Calorie restriction in primates: Will it work and how will we know?

Journal of the American Geriatrics Society

Volumn 47, Issue 7, 1999, Pages 896-903

  Roth, George S ^a   Ingram, Donald K ^a   Lane, Mark A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Caloric restriction; Humans; Primates

Indexed keywords

ABSORPTIOMETRY; AGED; AGING; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; LIFESPAN; LONGEVITY; MALE; NONHUMAN; PRIMATE;

EID: 0032766181     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.1999.tb03851.x     Document Type: Article

References (40)

1. Weindruch R, Walford RL. The Retardation of Aging and Disease by Dietary Restriction. Springfield, Ill: Thomas, 1998.
2. McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutrition 1935;10:63-79.
3. McCay CM, Sperling G, Barnes LL. Growth, aging, chronic diseases and life span in rats. Arch Biochem 1943;2:469-479.
4. Ingram DK, Cutler RG, Weindruch R et al. Dietary restriction and aging: The initiation of a primate study. J Gerontol 1990;45:B148-163.
5. Kemnitz JW, Weindruch R, Roecket EB et al. Dietary restriction of adult rhesus monkeys: Design, methodology and preliminary findings from the first year of the study. J Gerontol 1993;48:B17-26.
6. Bodkin NL, Ortmeyer HK, Hansen BC. Long-term dietary restriction in older-aged rhesus monkeys: Effects on insulin resistance. J Gerontol Biol Sci 1995;50A:B142-147.
7. Cefalu WT, Wagner JD, Wang ZQ et al. A study of caloric restriction in cynomolgus monkeys. (Macaca fascicularis): A potential model for aging research. J Gerontol Biol Sci 1997;52A:B10-19.
8. Lane MA, Ingram DK, Roth GS. Beyond the rodent model: Caloric restriction in rhesus monkeys. Age 1997;45-56.
9. Kemnitz JW, Roecker EB, Weindruch R et al. Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol 1994;266:E540-547.
10. Lane MA, Ball SS, Ingram DK et al. Diet restriction in rhesrfs monkeys lowers fasting and glucose-stimulated glucose regulatory end points. Am J Physiol 1995;268 E941-948.
11. Verdery RB, Ingram DK, Roth GS, Lane ML. Caloric restriction increases HDLjt levels in rhesus monkeys (macaca mulatto), a mechanism for extending lifespan by preventing atherosclerosis. Am J Physiol 1997;36:E714-719.
12. Adelman RC. Biomarkers of aging. Exp Gerontol 1987;22:227-229.
13. Baker GT, Sprott RL. Biomarker of aging. Exp Gerontol 1988;23:223-239.
14. Masoro EJ. Physiological system markers of aging. Exp Gerontol 1988;23:391-394.
15. Ingram DK. Is aging measurable. In: Ludwig FC, ed. Life Span Extension. New York: Springer, 1991, pp 18-42.
16. Balin, AK. Handbook of Human Biologic Age Determination. Boca Raton, FL: CRC Press, 1994.
17. Nakamara E, Lane MA, Roth GS et al. Evaluating measures of hematology and blood chemistry in male rhesus monkeys as biomarkers of aging. Exp Gerontol 1994;29:151-177.
18. Nakamua E, Lane MA, Roth GS, Ingram DK. A strategy for identifying biomarkers of aging: Further evaluation of hematology and blood chemistry data from a calorie restriction study in rhesus monkeys. Exp Gerontol 1998;33:421-443.
19. Ingram DK. Cross-sectional, longitudinal and sequential studies in gerontology. In: Yu BP, ed. Methods in Aging Research. Boca Raton, FL: CRC Press, 1998, pp. 25-42.
20. Costa PT, McCrae RR. Functional age: A conceptual and empirical critique. In: Hayes SB, Feinleib M, eds. Epidemiology of Aging. Washington DC: US Government Printing Office, 1980, pp 23-48. (NIH Publ No 80969).
21. Vallejo EA. La dieta de hombre a dias alternes in la alimentacion de los viejos. Rev Clin Exp 1957;63:25-49.
22. Maislos M, Abow-Rabiah Y, Zuili I et al. Gorging and plasma HDLcholesterol -The Ramadan model. Eur J Clin Nutr 1998;52:127-130.
23. Kagawa Y. Impact of westernization on the nutrients of Japanese: Changes in physique, cancer, longevity and centenarians. Prev Med 1978;7:205-227.
24. Walford RL, Harris SB, Gunion MW. The calorically restricted low-fat nutrient dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol and blood pressure in humans. Proc Natl Acad Sci USA 1992;98:11533-11537.
25. Velthuis TE, Wierik EJM, Van der Berg H et al. Energy restriction, a useful intervention to retard human aging? Results of a feasibility study. Eur J Clin Nutr 1994;48:138-H8.
26. Lane MA, Baer DJ, Rumpler WJ et al. Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci USA 1996;93:4159-4164.
27. Verdery RB, Walford RL. Changes in plasma lipids and lipoproteins in humans during a two year period of dietary restriction in Biosphere 2. Arch Intern Med, in press.
28. Weindruch R, Lane MA, Ingram DK et al. Dietary restriction of rhesus monkeys: Lymphopenia and reduced mitogen-induced proliferation in peripheral blood mononuclear cells. Aging Clin Exp Res 1997;9:304-308.
29. Roecker EB, Kemnitz JW, Ershler WB, Weindruch R. Reduced immune responses in rhesus monkeys subjected to dietary restriction. J Gerontol Biol Sci 1996;51A:B276-279.
30. Keys A, Brozek J, Henschel A et al. Cancer and Other Neoplasms. The Biology of Human Starvation, Vols 1 and 2. Minneapolis, MN: University of Minnesota Press, 1950.
31. Haas BS, Lewis SM, Duffy PH et al. Dietary restriction in humans: Report on the Linie Rock Conference on the value, feasibility and parameters of a proposed study. Mech Aging Dev 1996;91:79-94.
32. Widdowson EM. Physiological processes of aging: Are there special nutritional requirements for elderly people? Do McCay's findings apply to humans? Am J Clin Nutr 1992;55:1246-1249s.
33. Lane MA, Ingram DK, Ball SS, Roth GS. Dehydroepiandrosterone sulfate: A biomarker of primate aging slowed by caloric restriction. J Clin Endocrinol Metab 1997;82:2093-2096.
34. Orentreich N, Brind JL, Rizer RL, Vogelman JH. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentration throughout adulthood. J Clin Endocrinol Metab 1989;59:551-555.
35. Small M, Gray CE, Beastall GH, MacCuisl AC. Adrenal androgens and insulin-dependent diabetes mellitus. Diabetes Res 1989;11:93-95.
36. Zumoff B, Levin J, Rosenfeld RC et al. Abnormal 24 hr mean plasma concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulfate in women with primary operable breast cancer. Cancer Res 1986;41:3360-3363.
37. Barret-Connor E, Khaw K, Yen S. A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease. N Engl J Med 1986;315:1519-1524.
38. Yen SSC, Morales J, Khorram O. Replacement of DHEA in aging men and women. Ann N Y Acad Sci 1995;774:128-142.
39. Yen S, Allan J, Acton J, Greenberg M. Prevention of obesity in Avy/a mice by dehydroepiandrosterone. Lipids 1977;12:409-413.
40. Ben-David M, Dikstein S, Bismuth G, Sulman F, Antihypercholesterolemic effect of dehydroepiandrosterone in rats. Proc Soc Exp Biol Med 1967;125:1136-1142.