Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: Role of AMPK

Journal of Cellular and Molecular Medicine

Volumn 15, Issue 8, 2011, Pages 1737-1746

  Ge, Wei ^a,b   Li, Qun ^b   Turdi, Subat ^b   Wang, Xiao Ming ^a   Ren, Jun ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Alcoholism; AMPK; Cardiomyocytes; Contractile function; IGF 1

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE IV; CALCIUM; CASPASE 3; CENTRAL DEPRESSANT AGENT; DRUG DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN BCL 2; RIBONUCLEOSIDE; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL; ARTICLE; C57BL MOUSE; CELL CULTURE; CELL SHAPE; DRUG EFFECT; FEMALE; GENETICS; HEART; HEART MUSCLE; HEART MUSCLE CELL; LIVER; MALE; METABOLISM; MOUSE; MOUSE MUTANT; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALCOHOL DEHYDROGENASE; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CALCIUM; CASPASE 3; CELL SHAPE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FEMALE; HEART; INSULIN-LIKE GROWTH FACTOR I; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; ORGAN SIZE; PROTO-ONCOGENE PROTEINS C-BCL-2; RIBONUCLEOSIDES;

MUS;

EID: 79960323604     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2010.01158.x     Document Type: Article

References (28)

1. Ren J, Samson WK, Sowers JR. Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease. J Mol Cell Cardiol. 1999; 31: 2049-61.
2. Gola M, Bonadonna S, Doga M, et al. Cardiovascular risk in aging and obesity: is there a role for GH. J Endocrinol Invest. 2005; 28: 759-67.
3. Yakar S, Sun H, Zhao H, et al. Metabolic effects of IGF-I deficiency: lessons from mouse models. Pediatr Endocrinol Rev. 2005; 3: 11-9.
4. Climent V, Marin F, Pico A, et al. Growth hormone therapy, is it always good for the heart? Eur Heart J. 2004; 25: 183.
5. Li Q, Yang X, Sreejayan N, et al. Insulin-like growth factor I deficiency prolongs survival and antagonizes paraquat-induced cardiomyocyte dysfunction: role of oxidative stress. Rejuvenation Res. 2007; 10: 501-12.
6. Li Q, Ceylan-Isik AF, Li J, et al. Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction. Rejuvenation Res. 2008; 11: 725-33.
7. Corpas E, Harman SM, Blackman MR. Human growth-hormone and human aging. Endocrine Reviews. 1993; 14: 20-39.
8. Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003; 421: 182-7.
9. Pecherskaya A, Rubin E, Solem M. Alterations in insulin-like growth factor-I signaling in cardiomyocytes from chronic alcohol-exposed rats. Alcohol Clin Exp Res. 2002; 26: 995-1002.
10. Rojdmark S, Brismar K. Decreased IGF-I bioavailability after ethanol abuse in alcoholics: partial restitution after short-term abstinence. J Endocrinol Invest. 2001; 24: 476-82.
11. Hintz KK, Relling DP, Saari JT, et al. Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion. Alcohol Clin Exp Res. 2003; 27: 1090-8.
12. Li Q, Ren J. Cardiac overexpression of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of rapamycin and ribosomal p70s6 kinase. Alcohol Alcohol. 2006; 41: 585-92.
13. Lang CH, Lynch CJ, Vary TC. Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase. J Nutr. 2010; 140: 932-8.
14. Dees WL, Srivastava V, Hiney JK. Actions and interactions of alcohol and insulin-like growth factor-1 on female pubertal development. Alcohol Clin Exp Res. 2009; 33: 1847-56.
15. Yakar S, Liu JL, Stannard B, et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA. 1999; 96: 7324-9.
16. Keane B, Leonard BE. Rodent models of alcoholism: a review. Alcohol Alcohol. 1989; 24: 299-309.
17. Nyblom HK, Sargsyan E, Bergsten P. AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels. J Mol Endocrinol. 2008; 41: 187-94.
18. Yang X, Doser TA, Fang CX, et al. Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress. FASEB J. 2006; 20: 1024-6.
19. Doser TA, Turdi S, Thomas DP, et al. Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. Circulation. 2009; 119: 1941-9.
20. Fang CX, Dong F, Thomas DP, et al. Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription. Am J Physiol Heart Circ Physiol. 2008; 295: H1206-15.
21. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72: 248-54.
22. Wold LE, Relling DP, Duan J, et al. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Hypertension. 2002; 39: 69-74.
23. Steinberg GR, Kemp BE. AMPK in Health and Disease. Physiol Rev. 2009; 89:1025-78.
24. Liangpunsakul S, Wou SE, Zeng Y, et al. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation. Am J Physiol Gastrointest Liver Physiol. 2008; 295: G1173-81.
25. Hiney JK, Srivastava VK, Les DW. Insulin-like growth factor-1 stimulation of hypothalamic KiSS-1 gene expression is mediated by Akt: effect of alcohol. Neuroscience. 2010; 166: 625-32.
26. Ila R, Solem M. Chronic-alcohol exposure alters IGF1 signaling in H9c2 cellsviachanges in PKC delta. Alcohol. 2006; 39: 169-78.
27. Chen CH, Budas GR, Churchill EN, et al. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008; 321: 1493-5.
28. Rojdmark S, Rydvald Y, Aquilonius A, et al. Insulin-like growth factor (IGF)-1 and IGF-binding protein-1 concentrations in serum of normal subjects after alcohol ingestion: evidence for decreased IGF-1 bioavailability. Clin Endocrinol. 2000; 52: 313-8.