Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis

Drug Metabolism and Disposition

Volumn 32, Issue 4, 2004, Pages 437-441

  Masubuchi, Yasuhiro ^a   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENOL; ALANINE AMINOTRANSFERASE; CYTOCHROME P450; DEXTRAN SULFATE; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GALACTOSAMINE; METRONIDAZOLE; PHENACETIN; POLYMYXIN B; PROPANOL; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; COLITIS; CONTROLLED STUDY; DRUG HYDROXYLATION; ENZYME ACTIVITY; LIVER MICROSOME METABOLISM; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG THERAPY, COMBINATION; DRUG TOLERANCE; ENDOTOXINS; GALACTOSAMINE; IMMUNE TOLERANCE; INJECTIONS, INTRAPERITONEAL; LIPOPOLYSACCHARIDES; LIVER; MALE; METRONIDAZOLE; MICROSOMES, LIVER; POLYMYXIN B; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 1842536819     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.4.437     Document Type: Article

References (29)

1. Decker K and Keppler D (1974) Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev Physiol Biochem Pharmacol 71:77-106.
2. Desmet VJ and Geboes K (1987) Liver lesions in inflammatory bowel disorders. J Pathol 151:247-255.
3. Dieleman LA, Palmen MJ, Akol H, Bloemena E, Pena AS, Meuwissen SG, and Van Rees EP (1998) Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol 114:385-391.
4. Fausa O, Schrumpf E, and Elgjo K (1991) Relationship of inflammatory bowel disease and primary sclerosing cholangitis. Semin Liver Dis 11:31-39.
5. Freudenberg MA and Galanos C (1988) Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages. Infect Immun 56:1352-1357.
6. Galanos C, Freudenberg MA, and Reutter W (1979) Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA 76:5939-5943.
7. Imaoka S, Terano Y, and Funae Y (1988) Constitutive testosterone 6β-hydroxylase in rat liver. J Biochem (Tokyo) 104:481-487.
8. Kabashima K, Saji T, Murata T, Nagamachi M, Matsuoka T, Segi E, Tsuboi K, Sugimoto Y, Kobayashi T, Miyachi Y, et al. (2002) The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Investig 109:883-893.
9. Lichtman SN, Keku J, Schwab JH, and Sartor RB (1991) Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Gastroenterology 100:513-519.
10. Lichtman SN, Okoruwa EE, Keku J, Schwab JH, and Sartor RB (1992) Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth. J Clin Investig 90:1313-1322.
11. Lorentsen KJ, Hendrix CW, Collins JM, Kornhauser DM, Petty BG, Klecker RW, Flexner C, Eckel RH, and Lietman PS (1989) Dextran sulfate is poorly absorbed after oral administration. Ann Intern Med 111:561-566.
12. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
13. Masubuchi Y, Hosokawa S, Horie T, Suzuki T, Ohmori S, Kitada M, and Narimatsu S (1994) Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos 22:909-915.
14. Masubuchi Y, Kagimoto N, Narimatsu S, Fujita S, and Suzuki T (1993) Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes. Drug Metab Dispos 21:1012-1016.
15. Masubuchi Y, Takahashi C, Fujio N, Horie T, Suzuki T, Imaoka S, Funae Y, and Narimatsu S (1995) Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats. Drug Metab Dispos 23:999-1003.
16. Ni J, Chen SF, and Hollander D (1996) Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes. Gut 39:234-241.
17. Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, and Akira S (2000) Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 164:3476-3479.
18. Oatis JE Jr, Russell MP, Knapp DR, and Walle T (1981) Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers. J Med Chem 24:309-314.
19. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, and Nakaya R (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694-702.
20. Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
21. Oshima S, Fujimura M, and Fukimiya M (1999) Changes in number of serotonin-containing cells and serotonin levels in the intestinal mucosa of rats with colitis induced by dextran sodium sulfate. Histochem Cell Biol 112:257-263.
22. Rachmilewitz D, Simon PL, Schwartz LW, Griswold DE, Fondacaro JD, and Wasserman MA (1989) Inflammatory mediators of experimental colitis in rats. Gastroenterology 97:326-337.
23. Reinke LA and Moyer MJ (1985) p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab Dispos 13:548-552.
24. Roth RA, Harkema JR, Pestka JP, and Ganey PE (1997) Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents? Toxicol Appl Pharmacol 147:300-311.
25. Schierwagen C, Bylund-Fellenius AC, and Lundberg C (1990) Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity. J Pharmacol Methods 23:179-186.
26. Sesardic D, Edwards RJ, Davies DS, Thomas PE, Levin W, and Boobis AR (1990) High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat. Biochem Pharmacol 39:489-498.
27. Siewert E, Bort R, Kluge R, Heinrich PC, Castell J, and Jover R (2000) Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent. Hepatology 32:49-55.
28. Stachlewitz RF, Seabra V, Bradford B, Bradham CA, Rusyn I, Germolec D, and Thurman RG (1999) Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells. Hepatology 29:737-745.
29. Tassaneeyakul W, Veronese ME, Birkett DJ, and Miners JO (1993) High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomes. J Chromatogr 616:73-78.