Cytoplasmic domains of the leukemia inhibitory factor receptor required for STAT3 activation, differentiation, and growth arrest of myeloid leukemic cells

Blood

Volumn 93, Issue 6, 1999, Pages 1934-1941

  Tomida, Mikio ^a   Heike, Toshio ^b   Yokota, Takashi ^b  

^a SAITAMA CANCER CENTER   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOPLASMIC RECEPTOR; GLYCOPROTEIN GP 130; LEUKEMIA INHIBITORY FACTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CHIMERA; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GROWTH INHIBITION; LEUKEMIA CELL; LEUKEMIA CELL LINE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

EID: 0033559707     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.6.1934.406k05_1934_1941     Document Type: Article

References (39)

1. Tomida M, Yamamoto-Yamaguchi Y, Hozumi M: Purification of a factor inducing differentiation of mouse myeloid leukemic M1 cells from conditioned medium of mouse fibroblast L929 cells. J Biol Chem 259:10978, 1984
2. Tomida M, Yamamoto-Yamaguchi Y, Hozumi M, Okabe T, Takaku F: Induction by recombinant human granulocyte colony-stimulating factor of differentiation of mouse myeloid leukemic M1 cells. FEBS Lett 207:271, 1986
3. Gearing DP, Gough NM, King JA, Hilton DJ, Nicola NA, Simpson RJ, Nice EC, Kelso A, Metcalf D: Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J 6:3995, 1987
4. Lowe DG, Nunes W, Bombara M, McCabe S, Ranges GE, Henzel W, Tomida M, Yamamoto-Yamaguchi Y, Hozumi M, Goeddel DV: Genomic cloning and heterologous expression of human differentiation-stimulating factor. DNA 8:351, 1989
5. + leukemic cells transfected with differentiation-stimulating factor/leukemia inhibitory factor receptor cDNA. Blood 85:217, 1995
6. Gearing DP: The leukemia inhibitory factor and its receptor. Adv Immunol 53:31, 1993
7. Alexander HR, Billingsley KG, Block MI, Fraker DL: D-factor/ leukaemia inhibitory factor: Evidence for its role as a mediator in acute and chronic inflammatory disease. Cytokine 6:589, 1994
8. Baumann H, Symes AJ, Comeau MR, Morella KK, Wang Y, Friend D, Ziegler SF, Fink JS, Gearing DP: Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells. Mol Cell Biol 14:138, 1994
9. Ernst M, Oates A, Dunn AR: gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways. J Biol Chem 271:30136, 1996
10. Pennica D, Shaw KJ, Swanson TA, Moore MW, Shelton DL, Zioncheck KA, Rosenthal A, Taga T, Paoni NF, Wood WI: Cardiotrophin-1: Biological activities and binding to the leukemia inhibitory factor receptor/gp130. J Biol Chem 270:10915, 1995
11. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR: Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway: Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem 272:5783, 1997
12. Kishimoto T, Akira S, Narazaki M, Taga T: Interleukin-6 family of cytokines and gp130. Blood 86:1243, 1995
13. Ware CB, Horowitz MC, Renshaw BR, Hunt JS, Liggitt D, Koblar SA, Gliniak BC, Mckenna HJ, Papayannopoulou T, Thoma B, Cheng L, Donovan P J, Peschon JJ, Bartlett PF, Willis CR, Wright BD, Carpenter MK, Davison BL, Gearing DP: Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic detects, and results in perinatal death. Development 121:1283, 1995
14. Li M, Sendtner M, Smith A: Essential function of LIF receptor in motor neurons. Nature 378:724, 1995
15. Miyajima A, Mui AL-F, Ogorochi T, Sakamaki K: Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82:1960, 1993
16. Ihle JN, Kerr IM: Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 11:69, 1995
17. Darnell JE Jr, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415, 1994
18. Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE Jr, Yancopoulos GD: Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349, 1995
19. Kuropatwinski KK, De Imus C, Gearing D, Baumann H, Mosley B: Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6. J Biol Chem 272:15135, 1997
20. Gearing DP, Thut CJ, VandenBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D, Beckmann MP: Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J 10:2839, 1991
21. Tomida M, Yamamoto-Yamaguchi Y, Hozumi M: Three different cDNAs encoding mouse D-factor/LIF receptor. J Biochem 115:557, 1994
22. Niwa H, Yamamura K, Miyazaki J: Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193, 1991
23. Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR: Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51, 1989
24. Higuchi R: Recombinant PCR, in Innis MA, Gelfand DH, Shinsky JJ, White TJ (eds): PCR Protocols. San Diego, CA, Academic, 1990, p 177
25. O'Farrell A-M, Liu Y, Moore KW, Mui AL-F: IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and -independent pathways. EMBO J 17:1006, 1998
26. Metcalf D: The Hemopoietic Colony Stimulating Factors. Amsterdam, The Netherlands, Elsevier, 1984
27. Yamanaka Y, Nakajima K, Fukada T, Hibi M, Hirano T: Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J 15:1557, 1996
28. Nakajima K, Yamanaka Y, Nakae K, Kojima H, Ichiba M, Kiuchi N, Kitaoka T, Fukada T, Hibi M, Hirano T: A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J 15:3651, 1996
29. Minami M, Inoue M, Wei S, Takeda K, Matsumoto M, Kishimoto T, Akira S: STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci USA 93:3963, 1996
30. Mosley B, De Imus C, Fried D, Boiani N, Thoma B, Park LS, Cosman D: Dual oncostatinM(OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem 271:32635, 1996
31. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor. OB-R. Cell 83:1263, 1995
32. Yoshikawa A, Murakami H, Nagata S: Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor. EMBO J 14:5288, 1995
33. Nicholson SE, Starr R, Novak U, Hilton DJ, Layton JE: Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells. J Biol Chem 271:26947, 1996
34. Alexander WS, Maurer AB, Novak U, Harrison-Smith M: Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation. EMBO J 15:6531, 1996
35. Boulton TG, Stahl N, Yancopoulos GD: Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 269:11648, 1994
36. Schiemann WP, Nathanson NM: Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways. J Biol Chem 269:6376, 1994
37. Yin T, Yang Y: Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin-Min mouse 3T3-L1 cells. J Biol Chem 269:3731, 1994
38. Starr R, Novak U, Willson TA, Inglese M, Murphy V, Alexander WS, Metcalf D, Nicola NA, Hilton DJ, Ernst M: Distinct roles for leukemia inhibitory factor receptor α-chain and gp130 in cell type-specific signal transduction. J Biol Chem 272:19982, 1997
39. Nakamura T, Arai T, Takagi M, Sawada T, Matsuda T, Yokota T, Heike T: A selective switch-on system for self-renewal of embryonic stem cells using chimeric cytokine receptors. Biochem Biophys Res Commun 248:22, 1998