A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 2, 1999, Pages 766-772

  Liang, Qiangrong ^a   Carlson, Edward C ^a   Borgerding, Anthony J ^a   Epstein, Paul N ^a  

^a UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALPHA ACTIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ALCOHOL CONSUMPTION; ALCOHOLIC CARDIOMYOPATHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; HEART MUSCLE CONTRACTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SYNTHESIS; TRANSGENIC MOUSE;

ACETALDEHYDE; ACTINS; ANIMALS; ATRIAL NATRIURETIC FACTOR; CARDIOMEGALY; CARDIOMYOPATHY, ALCOHOLIC; DISEASE MODELS, ANIMAL; ETHANOL; L-LACTATE DEHYDROGENASE; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MYOCARDIAL CONTRACTION; NAD; RNA, MESSENGER; TIME FACTORS;

EID: 0032721817     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Agarwal DP and Goedde HW (1990) Pharmacogenetics of alcohol dehydrogenase (ADH). Pharmacol Ther 45:69-83.
2. Alexander CS, Forsyth GW, Nagasawa HT and Kohlhoff JG (1977a) Alcoholic cardiomyopathy in mice: Myocardial glycogen, lipids and certain enzymes. J Mol Cell Cardiol 9:235-245.
3. Alexander CS, Sekhri KK and Nagasawa HT (1977b) Alcoholic cardiomyopathy in mice: Electron microscopic observations. J Mol Cell Cardiol 9:247-254.
4. Brown RA, Crawford M, Natavio M, Petrovski P and Ren J (1998) Dietary magnesium supplementation attenuates ethanol-induced myocardial dysfunction. Alcohol Clin Exp Res 22:2062-2072.
5. Bulloch RT, Pearce MB, Murphy ML, Jenkins BJ and Davis JL (1972) Myocardial lesions in idiopathic and alcoholic cardiomyopathy: Study by ventricular septal biopsy. Am J Cardiol 29:15-25.
6. Capasso JM, Li P, Guideri G and Anversa P (1991) Left ventricular dysfunction induced by chronic alcohol ingestion in rats. Am J Physiol 261:H212-H219.
7. Capasso JM, Li P, Guideri G, Malhotra A, Cortese R and Anversa P (1992) Myocardial mechanical, biochemical, and structural alterations induced by chronic ethanol ingestion in rats. Circ Res 71:346-356.
8. Colbert MC, Hall DG, Kimball TR, Witt SA, Lorenz JN, Kirby ML, Hewett TE, Klevitsky R and Robbins J (1997) Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. J Clin Invest 100:1958-1968.
9. Crabb DW and Edenberg HJ (1987) Cloning and sequencing of a cDNA encoding rat liver alcohol dehydrogenase. Alcohol Alcohol Suppl 1:167-168.
10. Eriksson CJ, Atkinson N, Petersen DR and Deitrich RA (1984) Blood and liver acetaldehyde concentrations during ethanol oxidation in C57 and DBA mice. Biochem Pharmacol 33:2213-2216.
11. Espinet C and Argiles JM (1984) Ethanol and acetaldehyde levels in rat blood and tissues after an acute ethanol administration. IRCS Med Sci 12:830-831.
12. Ferrans VJ (1989) Pathologic anatomy of the dilated cardiomyopathies. Am J Cardiol 64:9C-11C.
13. Harcombe AA, Ramsay L, Kenna JG, Koskinas J, Why HJ, Richardson PJ, Weissberg PL and Alexander GJ (1995) Circulating antibodies to cardiac protein-acetaldehyde adducts in alcoholic heart muscle disease. Clin Sci (Colch) 88:263-268.
14. Hillbom ME, Sarviharju MS and Lindros KO (1983) Potentiation of ethanol toxicity by cyanamide in relation to acetaldehyde accumulation. Toxicol Appl Pharmacol 70:133-139.
15. Hoerner M, Behrens UJ, Worner TM, Blacksberg I, Braly LF, Schaffner F and Lieber CS (1988) The role of alcoholism and liver disease in the appearance of serum antibodies against acetaldehyde adducts. Hepatology 8:569-574.
16. Jones WK, Grupp IL, Doetschman T, Grupp G, Osinska H, Hewett TE, Boivin G, Gulick J, Ng WA and Robbins J (1996) Ablation of the marine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest 98:1906-1917.
17. Kang YJ, Chen Y and Epstein PN (1996) Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice. J Biol Chem 271: 12610-12616.
18. Kang YJ, Chen Y, Yu A, Voss-McCowan M and Epstein PN (1997) Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J Clin Invest 100:1501-1506.
19. Karnovsky MJ (1965) A formaldehyde-glutaraldehyde fixative for high osmolality for use in electron microscopy. J Cell Biol 35:137A-138A.
20. Klein H and Harmjanz D (1975) Effect of ethanol infusion on the ultrastructure of human myocardium. Postgrad Med J 51:325-329.
21. Klingenberg M (1985) Nicotinamide-adenine dinucleotides and dinucleotide phosphates. Methods Enzym Anal 7:251-271.
22. McNutt NS and Fawcett DW (1974) Myocardial ultrastructure, in Mammalian Myocardium. John Wiley & Sons, New York.
23. Mikami K, Sato S, Nakazawa N, Asano G and Watanabe T (1993) Ethanol-elicited structural and biochemical alterations in mitochondrial ATPase in cultured myocardial cells. Virch Arch B Cell Pathol Incl Mol Pathol 63:365-371.
24. Overbeek PA, Aguilar-Cordova E, Hanten G, Schaffner DL, Patel P, Lebovitz RM and Lieberman MW (1991) Coinjection strategy for visual identification of transgenic mice. Transgenic Res 1:31-37.
25. Patel VB, Why HJ, Richardson PJ and Preedy VR (1997) The effects of alcohol on the heart. Adverse Drug React Toxicol Rev 16:15-43.
26. Preedy VR and Richardson PJ (1994) Ethanol induced cardiovascular disease. Br Med Bull 50:152-163.
27. Redetzki JE, Griswold KE, Nopajaroonsri C and Redetzki HM (1983) Amelioration of cardiotoxic effects of alcohol by vitamin E. J Toxicol Clin Toxicol 20:319-331.
28. 2+ transients in adult rat ventricular myocytes. Cell Mol Biol 43:825-834.
29. Savage AO, Dunbar JC and Brown RA (1995) Effects of acetaldehyde on the isolated papillary muscle of diabetic rate. J Cardiovasc Pharmacol 26:251-258.
30. Thomas AP, Rozanaki DJ, Renard DC and Rubin E (1994) Effects of ethanol on the contractile function of the heart: A review. Alcohol Clin Exp Res 18:121-131.
31. Urbano-Marquez A, Estruch R, Fernandez-Sola J, Nicolas JM, Pare JC and Rubin E (1995) The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. J Am Med Assoc 274:149-154.
32. Urbano-Marquez A, Estruch R, Navarro-Lopez F, Grau JM, Mont L and Rubin E (1989) The effects of alcoholism on skeletal and cardiac muscle [see comments]. N Engl J Med 320-.409-415.
33. Voss-McCowan ME, Xu B and Epstein PN (1994) Insulin synthesis, secretory competence, and glucose utilization are sensitized by transgenic yeast hexokinase. J Biol Chem 269:15814-15818.
34. Weishaar R, Bertuglia S, Ashikawa K, Sarma JS and Bing RJ (1978) Comparative effects of chronic ethanol and acetaldehyde exposure on myocardial function in rats. J Clin Pharmacol 18:377-387.
35. Zou LY, Wu F, Altura BT, Barbour RL and Altura BM (1991) Beneficial effects of high magnesium on alcohol-induced cardiac failure. Magnes Trace Elem 10:409-419.