Interferon-α activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes

Gastroenterology

Volumn 122, Issue 4, 2002, Pages 1020-1034

  Radaeva, Svetlana ^a   Jaruga, Barbara ^a   Hong, Feng ^a   Kim, WonHo ^a   Fan, Saijun ^b   Cai, Hongbo ^c   Strom, Stephen ^c   Liu, Youhua ^c   ElAssal, Osama ^a   Gao, Bin ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; ALPHA INTERFERON RECEPTOR 2A; ALPHA INTERFERON RECEPTOR 2C; RECEPTOR SUBUNIT; SCATTER FACTOR RECEPTOR; STAT PROTEIN; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; DNA MICROARRAY; DOWN REGULATION; DRUG CHOICE; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; LIVER CELL; MOUSE; NONHUMAN; ONCOGENE C MET; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; VIRUS HEPATITIS; WESTERN BLOTTING;

EID: 0036211034     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.32388     Document Type: Article

References (60)

1. Management of hepatitis C: Current and future perspectives
2. Pathogenesis, natural history, treatment, and prevention of hepatitis C
3. Management of chronic hepatitis C: A consensus
4. Interferon alfa in the treatment of chronic viral hepatitis B and C
5. Can interferon alfa treatment prevent hepatocellular carcinoma in patients with chronic hepatitis C infection and compensated cirrhosis?
6. The prevention of hepatocellular carcinoma by interferon: The story continues
7. Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis
8. Interferon therapy reduces the risk for hepatocellular carcinoma
9. Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor: A prospective randomized study of hepatitis C virus-related liver cancer
10. The function of type I interferons in antimicrobial immunity
11. The type I interferon receptor: Structure, function, and evolution of a family business
12. The short form of the interferon alpha/beta receptor chain 2 acts as a dominant negative for type I interferon action
13. Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2
14. Interferon-induced nuclear signalling by Jak protein tyrosine kinases
15. How cells respond to interferons
16. Studies of IFN-induced transcriptional activation uncover the JAK-STAT pathway
17. PKR, apoptosis and cancer
18. Mx proteins: Mediators of innate resistance to RNA viruses
19. The human 2′,5′-oligoadenylate synthetase family: Interferon-induced proteins with unique enzymatic properties
20. Mechanisms of viral inhibition by interferons
21. Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines
22. Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma
23. Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: Involvement of TNF-alpha receptor 1-independent and -dependent mechanisms
24. Use of human hepatocytes to study P450 gene induction
25. The human hepatocyte growth factor receptor gene: Complete structural organization and promoter characterization
26. Tumor necrosis factor alpha attenuates interferon alpha signaling in the liver: Involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy
27. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster
28. The rat alpha 1B adrenergic receptor gene middle promoter contains multiple binding sites for sequence-specific proteins including a novel ubiquitous transcription factor
29. Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: Differential regulation by acute ethanol via a protein kinase C-dependent mechanism
30. IL-1 beta attenuates IFN-alpha beta-induced antiviral activity and STAT1 activation in the liver: Involvement of proteasome-dependent pathway
31. IL-lO attenuates IFN-alpha-activated STAT1 in the liver: Involvement of SOCS2 and SOCS3
32. Immune response in STAT2 knockout mice
33. Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
34. Targeted disruption of the mouse STAT1 gene results in compromised innate immunity to viral disease
35. STAT3 complements defects in an interferon-resistant cell line: Evidence for an essential role for STAT3 in interferon signaling and biological activities
36. Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt
37. PKR; a sentinel kinase for cellular stress
38. Regulation of the interferon-induced PKR: Can viruses cope?
39. Gene structure and function of the 2′-5′-oligoadenylate synthetase family
40. The nature of the catalytic domain of 2′-5′-oligoadenylate synthetases
41. Novel functions of interferon-induced proteins
42. MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes
43. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways
44. Partial inhibition of vesicular stomatitis virus by the interferon- induced human 9-27 protein
45. Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines
46. Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases
47. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays
48. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta
49. Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha
50. Interferon regulatory factors: The next generation
51. IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis of primary cultured hepatocytes
52. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
53. STAT1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation
54. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia
55. Tumor-suppressor effect of interferon regulatory factor-1 in human hepatocellular carcinoma
56. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis
57. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth
58. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth
59. pRB induces Sp1 activity by relieving inhibition mediated by MDM2
60. G1oBP, an E1A-inducible negative regulator of Sp1, represses transcription of the rat fibronectin gene