Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism

British Journal of Pharmacology

Volumn 139, Issue 7, 2003, Pages 1310-1316

  Folden, David V ^a   Gupta, Akanksha ^b   Sharma, Avadhesh C ^b   Li, Shi Yan ^a   Saari, Jack T ^c   Ren, Jun ^a,d  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

^c GRAND FORKS HUMAN NUTRITION RESEARCH CENTER   (United States)

^d UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Antioxidant; Intracellular Ca 2+; Malondialdehyde; MAP kinase; Myocyte shortening

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIOXIDANT; ASCORBIC ACID; CALCIUM ION; HYDROXYL RADICAL; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLUORESCENCE; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; LIPID PEROXIDATION; MALE; MUSCLE LENGTH; NONHUMAN; OXIDATIVE STRESS; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ASCORBIC ACID; CALCIUM; CALCIUM SIGNALING; CELL SIZE; CELLS, CULTURED; ELECTRIC STIMULATION; FLUORESCENCE; FLUORESCENT DYES; HEART VENTRICLES; IMIDAZOLES; MALE; MALONDIALDEHYDE; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION;

EID: 0042888686     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705384     Document Type: Article

References (35)

1. ADAMS, J.W., SAKATA, Y., DAVIS, M.G., SAH, V.P., WANG, Y., LIGGETT, S.B., CHIEN, K.R., BROWN, J.H. & DORN, II, G.W. (1998). Enhanced Gαq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc. Natl. Acad. Sci. U.S.A., 95, 10140-10145.
2. BERLETT, B.S. & STADTMAN, E.R. (1997). Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem., 272, 20313-20316.
3. BRAUGHLER, J.M., DUNCAN, L.A. & CHASE, R.L. (1986). The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation. J. Biol. Chem., 261, 10282-10289.
4. BUFFON, A., SANTINI, S.A., RAMAZZOTTI, V., RIGATTIERI, S., LIUZZO, G., BIASUCCI, L.M., CREA, F., GIARDINA, B. & MASERI, A. (2000). Large, sustained cardiac lipid peroxidation and reduced antioxidant capacity in the coronary circulation after brief episodes of myocardial ischemia. J. Am. Coll. Cardiol., 35, 633-639.
5. BURTON, G.W., FOSTER, D.O., PERLY, B., SLATER, T.F., SMITH, I.C.P. & INGOLD, K.U. (1985). Biological antioxidants. Philos Trans. R. Soc. London B, 311, 565-578.
6. CAIN, B.S., MELDRUM, D.R., MENG, X., DINARELLO, C.A., SHAMES, B.D., BANERJEE, A. & HARKEN, A.H. (1999). p38-MAPK inhibition decreases TNF-α production and enhances postischemic human myocardial function. J. Surg. Res., 83, 7-12.
7. CIGHETTI, G., DEBIASI, S., PARONI, R. & ALLEVI, P. (1999). Free and total malondialdehyde assessment in biological matrices by gas chromatography-mass spectrometry: what is needed for an accurate detection. Anal. Biochem., 266, 222-229.
8. DHALLA, A.K., HILL, M.F. & SINGAL, P.K. (1996). Role of oxidative stress in transition of hypertrophy in heart failure. J. Am. Coll. Cardiol., 28, 506-514.
9. DIAZ-VELEZ, C.R., GARCIA-CASTINEIRAS, S., MENDOZA-RAMOS, E. & HERNANDEZ-LOPEZ, E. (1996). Increased malondialdehyde in peripheral blood of patients with congestive heart failure. Am. Heart J., 131, 146-152.
10. DIETRICH, M., BLOCK, G., HUDES, M., MORROW, J.D., NORKUS, E.P., TRABER, M.G., CROSS, C.E. & PACKER, L. (2002). Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers. Cancer Epidemiol. Biomarkers Prev., 11, 7-13.
11. DUROT, I., MAUPOIL, V., PONSARD, B., CORDELET, C., VERGELY-VANDRIESSE, C., ROCHETTE, L. & ATHIAS, P. (2000). Oxidative injury of isolated cardiomyocytes: dependence on free radical species. Free Radic. Biol. Med., 29, 846-857.
12. FERDINANDY, P., DANIAL, H., AMBRUS, I., ROTHERY, R.A. & SCHULZ, R. (2000). Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ. Res., 87, 241-247.
13. GE, B., GRAM, H., DI PADOVA, F., HUANG, B., NEW, L., ULEVITCH, R.J., LUO, Y. & HAN, J. (2002). MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38α. Science., 295, 1291-1294.
14. GOLDHABER, J.I. & QAYYUM, M.S. (2000). Oxygen free radicals and excitation-contraction coupling. Antioxid. Redox. Signal., 2, 55-64.
15. GUTTERIDGE, J.M.C. & HALLIWELL, B. (1990). The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem. Sci., 15, 129-135.
16. HENDRICKSON, S.C., ST. LOUIS, J.D., LOWE, J.E. & ABDEL-ALEEM, S. (1997). Free fatty acid metabolism during myocardial ischemia and reperfusion. Mol. Cell. Biochem., 166, 85-94.
17. HOLVOET, P., PEREZ, G., ZHAO, Z., BROUWERS, E., BERNAR, H. & COLLEN, D. (1995). Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease. J. Clin. Invest., 95, 2611-2619.
18. KANEKO, M., MATSUMOTO, Y., HAYASHI, H., KOBAYASHI, A. & YAMAZAKI, N. (1994). Oxygen free radicals and calcium homeostasis in the heart. Mol. Cell. Biochem., 139, 91-100.
19. KATZ, S.D., RAO, R., BERMAN, J.W., SCHWARZ, M., DEMOPOULOS, L., BIJOU, R. & LEJEMTEL, T.H. (1994). Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation. Circulation, 90, 12-16.
20. KLEIN, H.H., PICH, S., LINDERT, S., NELENDAHL, K., NIEDMAGNN, P. & KNEUZER, H. (1989). Combination treatment with vitamin E and C in experimental myocardial infarction in pigs. Am. Heart J., 118, 667-673.
21. KOOY, N.W., LEWIS, S.J., ROYALL, J.A., YE, Y.Z., KELLY, D.R. & BECKMAN, J.S. (1997). Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite. Crit. Care. Med., 25, 812-819.
22. KULISZ, A., CHEN, N., CHANDEL, N.S., SHAO, Z. & SCHUMACKER, P.T. (2002). Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. Am. J. Physiol. Lung. Cell. Mol. Physiol., 282, L1324-L1329.
23. LEONARDUZZI, G., ARKAN, M.C., BASAGA, H., CHIARPOTTO, E., SEVANIAN, A. & POLI, G. (2000). Lipid oxidation products in cell signaling. Free Radic. Biol. Med., 28, 1370-1378.
24. LEUNG, H-W., VANG, M.J. & MAVIS, R.D. (1981). The cooperative interaction between vitamin E and vitamin C in suppression of peroxidation of membrane phospholipids. Biochem. Biophys. Acta, 664, 266-272.
25. LIAO, P., WANG, S.Q., WANG, S., ZHENG, M., ZHANG, S.J., CHENG, H., WANG, Y. & XIAO, R.P. (2002). p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. Circ. Res., 90, 190-196.
26. MA, X.L., KUMAR, S., GAO, F., LOUDEN, C.S., LOPEZ, B.L., CHRISTOPHER, T.A., WANG, C., LEE, J.C., FEUERSTEIN, G.Z. & YUE, T.L. (1999). Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation, 99, 1685-1691.
27. MARTIN-BLANCO, E. (2000). MAPK signalling cascades: ancient roles and new functions. Bioessays, 22, 637-645.
28. OBATA, T., BROWN, G.E. & YAFFE, M.B. (2000). MAP kinase pathways activated by stress: the p38 MAPK pathway. Crit. Care Med., 28, N67-N77.
29. POLLOCK, J.S., NAKANE, M., BUTTERY, L.D., MARTINEZ, A., SPRINGALL, D., POLAK, J.M., FORSTERMANN, U. & MURAD, F. (1993). Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J. Physiol., 265, C1379-C1387.
30. PORTER, N.A., CALDWELL, S.E. & MILLS, K.A. (1995). Mechanisms of free radical oxidation of unsaturated lipids. Lipids, 30, 277-290.
31. SATOH, H. & MATSUI, K. (1997). Electrical and mechanical modulations by oxygen-derived free-radical generating systems in guinea-pig heart muscles. J. Pharm. Pharmacol., 49, 505-510.
32. TORRE-AMINONE, G., KAPADIA, S., BENEDICT, C., ORAL, H., YOUNG, J.B. & MANN, D.L. (1996). Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J. Am. Coll. Cardiol., 27, 1201-1206.
33. WANG, Y., HUANG, S., SAH, V.P., ROSS, JR, J., BROWN, J.H., HAN, J. & CHIEN, K.R. (1998). Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J. Biol. Chem., 273, 2161-2168.
34. WOLD, L.E., RELLING, D.P., DUAN, J., NORBY, F.L. & REN, J. (2002). Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Hypertension, 39, 69-74.
35. YEO, H.C., HELBOCK, H.J., CHYU, D.W. & AMES, B.N. (1994). Assay of malondialdehyde in biological fluids by gas chromatography-mass spectrometry. Anal. Biochem., 220, 391-396.