Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: Roles of Akt, mTOR, GSK3β, and PTEN

Free Radical Biology and Medicine

Volumn 49, Issue 7, 2010, Pages 1238-1253

  Zhang, Bingfang ^a   Turdi, Subat ^b   Li, Quan ^c   Lopez, Faye L ^d   Eason, Anna R ^b   Anversa, Piero ^e   Ren, Jun ^b,d  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Akt; Alcohol; Cardiac hypertrophy; Contractile function; Foxo3a; Free radicals; GSK3 ; Intracellular Ca2+; MTOR

Indexed keywords

ALCOHOL; CALCIUM ION; COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SOMATOMEDIN C; TRANSCRIPTION FACTOR FKHRL1; UNCOUPLING PROTEIN 2;

ALCOHOL BLOOD LEVEL; ALCOHOLIC CARDIOMYOPATHY; ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BODY WEIGHT; CALCIUM CELL LEVEL; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; GENE EXPRESSION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART WEIGHT; HISTOLOGY; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CARDIOMYOPATHY, ALCOHOLIC; ETHANOL; GLYCOGEN SYNTHASE KINASE 3; HEART; HYPERTROPHY; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIUM; ORGAN SPECIFICITY; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SUPEROXIDE DISMUTASE; TOR SERINE-THREONINE KINASES; TRANSGENES;

MUS;

EID: 77956174889     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.07.020     Document Type: Article

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