메뉴 건너뛰기




Volumn 16, Issue 7, 2011, Pages 2794-2811

JAK-STAT signaling in hepatic fibrosis

Author keywords

Cholestasis; Cirrhosis; Gp130; Growth hormone; IGF 1; IL 6; Liver fibrosis; STAT3; STAT5

Indexed keywords

JANUS KINASE; STAT PROTEIN;

EID: 79959549307     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3886     Document Type: Article
Times cited : (53)

References (175)
  • 2
    • 49149090637 scopus 로고    scopus 로고
    • Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
    • I.M. Bochkis, N.E. Rubins, P. White, E.E. Furth, J.R. Friedman and K.H. Kaestner: Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat Med 14, 828-836 (2008)
    • (2008) Nat Med , vol.14 , pp. 828-836
    • Bochkis, I.M.1    Rubins, N.E.2    White, P.3    Furth, E.E.4    Friedman, J.R.5    Kaestner, K.H.6
  • 3
    • 7044264264 scopus 로고    scopus 로고
    • Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: A population-based study
    • DOI 10.1053/j.gastro.2004.07.020, PII S0016508504012442
    • J.A. Davila, R.O. Morgan, Y. Shaib, K.A. Mcglynn and H.B. El-Serag: Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology 127, 1372-1380 (2004) (Pubitemid 39457763)
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 1372-1380
    • Davila, J.A.1    Morgan, R.O.2    Shaib, Y.3    McGlynn, K.A.4    El-Serag, H.B.5
  • 4
    • 0642303165 scopus 로고    scopus 로고
    • The continuing increase in the incidence of hepatocellular carcinoma in the United States: An update
    • H.B. El-Serag, J.A. Davila, N.J. Petersen and K.A. Mcglynn: The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med 139, 817-823 (2003)
    • (2003) Ann Intern Med , vol.139 , pp. 817-823
    • El-Serag, H.B.1    Davila, J.A.2    Petersen, N.J.3    McGlynn, K.A.4
  • 5
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
    • DOI 10.1053/j.gastro.2004.09.014, PII S0016508504015938
    • G. Fattovich, T. Stroffolini, I. Zagni and F. Donato: Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 127, S35-50 (2004) (Pubitemid 39423368)
    • (2004) Gastroenterology , vol.127 , Issue.SUPPL.
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 6
    • 1942454793 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis
    • DOI 10.1055/s-2004-823098
    • E.M. Brunt: Nonalcoholic steatohepatitis. Semin Liver Dis 24, 3-20 (2004) (Pubitemid 38496045)
    • (2004) Seminars in Liver Disease , vol.24 , Issue.1 , pp. 3-20
    • Brunt, E.M.1
  • 7
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • P. Angulo: Nonalcoholic fatty liver disease. N Engl J Med 346, 1221-1231 (2002)
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 8
    • 2342444542 scopus 로고    scopus 로고
    • Natural history of compensated viral cirrhosis: A prospective study on the incidence and hierarchy of major complications
    • DOI 10.1136/gut.2003.020263
    • L. Benvegnu, M. Gios, S. Boccato and A. Alberti: Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications. Gut 53, 744-749 (2004) (Pubitemid 38561455)
    • (2004) Gut , vol.53 , Issue.5 , pp. 744-749
    • Benvegnu, L.1    Gios, M.2    Boccato, S.3    Alberti, A.4
  • 9
    • 0036840812 scopus 로고    scopus 로고
    • Effect of hepatitis B and C virus infections on the natural history of compensated cirrhosis: A cohort study of 297 patients
    • PII S0002927002054746
    • G. Fattovich, M. Pantalena, I. Zagni, G. Realdi, S.W. Schalm and E. Christensen: Effect of hepatitis B and C virus infections on the natural history of compensated cirrhosis: a cohort study of 297 patients. Am J Gastroenterol 97, 2886-2895 (2002) (Pubitemid 35265444)
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.11 , pp. 2886-2895
    • Fattovich, G.1    Pantalena, M.2    Zagni, I.3    Realdi, G.4    Schalm, S.W.5    Christensen, E.6
  • 11
    • 35348938581 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma in Hispanics in the United States
    • DOI 10.1001/archinte.167.18.1983
    • H.B. El-Serag, M. Lau, K. Eschbach, J. Davila and J. Goodwin: Epidemiology of hepatocellular carcinoma in Hispanics in the United States. Arch Intern Med 167, 1983-1989 (2007) (Pubitemid 47606639)
    • (2007) Archives of Internal Medicine , vol.167 , Issue.18 , pp. 1983-1989
    • El-Serag, H.B.1    Lau, M.2    Eschbach, K.3    Davila, J.4    Goodwin, J.5
  • 12
    • 14744295457 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma
    • DOI 10.1016/j.bpg.2004.11.008, PII S1521691804001763
    • H.E. Blum: Treatment of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 19, 129-145 (2005) (Pubitemid 40331502)
    • (2005) Best Practice and Research: Clinical Gastroenterology , vol.19 , Issue.1 SPEC. ISSUE , pp. 129-145
    • Blum, H.E.1
  • 13
    • 31144437639 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Therapy and prevention
    • H.E. Blum: Hepatocellular carcinoma: therapy and prevention. World J Gastroenterol 11, 7391-7400 (2005) (Pubitemid 43126017)
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.47 , pp. 7391-7400
    • Blum, H.E.1
  • 17
    • 56349107309 scopus 로고    scopus 로고
    • Hepatic fibrosis - overview
    • S.L. Friedman: Hepatic fibrosis - overview. Toxicology 254, 120-129 (2008)
    • (2008) Toxicology , vol.254 , pp. 120-129
    • Friedman, S.L.1
  • 18
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of Hepatic Fibrogenesis
    • DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
    • S.L. Friedman: Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655-1669 (2008) (Pubitemid 351615417)
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 20
    • 34247619364 scopus 로고    scopus 로고
    • Gene Expression Profiles During Hepatic Stellate Cell Activation in Culture and In Vivo
    • DOI 10.1053/j.gastro.2007.02.033, PII S0016508507003903
    • S. de Minicis, E. Seki, H. Uchinami, J. Kluwe, Y. Zhang, D.A. Brenner and R.F. Schwabe: Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 132, 1937-1946 (2007) (Pubitemid 46677935)
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1937-1946
    • De Minicis, S.1    Seki, E.2    Uchinami, H.3    Kluwe, J.4    Zhang, Y.5    Brenner, D.A.6    Schwabe, R.F.7
  • 21
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • DOI 10.1126/science.1140485
    • W.E. Naugler, T. Sakurai, S. Kim, S. Maeda, K. Kim, A.M. Elsharkawy and M. Karin: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007) (Pubitemid 47056470)
    • (2007) Science , vol.317 , Issue.5834 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 24
    • 58149380810 scopus 로고    scopus 로고
    • Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells
    • S. de Minicis, E. Seki, C. Oesterreicher, B. Schnabl, R.F. Schwabe and D.A. Brenner: Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology 48, 2016-2026 (2008)
    • (2008) Hepatology , vol.48 , pp. 2016-2026
    • De Minicis, S.1    Seki, E.2    Oesterreicher, C.3    Schnabl, B.4    Schwabe, R.F.5    Brenner, D.A.6
  • 26
    • 0031454239 scopus 로고    scopus 로고
    • Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-β1 transgenic mice
    • D.E. Clouthier, S.A. Comerford and R.E. Hammer: Hepatic fibrosis, glomerulosclerosis, and a lipodystrophylike syndrome in PEPCK-TGF-beta1 transgenic mice. J Clin Invest 100, 2697-2713 (1997) (Pubitemid 28007537)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.11 , pp. 2697-2713
    • Clouthier, D.E.1    Comerford, S.A.2    Hammer, R.E.3
  • 29
    • 0038374866 scopus 로고    scopus 로고
    • Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis
    • DOI 10.1053/jhep.2003.50196
    • E. Ueberham, R. Low, U. Ueberham, K. Schonig, H. Bujard and R. Gebhardt: Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology 37, 1067-1078 (2003) (Pubitemid 36538683)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1067-1078
    • Ueberham, E.1    Low, R.2    Ueberham, U.3    Schonig, K.4    Bujard, H.5    Gebhardt, R.6
  • 35
    • 27744512904 scopus 로고    scopus 로고
    • Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes
    • DOI 10.1016/j.jhep.2005.06.025, PII S0168827805004885
    • Y. Popov, E. Patsenker, P. Fickert, M. Trauner and D. Schuppan: Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J Hepatol 43, 1045-1054 (2005) (Pubitemid 41627991)
    • (2005) Journal of Hepatology , vol.43 , Issue.6 , pp. 1045-1054
    • Popov, Y.1    Patsenker, E.2    Fickert, P.3    Trauner, M.4    Schuppan, D.5
  • 37
    • 0035142665 scopus 로고    scopus 로고
    • Activation of STAT proteins and growth control
    • DOI 10.1002/1521-1878(200102)23: 2<161::AID-BIES1023>3.0.CO;2-0
    • J.F. Bromberg: Activation of STAT proteins and growth control. Bioessays 23, 161-169 (2001) (Pubitemid 32116649)
    • (2001) BioEssays , vol.23 , Issue.2 , pp. 161-169
    • Bromberg, J.F.1
  • 38
    • 0037138370 scopus 로고    scopus 로고
    • Signaling through the JAK/STAT pathway, recent advances and future challenges
    • DOI 10.1016/S0378-1119(02)00398-0, PII S0378111902003980
    • T. Kisseleva, S. Bhattacharya, J. Braunstein and C.W. Schindler: Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285, 1-24 (2002) (Pubitemid 34246317)
    • (2002) Gene , vol.285 , Issue.1-2 , pp. 1-24
    • Kisseleva, T.1    Bhattacharya, S.2    Braunstein, J.3    Schindler, C.W.4
  • 39
    • 0033213901 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling: STAT-induced STAT inhibitor
    • DOI 10.1016/S0968-0004(99)01454-1, PII S0968000499014541
    • T. Naka, M. Fujimoto and T. Kishimoto: Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. Trends Biochem Sci 24, 394-398 (1999) (Pubitemid 29450447)
    • (1999) Trends in Biochemical Sciences , vol.24 , Issue.10 , pp. 394-398
    • Naka, T.1    Fujimoto, M.2    Kishimoto, T.3
  • 41
    • 33748158716 scopus 로고    scopus 로고
    • The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition
    • DOI 10.1007/s10911-006-9014-4
    • S. Desrivieres, C. Kunz, I. Barash, V. Vafaizadeh, C. Borghouts and B. Groner: The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition. J Mammary Gland Biol Neoplasia 11, 75-87 (2006) (Pubitemid 44309191)
    • (2006) Journal of Mammary Gland Biology and Neoplasia , vol.11 , Issue.1 , pp. 75-87
    • Desrivieres, S.1    Kunz, C.2    Barash, I.3    Vafaizadeh, V.4    Borghouts, C.5    Groner, B.6
  • 42
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • DOI 10.1016/j.ejca.2005.08.016, PII S0959804905007094, Transcription Factors in Cancer
    • D.R. Hodge, E.M. Hurt and W.L. Farrar: The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41, 2502-2512 (2005) (Pubitemid 41540626)
    • (2005) European Journal of Cancer , vol.41 , Issue.16 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 43
    • 77951025336 scopus 로고    scopus 로고
    • STAT1 and pathogens, not a friendly relationship
    • I. Najjar and R. Fagard: STAT1 and pathogens, not a friendly relationship. Biochimie 92, 425-444 (2010)
    • (2010) Biochimie , vol.92 , pp. 425-444
    • Najjar, I.1    Fagard, R.2
  • 44
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • DOI 10.1189/jlb.0603252
    • K. Schroder, P.J. Hertzog, T. Ravasi and D.A. Hume: Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75, 163-189 (2004) (Pubitemid 38174573)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 49
    • 7644234676 scopus 로고    scopus 로고
    • Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-γ)
    • DOI 10.1053/j.gastro.2004.08.055, PII S0016508504015562
    • R. Sun and B. Gao: Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology 127, 1525-1539 (2004) (Pubitemid 39457777)
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 1525-1539
    • Sun, R.1    Gao, B.2
  • 50
    • 33750617477 scopus 로고    scopus 로고
    • STAT1 contributes to dsRNA inhibition of liver regeneration after partial hepatectomy in mice
    • DOI 10.1002/hep.21344
    • R. Sun, O. Park, N. Horiguchi, S. Kulkarni, W.I. Jeong, H.Y. Sun, S. Radaeva and B. Gao: STAT1 contributes to dsRNA inhibition of liver regeneration after partial hepatectomy in mice. Hepatology 44, 955-966 (2006) (Pubitemid 46489560)
    • (2006) Hepatology , vol.44 , Issue.4 , pp. 955-966
    • Sun, R.1    Park, O.2    Horiguchi, N.3    Kulkarni, S.4    Jeong, W.-I.5    Sun, H.-Y.6    Radaeva, S.7    Gao, B.8
  • 53
    • 0034515268 scopus 로고    scopus 로고
    • Immune response in Stat2 knockout mice
    • DOI 10.1016/S1074-7613(00)00077-7
    • C. Park, S. Li, E. Cha and C. Schindler: Immune response in Stat2 knockout mice. Immunity 13, 795-804 (2000) (Pubitemid 32041802)
    • (2000) Immunity , vol.13 , Issue.6 , pp. 795-804
    • Park, C.1    Li, S.2    Cha, E.3    Schindler, C.4
  • 54
    • 0036211034 scopus 로고    scopus 로고
    • Interferon-α activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes
    • S. Radaeva, B. Jaruga, F. Hong, W.H. Kim, S. Fan, H. Cai, S. Strom, Y. Liu, O. El-Assal and B. Gao: Interferonalpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes. Gastroenterology 122, 1020-1034 (2002) (Pubitemid 34267285)
    • (2002) Gastroenterology , vol.122 , Issue.4 , pp. 1020-1034
    • Radaeva, S.1    Jaruga, B.2    Hong, F.3    Kim, W.4    Fan, S.5    Cai, H.6    Strom, S.7    Liu, Y.8    ElAssal, O.9    Gao, B.10
  • 58
    • 0032771993 scopus 로고    scopus 로고
    • Cytokines and the hepatic acute-phase response
    • G. Ramadori and B. Christ: Cytokines and the hepatic acute-phase response. Semin Liver Dis 19, 141-155 (1999)
    • (1999) Semin Liver Dis , vol.19 , pp. 141-155
    • Ramadori, G.1    Christ, B.2
  • 60
    • 0037011992 scopus 로고    scopus 로고
    • L proteins
    • DOI 10.1038/sj.onc.1205016
    • F. Hong, W.H. Kim, Z. Tian, B. Jaruga, E. Ishac, X. Shen and B. Gao: Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins. Oncogene 21, 32-43 (2002) (Pubitemid 34076376)
    • (2002) Oncogene , vol.21 , Issue.1 , pp. 32-43
    • Hong, F.1    Kim, W.-H.2    Tian, Z.3    Jaruga, B.4    Ishac, E.5    Shen, X.6    Gao, B.7
  • 62
    • 0345146918 scopus 로고    scopus 로고
    • Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease
    • DOI 10.1016/S0006-291X(03)00572-2
    • Y. Masubuchi, M. Bourdi, T.P. Reilly, M.L. Graf, J.W. George and L.R. Pohl: Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease. Biochem Biophys Res Commun 304, 207-212 (2003) (Pubitemid 36434217)
    • (2003) Biochemical and Biophysical Research Communications , vol.304 , Issue.1 , pp. 207-212
    • Masubuchi, Y.1    Bourdi, M.2    Reilly, T.P.3    Graf, M.L.M.4    George, J.W.5    Pohl, L.R.6
  • 63
    • 34547435358 scopus 로고    scopus 로고
    • Impaired liver regeneration and increased oval cell numbers following T cell-mediated hepatitis
    • DOI 10.1002/hep.21674
    • I.N. Hines, M. Kremer, F. Isayama, A.W. Perry, R.J. Milton, A.L. Black, C.L. Byrd and M.D. Wheeler: Impaired liver regeneration and increased oval cell numbers following T cell-mediated hepatitis. Hepatology 46, 229-241 (2007) (Pubitemid 47171940)
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 229-241
    • Hines, I.N.1    Kremer, M.2    Isayama, F.3    Perry, A.W.4    Milton, R.J.5    Black, A.L.6    Byrd, C.L.7    Wheeler, M.D.8
  • 66
    • 0041321399 scopus 로고    scopus 로고
    • Interleukin 6 is important for survival after partial hepatectomy in mice
    • DOI 10.1053/jhep.2003.50378
    • A. Blindenbacher, X. Wang, I. Langer, R. Savino, L. Terracciano and M.H. Heim: Interleukin 6 is important for survival after partial hepatectomy in mice. Hepatology 38, 674-682 (2003) (Pubitemid 37052154)
    • (2003) Hepatology , vol.38 , Issue.3 , pp. 674-682
    • Blindenbacher, A.1    Wang, X.2    Langer, I.3    Savino, R.4    Terracciano, L.5    Heim, M.H.6
  • 67
    • 2342458559 scopus 로고    scopus 로고
    • Hydrodynamic gene delivery of interleukin-22 protects themouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3
    • H. Pan, F. Hong, S. Radaeva and B. Gao: Hydrodynamic gene delivery of interleukin-22 protects themouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol 1, 43-49 (2004)
    • (2004) Cell Mol Immunol , vol.1 , pp. 43-49
    • Pan, H.1    Hong, F.2    Radaeva, S.3    Gao, B.4
  • 69
    • 20644465187 scopus 로고    scopus 로고
    • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
    • C.A. Camargo, Jr., J.F. Madden, W. Gao, R.S. Selvan and P.A. Clavien: Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 26, 1513-1520 (1997) (Pubitemid 27520017)
    • (1997) Hepatology , vol.26 , Issue.6 , pp. 1513-1520
    • Camargo Jr., C.A.1    Madden, J.F.2    Gao, W.3    Selvan, R.S.4    Clavien, P.-A.5
  • 70
    • 0029846756 scopus 로고    scopus 로고
    • Liver failure and defective hepatocyte regeneration in interleukin-6- deficient mice
    • DOI 10.1126/science.274.5291.1379
    • D.E. Cressman, L.E. Greenbaum, R.A. Deangelis, G. Ciliberto, E.E. Furth, V. Poli and R. Taub: Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274, 1379-1383 (1996) (Pubitemid 26391463)
    • (1996) Science , vol.274 , Issue.5291 , pp. 1379-1383
    • Cressman, D.E.1    Greenbaum, L.E.2    DeAngelis, R.A.3    Ciliberto, G.4    Furth, E.E.5    Poli, V.6    Taub, R.7
  • 71
    • 0032985306 scopus 로고    scopus 로고
    • Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy
    • DOI 10.1002/hep.510290244
    • T. Sakamoto, Z. Liu, N. Murase, T. Ezure, S. Yokomuro, V. Poli and A.J. Demetris: Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. Hepatology 29, 403-411 (1999) (Pubitemid 29088443)
    • (1999) Hepatology , vol.29 , Issue.2 , pp. 403-411
    • Sakamoto, T.1    Liu, Z.2    Murase, N.3    Ezure, T.4    Yokomuro, S.5    Poli, V.6    Demetris, A.J.7
  • 72
  • 73
    • 0037047360 scopus 로고    scopus 로고
    • STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
    • DOI 10.1074/jbc.M202807200
    • W. Li, X. Liang, C. Kellendonk, V. Poli and R. Taub: STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem 277, 28411-28417 (2002) (Pubitemid 41079264)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.32 , pp. 28411-28417
    • Li, W.1    Liang, X.2    Kellendonk, C.3    Poli, V.4    Taub, R.5
  • 76
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • S. Whittaker, R. Marais and A.X. Zhu: The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29, 4989-5005 (2010)
    • (2010) Oncogene , vol.29 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 77
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • E.J. Park, J.H. Lee, G.Y. Yu, G. He, S.R. Ali, R.G. Holzer, C.H. Osterreicher, H. Takahashi and M. Karin: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140, 197-208 (2010)
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6    Osterreicher, C.H.7    Takahashi, H.8    Karin, M.9
  • 80
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4- deficient mice
    • DOI 10.1038/382174a0
    • M.H. Kaplan, Y.L. Sun, T. Hoey and M.J. Grusby: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174-177 (1996) (Pubitemid 26242885)
    • (1996) Nature , vol.382 , Issue.6587 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 81
    • 0032934156 scopus 로고    scopus 로고
    • Functional roles of STAT family proteins: Lessons from knockout mice
    • S. Akira: Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17, 138-146 (1999) (Pubitemid 29226664)
    • (1999) Stem Cells , vol.17 , Issue.3 , pp. 138-146
    • Akira, S.1
  • 82
    • 0037091021 scopus 로고    scopus 로고
    • Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4
    • A. Kato, A. Graul-Layman, M.J. Edwards and A.B. Lentsch: Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4. Transplantation 73, 1142-1145 (2002) (Pubitemid 34415450)
    • (2002) Transplantation , vol.73 , Issue.7 , pp. 1142-1145
    • Kato, A.1    Graul-Layman, A.2    Edwards, M.J.3    Lentsch, A.B.4
  • 83
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • DOI 10.1128/MCB.24.18.8037-8047.2004
    • Y. Cui, G. Riedlinger, K. Miyoshi, W. Tang, C. Li, C.X. Deng, G.W. Robinson and L. Hennighausen: Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24, 8037-8047 (2004) (Pubitemid 39167454)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3    Tang, W.4    Li, C.5    Deng, C.-X.6    Robinson, G.W.7    Hennighausen, L.8
  • 84
    • 34548321210 scopus 로고    scopus 로고
    • Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration
    • DOI 10.1002/hep.21713
    • Y. Cui, A. Hosui, R. Sun, K. Shen, O. Gavrilova, W. Chen, M.C. Cam, B. Gao, G.W. Robinson and L. Hennighausen: Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology 46, 504-513 (2007) (Pubitemid 47344786)
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 504-513
    • Cui, Y.1    Hosui, A.2    Sun, R.3    Shen, K.4    Gavrilova, O.5    Chen, W.6    Cam, M.C.7    Gao, B.8    Robinson, G.W.9    Hennighausen, L.10
  • 85
    • 41149149301 scopus 로고    scopus 로고
    • Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
    • DOI 10.1101/gad.1643908
    • L. Hennighausen and G.W. Robinson: Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev 22, 711-721 (2008) (Pubitemid 351439101)
    • (2008) Genes and Development , vol.22 , Issue.6 , pp. 711-721
    • Hennighausen, L.1    Robinson, G.W.2
  • 87
    • 4644246809 scopus 로고    scopus 로고
    • Role of Growth Hormone (GH) in liver regeneration
    • DOI 10.1210/en.2004-0655
    • P.A. Pennisi, J.J. Kopchick, S. Thorgeirsson, D. Leroith and S. Yakar: Role of growth hormone (GH) in liver regeneration. Endocrinology 145, 4748-4755 (2004) (Pubitemid 39281469)
    • (2004) Endocrinology , vol.145 , Issue.10 , pp. 4748-4755
    • Pennisi, P.A.1    Kopchick, J.J.2    Thorgeirsson, S.3    Leroith, D.4    Yakar, S.5
  • 88
    • 34249070257 scopus 로고    scopus 로고
    • Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
    • DOI 10.1101/gad.426007
    • D. Engblom, J.W. Kornfeld, L. Schwake, F. Tronche, A. Reimann, H. Beug, L. Hennighausen, R. Moriggl and G. Schutz: Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev 21, 1157-1162 (2007) (Pubitemid 46789873)
    • (2007) Genes and Development , vol.21 , Issue.10 , pp. 1157-1162
    • Engblom, D.1    Kornfeld, J.-W.2    Schwake, L.3    Tronche, F.4    Reimann, A.5    Beug, H.6    Hennighausen, L.7    Morigg, R.8    Schutz, G.9
  • 91
    • 33750559636 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition
    • DOI 10.1158/0008-5472.CAN-06-1092
    • T.K. Lee, K. Man, R.T. Poon, C.M. Lo, A.P. Yuen, I.O. Ng, K.T. Ng, W. Leonard and S.T. Fan: Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. Cancer Res 66, 9948-9956 (2006) (Pubitemid 44672047)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 9948-9956
    • Lee, T.K.1    Man, K.2    Poon, R.T.P.3    Lo, C.M.4    Yuen, A.P.5    Ng, I.O.6    Ng, K.T.7    Leonard, W.8    Fan, S.T.9
  • 92
    • 65549094595 scopus 로고    scopus 로고
    • Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation
    • A. Hosui, A. Kimura, D. Yamaji, B.M. Zhu, R. Na and L. Hennighausen: Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. J Exp Med 206, 819-831 (2009)
    • (2009) J Exp Med , vol.206 , pp. 819-831
    • Hosui, A.1    Kimura, A.2    Yamaji, D.3    Zhu, B.M.4    Na, R.5    Hennighausen, L.6
  • 93
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • DOI 10.1016/S1074-7613(00)80439-2
    • M.H. Kaplan, U. Schindler, S.T. Smiley and M.J. Grusby: Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4, 313-319 (1996) (Pubitemid 26132509)
    • (1996) Immunity , vol.4 , Issue.3 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 94
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • DOI 10.1038/nri954
    • K.M. Murphy and S.L. Reiner: The lineage decisions of helper T cells. Nat Rev Immunol 2, 933-944 (2002) (Pubitemid 37323214)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 95
    • 70349976548 scopus 로고    scopus 로고
    • Differential proteomic analysis of STAT6 knockout mice reveals new regulatory function in liver lipid homeostasis
    • J. Iff, W. Wang, T. Sajic, N. Oudry, E. Gueneau, G. Hopfgartner, E. Varesio and I. Szanto: Differential proteomic analysis of STAT6 knockout mice reveals new regulatory function in liver lipid homeostasis. J Proteome Res 8, 4511-4524 (2009)
    • (2009) J Proteome Res , vol.8 , pp. 4511-4524
    • Iff, J.1    Wang, W.2    Sajic, T.3    Oudry, N.4    Gueneau, E.5    Hopfgartner, G.6    Varesio, E.7    Szanto, I.8
  • 97
    • 85047697106 scopus 로고    scopus 로고
    • Reduced hepatic ischemia/reperfusion injury by IL-4: Potential anti- inflammatory role of STAT6
    • DOI 10.1007/s000110050592
    • A. Kato, H. Yoshidome, M.J. Edwards and A.B. Lentsch: Reduced hepatic ischemia/reperfusion injury by IL-4: potential anti-inflammatory role of STAT6. Inflamm Res 49, 275-279 (2000) (Pubitemid 30451610)
    • (2000) Inflammation Research , vol.49 , Issue.6 , pp. 275-279
    • Kato, A.1    Yoshidome, H.2    Edwards, M.J.3    Lentsch, A.B.4
  • 98
    • 0035178989 scopus 로고    scopus 로고
    • STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia
    • DOI 10.1172/JCI200113763
    • A.B. Lentsch, A. Kato, B. Davis, W. Wang, C. Chao and M.J. Edwards: STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia. J Clin Invest 108, 1475-1482 (2001) (Pubitemid 33091985)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.10 , pp. 1475-1482
    • Lentsch, A.B.1    Kato, A.2    Davis, B.3    Wang, W.4    Chao, C.5    Edwards, M.J.6
  • 99
    • 0042834253 scopus 로고    scopus 로고
    • Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: Up-regulating eotaxins and IL-5 and recruiting leukocytes
    • B. Jaruga, F. Hong, R. Sun, S. Radaeva and B. Gao: Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 171, 3233-3244 (2003) (Pubitemid 37093550)
    • (2003) Journal of Immunology , vol.171 , Issue.6 , pp. 3233-3244
    • Jaruga, B.1    Hong, F.2    Sun, R.3    Radaeva, S.4    Gao, B.5
  • 100
    • 32944463507 scopus 로고    scopus 로고
    • Cytokines, STATs and liver disease
    • B. Gao: Cytokines, STATs and liver disease. Cell Mol Immunol 2, 92-100 (2005)
    • (2005) Cell Mol Immunol , vol.2 , pp. 92-100
    • Gao, B.1
  • 101
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • P.J. Murray: The JAK-STAT signaling pathway: input and output integration. J Immunol 178, 2623-2629 (2007) (Pubitemid 46333135)
    • (2007) Journal of Immunology , vol.178 , Issue.5 , pp. 2623-2629
    • Murray, P.J.1
  • 103
    • 77952075414 scopus 로고    scopus 로고
    • Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis
    • W. Plum, D.F. Tschaharganeh, D.C. Kroy, E. Corsten, S. Erschfeld, U. Dierssen, H. Wasmuth, C. Trautwein and K.L. Streetz: Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis. Am J Pathol 176, 2236-2246
    • Am J Pathol , vol.176 , pp. 2236-2246
    • Plum, W.1    Tschaharganeh, D.F.2    Kroy, D.C.3    Corsten, E.4    Erschfeld, S.5    Dierssen, U.6    Wasmuth, H.7    Trautwein, C.8    Streetz, K.L.9
  • 104
    • 77952075414 scopus 로고    scopus 로고
    • Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis
    • W. Plum, D.F. Tschaharganeh, D.C. Kroy, E. Corsten, S. Erschfeld, U. Dierssen, H. Wasmuth, C. Trautwein and K.L. Streetz: Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis. Am J Pathol 176, 2236-2246 (2010)
    • (2010) Am J Pathol , vol.176 , pp. 2236-2246
    • Plum, W.1    Tschaharganeh, D.F.2    Kroy, D.C.3    Corsten, E.4    Erschfeld, S.5    Dierssen, U.6    Wasmuth, H.7    Trautwein, C.8    Streetz, K.L.9
  • 105
    • 85047689502 scopus 로고    scopus 로고
    • Hepatoprotection via the IL-6/Stat3 pathway
    • DOI 10.1172/JCI200319974
    • R. Taub: Hepatoprotection via the IL-6/Stat3 pathway. J Clin Invest 112, 978-980 (2003) (Pubitemid 38056310)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.7 , pp. 978-980
    • Taub, R.1
  • 106
    • 27544431934 scopus 로고    scopus 로고
    • Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes
    • DOI 10.1016/j.bcp.2005.08.020, PII S0006295205005691
    • P. Dent, S.I. Han, C. Mitchell, E. Studer, A. Yacoub, J. Grandis, S. Grant, G.W. Krystal and P.B. Hylemon: Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes. Biochem Pharmacol 70, 1685-1696 (2005) (Pubitemid 41540361)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.11 , pp. 1685-1696
    • Dent, P.1    Song, I.H.2    Mitchell, C.3    Studer, E.4    Yacoub, A.5    Grandis, J.6    Grant, S.7    Krystal, G.W.8    Hylemon, P.B.9
  • 108
    • 0036211298 scopus 로고    scopus 로고
    • Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes
    • DOI 10.1053/jhep.2002.32533
    • L. Qiao, A. Yacoub, E. Studer, S. Gupta, X.Y. Pei, S. Grant, P.B. Hylemon and P. Dent: Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 35, 779-789 (2002) (Pubitemid 34258371)
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 779-789
    • Qiao, L.1    Yacoub, A.2    Studer, E.3    Gupta, S.4    Pei, X.Y.5    Grant, S.6    Hylemon, P.B.7    Dent, P.8
  • 109
    • 0036151709 scopus 로고    scopus 로고
    • Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes
    • DOI 10.1053/jhep.2002.31104
    • Y.P. Rao, E.J. Studer, R.T. Stravitz, S. Gupta, L. Qiao, P. Dent and P.B. Hylemon: Activation of the Raf- 1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes. Hepatology 35, 307-314 (2002) (Pubitemid 34106369)
    • (2002) Hepatology , vol.35 , Issue.2 , pp. 307-314
    • Rao, Y.-P.1    Studer, E.J.2    Stravitz R.Todd3    Gupta, S.4    Qiao, L.5    Dent, P.6    Hylemon, P.B.7
  • 111
    • 33745698658 scopus 로고    scopus 로고
    • Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease
    • A.J. Demetris, J.G. Lunz, 3rd, S. Specht and I. Nozaki: Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease. World J Gastroenterol 12, 3512-3522 (2006) (Pubitemid 43997028)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.22 , pp. 3512-3522
    • Demetris, A.J.1    Lunz III, J.G.2    Specht, S.3    Nozaki, I.4
  • 113
  • 115
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • DOI 10.1016/S0168-8278(02)00102-2, PII S0168827802001022
    • I.A. Leclercq, G.C. Farrell, R. Schriemer and G.R. Robertson: Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 37, 206-213 (2002) (Pubitemid 34833082)
    • (2002) Journal of Hepatology , vol.37 , Issue.2 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 116
    • 33751545966 scopus 로고    scopus 로고
    • Leptin and liver tissue repair: Do rodent models provide the answers?
    • DOI 10.1016/j.jhep.2006.10.002, PII S0168827806005575
    • F. Marra: Leptin and liver tissue repair: do rodent models provide the answers? J Hepatol 46, 12-18 (2007) (Pubitemid 44834430)
    • (2007) Journal of Hepatology , vol.46 , Issue.1 , pp. 12-18
    • Marra, F.1
  • 117
    • 19544378172 scopus 로고    scopus 로고
    • The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology
    • X. Ding, N.K. Saxena, S. Lin, A. Xu, S. Srinivasan and F.A. Anania: The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol 166, 1655-1669 (2005) (Pubitemid 40734389)
    • (2005) American Journal of Pathology , vol.166 , Issue.6 , pp. 1655-1669
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Xu, A.4    Srinivasan, S.5    Anania, F.A.6
  • 118
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
    • DOI 10.1053/jhep.2002.32029
    • N.K. Saxena, K. Ikeda, D.C. Rockey, S.L. Friedman and F.A. Anania: Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 35, 762-771 (2002) (Pubitemid 34258369)
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 762-771
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.L.4    Anania, F.A.5
  • 119
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • A.M. de Vos, M. Ultsch and A.A. Kossiakoff: Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312 (1992)
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 120
    • 0346435095 scopus 로고    scopus 로고
    • Mechanisms of growth hormone (GH) action: Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation
    • DOI 10.1074/jbc.M309486200
    • J. Woelfle, D.J. Chia and P. Rotwein: Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation. J Biol Chem 278, 51261-51266 (2003) (Pubitemid 38020363)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.51 , pp. 51261-51266
    • Woelfle, J.1    Chia, D.J.2    Rotwein, P.3
  • 122
    • 0032230344 scopus 로고    scopus 로고
    • Binding of STAT5a and STAT5b to a single element resembling a γ-interferon-activated sequence mediates the growth hormone induction of the mouse acid-labile subunit promoter in liver cells
    • G.T. Ooi, K.R. Hurst, M.N. Poy, M.M. Rechler and Y.R. Boisclair: Binding of STAT5a and STAT5b to a single element resembling a gamma-interferon-activated sequence mediates the growth hormone induction of the mouse acid-labile subunit promoter in liver cells. Mol Endocrinol 12, 675-687 (1998) (Pubitemid 30659069)
    • (1998) Molecular Endocrinology , vol.12 , Issue.5 , pp. 675-687
    • Ooi, G.T.1    Hurst, K.R.2    Poy, M.N.3    Rechler, M.M.4    Boisclair, Y.R.5
  • 123
    • 33344457703 scopus 로고    scopus 로고
    • Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4α
    • DOI 10.1210/me.2005-0328
    • M.G. Holloway, E.V. Laz and D.J. Waxman: Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha. Mol Endocrinol 20, 647-660 (2006) (Pubitemid 43291215)
    • (2006) Molecular Endocrinology , vol.20 , Issue.3 , pp. 647-660
    • Holloway, M.G.1    Laz, E.V.2    Waxman, D.J.3
  • 125
    • 0028950070 scopus 로고
    • Growth hormone, insulinlike growth factor-1, and insulinlike growth factor binding proteins 1 and 3 in chronic liver disease
    • A. Donaghy, R. Ross, A. Gimson, S.C. Hughes, J. Holly and R. Williams: Growth hormone, insulinlike growth factor-1, and insulinlike growth factor binding proteins 1 and 3 in chronic liver disease. Hepatology 21, 680-688 (1995)
    • (1995) Hepatology , vol.21 , pp. 680-688
    • Donaghy, A.1    Ross, R.2    Gimson, A.3    Hughes, S.C.4    Holly, J.5    Williams, R.6
  • 126
    • 0031926536 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-1) in liver cirrhosis: A marker of hepatocellular dysfunction?
    • DOI 10.1016/S0168-8278(98)80023-8
    • L. Caregaro, F. Alberino, P. Angeli and A. Gatta: Insulin-like growth factor 1 (IGF-1) in liver cirrhosis: a marker of hepatocellular dysfunction? J Hepatol 29, 342 (1998) (Pubitemid 28352823)
    • (1998) Journal of Hepatology , vol.29 , Issue.2 , pp. 342
    • Caregaro, L.1    Alberino, F.2    Angeli, P.3    Gatta, A.4
  • 127
    • 0025096980 scopus 로고
    • Absence of growth-hormone receptor in hepatocellular carcinoma and cirrhotic liver
    • T.C. Chang, J.J. Lin, S.C. Yu and T.J. Chang: Absence of growth-hormone receptor in hepatocellular carcinoma and cirrhotic liver. Hepatology 11, 123-126 (1990)
    • (1990) Hepatology , vol.11 , pp. 123-126
    • Chang, T.C.1    Lin, J.J.2    Yu, S.C.3    Chang, T.J.4
  • 128
    • 44649157711 scopus 로고    scopus 로고
    • Growth hormone-stimulated IGF-1 generation in cirrhosis reflects hepatocellular dysfunction
    • N. Assy, Y. Pruzansky, D. Gaitini, Z. Shen Orr, Z. Hochberg and Y. Baruch: Growth hormone-stimulated IGF-1 generation in cirrhosis reflects hepatocellular dysfunction. J Hepatol 49, 34-42 (2008)
    • (2008) J Hepatol , vol.49 , pp. 34-42
    • Assy, N.1    Pruzansky, Y.2    Gaitini, D.3    Shen Orr, Z.4    Hochberg, Z.5    Baruch, Y.6
  • 129
    • 0029433778 scopus 로고
    • Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice
    • L.J. Murphy, K. Rajkumar and P. Molnar: Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice. Prog Growth Factor Res 6, 425-432 (1995)
    • (1995) Prog Growth Factor Res , vol.6 , pp. 425-432
    • Murphy, L.J.1    Rajkumar, K.2    Molnar, P.3
  • 130
    • 0030297050 scopus 로고    scopus 로고
    • Insulin-like growth factor-I serum concentrations and patterns of insulin-like growth factor binding proteins in patients with chronic liver disease
    • DOI 10.1016/S0168-8278(96)80240-6
    • J.G. Scharf, F. Schmitz, J. Frystyk, C. Skjaerbaek, H. Moesus, W.F. Blum, G. Ramadori and H. Hartmann: Insulin-like growth factor-I serum concentrations and patterns of insulin-like growth factor binding proteins in patients with chronic liver disease. J Hepatol 25, 689-699 (1996) (Pubitemid 26373887)
    • (1996) Journal of Hepatology , vol.25 , Issue.5 , pp. 689-699
    • Scharf, J.-G.1    Schmitz, F.2    Frystyk, J.3    Skjaerbaek, C.4    Moesus, H.5    Blum, W.F.6    Ramadori, G.7    Hartmann, H.8
  • 131
    • 33645560435 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 (IGFBP-5): A critical member of the IGF axis
    • J. Beattie, G.J. Allan, J.D. Lochrie and D.J. Flint: Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochem J 395, 1-19 (2006)
    • (2006) Biochem J , vol.395 , pp. 1-19
    • Beattie, J.1    Allan, G.J.2    Lochrie, J.D.3    Flint, D.J.4
  • 132
    • 56849118244 scopus 로고    scopus 로고
    • Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving IGF-binding protein-5
    • G.J. Allan, J. Beattie and D.J. Flint: Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving IGF-binding protein-5. J Endocrinol 199, 155-164 (2008)
    • (2008) J Endocrinol , vol.199 , pp. 155-164
    • Allan, G.J.1    Beattie, J.2    Flint, D.J.3
  • 133
    • 0030817309 scopus 로고    scopus 로고
    • Hepatoprotective effects of insulin-like growth factor I in rats with carbon tetrachloride-induced cirrhosis
    • DOI 10.1053/gast.1997.v113.pm9352873
    • I. Castilla-Cortazar, M. Garcia, B. Muguerza, J. Quiroga, R. Perez, S. Santidrian and J. Prieto: Hepatoprotective effects of insulin-like growth factor I in rats with carbon tetrachloride-induced cirrhosis. Gastroenterology 113, 1682-1691 (1997) (Pubitemid 27461257)
    • (1997) Gastroenterology , vol.113 , Issue.5 , pp. 1682-1691
    • Castilla-Cortazar, I.1    Garcia, M.2    Muguerza, B.3    Quiroga, J.4    Perez, R.5    Santidrian, S.6    Prieto, J.7
  • 135
    • 0344099082 scopus 로고    scopus 로고
    • Protective Effect of IGF-1 on Experimental Liver Cirrhosis-Induced Common Bile Duct Ligation
    • N.Z. Canturk, Z. Canturk, M. Ozden, H. Dalcik, M. Yardimoglu and F. Tulubas: Protective effect of IGF-1 on experimental liver cirrhosis-induced common bile duct ligation. Hepatogastroenterology 50, 2061-2066 (2003) (Pubitemid 37467995)
    • (2003) Hepato-Gastroenterology , vol.50 , Issue.54 , pp. 2061-2066
    • Canturk, N.Z.1    Canturk, Z.2    Ozden, M.3    Dalcik, H.4    Yardimoglu, M.5    Tulubas, F.6
  • 136
    • 4143074965 scopus 로고    scopus 로고
    • An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis
    • DOI 10.1016/j.bcp.2004.05.029, PII S0006295204003545
    • C. Alexia, G. Fallot, M. Lasfer, G. Schweizer-Groyer and A. Groyer: An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 68, 1003-1015 (2004) (Pubitemid 39094263)
    • (2004) Biochemical Pharmacology , vol.68 , Issue.6 , pp. 1003-1015
    • Alexia, C.1    Fallot, G.2    Lasfer, M.3    Schweizer-Groyer, G.4    Groyer, A.5
  • 139
    • 0031891727 scopus 로고    scopus 로고
    • Characterization and regulation of insulin-like growth factor binding proteins in human hepatic stellate cells
    • DOI 10.1002/(SICI)1097-4652(199802 )174:2<240::AID-JCP11>3.0.CO;2-G
    • A. Gentilini, D. Feliers, M. Pinzani, K. Woodruff and S. Abboud: Characterization and regulation of insulin-like growth factor binding proteins in human hepatic stellate cells. J Cell Physiol 174, 240-250 (1998) (Pubitemid 28112634)
    • (1998) Journal of Cellular Physiology , vol.174 , Issue.2 , pp. 240-250
    • Gentilini, A.1    Feliers, D.2    Pinzani, M.3    Woodruff, K.4    Abboud, S.5
  • 140
    • 0033968019 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells
    • A. Gentilini, F. Marra, P. Gentilini and M. Pinzani: Phosphatidylinositol-3 kinase and extracellular signalregulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells. J Hepatol 32, 227-234 (2000) (Pubitemid 30093901)
    • (2000) Journal of Hepatology , vol.32 , Issue.2 , pp. 227-234
    • Gentilini, A.1    Marra, F.2    Gentilini, P.3    Pinzani, M.4
  • 141
    • 17144366279 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis
    • W.H. Kim, K. Matsumoto, K. Bessho and T. Nakamura: Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 166, 1017-1028 (2005) (Pubitemid 40524427)
    • (2005) American Journal of Pathology , vol.166 , Issue.4 , pp. 1017-1028
    • Kim, W.-H.1    Matsumoto, K.2    Bessho, K.3    Nakamura, T.4
  • 144
    • 52449117167 scopus 로고    scopus 로고
    • Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice
    • M. Wang, M. Chen, G. Zheng, B. Dillard, M. Tallarico, Z. Ortiz and A.X. Holterman: Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am J Physiol Gastrointest Liver Physiol 295, G357-366 (2008)
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295
    • Wang, M.1    Chen, M.2    Zheng, G.3    Dillard, B.4    Tallarico, M.5    Ortiz, Z.6    Holterman, A.X.7
  • 145
    • 0029890897 scopus 로고    scopus 로고
    • Expression of leukemia inhibitory factor and its receptor during liver regeneration in the adult rat
    • N. Omori, R.P. Evarts, M. Omori, Z. Hu, E.R. Marsden and S.S. Thorgeirsson: Expression of leukemia inhibitory factor and its receptor during liver regeneration in the adult rat. Lab Invest 75, 15-24 (1996) (Pubitemid 26250269)
    • (1996) Laboratory Investigation , vol.75 , Issue.1 , pp. 15-24
    • Omori, N.1    Evarts, R.P.2    Omori, M.3    Hu, Z.4    Marsden, E.R.5    Thorgeirsson, S.S.6
  • 146
    • 0034456218 scopus 로고    scopus 로고
    • Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone
    • DOI 10.1210/me.14.2.285
    • O. Lahuna, M. Rastegar, D. Maiter, J.P. Thissen, F.P. Lemaigre and G.G. Rousseau: Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone. Mol Endocrinol 14, 285-294 (2000) (Pubitemid 32295397)
    • (2000) Molecular Endocrinology , vol.14 , Issue.2 , pp. 285-294
    • Lahuna, O.1    Rastegar, M.2    Maiter, D.3    Thissen, J.-P.4    Lemaigre, F.P.5    Rousseau, G.G.6
  • 147
    • 0022892554 scopus 로고
    • In vivo evaluation of cholesterol 7α-hydroxylation in humans: Effect of disease and drug treatment
    • M. Bertolotti, N. Carulli, D. Menozzi, F. Zironi, A. Digrisolo, A. Pinetti and M.G. Baldini: In vivo evaluation of cholesterol 7 alpha-hydroxylation in humans: effect of disease and drug treatment. J Lipid Res 27, 1278-1286 (1986) (Pubitemid 17009489)
    • (1986) Journal of Lipid Research , vol.27 , Issue.12 , pp. 1278-1286
    • Bertolotti, M.1    Carulli, N.2    Menozzi, D.3
  • 149
    • 13644251918 scopus 로고    scopus 로고
    • Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA
    • T. Hisaka, A. Desmouliere, J.L. Taupin, S. Daburon, V. Neaud, N. Senant, J.F. Blanc, J.F. Moreau and J. Rosenbaum: Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA. Comp Hepatol 3, 10 (2004)
    • (2004) Comp Hepatol , vol.3 , pp. 10
    • Hisaka, T.1    Desmouliere, A.2    Taupin, J.L.3    Daburon, S.4    Neaud, V.5    Senant, N.6    Blanc, J.F.7    Moreau, J.F.8    Rosenbaum, J.9
  • 150
    • 0033559707 scopus 로고    scopus 로고
    • Cytoplasmic domains of the leukemia inhibitory factor receptor required for STAT3 activation, differentiation, and growth arrest of myeloid leukemic cells
    • M. Tomida, T. Heike and T. Yokota: Cytoplasmic domains of the leukemia inhibitory factor receptor required for STAT3 activation, differentiation, and growth arrest of myeloid leukemic cells. Blood 93, 1934-1941 (1999) (Pubitemid 29128495)
    • (1999) Blood , vol.93 , Issue.6 , pp. 1934-1941
    • Tomida, M.1    Heike, T.2    Yokota, T.3
  • 151
    • 0030907589 scopus 로고    scopus 로고
    • Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6
    • DOI 10.1074/jbc.272.24.15135
    • K.K. Kuropatwinski, C. de Imus, D. Gearing, H. Baumann and B. Mosley: Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6. J Biol Chem 272, 15135-15144 (1997) (Pubitemid 27255528)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.24 , pp. 15135-15144
    • Kuropatwinski, K.K.1    De Imus, C.2    Gearing, D.3    Baumann, H.4    Mosley, B.5
  • 152
    • 37849018468 scopus 로고    scopus 로고
    • Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings
    • E. Seki, Y. Kondo, Y. Iimuro, T. Naka, G. Son, T. Kishimoto, J. Fujimoto, H. Tsutsui and K. Nakanishi: Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings. J Hepatol 48, 237-245 (2008)
    • (2008) J Hepatol , vol.48 , pp. 237-245
    • Seki, E.1    Kondo, Y.2    Iimuro, Y.3    Naka, T.4    Son, G.5    Kishimoto, T.6    Fujimoto, J.7    Tsutsui, H.8    Nakanishi, K.9
  • 153
    • 36448984298 scopus 로고    scopus 로고
    • Gene expression profiling of longlived dwarf mice: Longevity-associated genes and relationships with diet, gender and aging
    • W.R. Swindell: Gene expression profiling of longlived dwarf mice: longevity-associated genes and relationships with diet, gender and aging. BMC Genomics 8, 353 (2007)
    • (2007) BMC Genomics , vol.8 , pp. 353
    • Swindell, W.R.1
  • 155
    • 33845644601 scopus 로고    scopus 로고
    • STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity
    • DOI 10.1002/hep.21419
    • W.I. Jeong, O. Park, S. Radaeva and B. Gao: STAT1 inhibits liver fibrosis in mice by inhibiting stellate cellproliferation and stimulating NK cell cytotoxicity. Hepatology 44, 1441-1451 (2006) (Pubitemid 44953650)
    • (2006) Hepatology , vol.44 , Issue.6 , pp. 1441-1451
    • Jeong, W.-I.1    Park, O.2    Radaeva, S.3    Gao, B.4
  • 156
    • 0029887586 scopus 로고    scopus 로고
    • Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis
    • DOI 10.1053/jhep.1996.v23.pm0008621153
    • G.S. Baroni, L. D'ambrosio, P. Curto, A. Casini, R. Mancini, A.M. Jezequel and A. Benedetti: Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology 23, 1189-1199 (1996) (Pubitemid 26137066)
    • (1996) Hepatology , vol.23 , Issue.5 , pp. 1189-1199
    • Baroni, G.S.1    D'Ambrosio, L.2    Curto, P.3    Casini, A.4    Mancini, R.5    Jezequel, A.M.6    Benedetti, A.7
  • 158
    • 0028679641 scopus 로고
    • Interferon gamma inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: Implications for treatment of hepatic fibrosis
    • D.C. Rockey and J.J. Chung: Interferon gamma inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: implications for treatment of hepatic fibrosis. J Investig Med 42, 660-670 (1994)
    • (1994) J Investig Med , vol.42 , pp. 660-670
    • Rockey, D.C.1    Chung, J.J.2
  • 159
    • 32044443617 scopus 로고    scopus 로고
    • Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
    • DOI 10.1053/j.gastro.2005.10.055, PII S0016508505022316
    • S. Radaeva, R. Sun, B. Jaruga, V.T. Nguyen, Z. Tian and B. Gao: Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing liganddependent manners. Gastroenterology 130, 435-452 (2006) (Pubitemid 43202042)
    • (2006) Gastroenterology , vol.130 , Issue.2 , pp. 435-452
    • Radaeva, S.1    Sun, R.2    Jaruga, B.3    Nguyen, V.T.4    Tian, Z.5    Gao, B.6
  • 162
    • 33646011268 scopus 로고    scopus 로고
    • Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection
    • A.J. Muir, P.B. Sylvestre and D.C. Rockey: Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection. J Viral Hepat 13, 322-328 (2006)
    • (2006) J Viral Hepat , vol.13 , pp. 322-328
    • Muir, A.J.1    Sylvestre, P.B.2    Rockey, D.C.3
  • 164
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • DOI 10.1074/jbc.275.17.12848
    • J. Schmitz, M. Weissenbach, S. Haan, P.C. Heinrich and F. Schaper: SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275, 12848-12856 (2000) (Pubitemid 30241440)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.17 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5
  • 166
    • 0035008978 scopus 로고    scopus 로고
    • SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo
    • DOI 10.1016/S1074-7613(01)00132-7
    • T. Naka, H. Tsutsui, M. Fujimoto, Y. Kawazoe, H. Kohzaki, Y. Morita, R. Nakagawa, M. Narazaki, K. Adachi, T. Yoshimoto, K. Nakanishi and T. Kishimoto: SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFNgamma and IL-4 signaling in vivo. Immunity 14, 535-545 (2001) (Pubitemid 32520865)
    • (2001) Immunity , vol.14 , Issue.5 , pp. 535-545
    • Naka, T.1    Tsutsui, H.2    Fujimoto, M.3    Kawazoe, Y.4    Kohzaki, H.5    Morita, Y.6    Nakagawa, R.7    Narazaki, M.8    Adachi, K.9    Yoshimoto, T.10    Nakanishi, K.11    Kishimoto, T.12
  • 174
    • 0033970969 scopus 로고    scopus 로고
    • Increased toxin-induced liver injury and fibrosis in interleukin-6- deficient mice
    • K. Kovalovich, R.A. Deangelis, W. Li, E.E. Furth, G. Ciliberto and R. Taub: Increased toxin-induced liver injury and fibrosis in interleukin-6- deficient mice. Hepatology 31, 149-159 (2000) (Pubitemid 30033701)
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 149-159
    • Kovalovich, K.1    Deangelis, R.A.2    Li, W.3    Furth, E.E.4    Ciliberto, G.5    Taub, R.6
  • 175
    • 75449098273 scopus 로고    scopus 로고
    • Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice
    • D.C. Kroy, N. Beraza, D.F. Tschaharganeh, L.E. Sander, S. Erschfeld, A. Giebeler, C. Liedtke, H.E. Wasmuth, C. Trautwein and K.L. Streetz: Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice. Hepatology 51, 463-473 (2010)
    • (2010) Hepatology , vol.51 , pp. 463-473
    • Kroy, D.C.1    Beraza, N.2    Tschaharganeh, D.F.3    Sander, L.E.4    Erschfeld, S.5    Giebeler, A.6    Liedtke, C.7    Wasmuth, H.E.8    Trautwein, C.9    Streetz, K.L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.