The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis

International Journal of Molecular Medicine

Volumn 21, Issue 4, 2008, Pages 423-428

  Zhou, Mian ^a   Maitra, Subir R ^a   Wang, Ping ^a  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

Author keywords

Cecal ligation and puncture; Hepatic cytochrome P 450 isoform 1A2; Hepatoma cells; Interleukin 1 ; Liver; Tumor necrosis factor

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A2; INTERLEUKIN 1BETA; LIVER PROTEIN; POLYMYXIN B; TUMOR NECROSIS FACTOR ALPHA; CYP1A2 PROTEIN, RAT; ENDOTOXIN; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENE DISRUPTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; WESTERN BLOTTING; ACTIVE TRANSPORT; ANIMAL; CELL LINE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; LIVER; METABOLISM; NUCLEOTIDE SEQUENCE; SPRAGUE DAWLEY RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BASE SEQUENCE; CELL LINE; CYTOCHROME P-450 CYP1A2; DNA PRIMERS; DOWN-REGULATION; ENDOTOXINS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; LIVER; MALE; POLYMYXIN B; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 44649174954     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijmm.21.4.423     Document Type: Article

References (41)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303-1310, 2001.
2. Baue AE: Multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome: Why no magic bullets? Arch Surg 132: 703-707, 1997.
3. Wang P and Chaudry IH: Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am J Physiol 270: R927-R938, 1996.
4. Wang P and Chaudry IH: A single hit model of polymicrobial sepsis: Cecal ligation and puncture. Sepsis 2: 227-233, 1998.
5. Yang, S, Cioffi WG, Bland KI, Chaudry IH and Wang P: Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis. J Trauma 47: 706-712, 1999.
6. Deitch EA: Animal models of sepsis and shock: A review and lessons learned. Shock 9: 1-11, 1998.
7. Morgan ET: Regulation of cytochrome P450 by inflammatory mediators: why and how? Drug Metab Dispos 29: 207-212, 2001.
8. Monshouwer M, McLellan RA, Delaporte E, Witkamp RF, VanMiest AS and Renton KW: Differential effect of pentoxifylline on Lipopolysaccharide-induced downregulation of cytochrome P450. Biochem Pharmacol 52: 1195-2000, 1996.
9. McKindley DS, Boulet J, Sachdeva K, Wang P and Chichester C: Endotoxic shock alters the pharmacokinetics of lidocane and monoethylglycinexylidide. Shock 17: 199-204, 2002.
10. Iber H, Sewer MB, Barclay TB, Mitchell SR, Li T and Morgan ET: Modulation of drug metabolism in infectious and inflammatory diseases. Drug Metab Rev 31: 29-41, 1999.
11. Shedlofsky SI, Israel BC, McClain CJ, Hill DB and Blouin RA: Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J Clin Invest 94: 2209-2214, 1994.
12. Spatzenegger M, Horsmans Y and Verbeeck RK: Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats. Pharmacol Toxicol 86: 71-77, 2000.
13. Crawford JH, Yang S, Zhou M, Simms, HH, and Wang P: Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis. Crit Care Med 32: 502-508, 2004.
14. Honkakoski P and Negishi M: Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 341: 321-337, 2000.
15. Waxman DJ: P450 gene induction by structurally diverse xenochemicals: central role of nuclear CAR, PXR, and PPAR. Arch Biochem Biophys 369: 11-23, 1999.
16. Wu R, Cui X, Dong W, Zhou M, Simms H and Wang P: Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: The central role of proinflammatory cytokines. Int J Mol Med 18: 339-346, 2006.
17. Wu R, Cui X, Lim YP, Bendelja K, Zhou M, Simms HH and Wang, P: Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis. Crit Care Med 32: 1747-1752, 2004.
18. Yang S, Zhou MN, Chaudry IH and Wang P: The role of lipopolysaccharide in stimulating Adrenomedullin production during polymicrobial sepsis. Biochim Biophys Acta 1537: 167-174, 2001.
19. Morrison DC and Jacobs DM: Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry 13: 813-818, 1976.
20. Greschik H and Moras D: Structure-activity relationship of nuclear receptor-ligand interactions. Curr Top Med Chem 3: 1573-1599, 2003.
21. Beato M, Herrlich P and Schultz G: Steroid hormone receptors: many actors in search of a plot. Cell 83: 851-857, 1995.
22. Mangelsdorf DJ, Thimmel C, Beato M, Herrlich P, Schultz G, Umesono K, Blumberg B, Kastner P, Mark M and Chambon P: The nuclear receptor superfamily: the second decade. Cell 83: 835-839, 1995.
23. Forman BM, Chen J and Evans RM: The peroxisome proliferators-activated receptors: ligands and activators. Ann NY Acad Sci 804: 266-275, 1996.
24. Handschin C and Meyer UA: Induction of drug metabolism: the role of nuclear receptors. Pharmacol Rev 55: 649-673, 2003.
25. Hankakoski P and Negishi M: Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 347: 321-337, 2000.
26. Waxman DJ: P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR and PPAR. Arch Biochem Biophys 369: 11-23, 1999.
27. Hankinson O: The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35: 307-340, 1995.
28. Roberts EA, Harper PA, Wong JM, Wang Y and Yang S: Failure of Ah receptor to mediate induction of cytochromes P450 in the CYP1 family in the human hepatoma line SK-Hep-1. Arch Biochem Biophys 3384: 190-198, 2000.
29. Grandin K, McGuire J, Wenger RH, Kvietikova I, Fhitelaw ML, Toftgard R, Tora L, Gasssmann M and Poellinger L: Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol Cell Biol 16: 5221-5231, 1996.
30. Tomita S, Signal CJ, Yim SH and Gonzalez FJ: Conditional disruption of the Aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor lalpha. Mol Endocrinol 14: 1674-1681, 2000.
31. Reyes H, Reisz-Porszasz S and Hankinson O: Identification of the AH receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256: 1193-1195, 1992.
32. Poellinger L: Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor. Mol Cell Biol 13: 2504-2514, 1993.
33. Coumailleau P, Poellinger L, Gustafsson JA and Whitelaw ML: Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity. J Biol Chem 270: 5291-5300, 1995.
34. Whitelaw ML, McGuire J, Picard D, Gustafsson JA and Poellinger L: Heat shock protein hsp90 regulates dioxin receptor function in vivo. Proc Natl Acad Sci USA 92: 4437-4441, 1995.
35. Spatzenegger M, Horsmans Y and Verbeeck RK: Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats. Pharmacol Toxicol 86: 71-77, 2000.
36. Morgan ET: Regulation of cytochromes P450 during inflammation and infection. Drug Metab Rev 29: 1129-1188, 1997.
37. Barker CW, Fagan JB and Pasco DS: Interleukin-1 beta suppresses the induction of P4501A1 mRNAs in isolated hepatocytes. J Biol Chem 267: 8050-8055, 1992.
38. Nicholson TE and Renton KW: Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver. Biochem Pharmacol 62: 1709-1717, 2001.
39. Ertel W, Morrison MH, Wang P, Ba ZF, Ayala A, and Chaudry IH: The complex pattern of cytokines in sepsis: Association between prostaglandins, cachectin and interleukins. Ann Surg 214: 141-148, 1991.
40. Milosevic N, Schawalder H and Maier P: Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes. Eur J Pharmacol 368: 75-87, 1999.
41. Piscitelli SC, Reiss WG, Figg WD and Petros WP: Pharmacokinetic studies with recombinant cytokines. Scientific issues and practical considerations. Clin Pharmacokinet 32: 368-381, 1997.