New insights into growth hormone action

Journal of Molecular Endocrinology

Volumn 36, Issue 1, 2006, Pages 1-7

  Waters, M J ^a   Hoang, H N ^a   Fairlie, D P ^a   Pelekanos, R A ^a   Brown, R J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; JANUS KINASE 2; SOMATOMEDIN C; STAT5A PROTEIN; STAT5B PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; GENE IDENTIFICATION; HOMOZYGOSITY; HORMONE RECEPTOR INTERACTION; MOLECULAR CLONING; MOLECULAR MECHANICS; MOUSE; NONHUMAN; ONTOGENY; PHENOTYPE; POSTNATAL GROWTH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; GROWTH HORMONE; HUMANS; JANUS KINASE 2; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR;

EID: 33244480332     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01933     Document Type: Review

References (21)

1. Bernat B, Pal G, Sun M & Kossiakoff AA 2003 Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. PNAS 100 952-957.
2. Brown RJ, Adams JJ, Pelekanos RA, Wan Y, McKinstry WJ, Palethorpe K, Seeber RM, Monks TA, Eidne KA, Parker MW & Waters MJ 2005 A model for GH receptor activation based on subunit rotation within a receptor dimer. Nature Structural & Molecular Biology 12 814-821.
3. Chen C-M, Brinkworth R & Waters MJ 1997 The role of receptor dimerization domain residues in GH signalling. Journal of Biological Chemistry 272 5133-5140.
4. deVos AM, Ultsch M & Kossiakoff AA 1992 Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255 306-312.
5. Fuh G, Cunningham BC, Fukunaga S, Nagata S, Goeddel DV & Wells JA 1992 Rational design of potent antagonists to the human growth hormone receptor. Science 256 1677-1680.
6. Gent J, van Kerkhof P, Roza M, Bu G & Strous GJ 2002 Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis. PNAS 99 9858-9863.
7. Harding PA, Wang X, Okada S, Chen WY, Wan W & Kopchick JJ 1996 Growth hormone (GH) and a GH antagonist promote GH receptor dimerization and internalization. Journal of Biological Chemistry 271 6708-6712.
8. Jiang J, Wang X, He K, Li X, Chen C-M, Sayeski PP, Waters MJ & Frank SJ 2004 A conformationally sensitive GHR antibody; impact on GH signalling and proteolysis. Molecular Endocrinology 18 2981-2996.
9. Kofoed EM, Hwa V, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A et al. 2003 Growth hormone insensitivity associated with a STAT5b mutation. New England Journal of Medicine 349 1139-1147.
10. Kubatzky KF, Ruan W, Gurezka R, Cohen J, Ketteler R, Watowich SS, Neumann D, Langosch D & Klingmuller U 2001 Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor. Current Biology 11 110-115.
11. Pearce KH Jr, Cunningham BC, Fuh G, Teeri T & Wells JA 1999 GH binding affinity for its receptor surpasses the requirements for cellular activity. Biochemistry 38 81-89
12. Rowland JE, Lichanska AM, Kerr LM, White M, D'Aniello EM, Maher SL, Brown RJ, Teasdale R, Noakes PG & Waters MJ 2005 In vivo analysis of growth hormone receptor signalling domains and their associated transcripts. Molecular Cell Biology 25 66-77.
13. Rowlinson SW, Behncken SN, Rowland JE, Clarkson RW, Strasburger CJ, Wu Z, Baumbach W & Waters MJ 1998 Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling. Journal of Biological Chemistry 273 5307-5314.
14. Schneider H, Chaovapong W, Matthews DJ, Karkaria C, Cass RT, Zhan H, Boyle M, Lorenzini T, Elliott SG & Giebel LB 1997 Homodimerization of erythropoietin receptor by a bivalent monoclonal antibody triggers cell proliferation and differentiation of erythroid precursors. Blood 89 473-482.
15. Seubert N, Royer Y, Staerk J, Kubatzky KF, Moucadel V, Krishnakumar S, Smith SO & Constantinescu SN 2003 Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Molecular Cell 12 1239-1250.
16. van Kerkhof P, Smeets M & Strous GJ 2002 The ubiquitin-proteasome pathway regulates the availability of the GH receptor. Endocrinology 143 1243-1252.
17. Wan Y, Zheng YZ, Harris JM, Brown R & Waters MJ 2003 Epitope map for a GH receptor agonist monoclonal antibody, MAb 263. Molecular Endocrinology 17 2240-2250.
18. Wan Y, McDevitt A, Shen B, Smythe ML & Waters MJ 2004 Increased Site 1 affinity improves biopotency of porcine growth hormone: evidence against diffusion dependent receptor dimerization. Journal of Biological Chemistry 279 44775-44784.
19. Woelfe J, Chia DJ & Rotwein P 2003a Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation. Journal of Biological Chemistry 278 51261-51266.
20. Woelfe J, Billiard J & Rotwein P 2003b Acute control of IGF-I gene transcription by growth hormone through Stat5b. Journal of Biological Chemistry 278 22696-22702.
21. Zhou Y, Xu BC, Maheshwari HG, He L, Reed M, Lozykowski M, Okada S, Cataldo L, Coschigamo K, Wagner TE et al. 1997 A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). PNAS 94 13215-13220.