Polymorphism of ethanol-metabolism genes and alcoholism: Correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences

Chemico-Biological Interactions

Volumn 178, Issue 1-3, 2009, Pages 2-7

  Chen, Yi Chyan ^a   Peng, Giia Sheun ^a   Wang, Ming Fang ^b   Tsao, Tien Ping ^a   Yin, Shih Jiun ^b  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Alcohol dehydrogenase; Alcoholism; Aldehyde dehydrogenase; Pharmacodynamics; Pharmacokinetics; Single nucleotide polymorphism

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE;

ALCOHOLISM; CIRCULATION; DNA POLYMORPHISM; ENZYME METABOLISM; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; GENOTYPE; HEMODYNAMICS; HETEROZYGOSITY; HOMOZYGOSITY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PHARMACODYNAMICS; PHARMACOKINETICS; PHYSIOLOGY; PROTEIN INTERACTION; PSYCHOLOGY; REVIEW;

ALCOHOL DEHYDROGENASE; ALCOHOLISM; ALDEHYDE DEHYDROGENASE; ALLELES; ETHANOL; HUMANS; POLYMORPHISM, GENETIC;

EID: 59049104586     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.10.029     Document Type: Review

References (34)

1. Li T.K. Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. J. Stud. Alcohol 61 (2000) 5-12
2. Li T.K., Yin S.J., Crabb D.W., O'Connor S., and Ramchandani V.A. Genetic and environmental influences on alcohol metabolism in humans. Alcohol. Clin. Exp. Res. 25 (2001) 136-144
3. Deitrich R.A. Acetaldehyde: déjà vu du jour. J. Stud. Alcohol 65 (2004) 557-572
4. Quertemont E. Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. Mol. Psychiatry 9 (2004) 570-581
5. Yin S.J., and Agarwal D.P. Functional polymorphism of alcohol and aldehyde dehydrogenases: alcohol metabolism, alcoholism, and alcohol-induced organ damage. In: Agarwal D.P., and Seitz H.K. (Eds). Alcohol in Health and Disease (2001), Marcel Dekker, New York, NY 1-26
6. Crabb D.W., Matsumoto M., Chang D., and You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc. Nutr. Soc. 63 (2004) 49-63
7. Yin S.J., Lee S.L., Han C.L., Chou C.F., and Wang M.F. Pharmacogenetic determinants of alcohol metabolism and alcoholism in the human alcohol dehydrogenase family. In: Weiner H., Lindahl R., Plapp B.V., and Maser E. (Eds). Enzymology and Molecular Biology of Carbonyl Metabolism vol. 12 (2006), Purdue University, West Lafayette, IN 161-170
8. Duester G., Farrés J., Felder M.R., Holmes R.S., Höög J.O., Parés X., Plapp B.V., Yin S.J., and Jörnvall H. Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem. Pharmacol. 58 (1999) 389-395
9. Niederhut M.S., Gibbons B.J., Perez-Miller S., and Hurley T.D. Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Sci. 10 (2001) 697-706
10. 2 alcohol dehydrogenases affect hydride transfer and coenzyme dissociation rate constants. J. Biol. Chem. 268 (1993) 892-899
11. 2. J. Biol. Chem. 275 (2000) 11569-11575
12. Li H., Mukherjee N., Soundararajan U., Tarnok Z., Barta C., Khaliq S., Mohyuddin A., Kajuna S.L., Mehdi S.Q., Kidd J.R., and Kidd K.K. Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. Am. J. Hum. Genet. 81 (2007) 842-846
13. Yin S.J., Lee S.L., Yao C.T., and Lai C.L. Functional roles of alcohol dehydrogenases in human ethanol metabolism. In: Weiner H., Maser E., Lindahl R., and Plapp B.V. (Eds). Enzymology and Molecular Biology of Carbonyl Metabolism vol. 13 (2007), Purdue University, West Lafayette, IN 134-143
14. Höög J.O., Stromberg P., Hedberg J.J., and Griffiths W.J. The mammalian alcohol dehydrogenases interact in several metabolic pathways. Chem. Biol. Interact. 143-144 (2003) 175-181
15. Chen C.C., Lu R.B., Chen Y.C., Wang M.F., Chang Y.C., Li T.K., and Yin S.J. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am. J. Hum. Genet. 65 (1999) 795-807
16. Edenberg H.J., Xuei X., Chen H.J., Tian H., Wetherill L.F., Dick D.M., Almasy L., Bierut L., Bucholz K.K., Goate A., Hesselbrock V., Kuperman S., Nurnberger J., Porjesz B., Rice J., Schuckit M., Tischfield J., Begleiter H., and Foroud T. Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum. Mol. Genet. 15 (2006) 1539-1549
17. Luo X., Kranzler H.R., Zuo L., Wang S., Schork N.J., and Gelernter J. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Am. J. Hum. Genet. 78 (2006) 973-987
18. Kim D.J., Choi I.G., Park B.L., Lee B.C., Ham B.J., Yoon S., Bae J.S., Cheong H.S., and Shin H.D. Major genetic components underlying alcoholism in Korean population. Hum. Mol. Genet. 17 (2008) 854-858
19. Kuo P.H., Kalsi G., Prescott C.A., Hodgkinson C.A., Goldman D., van den Oord E.J., Alexander J., Jiang C., Sullivan P.F., Patterson D.G., Walsh D., Kendler K.S., and Riley B.F. Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcohol. Clin. Exp. Res. 32 (2008) 785-795
20. Lee S.L., Höög J.O., and Yin S.J. Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. Pharmacogenetics 14 (2004) 725-732
21. Sophos N.A., Black W.J., and Vasiliou V. An update of the ALDH gene superfamily. In: Weiner H., Lindahl R., Plapp B.V., and Maser E. (Eds). Enzymology and Molecular Biology of Carbonyl Metabolism vol. 12 (2006), Purdue University, West Lafayette, IN 3-7
22. Yin S.J., and Peng G.S. Overview of ALDH polymorphism: relation to cardiovascular effects of alcohol. In: Preedy V.R., and Watson R.R. (Eds). Comprehensive Handbook of Alcohol Related Pathology vol. 1 (2005), Elsevier Academic, London 409-424
23. Ni L., Zhou J., Hurley T.D., and Weiner H. Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. Protein Sci. 8 (1999) 2784-2790
24. Zhou J., and Weiner H. Basis for half-of-the-site reactivity and the dominance of the K487 oriental subunit over the E487 subunit in heterotetrameric human liver mitochondrial aldehyde dehydrogenase. Biochemistry 39 (2000) 12019-12024
25. Larson H.N., Zhou J., Chen Z., Stamler J.S., Weiner H., and Hurley T.D. Structural and functional consequences of coenzyme binding to the inactive Asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. J. Biol. Chem. (2007) 12940-12950
26. Higuchi S., Matsushita S., Imazeki H., Kinoshita T., Takagi S., and Kono H. Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343 (1994) 741-742
27. Chen Y.C., Lu R.B., Peng G.S., Wang M.F., Wang H.K., Ko H.C., Chang Y.C., Lu J.J., Li T.K., and Yin S.J. Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol. Clin. Exp. Res. 23 (1999) 1853-1860
28. Peng G.S., Wang M.F., Chen C.Y., Luu S.U., Chou H.C., Li T.K., and Yin S.J. Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 9 (1999) 463-476
29. Peng G.S., Chen Y.C., Tsao T.P., Wang M.F., and Yin S.J. Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet. Genom. 17 (2007) 845-855
30. Lee S.L., Chau G.Y., Yao C.T., Wu C.W., and Yin S.J. Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol. Clin. Exp. Res. 30 (2006) 1132-1142
31. Neumark Y.D., Friedlander Y., Durst R., Leitersdorf E., Jaffe D., Ramchandani V.A., O'Connor S., Carr L.G., and Li T.K. Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population. Alcohol. Clin. Exp. Res. 28 (2004) 10-14
32. Peng G.S., Yin J.H., Wang M.F., Lee J.T., Hsu Y.D., and Yin S.J. Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes. J. Formos. Med. Assoc. 101 (2002) 769-774
33. Mizoi Y., Yamamoto K., Ueno Y., Fukunaga T., and Harada S. Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol. 29 (1994) 707-710
34. Hahn C.Y., Huang S.Y., Ko H.C., Hsieh C.H., Lee I.H., Yeh T.L., Yang Y.K., Lee J.F., Lin W.W., and Lu R.B. Acetaldehyde involvement in positive and negative alcohol expectancies in Han Chinese persons with alcoholism. Arch. Gen. Psychiatry 63 (2006) 817-823