol and iron
25. Vitamin E decreases hepatic levels of aldehyde-derived peroxidation products in rats with iron overload
26. Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs
27. Occurrence of acetaldehyde protein adducts formed in various organs of chronically ethanol fed rats: An immunohistochemical study
28. Iron overload in the rat pancreas following portacaval shunting and dietary iron supplementation
29. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat
30. Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis
31. Bacteriocolonic pathway for ethanol oxidation
32. Covalent adducts of proteins with acetaldehyde in the liver as a result of acetaldehyde administration in drinking water
33. Immunohistochemical study on acetaldehyde adducts in alcohol-fed mice
34. Evidence of acetaldehyde-protein adduct formation in rat brain after lifelong consumption of ethanol
35. Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: Preferential localisation in the sarcolemmal and sub-sarcolemmal region
36. Hemoglobin-acetaldehyde adducts in human alcohol abusers
37. Hemoglobin-acetaldehyde adducts are elevated in women with alcohol-damaged fetuses
38. Acetaldehyde adducts in blood and bone marrow of patients with ethanol-induced erythrocyte abnormalities
39. Protein-acetaldehyde adducts in serum of alcoholic patients
40. Effect of ethanol on cytochrome P450 (CYP2E1), lipid peroxidation and serum protein adduct formation in relation to liver pathology
41. Serum low-density lipoprotein of alcoholic patients is chemically modified in vivo and induces apolipoprotein E synthesis by macrophages
42. Association of malondialde-hyde-acetaldehyde (MAA) adducted proteins with atherosclerot-ic-induced vascular inflammatory injury
43. Nucleoside adducts are formed by cooperative reaction of acetaldehyde and alcohols: A possible mechanism in carcinogenesis
44. Perivenular fibrosis in alcoholic liver injury: Ultrastructure and histologic progression
45. Antibodies against acetaldehyde-modified protein epitopes in human alcoholics
46. Antibodies against acetaldehyde-modified epitopes: An elevated IgA response in alcoholics
47. Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis
48. Detection of circulating antibodies to malon-dialdehyde-acetaldehyde adducts in ethanol-fed rats
49. Serum IgA, IgG, and IgM antibodies directed against acetaldehyde-derived epitopes: Relationship to liver disease severity and alcohol consumption
50. Autoimmune responses against oxidant stress and acetaldehyde-derived epitopes in human alcohol consumers
51. Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease