Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions: IL-1β effect and protection by N-acetylcysteine

Toxicology Letters

Volumn 138, Issue 3, 2003, Pages 243-251

  Malaplate Armand, C ^a   Ferrari, L ^a   Masson, C ^a   Siest, G ^a   Batt, A M ^a  

^a Centre du Medicament URA CNRS 597   (France)

Author keywords

Astrocytoma; CYP1B1; CYP2D6; Cytochrome P450; Interleukin 1

Indexed keywords

ACETYLCYSTEINE; CYTOCHROME P450 1B1; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 4A; CYTOCHROME P450 ISOENZYME; INTERLEUKIN 1BETA; MESSENGER RNA;

ARTICLE; ASTROCYTOMA CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; MACROGLIA; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA ANALYSIS;

ACETYLCYSTEINE; ARYL HYDROCARBON HYDROXYLASES; ASTROCYTES; ASTROCYTOMA; CYTOCHROME P-450 CYP2D6; DRUG INTERACTIONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERLEUKIN-1; ISOENZYMES; MICROSOMES; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0037416727     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00417-4     Document Type: Article

References (41)

1. Alexander J.J., Snyder A., Tonsgard J.H. Omega-oxidation of monocarboxylic acids in rat brain. Neurochem. Res. 23:1998;227-233.
2. Alkayed N.J., Narayanan J., Gebremedhin D., Medhora M., Roma R.J., Harder D.R. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke. 27:1996;971-979.
3. Barclay T.B., Peters J.M., Sewer M.B., Ferrari L., Gonzalez F.J., Morgan E.T. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. J. Pharmacol. Exp. Ther. 290:1999;1250-1257.
4. Baron J.M., Zwadlo-Klarwasser G., Jugert F., Hamann W., Rübben A., Mukhtar H., Merk H.F. Cytochrome 1B1: a major P450 isoenzymes in human blood monocytes and macrophage subsets. Biochem. Pharmacol. 56:1998;1105-1110.
5. Barouki R., Morel Y. Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological implications. Biochem. Pharmacol. 61:2001;511-516.
6. Burnette W.N. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112:1981;195-203.
7. Coutts R.T., Urichuk L.J. Polymorphic cytochromes P450 and drugs used in psychiatry. Cell. Mol. Neurobiol. 19:1999;325-354.
8. Ferrari L., Kremers P., Batt A.M., Gielen J.E., Siest G. Differential effects of human recombinant interleukin-1 beta on cytochrome P-450-dependent activities in cultured fetal rat hepatocytes. Drug Metab. Dispos. 20:1992;407-412.
9. Fratelli M., Gagliardini V., Galli G.P., Ghiara P., Ghezzi P. Autocrine interleukin-1 beta regulates both proliferation and apoptosis in EL4-6.1 thymona cells. Blood. 85:1995;3532-3537.
10. Gorski J.C., Hall S.D., Becker P., Affrme M.B., Cutler D.L., Haehner-Damiels B. In vivo effects of interleukin-10 on human cytochrome P450 activity. Clin. Pharm. Ther. 67:2000;32-43.
11. Gu J., Su T., Chen Y., Zhang Q.Y., Ding X. Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity. Toxicol. Appl. Pharmacol. 165:2000;158-162.
12. Hayes C.L., Spink D.C., Spink B.C., Cao J.Q., Walker N.J., Sutter T.R. 17β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl. Acad. Sci. USA. 93:1996;9776-9781.
13. Hiroi T., Imaoka S., Funae Y. Dopamine formation from tyramine by CYP2D6. Biochem. Biophys. Res. Comm. 249:1998;838-843.
14. Ibach B., Appel K., Gebicke-Haerter P., Meyer R.P., Friedberg T., Knoth R., Volk B. Effect of phenytoin on cytochrome P450 2B mRNA expression in primary rat astrocyte cultures. J. Neurosci. Res. 54:1998;402-411.
15. Kerzee J.K., Ramos K.S. Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor. Circ. Res. 89:2001;573-582.
16. Kirches E., Scherlach C., von Bossanyi P., Schneider T., Szibor R., Kutz E., Warich-Kirches M., Dietzmann K. MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas. Clin. Neuropathol. 18:1999;1-8.
17. Klose T.S., Blaisdell J.A., Goldstein J.A. Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J. Biochem. Mol. Toxicol. 13:1999;289-295.
18. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
19. Lowry O.H., Rosebrough N.J., Farr L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
20. Maas R.M., Reus K., Diesel B., Steudel W.I., Feiden W., Fischer U., Meese E. Amplification and expression of splice variants of the gene encoding the P450 cytochrome 25-hydroxyvitamin D(3) 1,alpha-hydroxylase (CYP 27B1) in human malignant glioma. Clin. Cancer Res. 7:2001;868-875.
21. Makar T.K., Nedergaard M., Preuss A., Gelbard A.S., Perumal A.S., Cooper A.J. Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J. Neurochem. 62:1994;45-53.
22. Malaplate-Armand C., Gueguen Y., Bertrand P., Ferrari L., Batt A.M. U373-MG response to interleukin-1β-induced oxidative stress. Cell Biol. Toxicol. 16:2000;155-163.
23. Meyer R.P., Knoth R., Schiltz E., Volk B. Possible function of astrocyte cytochrome P450 in control of xenobiotic phenytoin in the brain: in vitro studies on murine astrocyte primary cultures. Exp. Neurol. 16:2001;376-384.
24. Morgan E.T. Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev. 29:2001;207-212.
25. Murray G.I. The role of cytochrome P450 in tumour development and progression and its potential in therapy. J. Pathol. 192:2000;419-426.
26. Muskhelishvili L., Thompson P.A., Kusewitt D.F., Wang C., Kadlubar F.F. In situ hybridization and immunohistochemical analysis of cytochrome 1B1 expression in human normal tissues. J. Histochem. Cytochem. 49:2001;229-236.
27. Nicholson T.E., Renton K.W. Modulation of cytochrome P450 by inflammation in astrocytes. Brain Res. 827:1999;12-18.
28. Palmer C.N., Richardson T.H., Griffin K.J., Hsu M.H., Muerhoff A.S., Clark J.E., Johnson E.F. Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. Biochim. Biophys. Acta. 1172:1993;161-166.
29. Piscaglia F., Knittel T., Kobold D., Barnikol-Watanabe S., Di Rocco P., Ramadori G. Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokines. Biochem. Pharmacol. 8:1999;157-165.
30. Rieder C.R., Ramsden D.B., Williams A.C. Cytochrome P450 1B1 mRNA in the human central nervous system. Mol. Pathol. 51:1998;138-142.
31. Rieder C.R.M., Richard B.P., Fitch N.J.S., William A.C., Ramsden D.B. Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz(a)anthracene in astrocytoma cell line (MOG-G-CCM). Neurosci. Lett. 278:2000;177-180.
32. Rochat B., Morsman J.M., Murray G.I., Figg W.D., Mc Leod H.L. Human CYP1B1 and anticancer metabolism: mechanism for tumor-specific drug inactivation. J. Pharmacol. Exp. Ther. 296:2001;537-541.
33. Shehin S.E., Stephenson R.O., Greenlee W.F. Transcriptional regulation of the human CYP1B1 gene. Evidence for involvement of an aryl hydrocarbon receptor response element in constitutive expression. J. Biol. Chem. 275:2000;6770-6776.
34. Siegle I., Fritz P., Eckhardt K., Zanger U.M., Eichelbaum M. Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics. 11:2001;237-245.
35. Spink B.C., Fasco M.J., Gierthy J.F., Spink D.C. 12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells. J. Cell Biochem. 70:1998;289-296.
36. Thum T., Borlak J. Gene expression in distinct regions of the heart. Lancet. 355:2000;979-983.
37. Tian Y.K.S., Denison M.S., Rabson A.B., Gallo M.A. Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. J. Biol. Chem. 274:1999;510-515.
38. Tindberg N., Baldwin H.A., Cross A.J., Ingelman-Sundberg M. Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammation factors and ischemic injury. Mol. Pharmacol. 50:1996;1065-1072.
39. Utal A.K., Stopka A.L., Coleman P.D. Interleukin-1 beta stimulates mitogen-activated protein kinase in U373 astrocytoma cells without the production of lipid second messengers. Neurochem. Res. 23:1998;235-242.
40. Villard P.H., Sampol E., Elkaim J.L., Pyoou F., Casanova D., Sérée E., Durand A., Lacarelle B. Increase of CYP1B1 transcription in human keratinocytes and HaCat cells after UV-B exposure. Toxicol. Appl. Pharmacol. 178:2002;137-143.
41. Zwain I.H., Yen S.S., Cheng C.Y. Astrocytes cultured in vitro produce estradiol-17beta and express aromatase cytochrome P-450 (P-450 AROM) mRNA. Biochim. Biophys. Acta. 1334:1997;338-348.