Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway

Carcinogenesis

Volumn 31, Issue 6, 2010, Pages 1149-1157

  Dreij, Kristian ^a,b   Rhrissorrakrai, Kahn ^a   Gunsalus, Kristin C ^a   Geacintov, Nicholas E ^a   Scicchitano, David A ^a  

^a NEW YORK UNIVERSITY   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLOOXYGENASE 2; DIHYDROXYBENZO[A]PYRENE OXIDE; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROSTAGLANDIN E2; PROTEIN C JUN; PROTEIN P53; SERINE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4;

ARTICLE; CELL CYCLE PROGRESSION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA DAMAGE; DNA REPAIR; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; INFLAMMATION; LUNG CANCER; LUNG CARCINOGENESIS; LUNG FIBROBLAST; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; LUNG; METABOLISM; PATHOLOGY;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; HUMANS; INFLAMMATION; LUNG; MAP KINASE KINASE 4; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953918281     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq073     Document Type: Article

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