2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs an insulin signaling pathway through the induction of tumor necrosis factor-α in adipocytes

Toxicological Sciences

Volumn 115, Issue 2, 2010, Pages 482-491

  Nishiumi, Shin ^a   Yoshida, Masaru ^a   Azuma, Takeshi ^a   Yoshida, Ken Ichi ^b   Ashida, Hitoshi ^b  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Adipocytes; AhR; Insulin resistance; TCDD; TNF

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA SUBUNIT; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE TRANSPORT; INSULIN RESISTANCE; NONHUMAN; PROTEIN EXPRESSION; SERODIAGNOSIS; SIGNAL TRANSDUCTION; UPREGULATION;

ADIPOCYTES; ANIMALS; BALB 3T3 CELLS; CELL DIFFERENTIATION; CELL SURVIVAL; DOWN-REGULATION; ENVIRONMENTAL POLLUTANTS; FIBROBLASTS; GENE EXPRESSION; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; MICE; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954070319     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq052     Document Type: Article

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