Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

Journal of Biological Chemistry

Volumn 280, Issue 22, 2005, Pages 20978-20986

  Honda, Kazuhiro ^a   Smithi, Mark A ^a   Zhu, Xiongwei ^a   Baus, Diane ^a   Merrick, William C ^a   Tartakoff, Alan M ^a   Hattier, Thomas ^a   Harris, Peggy L ^a   Siedlak, Sandra L ^a   Fujioka, Hisashi ^a   Liu, Quan ^a   Moreira, Paula I ^a,b   Miller, Frank P ^a   Nunomura, Akihiko ^c   Shimohama, Shun ^d   Perry, George ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CYTOLOGY; DISEASES; IRON COMPOUNDS; OXIDATION; PATHOLOGY; PHYSIOLOGY; REACTION KINETICS;

ALZHEIMER'S DISEASES; CYTOPLASMIC RNA; PATHOPHYSIOLOGY; RETICULUM;

RNA;

8 HYDROXYGUANOSINE; GUANOSINE DERIVATIVE; IRON; MESSENGER RNA; RIBOSOME RNA; TRANSFER RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FENTON REACTION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DENATURATION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; RNA BINDING; TRANSLATION REGULATION;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; BLOTTING, NORTHERN; BRAIN; CATTLE; CYTOPLASM; GUANOSINE; HIPPOCAMPUS; HUMANS; HYDROGEN PEROXIDE; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOPRECIPITATION; IRON; MICROSCOPY, ELECTRON; NEURONS; OXIDATION-REDUCTION; OXYGEN; PROTEIN BIOSYNTHESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASES; RIBOSOMES; RNA; RNA, RIBOSOMAL; RNA, TRANSFER;

ORYCTOLAGUS CUNICULUS;

EID: 20444383489     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500526200     Document Type: Article

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