Interactions of the aryl hydrocarbon receptor with inflammatory mediators: Beyond CYP1A regulation

Current Drug Metabolism

Volumn 12, Issue 2, 2011, Pages 89-103

  Vondráček, Jan ^a,b   Umannová, Lenka ^a,b   Machala, Miroslav ^b  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b VETERINARY RESEARCH INSTITUTE   (Czech Republic)

Author keywords

AhR; Antiinflammatory drugs; CYP1A1 1A2; CYP1B1; Eicosanoids; Innate immune response; Proinflammatory cytokines

Indexed keywords

ANTIINFLAMMATORY AGENT; AROMATIC HYDROCARBON RECEPTOR; CHEMOKINE; CYCLOOXYGENASE 2; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEFLUNOMIDE; SGA 360; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VAF 347; WAY 169916;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARCINOGENESIS; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; XENOBIOTIC METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARYL HYDROCARBON HYDROXYLASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; XENOBIOTICS;

EID: 79952799854     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920011795016827     Document Type: Article

References (213)

1. McIntosh, B. E.; Hogenesch, J. B.; Bradfield, C. A., Mammalian Per-Arnt-Sim proteins in environmental adaptation. Annu. Rev. Physiol., 2010, 72, 625-645.
2. Denison, M. S.; Nagy, S. R., Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxico.l, 2003, 43, 309-334. (Pubitemid 37372644)
3. Kazlauskas, A.; Poellinger, L.; Pongratz, I., Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90. J. Biol. Chem., 2002, 277(14), 11795-11801. (Pubitemid 34959963)
4. Meyer, B. K.; Pray-Grant, M. G.; Vanden Heuvel, J. P.; Perdew, G. H., Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol. Cell Biol., 1998, 18(2), 978-988. (Pubitemid 28063432)
5. Wilhelmsson, A.; Cuthill, S.; Denis, M.; Wikström, A. C.; Gustafsson, J. A.; Poellinger, L., The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein. Embo. J., 1990, 9(1), 69-76.
6. Nebert, D. W.; Dalton, T. P., The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat. Rev. Cancer., 2006, 6(12), 947-960. (Pubitemid 44862679)
7. Nebert, D. W.; Roe, A. L.; Dieter, M. Z.; Solis, W. A.; Yang, Y.; Dalton, T. P., Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem. Pharmacol., 2000, 59(1), 65-85.
8. Xu, C.; Li, C. Y.; Kong, A. N., Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res., 2005, 28(3), 249-268. (Pubitemid 44698742)
9. Dietrich, C.; Kaina, B., The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth. Carcinogenesis, 2010, 31(8), 1319-1328.
10. Haarmann-Stemmann, T.; Bothe, H.; Abel, J., Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochem. Pharmacol., 2009, 77(4), 508-520.
11. Hahn, M. E.; Allan, L. L.; Sherr, D. H., Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor. Biochem. Pharmacol., 2009, 77(4), 485-497.
12. Hirabayashi, Y.; Inoue, T., Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells. Biochem. Pharmacol., 2009, 77(4), 521-535.
13. Ikuta, T.; Namiki, T.; Fujii-Kuriyama, Y.; Kawajiri, K., AhR protein trafficking and function in the skin. Biochem. Pharmacol., 2009, 77(4), 588-596.
14. Kerkvliet, N. I., AHR-mediated immunomodulation: The role of altered gene transcription. Biochem. Pharmacol., 2009, 77(4), 746-760.
15. Kung, T.; Murphy, K. A.; White, L. A., The aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism. Biochem. Pharmacol., 2009, 77(4), 536-546.
16. Matsumura, F.; Puga, A.; Tohyama, C., Biological functions of the arylhydrocarbon receptor: Beyond induction of cytochrome P450s. Introduction to this special issue. Biochem. Pharmacol., 2009, 77(4), 473.
17. Puga, A.; Ma, C.; Marlowe, J. L., The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem. Pharmacol., 2009, 77(4), 713-722.
18. Ray, S.; Swanson, H. I., Activation of the aryl hydrocarbon receptor by TCDD inhibits senescence: A tumor promoting event? Biochem. Pharmacol., 2009, 77(4), 681-688.
19. Singh, K. P.; Casado, F. L.; Opanashuk, L. A.; Gasiewicz, T. A., The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations. Biochem. Pharmacol., 2009, 77(4), 577-587.
20. Henklová, P.; Vrzal, R.; Ulrichová, J.; Dvořák, Z., Role of mitogen- activated protein kinases in aryl hydrocarbon receptor signaling. Chem. Biol. Interact., 2008, 172(2), 93-104.
21. Beischlag, T. V.; Perdew, G. H., ER alpha-AHR-ARNT proteinprotein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. J. Biol. Chem., 2005, 280(22), 21607-21611. (Pubitemid 40805729)
22. Ohtake, F.; Baba, A.; Takada, I.; Okada, M.; Iwasaki, K.; Miki, H.; Takahashi, S.; Kouzmenko, A.; Nohara, K.; Chiba, T.; Fujii- Kuriyama, Y.; Kato, S., Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature, 2007, 446(7135), 562-566. (Pubitemid 46514731)
23. Safe, S.; Wormke, M., Inhibitory aryl hydrocarbon receptorestrogen receptor alpha cross-talk and mechanisms of action. Chem. Res. Toxicol., 2003, 16(7), 807-816. (Pubitemid 36898994)
24. Ke, S.; Rabson, A. B.; Germino, J. F.; Gallo, M. A.; Tian, Y., Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. J. Biol. Chem., 2001, 276(43), 39638-39644.
25. Kim, D. W.; Gazourian, L.; Quadri, S. A.; Romieu-Mourez, R.; Sherr, D. H.; Sonenshein, G. E., The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells. Oncogene, 2000, 19(48), 5498-5506. (Pubitemid 32000917)
26. Ruby, C. E.; Leid, M.; Kerkvliet, N. I., 2,3,7,8-Tetrachlorodibenzop- dioxin suppresses tumor necrosis factor-alpha and anti-CD40- induced activation of NF-kappaB/Rel in dendritic cells: P50 homodimer activation is not affected. Mol. Pharmacol., 2002, 62(3), 722-728. (Pubitemid 36329392)
27. Singh, N. P.; Nagarkatti, M.; Nagarkatti, P. S., Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8- tetrachlorodibenzo-p- dioxin-mediated regulation of Fas and Fas ligand expression. Mol. Pharmacol., 2007, 71(1), 145-157. (Pubitemid 46020984)
28. Tian, Y., Ah receptor and NF-kappaB interplay on the stage of epigenome. Biochem. Pharmacol., 2009, 77(4), 670-680.
29. Vogel, C. F.; Matsumura, F., A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-kappaB family. Biochem. Pharmacol., 2009, 77(4), 734-745.
30. Vogel, C. F.; Sciullo, E.; Matsumura, F., Involvement of RelB in aryl hydrocarbon receptor-mediated induction of chemokines. Biochem. Biophys. Res. Commun., 2007, 363(3), 722-726. (Pubitemid 47513689)
31. Hoffer, A.; Chang, C. Y.; Puga, A., Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. Toxicol. Appl. Pharmacol., 1996, 141(1), 238-247. (Pubitemid 26414370)
32. Weiss, C.; Faust, D.; Durk, H.; Kolluri, S. K.; Pelzer, A.; Schneider, S.; Dietrich, C.; Oesch, F.; Gottlicher, M., TCDD induces cjun expression via a novel Ah (dioxin) receptor-mediated p38- MAPK-dependent pathway. Oncogene, 2005, 24(31), 4975-4983. (Pubitemid 41129101)
33. Weiss, C.; Faust, D.; Schreck, I.; Ruff, A.; Farwerck, T.; Melenberg, A.; Schneider, S.; Oesch-Bartlomowicz, B.; Zatloukalová, J.; Vondrářek, J.; Oesch, F.; Dietrich, C., TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Oncogene, 2008, 27(15), 2198-2207. (Pubitemid 351483381)
34. Lim, E. J.; Májková, Z.; Xu, S.; Bachas, L.; Arzuaga, X.; Smart, E.; Tseng, M. T.; Toborek, M.; Hennig, B., Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Chem. Biol. Interact., 2008, 176(2-3), 71-78.
35. Májková, Z.; Toborek, M.; Hennig, B., The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants. J. Cell Mol. Med., 2010, 14(10), 2359-2370.
36. Oesterling, E.; Toborek, M.; Hennig, B., Benzo [a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway. Toxicol. Appl. Pharmacol., 2008, 232(2), 309-316.
37. Aitken, A. E.; Richardson, T. A.; Morgan, E. T., Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu. Rev. Pharmacol. Toxicol., 2006, 46, 123-149. (Pubitemid 43271186)
38. Morgan, E. T., Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics. Clin. Pharmacol. Ther., 2009, 85(4), 434-438.
39. Renton, K. W., Cytochrome P450 regulation and drug biotransformation during inflammation and infection. Curr. Drug Metab., 2004, 5(3), 235-243. (Pubitemid 38735778)
40. Nebert, D. W.; Dalton, T. P.; Okey, A. B.; Gonzalez, F. J., Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J. Biol. Chem., 2004, 279(23), 23847-23850. (Pubitemid 38725238)
41. Cribb, A. E.; Knight, M. J.; Dryer, D.; Guernsey, J.; Hender, K.; Tesch, M.; Saleh, T. M., Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol. Biomarkers Prev., 2006, 15(3), 551-558.
42. Subramanian, A.; Salhab, M.; Mokbel, K., Oestrogen producing enzymes and mammary carcinogenesis: A review. Breast Cancer Res. Treat, 2008, 111(2), 191-202.
43. Nebert, D. W.; Karp, C. L., Endogenous functions of the aryl hydrocarbon receptor (AHR): Intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology. J. Biol. Chem., 2008, 283(52), 36061-36065.
44. Rifkind, A. B., CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates. Drug Metab. Rev., 2006, 38(1-2), 291-335. (Pubitemid 43739012)
45. Bleau, A. M.; Levitchi, M. C.; Maurice, H.; du Souich, P., Cytochrome P450 inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: The role of cytokines. Br. J. Pharmacol., 2000, 130(8), 1777-1784. (Pubitemid 30657504)
46. Bleau, A. M.; Maurel, P.; Pichette, V.; Leblond, F.; du Souich, P., Interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes. Eur. J. Pharmacol., 2003, 473(2-3), 197-206. (Pubitemid 36929885)
47. Richardson, T. A.; Morgan, E. T., Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice. J. Pharmacol. Exp. Ther., 2005, 314(2), 703-709. (Pubitemid 41043852)
48. Siewert, E.; Bort, R.; Kluge, R.; Heinrich, P. C.; Castell, J.; Jover, R., Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent. Hepatology, 2000, 32(1), 49-55. (Pubitemid 30432365)
49. De-Oliveira, A. C.; Da-Matta, A. C.; Paumgartten, F. J., Plasmodium berghei (ANKA): Infection induces CYP2A5 and 2E1 while depressing other CYP isoforms in the mouse liver. Exp. Parasitol., 2006, 113(4), 256-261. (Pubitemid 44061790)
50. Higuchi, S.; Wu, R.; Zhou, M.; Ravikumar, T. S.; Wang, P., Downregulation of hepatic cytochrome P-450 isoforms and PPARgamma: Their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis. J. Surg. Res., 2007, 137(1), 46-52. (Pubitemid 44879422)
51. Masubuchi, Y.; Horie, T., Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis. Drug Metab. Dispos., 2004, 32(4), 437-441. (Pubitemid 38420278)
52. Richardson, T. A.; Sherman, M.; Antonovic, L.; Kardar, S. S.; Strobel, H. W.; Kalman, D.; Morgan, E. T., Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice. Drug Metab. Dispos., 2006, 34(3), 354-360. (Pubitemid 43290892)
53. Bleau, A. M.; Fradette, C.; El-Kadi, A. O.; Cote, M. C.; du Souich, P., Cytochrome P450 down-regulation by serum from humans with a viral infection and from rabbits with an inflammatory reaction. Drug Metab. Dispos., 2001, 29(7), 1007-1012. (Pubitemid 32605916)
54. Giannini, E.; Fasoli, A.; Botta, F.; Romagnoli, P.; Malfatti, F.; Chiarbonello, B.; Mamone, M.; Savarino, V.; Testa, R., Helicobacter pylori infection is associated with greater impairment of cytochrome P-450 liver metabolic activity in anti-HCV positive cirrhotic patients. Dig. Dis. Sci., 2003, 48(4), 802-8. (Pubitemid 36390688)
55. Fisher, C. D.; Lickteig, A. J.; Augustine, L. M.; Ranger-Moore, J.; Jackson, J. P.; Ferguson, S. S.; Cherrington, N. J., Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab. Dispos., 2009, 37(10), 2087-2094.
56. Morgan, E. T., Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev., 1997, 29(4), 1129-1188. (Pubitemid 28133460)
57. El-Kadi, A. O.; Bleau, A. M.; Dumont, I.; Maurice, H.; du Souich, P., Role of reactive oxygen intermediates in the decrease of hepatic cytochrome P450 activity by serum of humans and rabbits with an acute inflammatory reaction. Drug Metab. Dispos., 2000, 28(9), 1112-1120. (Pubitemid 30660368)
58. Barouki, R.; Morel, Y., Repression of cytochrome P450 1A1 gene expression by oxidative stress: Mechanisms and biological implications. Biochem. Pharmacol., 2001, 61(5), 511-6. (Pubitemid 32178484)
59. Levitchi, M.; Fradette, C.; Bleau, A. M.; Michaud, D.; Kourylko, O.; Arcand, M.; du Souich, P., Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction. Biochem. Pharmacol., 2004, 68(3), 573-582. (Pubitemid 38887439)
60. Tian, Y.; Rabson, A. B.; Gallo, M. A., Ah receptor and NF-kappaB interactions: Mechanisms and physiological implications. Chem. Biol. Interact., 2002, 141(1-2), 97-115. (Pubitemid 35223207)
61. Sen, R.; Baltimore, D., Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell, 1986, 47(6), 921-928. (Pubitemid 17005065)
62. Gilmore, T. D., Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene, 2006, 25(51), 6680-6684. (Pubitemid 44657845)
63. Pahl, H. L., Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene, 1999, 18(49), 6853-6866.
64. Tian, Y.; Ke, S.; Chen, M.; Sheng, T., Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter. J. Biol. Chem., 2003, 278(45), 44041-44048. (Pubitemid 37377144)
65. Tian, Y.; Ke, S.; Denison, M. S.; Rabson, A. B.; Gallo, M. A., Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. J. Biol. Chem., 1999, 274(1), 510-515. (Pubitemid 29035090)
66. Hollingshead, B. D.; Beischlag, T. V.; Dinatale, B. C.; Ramadoss, P.; Perdew, G. H., Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Res., 2008, 68(10), 3609-3617.
67. Umannová, L.; Zatloukalová, J.; Machala, M.; Krčmář, P.; Májková, Z.; Hennig, B.; Kozubík, A.; Vondrářek, J., Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells. Toxicol. Sci., 2007, 99(1), 79-89. (Pubitemid 47250369)
68. Sutter, T. R.; Tang, Y. M.; Hayes, C. L.; Wo, Y. Y.; Jabs, E. W.; Li, X.; Yin, H.; Cody, C. W.; Greenlee, W. F., Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J. Biol. Chem., 1994, 269(18), 13092-13099. (Pubitemid 24206069)
69. Kim, J. H.; Stansbury, K. H.; Walker, N. J.; Trush, M. A.; Strickland, P. T.; Sutter, T. R., Metabolism of benzo [a]pyrene and benzo [a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis, 1998, 19(10), 1847-1853. (Pubitemid 28474651)
70. Shimada, T.; Gillam, E. M.; Oda, Y.; Tsumura, F.; Sutter, T. R.; Guengerich, F. P.; Inoue, K., Metabolism of benzo [a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo [a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Chem. Res. Toxicol., 1999, 12(7), 623-629. (Pubitemid 29354745)
71. Wen, X.; Walle, T., Cytochrome P450 1B1, a novel chemopreventive target for benzo [a]pyrene-initiated human esophageal cancer. Cancer Lett., 2007, 246(1-2), 109-14. (Pubitemid 44959380)
72. Murray, G. I.; Melvin, W. T.; Greenlee, W. F.; Burke, M. D., Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1. Annu. Rev. Pharmacol. Toxicol., 2001, 41, 297-316. (Pubitemid 32390115)
73. McFadyen, M. C.; Cruickshank, M. E.; Miller, I. D.; McLeod, H. L.; Melvin, W. T.; Haites, N. E.; Parkin, D.; Murray, G. I., Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Br. J. Cancer, 2001, 85(2), 242-246. (Pubitemid 32695746)
74. Murray, G. I.; Taylor, M. C.; McFadyen, M. C.; McKay, J. A.; Greenlee, W. F.; Burke, M. D.; Melvin, W. T., Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res., 1997, 57(14), 3026-3031. (Pubitemid 27315056)
75. Muskhelishvili, L.; Thompson, P. A.; Kusewitt, D. F.; Wang, C.; Kadlubar, F. F., In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues. J. Histochem. Cytochem., 2001, 49(2), 229-236. (Pubitemid 32113385)
76. Carnell, D. M.; Smith, R. E.; Daley, F. M.; Barber, P. R.; Hoskin, P. J.; Wilson, G. D.; Murray, G. I.; Everett, S. A., Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue. Int. J. Radiat. Oncol. Biol. Phys., 2004, 58(2), 500-509. (Pubitemid 38142477)
77. Bhattacharyya, K. K.; Brake, P. B.; Eltom, S. E.; Otto, S. A.; Jefcoate, C. R., Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. J. Biol. Chem., 1995, 270(19), 11595-11602.
78. Shimada, T.; Sugie, A.; Shindo, M.; Nakajima, T.; Azuma, E.; Hashimoto, M.; Inoue, K., Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. Toxicol. Appl. Pharmacol., 2003, 187(1), 1-10. (Pubitemid 36293561)
79. Shimada, T.; Hayes, C. L.; Yamazaki, H.; Amin, S.; Hecht, S. S.; Guengerich, F. P.; Sutter, T. R., Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res., 1996, 56(13), 2979-2984. (Pubitemid 26199741)
80. Hakkola, J.; Pasanen, M.; Pelkonen, O.; Hukkanen, J.; Evisalmi, S.; Anttila, S.; Rane, A.; Mantyla, M.; Purkunen, R.; Saarikoski, S.; Tooming, M.; Raunio, H., Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells. Carcinogenesis, 1997, 18(2), 391-397. (Pubitemid 28132434)
81. Doshi, M.; Marcus, C.; Bejjani, B. A.; Edward, D. P., Immunolocalization of CYP1B1 in normal, human, fetal and adult eyes. Exp. Eye Res., 2006, 82(1), 24-32. (Pubitemid 43063394)
82. Choudhary, D.; Jansson, I.; Rezaul, K.; Han, D. K.; Sarfarazi, M.; Schenkman, J. B., Cyp1b1 protein in the mouse eye during development: An immunohistochemical study. Drug Metab. Dispos., 2007, 35(6), 987-994. (Pubitemid 46798609)
83. Sarfarazi, M.; Stoilov, I., Molecular genetics of primary congenital glaucoma. Eye (Lond)., 2000, 14 ( Pt 3B), 422-428. (Pubitemid 30479743)
84. Sissung, T. M.; Price, D. K.; Sparreboom, A.; Figg, W. D., Pharmacogenetics and regulation of human cytochrome P450 1B1: Implications in hormone-mediated tumor metabolism and a novel target for therapeutic intervention. Mol. Cancer Res., 2006, 4(3), 135-150.
85. Brake, P. B.; Jefcoate, C. R., Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'- monophosphate and 2,3,7,8- tetrachlorodibenzo-p-dioxin. Endocrinology, 1995, 136(11), 5034-5041.
86. Zheng, W.; Jefcoate, C. R., Steroidogenic factor-1 interacts with cAMP response element-binding protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer. Mol. Pharmacol., 2005, 67(2), 499-512. (Pubitemid 40216743)
87. Wo, Y. Y.; Stewart, J.; Greenlee, W. F., Functional analysis of the promoter for the human CYP1B1 gene. J. Biol. Chem, 1997, 272(42), 26702-26707. (Pubitemid 27458896)
88. Zhang, L.; Savas, U.; Alexander, D. L.; Jefcoate, C. R., Characterization of the mouse Cyp1B1 gene. Identification of an enhancer region that directs aryl hydrocarbon receptor-mediated constitutive and induced expression. J. Biol. Chem., 1998, 273(9), 5174-5183. (Pubitemid 28108679)
89. Tsuchiya, Y.; Nakajima, M.; Kyo, S.; Kanaya, T.; Inoue, M.; Yokoi, T., Human CYP1B1 is regulated by estradiol via estrogen receptor. Cancer Res., 2004, 64(9), 3119-3125. (Pubitemid 38581412)
90. Cavalieri, E.; Frenkel, K.; Liehr, J. G.; Rogan, E.; Roy, D., Estrogens as endogenous genotoxic agents-DNA adducts and mutations. J. Natl. Cancer Inst. Monogr., 2000, (27), 75-93.
91. Hayes, C. L.; Spink, D. C.; Spink, B. C.; Cao, J. Q.; Walker, N. J.; Sutter, T. R., 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl. Acad. Sci. U S A, 1996, 93(18), 9776-9781. (Pubitemid 26296685)
92. Crewe, H. K.; Notley, L. M.; Wunsch, R. M.; Lennard, M. S.; Gillam, E. M., Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4- hydroxytamoxifen. Drug Metab. Dispos., 2002, 30(8), 869-874. (Pubitemid 34815415)
93. Piscaglia, F.; Knittel, T.; Kobold, D.; Barnikol-Watanabe, S.; Di Rocco, P.; Ramadori, G., Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokines. Biochem. Pharmacol., 1999, 58(1), 157-165. (Pubitemid 29246084)
94. Malaplate-Armand, C.; Ferrari, L.; Masson, C.; Siest, G.; Batt, A. M., Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions: IL-1beta effect and protection by Nacetylcysteine. Toxicol. Lett., 2003, 138(3), 243-251. (Pubitemid 36135927)
95. Umannová, L.; Machala, M.; Topinka, J.; Nováková, Z.; Milcová, A.; Kozubík, A.; Vondrářek, J., Tumor necrosis factor-alpha potentiates genotoxic effects of benzo [a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression. Mutat. Res., 2008, 640(1-2), 162-169.
96. Devlin, A. H.; McIlroy, M.; McKeen, H. D.; Bonde, P.; Menezes, A. A.; Swarbrick, C. J.; Robson, T.; Hirst, D. G.; Campbell, F. C.; McGuigan, J. A.; McKeown, S. R., Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux. Mol. Carcinog., 2009, 48(2), 110-117.
97. Dreij, K.; Rhrissorrakrai, K.; Gunsalus, K. C.; Geacintov, N. E.; Scicchitano, D. A., Benzo [a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Carcinogenesis, 2010, 31(6), 1149-1157.
98. Nel, A. E.; Diaz-Sanchez, D.; Li, N., The role of particulate pollutants in pulmonary inflammation and asthma: Evidence for the involvement of organic chemicals and oxidative stress. Curr. Opin. Pulm. Med., 2001, 7(1), 20-26. (Pubitemid 32003169)
99. Pei, X. H.; Nakanishi, Y.; Inoue, H.; Takayama, K.; Bai, F.; Hara, N., Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line. Cytokine, 2002, 19(5), 236-241. (Pubitemid 35257823)
100. Chen, S. Y.; Wang, L. Y.; Lunn, R. M.; Tsai, W. Y.; Lee, P. H.; Lee, C. S.; Ahsan, H.; Zhang, Y. J.; Chen, C. J.; Santella, R. M., Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls. Int. J. Cancer, 2002, 99(1), 14-21. (Pubitemid 34273192)
101. Wu, H. C.; Wang, Q.; Wang, L. W.; Yang, H. I.; Ahsan, H.; Tsai, W. Y.; Wang, L. Y.; Chen, S. Y.; Chen, C. J.; Santella, R. M., Polycyclic aromatic hydrocarbon- and aflatoxin-albumin adducts, hepatitis B virus infection and hepatocellular carcinoma in Taiwan. Cancer Lett., 2007, 252(1), 104-114. (Pubitemid 46734557)
102. Uno, S.; Dalton, T. P.; Dragin, N.; Curran, C. P.; Derkenne, S.; Miller, M. L.; Shertzer, H. G.; Gonzalez, F. J.; Nebert, D. W., Oral benzo [a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol. Pharmacol., 2006, 69(4), 1103-1114.
103. Penning, T. M.; Burczynski, M. E.; Hung, C. F.; McCoull, K. D.; Palackal, N. T.; Tsuruda, L. S., Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: Generation of reactive and redox active o-quinones. Chem. Res. Toxicol., 1999, 12(1), 1-18. (Pubitemid 29048827)
104. Hreljac, I.; Filipiř, M., Organophosphorus pesticides enhance the genotoxicity of benzo(a)pyrene by modulating its metabolism. Mutat. Res., 2009, 671(1-2), 84-92.
105. Aggarwal, B. B.; Shishodia, S.; Sandur, S. K.; Pandey, M. K.; Sethi, G., Inflammation and cancer: How hot is the link? Biochem. Pharmacol., 2006, 72(11), 1605-1621. (Pubitemid 44666739)
106. Balkwill, F.; Charles, K. A.; Mantovani, A., Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell, 2005, 7(3), 211-217. (Pubitemid 40568680)
107. Balkwill, F.; Mantovani, A., Inflammation and cancer: Back to Virchow? Lancet, 2001, 357(9255), 539-545. (Pubitemid 32173595)
108. Coussens, L. M.; Werb, Z., Inflammation and cancer. Nature, 2002, 420(6917), 860-7. (Pubitemid 36019639)
109. Apte, R. N.; Dotan, S.; Elkabets, M.; White, M. R.; Reich, E.; Carmi, Y.; Song, X.; Dvozkin, T.; Krelin, Y.; Voronov, E., The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev., 2006, 25(3), 387-408. (Pubitemid 44922357)
110. Krelin, Y.; Voronov, E.; Dotan, S.; Elkabets, M.; Reich, E.; Fogel, M.; Huszar, M.; Iwakura, Y.; Segal, S.; Dinarello, C. A.; Apte, R. N., Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors. Cancer Res., 2007, 67(3), 1062-1071.
111. Knaapen, A. M.; Gungor, N.; Schins, R. P.; Borm, P. J.; Van Schooten, F. J., Neutrophils and respiratory tract DNA damage and mutagenesis: A review. Mutagenesis, 2006, 21(4), 225-236. (Pubitemid 44543334)
112. Andrysík, Z.; Vondrářek, J.; Machala, M.; Krčmář, P.; řvihálková- řindlerová, L.; Kranz, A.; Weiss, C.; Faust, D.; Kozubík, A.; Dietrich, C., The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells. Mutat. Res., 2007, 615(1-2), 87-97. (Pubitemid 46054083)
113. Andreou, V.; D'Addario, M.; Zohar, R.; Sukhu, B.; Casper, R. F.; Ellen, R. P.; Tenenbaum, H. C., Inhibition of osteogenesis in vitro by a cigarette smoke-associated hydrocarbon combined with Porphyromonas gingivalis lipopolysaccharide: Reversal by resveratrol. J. Periodontol., 2004, 75(7), 939-48. (Pubitemid 39162102)
114. Celius, T.; Pansoy, A.; Matthews, J.; Okey, A. B.; Henderson, M. C.; Krueger, S. K.; Williams, D. E., Flavin-containing monooxygenase- 3: Induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver. Toxicol. Appl. Pharmacol., 2010, 247(1), 60-9.
115. Celius, T.; Roblin, S.; Harper, P. A.; Matthews, J.; Boutros, P. C.; Pohjanvirta, R.; Okey, A. B., Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab. Dispos., 2008, 36(12), 2499-505.
116. Ryu, S. D.; Yi, H. G.; Cha, Y. N.; Kang, J. H.; Kang, J. S.; Jeon, Y. C.; Park, H. K.; Yu, T. M.; Lee, J. N.; Park, C. S., Flavincontaining monooxygenase activity can be inhibited by nitric oxide- mediated S-nitrosylation. Life Sci., 2004, 75(21), 2559-2572.
117. Zhang, J.; Chaluvadi, M. R.; Reddy, R.; Motika, M. S.; Richardson, T. A.; Cashman, J. R.; Morgan, E. T., Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models. Drug Metab. Dispos., 2009, 37(3), 462-468.
118. Nioi, P.; Hayes, J. D., Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat. Res., 2004, 555(1-2), 149-171. (Pubitemid 39359178)
119. Gharavi, N.; El-Kadi, A. O., Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells. J. Pharm. Sci., 2005, 94(3), 493-506. (Pubitemid 40476515)
120. Gharavi, N.; El-Kadi, A. O., Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide. J. Pharm. Sci., 2007, 96(10), 2795-2807. (Pubitemid 47597828)
121. Richardson, T. A.; Sherman, M.; Kalman, D.; Morgan, E. T., Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney. Drug Metab. Dispos., 2006, 34(3), 351-353. (Pubitemid 43290891)
122. Heurtaux, T.; Benani, A.; Moulin, D.; Muller, N.; Netter, P.; Minn, A., Induction of UGT1A6 isoform by inflammatory conditions in rat astrocytes. Neuropharmacology, 2006, 50(3), 317-328. (Pubitemid 43184360)
123. Monshouwer, M.; Witkamp, R. F.; Nujmeijer, S. M.; Van Amsterdam, J. G.; Van Miert, A. S., Suppression of cytochrome P450- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes. Toxicol. Appl. Pharmacol., 1996, 137(2), 237-244. (Pubitemid 26130141)
124. Davies, E.; Tsang, C. W.; Ghazali, A. R.; Harris, R. M.; Waring, R. H., Effects of culture with TNF-alpha, TGF-beta and insulin on sulphotransferase (SULT 1A1 and 1A3) activity in human colon and neuronal cell lines. Toxicol. In Vitro., 2004, 18(6), 749-754. (Pubitemid 39311885)
125. Morgan, E. T., Regulation of cytochrome p450 by inflammatory mediators: Why and how? Drug. Metab. Dispos., 2001, 29(3), 207-212. (Pubitemid 32179517)
126. Stevens, E. A.; Mezrich, J. D.; Bradfield, C. A., The aryl hydrocarbon receptor: A perspective on potential roles in the immune system. Immunology, 2009, 127(3), 299-311.
127. Esser, C., The immune phenotype of AhR null mouse mutants: Not a simple mirror of xenobiotic receptor over-activation. Biochem. Pharmacol., 2009, 77(4), 597-607.
128. Esser, C.; Rannug, A.; Stockinger, B., The aryl hydrocarbon receptor in immunity. Trends Immunol., 2009, 30(9), 447-454.
129. Pande, K.; Moran, S. M.; Bradfield, C. A., Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines. Mol. Pharmacol., 2005, 67(5), 1393-1398. (Pubitemid 40594137)
130. Clark, G. C.; Taylor, M. J.; Tritscher, A. M.; Lucier, G. W., Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxinmediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus. Toxicol. Appl. Pharmacol., 1991, 111(3), 422-431.
131. Moos, A. B.; Baecher-Steppan, L.; Kerkvliet, N. I., Acute inflammatory response to sheep red blood cells in mice treated with 2,3,7,8- tetrachlorodibenzo-p-dioxin: The role of proinflammatory cytokines, IL-1 and TNF. Toxicol. Appl. Pharmacol., 1994, 127(2), 331-335. (Pubitemid 24263723)
132. Taylor, M. J.; Lucier, G. W.; Mahler, J. F.; Thompson, M.; Lockhart, A. C.; Clark, G. C., Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol. Appl. Pharmacol., 1992, 117(1), 126-32.
133. Shi, L. Z.; Faith, N. G.; Nakayama, Y.; Suresh, M.; Steinberg, H.; Czuprynski, C. J., The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice. J. Immunol., 2007, 179(10), 6952-62.
134. Thatcher, T. H.; Maggirwar, S. B.; Baglole, C. J.; Lakatos, H. F.; Gasiewicz, T. A.; Phipps, R. P.; Sime, P. J., Aryl hydrocarbon receptor- deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am. J. Pathol., 2007, 170(3), 855-64. (Pubitemid 47339355)
135. Sanchez, Y.; Rosado Jde, D.; Vega, L.; Elizondo, G.; Estrada- Muniz, E.; Saavedra, R.; Juarez, I.; Rodriguez-Sosa, M., The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. J. Biomed. Biotechnol., 2010, 2010, 505694.
136. Sekine, H.; Mimura, J.; Oshima, M.; Okawa, H.; Kanno, J.; Igarashi, K.; Gonzalez, F. J.; Ikuta, T.; Kawajiri, K.; Fujii-Kuriyama, Y., Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol. Cell Biol., 2009, 29(24), 6391-6400.
137. Patel, R. D.; Murray, I. A.; Flaveny, C. A.; Kusnadi, A.; Perdew, G. H., Ah receptor represses acute-phase response gene expression without binding to its cognate response element. Lab Invest., 2009, 89(6), 695-707.
138. Arsenescu, R.; Arsenescu, V.; Zhong, J.; Nasser, M.; Melinte, R.; Dingle, R. W.; Swanson, H.; de Villiers, W. J., Role of the xenobiotic receptor in inflammatory bowel disease. Inflamm. Bowel Dis., 2011, n/a. doi: 10.1002/ibd.21463
139. Kimura, A.; Naka, T.; Nakahama, T.; Chinen, I.; Masuda, K.; Nohara, K.; Fujii-Kuriyama, Y.; Kishimoto, T., Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J. Exp. Med., 2009, 206(9), 2027-35.
140. Machado, F. S.; Johndrow, J. E.; Esper, L.; Dias, A.; Bafica, A.; Serhan, C. N.; Aliberti, J., Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat. Med., 2006, 12(3), 330-4. (Pubitemid 43355082)
141. Wajant, H.; Pfizenmaier, K.; Scheurich, P., Tumor necrosis factor signaling. Cell Death Differ., 2003, 10(1), 45-65. (Pubitemid 36511832)
142. Kerkvliet, N. I., Immunological effects of chlorinated dibenzo-pdioxins. Environ. Health Perspect., 1995, 103 Suppl 9, 47-53.
143. Nishiumi, S.; Yoshida, M.; Azuma, T.; Yoshida, K.; Ashida, H., 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs an insulin signaling pathway through the induction of tumor necrosis factor-alpha in adipocytes. Toxicol. Sci., 2010, 115(2), 482-491.
144. Cheon, H.; Woo, Y. S.; Lee, J. Y.; Kim, H. S.; Kim, H. J.; Cho, S.; Won, N. H.; Sohn, J., Signaling pathway for 2,3,7,8- tetrachlorodibenzo-p-dioxin- induced TNF-alpha production in differentiated THP-1 human macrophages. Exp. Mol. Med., 2007, 39(4), 524-534. (Pubitemid 47443867)
145. Vogel, C. F.; Sciullo, E.; Matsumura, F., Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation. Cardiovasc. Toxicol., 2004, 4(4), 363-373. (Pubitemid 39552105)
146. Vogel, C. F.; Sciullo, E.; Wong, P.; Kuzmicky, P.; Kado, N.; Matsumura, F., Induction of proinflammatory cytokines and Creactive protein in human macrophage cell line U937 exposed to air pollution particulates. Environ. Health Perspect., 2005, 113(11), 1536-1541. (Pubitemid 41614908)
147. Lecureur, V.; Ferrec, E. L.; N'Diaye, M.; Vee, M. L.; Gardyn, C.; Gilot, D.; Fardel, O., ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages. FEBS Lett., 2005, 579(9), 1904-1910. (Pubitemid 40404029)
148. Apte, R. N.; Voronov, E., Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy? Immunol. Rev., 2008, 222, 222-241. (Pubitemid 351430377)
149. Sparfel, L.; Pinel-Marie, M. L.; Boize, M.; Koscielny, S.; Desmots, S.; Pery, A.; Fardel, O., Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol. Sci., 2010, 114(2), 247-259.
150. Vogel, C.; Donat, S.; Dohr, O.; Kremer, J.; Esser, C.; Roller, M.; Abel, J., Effect of subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on immune system and target gene responses in mice: Calculation of benchmark doses for CYP1A1 and CYP1A2 related enzyme activities. Arch. Toxicol., 1997, 71(6), 372-382. (Pubitemid 27214470)
151. Yang, J. H., Expression of dioxin-responsive genes in human endometrial cells in culture. Biochem Biophys. Res. Commun., 1999, 257(2), 259-263.
152. Kobayashi, S.; Okamoto, H.; Iwamoto, T.; Toyama, Y.; Tomatsu, T.; Yamanaka, H.; Momohara, S., A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. Rheumatology (Oxford), 2008, 47(9), 1317-1322.
153. Tamaki, A.; Hayashi, H.; Nakajima, H.; Takii, T.; Katagiri, D.; Miyazawa, K.; Hirose, K.; Onozaki, K., Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor. Biol.Pharm. Bull., 2004, 27(3), 407-410. (Pubitemid 41685488)
154. Henley, D. V.; Bellone, C. J.; Williams, D. A.; Ruh, T. S.; Ruh, M. F., Aryl hydrocarbon receptor-mediated posttranscriptional regulation of IL-1beta. Arch. Biochem. Biophys., 2004, 422(1), 42-51. (Pubitemid 38064309)
155. Kietz, S.; Fischer, B., Polychlorinated biphenyls affect gene expression in the rabbit preimplantation embryo. Mol. Reprod. Dev., 2003, 64(3), 251-60. (Pubitemid 36139802)
156. Murray, I. A.; Krishnegowda, G.; DiNatale, B. C.; Flaveny, C.; Chiaro, C.; Lin, J. M.; Sharma, A. K.; Amin, S.; Perdew, G. H., Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem. Res. Toxicol., 2010, 23(5), 955-966.
157. Ettmayer, P.; Mayer, P.; Kalthoff, F.; Neruda, W.; Harrer, N.; Hartmann, G.; Epstein, M. M.; Brinkmann, V.; Heusser, C.; Woisetschlager, M., A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation. Am. J. Respir. Crit. Care Med., 2006, 173(6), 599-606. (Pubitemid 43363800)
158. Lawrence, B. P.; Denison, M. S.; Novak, H.; Vorderstrasse, B. A.; Harrer, N.; Neruda, W.; Reichel, C.; Woisetschlager, M., Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood, 2008, 112(4), 1158-1165.
159. DiNatale, B. C.; Schroeder, J. C.; Francey, L. J.; Kusnadi, A.; Perdew, G. H., Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling. J. Biol. Chem., 2010, 285(32), 24388-24397.
160. Naugler, W. E.; Karin, M., The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med., 2008, 14(3), 109-119.
161. Vogel, C. F.; Nishimura, N.; Sciullo, E.; Wong, P.; Li, W.; Matsumura, F., Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) in mice. Arch. Biochem. Biophys., 2007, 461(2), 169-175. (Pubitemid 46677883)
162. Monteiro, P.; Gilot, D.; Le Ferrec, E.; Rauch, C.; Lagadic- Gossmann, D.; Fardel, O., Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/ calmodulin/CaMKIalpha pathway. Mol. Pharmacol., 2008, 73(3), 769-777. (Pubitemid 351397882)
163. N'Diaye, M.; Le Ferrec, E.; Lagadic-Gossmann, D.; Corre, S.; Gilot, D.; Lecureur, V.; Monteiro, P.; Rauch, C.; Galibert, M. D.; Fardel, O., Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo [a]pyrene. J. Biol. Chem., 2006, 281(29), 19906-19915. (Pubitemid 44065764)
164. Hennig, B.; Meerarani, P.; Slim, R.; Toborek, M.; Daugherty, A.; Silverstone, A. E.; Robertson, L. W., Proinflammatory properties of coplanar PCBs: In vitro and in vivo evidence. Toxicol. Appl. Pharmacol., 2002, 181(3), 174-183. (Pubitemid 34757087)
165. Májková, Z.; Smart, E.; Toborek, M.; Hennig, B., Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicol. Appl. Pharmacol., 2009, 237(1), 1-7.
166. Øvrevik, J.; Arlt, V. M.; Oya, E.; Nagy, E.; Mollerup, S.; Phillips, D. H.; Lag, M.; Holme, J. A., Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells. Toxicol. Appl. Pharmacol., 2010, 242(3), 270-280.
167. Gualtieri, M.; Ovrevik, J.; Holme, J. A.; Perrone, M. G.; Bolzacchini, E.; Schwarze, P. E.; Camatini, M., Differences in cytotoxicity versus pro-inflammatory potency of different PM fractions in human epithelial lung cells. Toxicol. In Vitro., 24(1), 29-39.
168. Øvrevik, J.; Lag, M.; Holme, J. A.; Schwarze, P. E.; Refsnes, M., Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution. Toxicology, 2009, 259(1-2), 46-53.
169. de Kok, T. M.; Driece, H. A.; Hogervorst, J. G.; Briede, J. J., Toxicological assessment of ambient and traffic-related particulate matter: A review of recent studies. Mutat. Res., 2006, 613(2-3), 103-122. (Pubitemid 44750846)
170. Lewtas, J., Air pollution combustion emissions: Characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects. Mutat Res, 2007, 636(1-3), 95-133. (Pubitemid 350123761)
171. Harizi, H.; Corcuff, J. B.; Gualde, N., Arachidonic-acid-derived eicosanoids: Roles in biology and immunopathology. Trends Mol. Med., 2008, 14(10), 461-469.
172. Serhan, C. N., Resolution phase of inflammation: Novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu. Rev. Immunol., 2007, 25, 101-137. (Pubitemid 46697904)
173. Arnold, C.; Konkel, A.; Fischer, R.; Schunck, W. H., Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids. Pharmacol. Rep., 2010, 62(3), 536-547.
174. Wang, D.; Dubois, R. N., Eicosanoids and cancer. Nat. Rev. Cancer, 10(3), 181-193.
175. Dubois, R. N.; Abramson, S. B.; Crofford, L.; Gupta, R. A.; Simon, L. S.; Van De Putte, L. B.; Lipsky, P. E., Cyclooxygenase in biology and disease. Faseb. J., 1998, 12(12), 1063-1073. (Pubitemid 28418937)
176. Yang, F.; Bleich, D., Transcriptional regulation of cyclooxygenase- 2 gene in pancreatic beta-cells. J. Biol. Chem., 2004, 279(34), 35403-35411. (Pubitemid 39100540)
177. Sciullo, E. M.; Vogel, C. F.; Li, W.; Matsumura, F., Initial and extended inflammatory messages of the nongenomic signaling pathway of the TCDD-activated Ah receptor in U937 macrophages. Arch. Biochem. Biophys., 2008, 480(2), 143-155.
178. Vogel, C. F.; Li, W.; Sciullo, E.; Newman, J.; Hammock, B.; Reader, J. R.; Tuscano, J.; Matsumura, F., Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. Am. J. Pathol., 2007, 171(5), 1538-1548. (Pubitemid 350158315)
179. Borza, A.; Plottner, S.; Wolf, A.; Behm, C.; Selinski, S.; Hengstler, J. G.; Roos, P. H.; Bolt, H. M.; Kuhlmann, J.; Follmann, W., Synergism of aromatic amines and benzo [a]pyrene in induction of Ah receptor-dependent genes. Arch. Toxicol., 2008, 82(12), 973-980.
180. Dong, B.; Nishimura, N.; Vogel, C. F.; Tohyama, C.; Matsumura, F., TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys. Biochem. Pharmacol., 2010, 79(3), 487-497.
181. Chang, L. W.; Chang, Y. C.; Ho, C. C.; Tsai, M. H.; Lin, P., Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol. Carcinogenesis, 2007, 28(7), 1606-1612. (Pubitemid 47241812)
182. Martey, C. A.; Baglole, C. J.; Gasiewicz, T. A.; Sime, P. J.; Phipps, R. P., The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol., 2005, 289(3), L391-9. (Pubitemid 41192713)
183. Tsai, K. S.; Yang, R. S.; Liu, S. H., Benzo [a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase- 2 pathway. Chem. Res. Toxicol., 2004, 17(5), 679-684. (Pubitemid 38669525)
184. Degner, S. C.; Kemp, M. Q.; Hockings, J. K.; Romagnolo, D. F., Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: Repressive effects of conjugated linoleic acid. Nutr. Cancer, 2007, 59(2), 248-257. (Pubitemid 350230742)
185. Degner, S. C.; Papoutsis, A. J.; Selmin, O.; Romagnolo, D. F., Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase- 2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. J. Nutr., 2009, 139(1), 26-32.
186. Wong, P. S.; Li, W.; Vogel, C. F.; Matsumura, F., Characterization of MCF mammary epithelial cells overexpressing the Arylhydrocarbon receptor (AhR). BMC Cancer, 2009, 9, 234.
187. Matsumura, F., The significance of the nongenomic pathway in mediating inflammatory signaling of the dioxin-activated Ah receptor to cause toxic effects. Biochem. Pharmacol., 2009, 77(4), 608-626.
188. Baglole, C. J.; Maggirwar, S. B.; Gasiewicz, T. A.; Thatcher, T. H.; Phipps, R. P.; Sime, P. J., The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. J. Biol. Chem., 2008, 283(43), 28944-28957.
189. Ouyang, W.; Ma, Q.; Li, J.; Zhang, D.; Ding, J.; Huang, Y.; Xing, M. M.; Huang, C., Benzo [a]pyrene diol-epoxide (B [a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKbeta/NF-kappaB in mouse epidermal Cl41 cells. Mol. Carcinog., 2007, 46(1), 32-41. (Pubitemid 46095231)
190. Mizuyachi, K.; Son, D. S.; Rozman, K. K.; Terranova, P. F., Alteration in ovarian gene expression in response to 2,3,7,8- tetrachlorodibenzo-p-dioxin: Reduction of cyclooxygenase-2 in the blockage of ovulation. Reprod. Toxicol., 2002, 16(3), 299-307. (Pubitemid 34966269)
191. Hauben, E.; Gregori, S.; Draghici, E.; Migliavacca, B.; Olivieri, S.; Woisetschlager, M.; Roncarolo, M. G., Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells. Blood, 2008, 112(4), 1214-1222.
192. Platzer, B.; Richter, S.; Kneidinger, D.; Waltenberger, D.; Woisetschlager, M.; Strobl, H., Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells. J. Immunol., 2009, 183(1), 66-74.
193. Murray, I. A.; Morales, J. L.; Flaveny, C. A.; Dinatale, B. C.; Chiaro, C.; Gowdahalli, K.; Amin, S.; Perdew, G. H., Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity. Mol. Pharmacol., 2009, 77(2), 247-254.
194. Chadwick, C. C.; Chippari, S.; Matelan, E.; Borges-Marcucci, L.; Eckert, A. M.; Keith, J. C., Jr.; Albert, L. M.; Leathurby, Y.; Harris, H. A.; Bhat, R. A.; Ashwell, M.; Trybulski, E.; Winneker, R. C.; Adelman, S. J.; Steffan, R. J.; Harnish, D. C., Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity. Proc. Natl. Acad. Sci. U S A, 2005, 102(7), 2543-2548. (Pubitemid 40279413)
195. O'Donnell, E. F.; Saili, K. S.; Koch, D. C.; Kopparapu, P. R.; Farrer, D.; Bisson, W. H.; Mathew, L. K.; Sengupta, S.; Kerkvliet, N. I.; Tanguay, R. L.; Kolluri, S. K., The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One, 2010, 5(10).
196. Jeong, H. G., Cytokine-mediated suppression of cytochrome P450 1A1 in Hepa-1c1c7 cells by pokeweed mitogen. Toxicol. Lett., 2001, 119(2), 125-132. (Pubitemid 32304374)
197. Calleja, C.; Eeckhoutte, C.; Larrieu, G.; Dupuy, J.; Pineau, T.; Galtier, P., Differential effects of interleukin-1 beta, interleukin-2, and interferon-gamma on the inducible expression of CYP 1A1 and CYP 1A2 in cultured rabbit hepatocytes. Biochem. Biophys. Res. Commun., 1997, 239(1), 273-278. (Pubitemid 27480355)
198. Barker, C. W.; Fagan, J. B.; Pasco, D. S., Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes. J.Biol. Chem., 1992, 267(12), 8050-8055.
199. Fukuda, Y.; Ishida, N.; Noguchi, T.; Kappas, A.; Sassa, S., Interleukin- 6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells. Biochem. Biophys. Res. Commun., 1992, 184(2), 960-965.
200. Ghanem, M. M.; Battelli, L. A.; Mercer, R. R.; Scabilloni, J. F.; Kashon, M. L.; Ma, J. Y.; Nath, J.; Hubbs, A. F., Apoptosis and Bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon-exposed lung. Environ. Health. Perspect., 2006, 114(9), 1367-1373. (Pubitemid 44314759)
201. Ferrari, L.; Kremers, P.; Batt, A. M.; Gielen, J. E.; Siest, G., Differential effects of human recombinant interleukin-1 beta on cytochrome P-450-dependent activities in cultured fetal rat hepatocytes. Drug Metab. Dispos., 1992, 20(3), 407-412.
202. Wu, R.; Cui, X.; Dong, W.; Zhou, M.; Simms, H. H.; Wang, P., Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: The central role of proinflammatory cytokines. Int. J. Mol. Med., 2006, 18(2), 339-346.
203. Muntane-Relat, J.; Ourlin, J. C.; Domergue, J.; Maurel, P., Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. Hepatology, 1995, 22(4 Pt 1), 1143-1153.
204. Abdel-Razzak, Z.; Corcos, L.; Fautrel, A.; Campion, J. P.; Guillouzo, A., Transforming growth factor-beta 1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture. Mol. Pharmacol., 1994, 46(6), 1100-1110.
205. Abdel-Razzak, Z.; Loyer, P.; Fautrel, A.; Gautier, J. C.; Corcos, L.; Turlin, B.; Beaune, P.; Guillouzo, A., Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol. Pharmacol., 1993, 44(4), 707-715. (Pubitemid 23317282)
206. Zhou, M.; Maitra, S. R.; Wang, P., The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis. Int. J. Mol. Med., 2008, 21(4), 423-428. (Pubitemid 351802636)
207. Moos, A. B.; Oughton, J. A.; Kerkvliet, N. I., The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on tumor necrosis factor (TNF) production by peritoneal cells. Toxicol. Lett., 1997, 90(2- 3), 145-153. (Pubitemid 27096529)
208. Springs, A. E.; Rice, C. D., The Effects of Indirubin-3'-Monoxime, A Novel AHR Ligand, on Stress and Toxicity-Related Gene/Protein Expression in Human U937 Cells Undergoing Differentiation and Activation. J. Immunotoxicol., 2006, 3(1), 1-10. (Pubitemid 43336372)
209. Rier, S. E.; Coe, C. L.; Lemieux, A. M.; Martin, D. C.; Morris, R.; Lucier, G. W.; Clark, G. C., Increased tumor necrosis factor-alpha production by peripheral blood leukocytes from TCDD-exposed rhesus monkeys. Toxicol. Sci., 2001, 60(2), 327-37. (Pubitemid 32273322)
210. Mitchell, K. A.; Lockhart, C. A.; Huang, G.; Elferink, C. J., Sustained aryl hydrocarbon receptor activity attenuates liver regeneration. Mol. Pharmacol., 2006, 70(1), 163-170.
211. Almahmeed, T.; Boyle, J. O.; Cohen, E. G.; Carew, J. F.; Du, B.; Altorki, N. K.; Kopelovich, L.; Fang, J. L.; Lazarus, P.; Subbaramaiah, K.; Dannenberg, A. J., Benzo [a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo [a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. Carcinogenesis, 2004, 25(5), 793-799. (Pubitemid 38618533)
212. DiNatale, B. C.; Murray, I. A.; Schroeder, J. C.; Flaveny, C. A.; Lahoti, T. S.; Laurenzana, E. M.; Omiecinski, C. J.; Perdew, G. H., Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol. Sci., 2010, 115(1), 89-97.
213. Zhao, D.; Pritts, E. A.; Chao, V. A.; Savouret, J. F.; Taylor, R. N., Dioxin stimulates RANTES expression in an in-vitro model of endometriosis. Mol.Hum. Reprod., 2002, 8(9), 849-854. (Pubitemid 35012473)