Activation of STAT proteins and growth control

BioEssays

Volumn 23, Issue 2, 2001, Pages 161-169

  Bromberg, Jacqueline F ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; MILK PROTEIN; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN; STAT1 PROTEIN, MOUSE; STAT2 PROTEIN; STAT2 PROTEIN, HUMAN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; STAT4 PROTEIN; STAT4 PROTEIN, HUMAN; STAT4 PROTEIN, MOUSE; STAT5 PROTEIN; STAT6 PROTEIN; STAT6 PROTEIN, HUMAN; STAT6 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL; APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; CHEMISTRY; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REVIEW; TRANSACTIVATION;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; DNA-BINDING PROTEINS; HUMANS; MICE; MILK PROTEINS; PROTEIN STRUCTURE, TERTIARY; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT4 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 0035142665     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-1878(200102)23:2<161::AID-BIES1023>3.0.CO;2-0     Document Type: Review

References (83)

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4. A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1
5. Maximal activation of transcription of Stat1 and Stat3 requires both tyrosine and serine phosphorylation
6. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation
7. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling
8. The linker domain of Stat1 is required for gamma interferon-driven transcription
9. Cooperative DNA binding and sequence selective recognition conferred by the Stat amino terminal domain
10. The significance of tetramerization in promoter recruitment by Stat5
11. Stat 1 depends on transcriptional synergy with Sp1
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13. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
14. Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements
15. Structure and function of the interferon-beta enhanceosome
16. Ligand-induced assembly and activation of the gamma interferon receptor in intact cells
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18. The IFN gamma receptor: A paradigm for cytokine receptor signaling
19. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
20. Jak2 is essential for signaling through a variety of cytokine receptors
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22. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
23. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
24. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor
25. RANTES and MIP-1alpha activate stats in T cells
26. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein
27. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
28. STATs in oncogenesis
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30. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
31. Negative regulation of the JAK/STAT pathway
32. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
33. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
34. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
35. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
36. SOCS3 is essential in the regulation of fetal liver erythropoiesis
37. Specific inhibition of Stat3 signal transduction by PIAS3
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39. Localization of a target region of allelic loss to a 1-cM interval on chromosome 16p.13.13 in hepatocellular carcinoma
40. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
41. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
42. Essential role of Stat6 in IL-4 signalling
43. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
44. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
45. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
46. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice
47. Loss of STAT1 expression confers resistance to IFN-gamma-induced apoptosis in ME180 cells
48. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha
49. Transcriptionally active Stat1 is required for the antiproliferative effects of both IFN-α and IFN-γ
50. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
51. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
52. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
53. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
54. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
55. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
56. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL is required for leukemogenesis
57. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
58. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
59. Stat5a is mandatory for adult mammary gland development and lactogenesis
60. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
61. Requirement of Stat5b for sexual dimorphism of body growth rates and liver gene expression
62. Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells
63. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
64. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: A direct role for Stat5 in BcI-X(L) induction
65. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth in vitro
66. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
67. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
68. Stat3 activation is required for cellular transformation by v-src
69. Stat3 activation by Src induces specific gene regulation and is required for cell transformation
70. Stat3 as an Oncogene
71. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
72. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6
73. Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells
74. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
75. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell- specific Stat3-deficient mice
76. Keratinocyte-specific ablation of stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
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79. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and -independent pathways
80. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of STAT3
81. A matter of life and cell death
82. Traps to catch unwary oncogenes
83. Epidermal growth factor-induced growth inhibition requires Stat1 activation