Huntington's disease and group I metabotropic glutamate receptors

Molecular Neurobiology

Volumn 43, Issue 1, 2011, Pages 1-11

  Ribeiro, Fabiola M ^a   Pires, Rita G W ^b   Ferguson, Stephen S G ^c  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^c ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

htt protein; Huntington's disease; Metabotropic glutamate receptor (mGluR)

Indexed keywords

CANNABINOID RECEPTOR; G PROTEIN COUPLED RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROTRANSMITTER; PROTEIN KINASE B;

ARTICLE; BRAIN CORTEX; CALCIUM TRANSPORT; CELL SURVIVAL; CORPUS STRIATUM; DISEASE COURSE; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; GABAERGIC SYSTEM; HUMAN; HUNTINGTON CHOREA; INTRACELLULAR SIGNALING; NERVE CELL NECROSIS; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 79951552862     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12035-010-8153-1     Document Type: Article

References (149)

1. SH Li XJ Li 2004 Huntingtin-protein interactions and the pathogenesis of Huntington's disease Trends Genet 20 146 154 15036808 10.1 (Pubitemid 38230029)
2. AB Young 2003 Huntingtin in health and disease J Clin Invest 111 299 302 1:CAS:528:DC%2BD3sXpvFSgtg%3D%3D 12569151 (Pubitemid 36182202)
3. KW Heathfield 1967 Huntington's chorea. Investigation into the prevalence of this disease in the area covered by the North East Metropolitan Regional Hospital Board Brain 90 203 232 1:STN:280:DyaF2s7jsVOlsQ%3D%3D 4225726 10.1093/brain/90.1.203
4. V Perez-De La Cruz A Santamaria 2007 Integrative hypothesis for Huntington's disease: a brief review of experimental evidence Physiol Res 56 513 526 1:CAS:528:DC%2BD2sXhsVGrt7rK 17184144
5. Huntington's Disease Collaborative Research Group 1993 A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 72 971 983 10.1016/0092-8674(93)90585-E (Pubitemid 23110238)
6. B Kremer P Goldberg SE Andrew J Theilmann H Telenius J Zeisler F Squitieri B Lin A Bassett E Almqvist 1994 A worldwide study of the Huntington's disease mutation. The sensitivity and specificity of measuring CAG repeats N Engl J Med 330 1401 1406 1:STN:280:DyaK2c3htFaguw%3D%3D 8159192 10.1056/NEJM199405193302001 (Pubitemid 24139231)
7. I Dragatsis P Dietrich S Zeitlin 2000 Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse Neurosci Lett 282 37 40 1:CAS:528:DC%2BD3cXhsFGrsrs%3D 10713390 10.1016/S0304-3940(00) 00872-7 (Pubitemid 30129163)
8. D Rigamonti JH Bauer C De-Fraja L Conti S Sipione C Sciorati E Clementi A Hackam MR Hayden Y Li JK Cooper CA Ross S Govoni C Vincenz E Cattaneo 2000 Wild-type huntingtin protects from apoptosis upstream of caspase-3 J Neurosci 20 3705 3713 1:CAS:528:DC%2BD3cXjtlKqsLo%3D 10804212 (Pubitemid 30266233)
9. J Nasir SB Floresco JR O'Kusky VM Diewert JM Richman J Zeisler A Borowski JD Marth AG Phillips MR Hayden 1995 Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes Cell 81 811 823 1:CAS:528:DyaK2MXmtFOiurc%3D 7774020 10.1016/0092-8674(95)90542-1
10. S Zeitlin JP Liu DL Chapman VE Papaioannou A Efstratiadis 1995 Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue Nat Genet 11 155 163 1:CAS:528:DyaK2MXosF2rtr0%3D 7550343 10.1038/ng1095-155
11. MF Beal RJ Ferrante KJ Swartz NW Kowall 1991 Chronic quinolinic acid lesions in rats closely resemble Huntington's disease J Neurosci 11 1649 1659 1:CAS:528:DyaK3MXlsFKgtLo%3D 1710657
12. BR Jarabek RP Yasuda BB Wolfe 2004 Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model Brain 127 505 516 14662521 10.1093/brain/awh058 (Pubitemid 38295468)
13. JY Li M Plomann P Brundin 2003 Huntington's disease: a synaptopathy? Trends Mol Med 9 414 420 1:CAS:528:DC%2BD3sXnvVKkuro%3D 14557053 10.1016/j.molmed.2003.08.006 (Pubitemid 37309642)
14. D Lim L Fedrizzi M Tartari C Zuccato E Cattaneo M Brini E Carafoli 2008 Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease J Biol Chem 283 5780 5789 1:CAS:528:DC%2BD1cXit1Omtbg%3D 18156184 10.1074/jbc.M704704200
15. RH Myers JP Vonsattel TJ Stevens LA Cupples EP Richardson JB Martin ED Bird 1988 Clinical and neuropathologic assessment of severity in Huntington's disease Neurology 38 341 347 1:STN:280:DyaL1c7lslWiuw%3D%3D 2964565 (Pubitemid 18083664)
16. G Bates 2003 Huntingtin aggregation and toxicity in Huntington's disease Lancet 361 1642 1644 1:CAS:528:DC%2BD3sXjs1Wluro%3D 12747895 10.1016/S0140-6736(03)13304-1 (Pubitemid 36579005)
17. M Arrasate S Mitra ES Schweitzer MR Segal S Finkbeiner 2004 Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death Nature 431 805 810 1:CAS:528:DC%2BD2cXotl2ktrc%3D 15483602 10.1038/nature02998 (Pubitemid 39434070)
18. J Miller M Arrasate BA Shaby S Mitra E Masliah S Finkbeiner 2010 Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis J Neurosci 30 10541 10550 1:CAS:528:DC%2BC3cXhtVCrsrjL 20685997 10.1523/JNEUROSCI.0146-10.2010
19. M DiFiglia 1990 Excitotoxic injury of the neostriatum: a model for Huntington's disease Trends Neurosci 13 286 289 1:STN:280:DyaK3czitVSltw%3D%3D 1695405 10.1016/0166-2236(90)90111-M
20. P Calabresi D Centonze A Pisani G Bernardi 1999 Metabotropic glutamate receptors and cell-type-specific vulnerability in the striatum: implication for ischemia and Huntington's disease Exp Neurol 158 97 108 1:CAS:528: DyaK1MXltVKlsrY%3D 10448421 10.1006/exnr.1999.7092 (Pubitemid 29344321)
21. F Ferraguti L Crepaldi F Nicoletti 2008 Metabotropic glutamate 1 receptor: current concepts and perspectives Pharmacol Rev 60 536 581 1:CAS:528:DC%2BD1MXhsFGls7g%3D 19112153 10.1124/pr.108.000166
22. S Nakanishi M Masu 1994 Molecular diversity and functions of glutamate receptors Annu Rev Biophys Biomol Struct 23 319 348 1:CAS:528:DyaK2cXksFSitbg%3D 7919785 10.1146/annurev.bb.23.060194.001535 (Pubitemid 24217371)
23. GK Dhami SS Ferguson 2006 Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis Pharmacol Ther 111 260 271 1:CAS:528:DC%2BD28XltVekt78%3D 16574233 10.1016/j.pharmthera.2005.01.008 (Pubitemid 43765534)
24. JW Olney 1994 New mechanisms of excitatory transmitter neurotoxicity J Neural Transm Suppl 43 47 51 1:CAS:528:DyaK2MXktlejsb4%3D 7884406 (Pubitemid 24362359)
25. R Dingledine K Borges D Bowie SF Traynelis 1999 The glutamate receptor ion channels Pharmacol Rev 51 7 61 1:CAS:528:DyaK1MXitFWgurs%3D 10049997 (Pubitemid 29113865)
26. JP Pin T Galvez L Prezeau 2003 Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors Pharmacol Ther 98 325 354 1:CAS:528:DC%2BD3sXktVOqsb8%3D 12782243 10.1016/S0163-7258(03)00038-X (Pubitemid 36638547)
27. Ribeiro FM, Paquet M, Cregan SP, Ferguson SS (2010) Group I metabotropic glutamate receptor signalling and its implication in neurological disease. CNS Neurol Disord Drug Targets
28. JP Pin R Duvoisin 1995 The metabotropic glutamate receptors: structure and functions Neuropharmacology 34 1 26 1:CAS:528:DyaK2MXktF2ns7o%3D 7623957 10.1016/0028-3908(94)00129-G
29. PJ Conn JP Pin 1997 Pharmacology and functions of metabotropic glutamate receptors Annu Rev Pharmacol Toxicol 37 205 237 1:CAS:528:DyaK2sXisl2ktr0%3D 9131252 10.1146/annurev.pharmtox.37.1.205 (Pubitemid 27238875)
30. F Ferraguti R Shigemoto 2006 Metabotropic glutamate receptors Cell Tissue Res 326 483 504 1:CAS:528:DC%2BD28XpvFalt70%3D 16847639 10.1007/s00441-006- 0266-5 (Pubitemid 44435821)
31. JM Wieronska A Pilc 2009 Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs Neurochem Int 55 85 97 1:CAS:528:DC%2BD1MXltVKrsb8%3D 19428811 10.1016/j.neuint.2009.02.019
32. DD Schoepp 2001 Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system J Pharmacol Exp Ther 299 12 20 1:CAS:528:DC%2BD3MXntFWltr4%3D 11561058 (Pubitemid 32905113)
33. R Shigemoto S Nomura H Ohishi H Sugihara S Nakanishi N Mizuno 1993 Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain Neurosci Lett 163 53 57 1:CAS:528:DyaK2cXisVWitg%3D%3D 8295733 10.1016/0304-3940(93)90227-C (Pubitemid 23349393)
34. R Shigemoto A Kinoshita E Wada S Nomura H Ohishi M Takada PJ Flor A Neki T Abe S Nakanishi N Mizuno 1997 Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus J Neurosci 17 7503 7522 1:CAS:528:DyaK2sXmtl2lt7s%3D 9295396 (Pubitemid 27413281)
35. A Baude Z Nusser JD Roberts E Mulvihill RA McIlhinney P Somogyi 1993 The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction Neuron 11 771 787 1:CAS:528:DyaK2cXhsFCmtr4%3D 8104433 10.1016/0896-6273(93)90086-7 (Pubitemid 23321784)
36. YK Park J Galik PD Ryu M Randic 2004 Activation of presynaptic group I metabotropic glutamate receptors enhances glutamate release in the rat spinal cord substantia gelatinosa Neurosci Lett 361 220 224 1:CAS:528: DC%2BD2cXjvVGksLg%3D 15135933 10.1016/j.neulet.2003.12.075 (Pubitemid 38609256)
37. MA Abdul-Ghani TA Valiante PL Carlen PS Pennefather 1996 Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons J Neurophysiol 76 2691 2700 1:CAS:528:DyaK28XmvFKgt70%3D 8899638 (Pubitemid 26346440)
38. E Hermans RA Challiss 2001 Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors Biochem J 359 465 484 1:CAS:528:DC%2BD3MXovVSis7o%3D 11672421 10.1042/0264-6021:3590465 (Pubitemid 33063371)
39. P Chavis L Fagni JB Lansman J Bockaert 1996 Functional coupling between ryanodine receptors and L-type calcium channels in neurons Nature 382 719 722 1:CAS:528:DyaK28Xlt1ylt7o%3D 8751443 10.1038/382719a0 (Pubitemid 26282178)
40. L Fagni P Chavis F Ango J Bockaert 2000 Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons Trends Neurosci 23 80 88 1:CAS:528:DC%2BD3cXpsFKjtA%3D%3D 10652549 10.1016/S0166-2236(99)01492-7 (Pubitemid 30084765)
41. + channel by stimulation of glutamate phosphoinositide-coupled receptors in cultured cerebellar granule cells Eur J Neurosci 3 778 789 12106464 10.1111/j.1460-9568.1991.tb01674.x
42. + channel, GIRK, in Xenopus oocytes J Gen Physiol 109 477 490 1:CAS:528:DyaK2sXisFygsL8%3D 9101406 10.1085/jgp.109.4.477 (Pubitemid 27164465)
43. WY Lu ZG Xiong S Lei BA Orser E Dudek MD Browning JF Macdonald 1999 G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors Nat Neurosci 2 331 338 1:CAS:528:DyaK1MXitFGjs78%3D 10204539 10.1038/7243 (Pubitemid 30491275)
44. JC Tu B Xiao S Naisbitt JP Yuan RS Petralia P Brakeman A Doan VK Aakalu AA Lanahan M Sheng PF Worley 1999 Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins Neuron 23 583 592 1:CAS:528:DyaK1MXltVynurc%3D 10433269 10.1016/S0896-6273(00)80810-7 (Pubitemid 29359928)
45. H Husi MA Ward JS Choudhary WP Blackstock SG Grant 2000 Proteomic analysis of NMDA receptor-adhesion protein signaling complexes Nat Neurosci 3 661 669 1:CAS:528:DC%2BD3cXkvFaqtrw%3D 10862698 10.1038/76615 (Pubitemid 30437200)
46. L Mao L Yang Q Tang S Samdani G Zhang JQ Wang 2005 The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons J Neurosci 25 2741 2752 1:CAS:528:DC%2BD2MXis1ygsbw%3D 15758184 10.1523/JNEUROSCI.4360-04.2005 (Pubitemid 40365185)
47. R Rong JY Ahn H Huang E Nagata D Kalman JA Kapp J Tu PF Worley SH Snyder K Ye 2003 PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis Nat Neurosci 6 1153 1161 1:CAS:528: DC%2BD3sXosVOiurg%3D 14528310 10.1038/nn1134 (Pubitemid 37346035)
48. L Hou E Klann 2004 Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression J Neurosci 24 6352 6361 1:CAS:528:DC%2BD2cXmtFersb0%3D 15254091 10.1523/JNEUROSCI.0995-04.2004 (Pubitemid 38944226)
49. FM Ribeiro M Paquet LT Ferreira T Cregan P Swan SP Cregan SS Ferguson 2010 Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease J Neurosci 30 316 324 1:CAS:528:DC%2BC3cXmtVCisg%3D%3D 20053912 10.1523/JNEUROSCI.4974-09.2010
50. P Harjes EE Wanker 2003 The hunt for huntingtin function: interaction partners tell many different stories Trends Biochem Sci 28 425 433 1:CAS:528:DC%2BD3sXmsVGqsLg%3D 12932731 10.1016/S0968-0004(03)00168-3 (Pubitemid 36976745)
51. JH Cha CM Kosinski JA Kerner SA Alsdorf L Mangiarini SW Davies JB Penney GP Bates AB Young 1998 Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene Proc Natl Acad Sci U S A 95 6480 6485 1:CAS:528:DyaK1cXjtlKgtLc%3D 9600992 10.1073/pnas.95.11.6480 (Pubitemid 28249039)
52. EE Wanker C Rovira E Scherzinger R Hasenbank S Walter D Tait J Colicelli H Lehrach 1997 HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system Hum Mol Genet 6 487 495 1:CAS:528:DyaK2sXhvFKqsrc%3D 9147654 10.1093/hmg/6.3.487 (Pubitemid 27116471)
53. MA Kalchman HB Koide K McCutcheon RK Graham K Nichol K Nishiyama P Kazemi-Esfarjani FC Lynn C Wellington M Metzler YP Goldberg I Kanazawa RD Gietz MR Hayden 1997 HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain Nat Genet 16 44 53 1:CAS:528:DyaK2sXivFKhsLc%3D 9140394 10.1038/ng0597-44
54. RR Singaraja S Hadano M Metzler S Givan CL Wellington S Warby A Yanai CA Gutekunst BR Leavitt H Yi K Fichter L Gan K McCutcheon V Chopra J Michel SM Hersch JE Ikeda MR Hayden 2002 HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis Hum Mol Genet 11 2815 2828 1:CAS:528:DC%2BD38XptFKnsbg%3D 12393793 10.1093/hmg/11.23.2815 (Pubitemid 35331814)
55. E Cattaneo D Rigamonti D Goffredo C Zuccato F Squitieri S Sipione 2001 Loss of normal huntingtin function: new developments in Huntington's disease research Trends Neurosci 24 182 188 1:CAS:528:DC%2BD3MXht12isL4%3D 11182459 10.1016/S0166-2236(00)01721-5 (Pubitemid 32166824)
56. PH Anborgh C Godin M Pampillo GK Dhami LB Dale SP Cregan R Truant SS Ferguson 2005 Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin J Biol Chem 280 34840 34848 1:CAS:528:DC%2BD2MXhtVyks77P 16091361 10.1074/jbc.M504508200 (Pubitemid 41504618)
57. JH Cha 2007 Transcriptional signatures in Huntington's disease Prog Neurobiol 83 228 248 1:CAS:528:DC%2BD2sXhtF2msLnN 17467140 10.1016/j.pneurobio. 2007.03.004 (Pubitemid 47588642)
58. SJ Augood RL Faull DR Love PC Emson 1996 Reduction in enkephalin and substance P messenger RNA in the striatum of early grade Huntington's disease: a detailed cellular in situ hybridization study Neuroscience 72 1023 1036 1:STN:280:DyaK28zitl2jtQ%3D%3D 8735227 10.1016/0306-4522(95)00595-1 (Pubitemid 26135583)
59. L Menalled H Zanjani L MacKenzie A Koppel E Carpenter S Zeitlin MF Chesselet 2000 Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease Exp Neurol 162 328 342 1:CAS:528:DC%2BD3cXitVWqsbk%3D 10739639 10.1006/exnr.1999.7327 (Pubitemid 30217728)
60. JA Bibb Z Yan P Svenningsson GL Snyder VA Pieribone A Horiuchi AC Nairn A Messer P Greengard 2000 Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice Proc Natl Acad Sci U S A 97 6809 6814 1:CAS:528:DC%2BD3cXktFahsrw%3D 10829080 10.1073/pnas.120166397 (Pubitemid 30412796)
61. SJ Augood RL Faull PC Emson 1997 Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease Ann Neurol 42 215 221 1:CAS:528:DyaK2sXls1ynsb8%3D 9266732 10.1002/ana.410420213 (Pubitemid 27340467)
62. A Tarditi A Camurri K Varani PA Borea B Woodman G Bates E Cattaneo MP Abbracchio 2006 Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease Neurobiol Dis 23 44 53 1:CAS:528:DC%2BD28XlvFyqtLo%3D 16651003 10.1016/j.nbd.2006.01.014 (Pubitemid 43903630)
63. EM Denovan-Wright HA Robertson 2000 Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice Neuroscience 98 705 713 1:CAS:528:DC%2BD3cXks12ntr0%3D 10891614 10.1016/S0306-4522(00)00157-3 (Pubitemid 30417587)
64. EA McCaw H Hu GT Gomez AL Hebb ME Kelly EM Denovan-Wright 2004 Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice Eur J Biochem 271 4909 4920 1:CAS:528:DC%2BD2MXjvFCrtg%3D%3D 15606779 10.1111/j.1432-1033.2004.04460.x (Pubitemid 40065594)
65. N Chen T Luo C Wellington M Metzler K McCutcheon MR Hayden LA Raymond 1999 Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin J Neurochem 72 1890 1898 1:CAS:528:DyaK1MXis12lsbk%3D 10217265 10.1046/j.1471-4159.1999.0721890.x (Pubitemid 29185991)
66. Y Sun A Savanenin PH Reddy YF Liu 2001 Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-d-aspartate receptors via post-synaptic density 95 J Biol Chem 276 24713 24718 1:CAS:528:DC%2BD3MXlt1agsbY%3D 11319238 10.1074/jbc.M103501200
67. AV Panov CA Gutekunst BR Leavitt MR Hayden JR Burke WJ Strittmatter JT Greenamyre 2002 Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines Nat Neurosci 5 731 736 1:CAS:528: DC%2BD38XlsFaqu7g%3D 12089530 (Pubitemid 34827590)
68. YS Choo GV Johnson M MacDonald PJ Detloff M Lesort 2004 Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release Hum Mol Genet 13 1407 1420 1:CAS:528:DC%2BD2cXlt1WlsL4%3D 15163634 10.1093/hmg/ddh162 (Pubitemid 39023049)
69. 2+ signaling and apoptosis of medium spiny neurons in Huntington's disease Proc Natl Acad Sci U S A 102 2602 2607 1:CAS:528:DC%2BD2MXhvFKiu7s%3D 15695335 10.1073/pnas.0409402102 (Pubitemid 40279423)
70. TS Tang H Tu EY Chan A Maximov Z Wang CL Wellington MR Hayden I Bezprozvanny 2003 Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1 Neuron 39 227 239 1:CAS:528:DC%2BD3sXlvFyrs7Y%3D 12873381 10.1016/S0896-6273(03)00366-0 (Pubitemid 36897546)
71. S Gines E Ivanova IS Seong CA Saura ME MacDonald 2003 Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-d-aspartate receptor activation in Huntington's disease knock-in striatal cells J Biol Chem 278 50514 50522 1:CAS:528:DC%2BD3sXpslSqtLc%3D 14522959 10.1074/jbc.M309348200 (Pubitemid 37548897)
72. SR Datta A Brunet ME Greenberg 1999 Cellular survival: a play in three Akts Genes Dev 13 2905 2927 1:CAS:528:DyaK1MXnvVCltLo%3D 10579998 10.1101/gad.13.22.2905
73. ES Kandel N Hay 1999 The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB Exp Cell Res 253 210 229 1:CAS:528: DyaK1MXnsF2it7s%3D 10579924 10.1006/excr.1999.4690
74. S Humbert EA Bryson FP Cordelieres NC Connors SR Datta S Finkbeiner ME Greenberg F Saudou 2002 The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt Dev Cell 2 831 837 1:CAS:528:DC%2BD38XkslWqurk%3D 12062094 10.1016/S1534-5807(02)00188-0 (Pubitemid 34650078)
75. SC Warby CN Doty RK Graham J Shively RR Singaraja MR Hayden 2009 Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments Mol Cell Neurosci 40 121 127 1:CAS:528:DC%2BD1MXhs1akur4%3D 18992820 10.1016/j.mcn.2008.09.007
76. V Ries C Henchcliffe T Kareva M Rzhetskaya R Bland MJ During N Kholodilov RE Burke 2006 Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease Proc Natl Acad Sci U S A 103 18757 18762 1:CAS:528:DC%2BD28Xhtlahtb7P 17116866 10.1073/pnas.0606401103 (Pubitemid 44913483)
77. DP Hanger K Hughes JR Woodgett JP Brion BH Anderton 1992 Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase Neurosci Lett 147 58 62 1:CAS:528:DyaK3sXpvFGksg%3D%3D 1336152 10.1016/0304-3940(92)90774-2
78. J Magrane KM Rosen RC Smith K Walsh GK Gouras HW Querfurth 2005 Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response J Neurosci 25 10960 10969 1:CAS:528: DC%2BD2MXht1yks7%2FE 16306409 10.1523/JNEUROSCI.1723-05.2005 (Pubitemid 41692626)
79. M Cyr JM Beaulieu A Laakso TD Sotnikova WD Yao LM Bohn RR Gainetdinov MG Caron 2003 Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons Proc Natl Acad Sci U S A 100 11035 11040 1:CAS:528:DC%2BD3sXnslynu74%3D 12958210 10.1073/pnas.1831768100 (Pubitemid 37140148)
80. M Cyr TD Sotnikova RR Gainetdinov MG Caron 2006 Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin FASEB J 20 2541 2543 1:CAS:528:DC%2BD28Xht1ynsrzK 17065224 10.1096/fj.06-6533fje (Pubitemid 44953774)
81. D Charvin P Vanhoutte C Pages E Borrelli J Caboche 2005 Unraveling a role for dopamine in Huntington's disease: the dual role of reactive oxygen species and D2 receptor stimulation Proc Natl Acad Sci U S A 102 12218 12223 1:CAS:528:DC%2BD2MXps1yqsL8%3D 16103364 10.1073/pnas.0502698102 (Pubitemid 41291155)
82. A Benchoua Y Trioulier E Diguet C Malgorn MC Gaillard N Dufour JM Elalouf S Krajewski P Hantraye N Deglon E Brouillet 2008 Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II Hum Mol Genet 17 1446 1456 1:CAS:528:DC%2BD1cXltl2jurY%3D 18267960 10.1093/hmg/ddn033 (Pubitemid 351627341)
83. D Charvin E Roze V Perrin C Deyts S Betuing C Pages E Regulier R Luthi-Carter E Brouillet N Deglon J Caboche 2008 Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo Neurobiol Dis 29 22 29 1:CAS:528:DC%2BD2sXhsVSnsL7E 17905594 10.1016/j.nbd.2007.07.028 (Pubitemid 350182435)
84. C Deyts B Galan-Rodriguez E Martin N Bouveyron E Roze D Charvin J Caboche S Betuing 2009 Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation PLoS One 4 e8287 20016831 10.1371/journal.pone.0008287 1:CAS:528:DC%2BD1MXhsFOnu7%2FP
85. TS Tang X Chen J Liu I Bezprozvanny 2007 Dopaminergic signaling and striatal neurodegeneration in Huntington's disease J Neurosci 27 7899 7910 1:CAS:528:DC%2BD2sXoslSjsL8%3D 17652581 10.1523/JNEUROSCI.1396-07.2007 (Pubitemid 47173323)
86. P Paoletti I Vila M Rife JM Lizcano J Alberch S Gines 2008 Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5 J Neurosci 28 10090 10101 1:CAS:528:DC%2BD1cXht1ChsLfN 18829967 10.1523/JNEUROSCI.3237-08.2008
87. Y Gaoni R Mechoulam 1964 Isolation, structure and partial synthesis of an active constituent of hashish J Am Chem Soc 86 1646 1647 1:CAS:528: DyaF2cXkt1GhtLs%3D 10.1021/ja01062a046
88. LA Matsuda SJ Lolait MJ Brownstein AC Young TI Bonner 1990 Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 561 564 1:CAS:528:DyaK3cXls1Ghu7w%3D 2165569 10.1038/346561a0 (Pubitemid 20238806)
89. S Munro KL Thomas M bu-Shaar 1993 Molecular characterization of a peripheral receptor for cannabinoids Nature 365 61 65 1:CAS:528: DyaK3sXmsVWiurk%3D 7689702 10.1038/365061a0 (Pubitemid 23305569)
90. WA Devane L Hanus A Breuer RG Pertwee LA Stevenson G Griffin D Gibson A Mandelbaum A Etinger R Mechoulam 1992 Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 258 1946 1949 1:CAS:528:DyaK3sXpvVKntg%3D%3D 1470919 10.1126/science.1470919 (Pubitemid 23026736)
91. N Stella P Schweitzer D Piomelli 1997 A second endogenous cannabinoid that modulates long-term potentiation Nature 388 773 778 1:CAS:528: DyaK2sXls1Gqs7w%3D 9285589 10.1038/42015 (Pubitemid 27375156)
92. RI Wilson RA Nicoll 2001 Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses Nature 410 588 592 1:CAS:528: DC%2BD3MXis1Gru7w%3D 11279497 10.1038/35069076 (Pubitemid 32267203)
93. A Ameri 1999 The effects of cannabinoids on the brain Prog Neurobiol 58 315 348 1:CAS:528:DyaK1MXjs1ejs7c%3D 10368032 10.1016/S0301-0082(98)00087-2 (Pubitemid 29230000)
94. L Iversen 2003 Cannabis and the brain Brain 126 1252 1270 12764049 10.1093/brain/awg143 (Pubitemid 36644373)
95. AL De Oliveira BP Genro F Diehl JA Quillfeldt 2008 Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms Neurobiol Learn Mem 90 1 9 10.1016/j.nlm.2008.01.009 1:CAS:528:DC%2BD1cXmvVKltrk%3D
96. SG Kinsey JZ Long BF Cravatt AH Lichtman 2010 Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms J Pain 11 12 1420 8 1:CAS:528:DC%2BC3cXhsVymsL%2FM 20554481 10.1016/j.jpain.2010.04.001
97. K Starowicz S Nigam V Di Marzo 2007 Biochemistry and pharmacology of endovanilloids Pharmacol Ther 114 13 33 1:CAS:528:DC%2BD2sXjs1Kqsbw%3D 17349697 10.1016/j.pharmthera.2007.01.005 (Pubitemid 46498161)
98. V Micale C Mazzola F Drago 2007 Endocannabinoids and neurodegenerative diseases Pharmacol Res 56 382 392 1:CAS:528:DC%2BD2sXht1KgsbzN 17950616 10.1016/j.phrs.2007.09.008 (Pubitemid 350026397)
99. E Fride R Mechoulam 1993 Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent Eur J Pharmacol 231 313 314 1:CAS:528:DyaK3sXhsVCgtbc%3D 8384116 10.1016/0014-2999(93)90468-W (Pubitemid 23050919)
100. M Beltramo FR de Fonseca M Navarro A Calignano MA Gorriti G Grammatikopoulos AG Sadile A Giuffrida D Piomelli 2000 Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor J Neurosci 20 3401 3407 1:CAS:528:DC%2BD3cXivFKhtbg%3D 10777802 (Pubitemid 30263155)
101. J Fernandez-Ruiz 2009 The endocannabinoid system as a target for the treatment of motor dysfunction Br J Pharmacol 156 1029 1040 1:CAS:528: DC%2BD1MXltFSmur0%3D 19220290 10.1111/j.1476-5381.2008.00088.x
102. J Fernandez-Ruiz M Hernandez JA Ramos 2010 Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders CNS Neurosci Ther 16 e72 e91 1:CAS:528:DC%2BC3cXotVyitbg%3D 20406253 10.1111/j.1755-5949. 2010.00144.x
103. M Glass RL Faull M Dragunow 1993 Loss of cannabinoid receptors in the substantia nigra in Huntington's disease Neuroscience 56 523 527 1:STN:280:DyaK2c%2Fnslegsg%3D%3D 8255419 10.1016/0306-4522(93)90352-G (Pubitemid 23290567)
104. M Glass M Dragunow RL Faull 2000 The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease Neuroscience 97 505 519 1:CAS:528:DC%2BD3cXjs1GltbY%3D 10828533 10.1016/S0306-4522(00)00008-7 (Pubitemid 30320757)
105. KJ Page L Besret M Jain EM Monaghan SB Dunnett BJ Everitt 2000 Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia Exp Brain Res 130 142 150 1:CAS:528:DC%2BD3cXjs1CitQ%3D%3D 10672467 10.1007/s002210050016 (Pubitemid 30088252)
106. I Lastres-Becker M Gomez MR De JA Ramos J Fernandez-Ruiz 2002 Loss of cannabinoid CB(1) receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington's disease Neurotox Res 4 601 608 1:CAS:528:DC%2BD38Xpsl2rur8%3D 12709298 10.1080/10298420290030514 (Pubitemid 35390309)
107. B Naver C Stub M Moller K Fenger AK Hansen L Hasholt SA Sorensen 2003 Molecular and behavioral analysis of the R6/1 Huntington's disease transgenic mouse Neuroscience 122 1049 1057 1:CAS:528:DC%2BD3sXpt1SqtLc%3D 14643771 10.1016/j.neuroscience.2003.08.053 (Pubitemid 37485854)
108. MJ Dowie HB Bradshaw ML Howard LF Nicholson RL Faull AJ Hannan M Glass 2009 Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease Neuroscience 163 456 465 1:CAS:528:DC%2BD1MXhtVSmsrzN 19524019 10.1016/j.neuroscience.2009.06.014
109. I Lastres-Becker F Fezza M Cebeira T Bisogno JA Ramos A Milone J Fernandez-Ruiz V Di Marzo 2001 Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease NeuroReport 12 2125 2129 1:CAS:528:DC%2BD3MXls1enu7s%3D 11447320 10.1097/00001756-200107200-00017 (Pubitemid 32646258)
110. I Lastres-Becker MR De PL De A Makriyannis V Di Marzo J Fernandez-Ruiz 2003 Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease J Neurochem 84 1097 1109 1:CAS:528:DC%2BD3sXit1ejtLs%3D 12603833 10.1046/j.1471-4159.2003.01595.x (Pubitemid 36330662)
111. B Connor M Dragunow 1998 The role of neuronal growth factors in neurodegenerative disorders of the human brain Brain Res Brain Res Rev 27 1 39 1:CAS:528:DyaK1cXjvFOlurs%3D 9639663 10.1016/S0165-0173(98)00004-6 (Pubitemid 28300281)
112. LR Gauthier BC Charrin M Borrell-Pages JP Dompierre H Rangone FP Cordelieres MJ De ME MacDonald V Lessmann S Humbert F Saudou 2004 Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules Cell 118 127 138 1:CAS:528: DC%2BD2cXlvFejtbc%3D 15242649 10.1016/j.cell.2004.06.018 (Pubitemid 38902819)
113. C Zuccato A Ciammola D Rigamonti BR Leavitt D Goffredo L Conti ME MacDonald RM Friedlander V Silani MR Hayden T Timmusk S Sipione E Cattaneo 2001 Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease Science 293 493 498 1:CAS:528:DC%2BD3MXlsFGjtr0%3D 11408619 10.1126/science. 1059581 (Pubitemid 32679077)
114. C Zuccato M Tartari A Crotti D Goffredo M Valenza L Conti T Cataudella BR Leavitt MR Hayden T Timmusk D Rigamonti E Cattaneo 2003 Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes Nat Genet 35 76 83 1:CAS:528:DC%2BD3sXmslemu78%3D 12881722 10.1038/ng1219 (Pubitemid 37048599)
115. E Perez-Navarro AM Canudas P Akerund J Alberch E Arenas 2000 Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease J Neurochem 75 2190 2199 1:CAS:528:DC%2BD3cXns1eisr0%3D 11183872 10.1046/j.1471-4159.2000.0752190.x
116. AP Kells DM Fong M Dragunow MJ During D Young B Connor 2004 AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease Mol Ther 9 682 688 1:CAS:528:DC%2BD2cXjs1altrY%3D 15120329 10.1016/j.ymthe.2004.02.016 (Pubitemid 38660421)
117. JK Ryu J Kim SJ Cho K Hatori A Nagai HB Choi MC Lee JG McLarnon SU Kim 2004 Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease Neurobiol Dis 16 68 77 1:CAS:528:DC%2BD2cXjs1altLk%3D 15207263 10.1016/j.nbd.2004.01.016 (Pubitemid 38569797)
118. EJ Huang LF Reichardt 2001 Neurotrophins: roles in neuronal development and function Annu Rev Neurosci 24 677 736 1:CAS:528:DC%2BD3MXls1ShsL4%3D 11520916 10.1146/annurev.neuro.24.1.677 (Pubitemid 32695243)
119. S Almeida M Laco T Cunha-Oliveira CR Oliveira AC Rego 2009 BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons Neurobiol Dis 35 448 456 1:CAS:528:DC%2BD1MXpsFyls7k%3D 19555760 10.1016/j.nbd.2009.06.006
120. DA Simmons CS Rex L Palmer V Pandyarajan V Fedulov CM Gall G Lynch 2009 Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice Proc Natl Acad Sci U S A 106 4906 4911 1:CAS:528:DC%2BD1MXktFOjtbs%3D 19264961 10.1073/pnas.0811228106
121. MM Zeron O Hansson N Chen CL Wellington BR Leavitt P Brundin MR Hayden LA Raymond 2002 Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease Neuron 33 849 860 1:CAS:528:DC%2BD38Xis1Wrsbk%3D 11906693 10.1016/S0896-6273(02)00615-3 (Pubitemid 34246352)
122. XX Dong Y Wang ZH Qin 2009 Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases Acta Pharmacol Sin 30 379 387 1:CAS:528:DC%2BD1MXjvF2htb8%3D 19343058 10.1038/aps.2009.24
123. WC Koller MG Cersosimo 2004 Neuroprotection in Parkinson's disease: an elusive goal Curr Neurol Neurosci Rep 4 277 283 15217541 10.1007/s11910-004- 0052-2 (Pubitemid 39023096)
124. AC Rego LP de Almeida 2005 Molecular targets and therapeutic strategies in Huntington's disease Curr Drug Targets CNS Neurol Disord 4 361 381 1:CAS:528:DC%2BD2MXmvVyktL4%3D 16101555 10.2174/1568007054546081 (Pubitemid 41086756)
125. JH Yi AS Hazell 2006 Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury Neurochem Int 48 394 403 1:CAS:528:DC%2BD28XitVClsL8%3D 16473439 10.1016/j.neuint.2005.12.001 (Pubitemid 43327279)
126. JC Corona LB Romo R Tapia 2007 Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis Expert Opin Ther Targets 11 1415 1428 1:CAS:528:DC%2BD2sXht1amsbnI 18028007 10.1517/14728222.11.11.1415 (Pubitemid 350200478)
127. AS Hazell 2007 Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies Neurochem Int 50 941 953 1:CAS:528:DC%2BD2sXmvVKmsLo%3D 17576023 10.1016/j.neuint.2007.04.026 (Pubitemid 46962821)
128. M Mamelak 2007 Alzheimer' s disease, oxidative stress and gammahydroxybutyrate Neurobiol Aging 28 1340 1360 1:CAS:528:DC%2BD2sXotlahs7g%3D 16837107 10.1016/j.neurobiolaging.2006.06.008 (Pubitemid 47081231)
129. KR Turley LH Toledo-Pereyra RU Kothari 2005 Molecular mechanisms in the pathogenesis and treatment of acute ischemic stroke J Invest Surg 18 207 218 16126632 10.1080/08941930591004449 (Pubitemid 41200613)
130. NR Sims H Muyderman 2010 Mitochondria, oxidative metabolism and cell death in stroke Biochim Biophys Acta 1802 1 80 91 1:CAS:528:DC%2BD1MXhsFanurbP 19751827
131. RL Albin AB Young JB Penney B Handelin R Balfour KD Anderson DS Markel WW Tourtellotte A Reiner 1990 Abnormalities of striatal projection neurons and N-methyl-d-aspartate receptors in presymptomatic Huntington's disease N Engl J Med 322 1293 1298 1:STN:280:DyaK3c3itVOrug%3D%3D 1691447 10.1056/ NEJM199005033221807 (Pubitemid 20152493)
132. AB Young JT Greenamyre Z Hollingsworth R Albin C D'Amato I Shoulson JB Penney 1988 NMDA receptor losses in putamen from patients with Huntington's disease Science 241 981 983 1:CAS:528:DyaL1cXlsVOgurY%3D 2841762 10.1126/science.2841762
133. MF Beal NW Kowall DW Ellison MF Mazurek KJ Swartz JB Martin 1986 Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid Nature 321 168 171 1:CAS:528:DyaL28XktVCmtrg%3D 2422561 10.1038/321168a0 (Pubitemid 16022019)
134. P Hantraye D Riche M Maziere O Isacson 1990 A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon Exp Neurol 108 91 104 1:STN:280:DyaK3c3kt12itg%3D%3D 2139853 10.1016/0014-4886(90)90014-J (Pubitemid 20153928)
135. MM Zeron N Chen A Moshaver AT Lee CL Wellington MR Hayden LA Raymond 2001 Mutant huntingtin enhances excitotoxic cell death Mol Cell Neurosci 17 41 53 1:CAS:528:DC%2BD3MXlsVSmtQ%3D%3D 11161468 10.1006/mcne.2000.0909 (Pubitemid 32113537)
136. GB Landwehrmeyer DG Standaert CM Testa JB Penney Jr AB Young 1995 NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum J Neurosci 15 5297 5307 1:CAS:528:DyaK2MXmvFCrsbw%3D 7623152
137. H Monyer N Burnashev DJ Laurie B Sakmann PH Seeburg 1994 Developmental and regional expression in the rat brain and functional properties of four NMDA receptors Neuron 12 529 540 1:CAS:528:DyaK2cXitlKku7w%3D 7512349 10.1016/0896-6273(94)90210-0 (Pubitemid 24100885)
138. CL Thompson DL Drewery HD Atkins FA Stephenson PL Chazot 2000 Immunohistochemical localization of N-methyl-d-aspartate receptor NR1, NR2A, NR2B and NR2C/D subunits in the adult mammalian cerebellum Neurosci Lett 283 85 88 1:CAS:528:DC%2BD3cXitVSrt7Y%3D 10739881 10.1016/S0304-3940(00)00930-7 (Pubitemid 30156739)
139. AM Gerber ML Vallano 2006 Structural properties of the NMDA receptor and the design of neuroprotective therapies Mini Rev Med Chem 6 805 815 1:CAS:528:DC%2BD28XlvFCnsLs%3D 16842130 10.2174/138955706777698651 (Pubitemid 44027733)
140. C Ikonomidou L Turski 2002 Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol 1 383 386 1:CAS:528:DC%2BD3sXkvFKrtr8%3D 12849400 10.1016/S1474-4422(02)00164-3 (Pubitemid 37159164)
141. J Schiefer A Sprunken C Puls HG Luesse A Milkereit E Milkereit V Johann CM Kosinski 2004 The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease Brain Res 1019 246 254 1:CAS:528:DC%2BD2cXmslemsbg%3D 15306259 10.1016/j.brainres.2004.06.005 (Pubitemid 39078630)
142. DE Pellegrini-Giampietro F Peruginelli E Meli A Cozzi S Albani-Torregrossa R Pellicciari F Moroni 1999 Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms Neuropharmacology 38 1607 1619 1:CAS:528: DyaK1MXlvVWntr0%3D 10530822 10.1016/S0028-3908(99)00097-0 (Pubitemid 29457742)
143. VJ De E Horvath R Schreiber 2001 Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620 Eur J Pharmacol 428 203 214 10.1016/S0014-2999(01)01296-1 (Pubitemid 33000142)
144. A Cozzi E Meli V Carla R Pellicciari F Moroni DE Pellegrini-Giampietro 2002 Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neuropharmacology 43 119 130 1:CAS:528: DC%2BD38Xms1Gqtb8%3D 12213266 10.1016/S0028-3908(02)00080-1 (Pubitemid 35247600)
145. E Meli R Picca S Attucci A Cozzi F Peruginelli F Moroni DE Pellegrini-Giampietro 2002 Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo Pharmacol Biochem Behav 73 439 446 1:CAS:528:DC%2BD38XltFaitrw%3D 12117599 10.1016/S0091-3057(02)00834-1 (Pubitemid 34765581)
146. K Murotomi N Takagi G Takayanagi M Ono S Takeo K Tanonaka 2008 mGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia J Neurochem 105 1625 1634 1:CAS:528:DC%2BD1cXntVCksLk%3D 18248625 10.1111/j.1471-4159.2008.05260.x (Pubitemid 351678489)
147. F Ferraguti C Pietra E Valerio C Corti C Chiamulera F Conquet 1997 Evidence against a permissive role of the metabotropic glutamate receptor 1 in acute excitotoxicity Neuroscience 79 1 5 1:CAS:528:DyaK2sXjvVahs70%3D 9178862 10.1016/S0306-4522(97)00074-2 (Pubitemid 27244997)
148. V Bruno G Battaglia A Copani VM Cespedes MF Galindo V Cena J Sanchez-Prieto F Gasparini R Kuhn PJ Flor F Nicoletti 2001 An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors Eur J Neurosci 13 1469 1478 1:STN:280:DC%2BD3Mzhs12ntg%3D%3D 11328342 10.1046/j.0953-816x.2001.01541.x (Pubitemid 32423335)
149. CG Werner T Scartabelli T Pancani E Landucci F Moroni DE Pellegrini-Giampietro 2007 Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of ischemic tolerance Eur J Neurosci 25 3597 3604 17610579 10.1111/j.1460-9568.2007.05614.x (Pubitemid 47020453)