Effect of subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on immune system and target gene responses in mice: Calculation of benchmark doses for CYP1A1 and CYPIA2 related enzyme activities

Archives of Toxicology

Volumn 71, Issue 6, 1997, Pages 372-382

  Vogel, Christoph ^a   Donat, Susanne ^a   Döhr, Olaf ^a   Kremer, Joachim ^a   Esser, Charlotte ^a   Roller, Markus ^a   Abel, Josef ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Benchmark dose; Cytochrome P450; Cytokines; Immunesystem; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450; INTERLEUKIN 1BETA; ISOENZYME; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG TISSUE LEVEL; ENZYME ACTIVITY; FEMALE; GENOTOXICITY; HISTOCHEMISTRY; IMMUNE SYSTEM; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; STATISTICAL MODEL; THYMOCYTE; THYMUS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BODY WEIGHT; CELL COUNT; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1; LIVER; LUNG; MICE; MICE, INBRED C57BL; ORGAN SIZE; POLYMERASE CHAIN REACTION; REGRESSION ANALYSIS; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; THYMUS GLAND; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030924265     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050401     Document Type: Article

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